{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T19:37:09Z","timestamp":1786390629525,"version":"build-2736575974"},"reference-count":49,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T00:00:00Z","timestamp":1720569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Hypoxia-inducible factor (HIF) plays a crucial role in regulating oxygen sensing and adaptation at the cellular level, overseeing cellular oxygen homeostasis, erythrocyte production, angiogenesis, and mitochondrial metabolism. The hypoxia-sensitive HIF-1\u03b1 subunit facilitates tissue adaptation to hypoxic conditions, including the stimulation of proangiogenic factors. Retinopathy of prematurity (ROP) is a proliferative vascular disease of the retina that poses a significant risk to prematurely born children. If untreated, ROP can lead to retinal detachment, severe visual impairment, and even blindness. The pathogenesis of ROP is not fully understood; however, reports suggest that premature birth leads to the exposure of immature ocular tissues to high levels of exogenous oxygen and hyperoxia, which increase the synthesis of reactive oxygen species and inhibit HIF expression. During the ischemic phase, HIF-1\u03b1 expression is stimulated in the hypoxia-sensitive retina, causing an overproduction of proangiogenic factors and the development of pathological neovascularization. Given the significant role of HIF-1\u03b1 in the development of ROP, considering it as a potential molecular target for therapeutic strategies appears justified. This review synthesizes information from the last six years (2018\u20132024) using databases such as PubMed, Google Scholar, and BASE, focusing on the role of HIF-1\u03b1 in the pathogenesis of ROP and its potential as a target for new therapies.<\/jats:p>","DOI":"10.3390\/jcm13144034","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T13:34:38Z","timestamp":1720618478000},"page":"4034","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Role of HIF-1\u03b1 in Retinopathy of Prematurity: A Review of Current Literature"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9221-8909","authenticated-orcid":false,"given":"Monika","family":"Modrzejewska","sequence":"first","affiliation":[{"name":"2nd Department of Ophthalmology, Pomeranian Medical University in Szczecin, Powsta\u0144c\u00f3w Wielkopolskich 72, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5432-3653","authenticated-orcid":false,"given":"Oliwia","family":"Zdanowska","sequence":"additional","affiliation":[{"name":"K. Marcinkowski University Hospital in Zielona G\u00f3ra, 65-046 Zielona G\u00f3ra, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7709-0651","authenticated-orcid":false,"given":"Piotr","family":"Po\u0142ubi\u0144ski","sequence":"additional","affiliation":[{"name":"Scientific Association of Students, 2nd Department of Ophthalmology, Pomeranian Medical University in Szczecin, Powsta\u0144c\u00f3w Wielkopolskich 72, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1001\/jamaophthalmol.2023.0809","article-title":"Epidemiology of Retinopathy of Prematurity in the US From 2003 to 2019","volume":"141","author":"Bhatnagar","year":"2023","journal-title":"JAMA Ophthalmol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Modrzejewska, M., and Bosy, W. 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