{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:28:12Z","timestamp":1790011692551,"version":"4.0.1"},"reference-count":40,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T00:00:00Z","timestamp":1719878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Psoriasis is a chronic, inflammatory, immuno-mediated cutaneous disease characterized by a prominent TNF\u03b1-IL23\/IL17 immune axis. In recent years, targeted therapies have become standard practice for managing moderate-to-severe psoriasis and have demonstrated efficacy. At the same time, identifying factors associated with the success or failure of TNF\u03b1 inhibitor therapy remains one of the most difficult aspects in psoriasis treatment. Methods: A clinical, non-randomized study was conducted to evaluate the impact of TNF\u03b1 inhibitors on the plasma cytokine profiles in patients with moderate-to-severe psoriasis vulgaris (ICD-10 code L40.0). The patients were treated with either etanercept, adalimumab, or infliximab for 16 weeks. Plasma cytokine profiles were assessed using a BioPlex200 System. Results: By the 16th week of therapy, a positive treatment response (PASI \u2265 75) was observed in 51 patients (63%), while 30 patients (37%) showed no response (PASI \u2264 50). When using etanercept, a positive effect was observed in 11 patients (41%), in 14 patients (52%) using adalimumab, and in 26 patients (96%) using infliximab. Analysis of the baseline cytokine levels revealed no differences between the \u201cpositive effect\u201d and \u201cno effect\u201d groups, except for IL20, which was 2.61 times higher in the \u201cpositive effect\u201d group compared to the \u201cno effect\u201d group, suggesting its potential predictive role in the effectiveness of therapy with TNF\u03b1 inhibitors. Treatment led to a decrease in IL17F, IL31, sCD40L, and VEGF for all patients, and in IL20 for the \u201cpositive effect\u201d group. The increase in ICAM1 in the \u201cno effect\u201d group suggests the possible retention of active migration and the fixation of T cells in the affected skin in these patients. No significant difference in cytokine levels was observed when categorizing patients into subgroups based on the effectiveness of therapy with etanercept, infliximab, and adalimumab; only a pre- and post-treatment difference in the whole cohort was noted. A random forest model showed the importance of VEGF, sCD40L, and ICAM1. Conclusions: The baseline levels of VEGF, sCD40L, and ICAM1, as well as IL20, could serve as potential predictors of treatment effectiveness using TNFa inhibitors. However, this hypothesis requires confirmation with a larger patient population.<\/jats:p>","DOI":"10.3390\/jcm13133895","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T11:23:55Z","timestamp":1719919435000},"page":"3895","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Plasma Cytokines for the Prediction of the Effectiveness of TNF\u03b1 Inhibitors Etanercept, Infliximab, and Adalimumab in the Treatment of Psoriasis"],"prefix":"10.3390","volume":"13","author":[{"given":"Arfenya","family":"Karamova","sequence":"first","affiliation":[{"name":"State Research Center of Dermatovenereology and Cosmetology, Moscow 107076, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludmila","family":"Znamenskaya","sequence":"additional","affiliation":[{"name":"State Research Center of Dermatovenereology and Cosmetology, Moscow 107076, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasiia","family":"Vorontsova","sequence":"additional","affiliation":[{"name":"State Research Center of Dermatovenereology and Cosmetology, Moscow 107076, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Obraztsova","sequence":"additional","affiliation":[{"name":"State Research Center of Dermatovenereology and Cosmetology, Moscow 107076, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandr","family":"Nikonorov","sequence":"additional","affiliation":[{"name":"State Research Center of Dermatovenereology and Cosmetology, Moscow 107076, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6360-2194","authenticated-orcid":false,"given":"Eugenia","family":"Nikonorova","sequence":"additional","affiliation":[{"name":"All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (VILAR), Moscow 117216, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9578-7947","authenticated-orcid":false,"given":"Dmitry","family":"Deryabin","sequence":"additional","affiliation":[{"name":"State Research Center of Dermatovenereology and Cosmetology, Moscow 107076, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexey","family":"Kubanov","sequence":"additional","affiliation":[{"name":"State Research Center of Dermatovenereology and Cosmetology, Moscow 107076, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e12946","DOI":"10.1111\/sji.12946","article-title":"The TNF\/IL-23\/IL-17 axis\u2014Head-to-head trials comparing different biologics in psoriasis treatment","volume":"92","author":"Petrovic","year":"2020","journal-title":"Scand. 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