{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:35Z","timestamp":1790899235025,"version":"4.1.0"},"reference-count":47,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T00:00:00Z","timestamp":1720742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>(1) Background: The prevention of proximal femoral fractures among people of very advanced age is relevant as they are common and increasing in number. The aim of this study was to determine if the hip axis length (HAL) and the neck-shaft angle (caput\u2013collum\u2013diaphyseal CCD) are risk factors for those fractures among people aged 80 years and over. Consequently, it was additionally analysed if these parameters are associated with a certain fracture type. (2) Methods: Anteroposterior radiographs of the pelvis were collected to form three groups (femoral neck fractures (FNFx), trochanteric fractures (TFx) and non-fractured femora (NFx)). Two independent blinded observers separately conducted each measurement of the HAL and CCD. Statistical analysis was performed to determine the association between the measured parameters and type of fracture. (3) Results: One hundred and fifty patients (50 per group) were examined, of which the mean age was 92.7 \u00b1 3.5 (range 81\u2013104) years. Both the HAL and CCD of the FNFx group were significantly larger than in the TFx group (p = 0.013, 0.003). The CCD was higher in the FNFx than that of the NFx group (p = 0.001). No further significant differences of HAL and CCD were observed between the groups. (4) Conclusions: For people aged 80 years and over, an increased HAL represented no risk factor for proximal femur fractures, and a large HAL was associated with an increased occurrence of FNFx instead of TFx. A large CCD was associated with an increased risk of suffering a femoral neck fracture, showing evidence of the CCD being a risk factor for the extremely old population.<\/jats:p>","DOI":"10.3390\/jcm13144071","type":"journal-article","created":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T08:16:57Z","timestamp":1720772217000},"page":"4071","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Hip Axis Length and Femoral Neck-Shaft Angle as Risk Factors for Proximal Femur Fractures in Octogenarians to Centenarians"],"prefix":"10.3390","volume":"13","author":[{"given":"Daniel Alexandre","family":"Gumuchdjian","sequence":"first","affiliation":[{"name":"Clinic for Orthopaedics, Trauma Surgery and Hand Surgery, Stadtspital Z\u00fcrich, Ti\u00e8chestrasse 99, 8037 Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8192-0233","authenticated-orcid":false,"given":"Manuel","family":"Waltensp\u00fcl","sequence":"additional","affiliation":[{"name":"Clinic for Orthopaedics, Trauma Surgery and Hand Surgery, Stadtspital Z\u00fcrich, Ti\u00e8chestrasse 99, 8037 Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2512-3368","authenticated-orcid":false,"given":"Michael","family":"Dietrich","sequence":"additional","affiliation":[{"name":"Clinic for Orthopaedics, Trauma Surgery and Hand Surgery, Stadtspital Z\u00fcrich, Ti\u00e8chestrasse 99, 8037 Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8946-9304","authenticated-orcid":false,"given":"Method","family":"Kabelitz","sequence":"additional","affiliation":[{"name":"Clinic for Orthopaedics, Trauma Surgery and Hand Surgery, Stadtspital Z\u00fcrich, Ti\u00e8chestrasse 99, 8037 Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.rbo.2016.10.015","article-title":"Radiographic anatomy of the proximal femur: Femoral neck fracture vs. transtrochanteric fracture","volume":"52","author":"Lima","year":"2017","journal-title":"Rev. Bras. Ortop."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jor.2021.02.012","article-title":"CCD angle & hip fractures\u2014Predictor of fracture symmetry?","volume":"24","author":"Thalmann","year":"2021","journal-title":"J. Orthop."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s12962-023-00482-4","article-title":"Cost-effectiveness analysis of surgical proximal femur fracture prevention in elderly: A Markov cohort simulation model","volume":"21","author":"Alnemer","year":"2023","journal-title":"Cost Eff. Resour. Alloc."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/BOT.0b013e3182a22744","article-title":"A risk calculator for short-term morbidity and mortality after hip fracture surgery","volume":"28","author":"Pugely","year":"2014","journal-title":"J. Orthop. Trauma"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1007\/s001980170015","article-title":"Impact of hip and vertebral fractures on quality-adjusted life years","volume":"12","author":"Tosteson","year":"2001","journal-title":"Osteoporos. Int."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Falaschi, P., and Marsh, D. (2021). How Can We Prevent Falls?. Orthogeriatrics: The Management of Older Patients with Fragility Fractures, Springer. [2nd ed.].","DOI":"10.1007\/978-3-030-48126-1"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e2138911","DOI":"10.1001\/jamanetworkopen.2021.38911","article-title":"Evaluation of Clinical Practice Guidelines on Fall Prevention and Management for Older Adults: A Systematic Review","volume":"4","author":"Kamkar","year":"2021","journal-title":"JAMA Netw. Open"},{"key":"ref_8","first-page":"Cd009848","article-title":"Exercise for reducing fear of falling in older people living in the community","volume":"2014","author":"Kendrick","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/jbmr.3877","article-title":"Secondary Fracture Prevention: Consensus Clinical Recommendations from a Multistakeholder Coalition","volume":"35","author":"Conley","year":"2020","journal-title":"J. Bone Miner. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1210\/jc.2014-4390","article-title":"Hip axis length is a FRAX- and bone density-independent risk factor for hip fracture in women","volume":"100","author":"Leslie","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1136\/bmj.312.7041.1254","article-title":"Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures","volume":"312","author":"Marshall","year":"1996","journal-title":"BMJ"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1503\/cmaj.070234","article-title":"Low bone mineral density and fracture burden in postmenopausal women","volume":"177","author":"Cranney","year":"2007","journal-title":"CMAJ"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00198-007-0543-5","article-title":"FRAX and the assessment of fracture probability in men and women from the, U.K","volume":"19","author":"Kanis","year":"2008","journal-title":"Osteoporos. Int."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1007\/s00198-022-06435-6","article-title":"Update of the fracture risk prediction tool FRAX: A systematic review of potential cohorts and analysis plan","volume":"33","author":"Vandenput","year":"2022","journal-title":"Osteoporos. Int."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1016\/j.arth.2022.06.015","article-title":"Fracture Risk Assessment Tool Scores and Radiographical Bone Measurements in Total Hip Arthroplasty Patients","volume":"37","author":"Wang","year":"2022","journal-title":"J. Arthroplast."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1093\/aje\/kwx128","article-title":"Fracture Risk Assessment with FRAX Using Real-World Data in a Population-Based Cohort from Israel","volume":"187","author":"Goldshtein","year":"2018","journal-title":"Am. J. Epidemiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"eAO4236","DOI":"10.1590\/s1679-45082018ao4236","article-title":"Fracture risk assessment in home care patients using the FRAX\u00ae tool","volume":"16","author":"Rocha","year":"2018","journal-title":"Einstein"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.ejrad.2008.04.061","article-title":"Assessment of fracture risk","volume":"71","author":"Kanis","year":"2009","journal-title":"Eur. J. Radiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1007\/s10067-010-1489-0","article-title":"Fracture risk assessment in Latin America: Is Frax an adaptable instrument for the region?","volume":"29","author":"Clark","year":"2010","journal-title":"Clin. Rheumatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/s00198-010-1461-5","article-title":"Spine-hip discordance and fracture risk assessment: A physician-friendly FRAX enhancement","volume":"22","author":"Leslie","year":"2011","journal-title":"Osteoporos. Int."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1507\/endocrj.EJ17-0331","article-title":"Fracture risk assessment tool (FRAX) and for the diagnosis of osteoporosis in Japanese middle-aged and elderly women: Chiba bone survey","volume":"65","author":"Oka","year":"2018","journal-title":"Endocr. J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1007\/s40520-015-0406-4","article-title":"Proximal femur geometry assessed by hip structural analysis in hip fracture in women","volume":"27","author":"Iolascon","year":"2015","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e467","DOI":"10.1259\/bjr\/57130600","article-title":"Prediction of incident hip fracture by femoral neck bone mineral density and neck-shaft angle: A 5-year longitudinal study in post-menopausal females","volume":"85","author":"Gnudi","year":"2012","journal-title":"Br. J. Radiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s00198-005-0019-4","article-title":"Femur strength index predicts hip fracture independent of bone density and hip axis length","volume":"17","author":"Faulkner","year":"2006","journal-title":"Osteoporos. Int."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s198-002-8340-2","article-title":"Proximal femur geometry to detect and distinguish femoral neck fractures from trochanteric fractures in postmenopausal women","volume":"13","author":"Gnudi","year":"2002","journal-title":"Osteoporos. Int."},{"key":"ref_26","first-page":"1","article-title":"Hip geometry and femoral neck fractures: A meta-analysis","volume":"13","author":"Fajar","year":"2018","journal-title":"J. Orthop. Transl."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.jocd.2015.07.004","article-title":"Adjusting Hip Fracture Probability in Men and Women Using Hip Axis Length: The Manitoba Bone Density Database","volume":"19","author":"Leslie","year":"2016","journal-title":"J. Clin. Densitom."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00256-012-1473-7","article-title":"Prediction of hip osteoporotic fractures from composite indices of femoral neck strength","volume":"42","author":"Li","year":"2013","journal-title":"Skelet. Radiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.bone.2005.08.004","article-title":"Hip axis length as an independent risk factor for hip fracture independently of femural bone mineral density in Caucasian elderly Brazilian women","volume":"37","author":"Frisoli","year":"2005","journal-title":"Bone"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1002\/jbmr.5650081008","article-title":"Simple measurement of femoral geometry predicts hip fracture: The study of osteoporotic fractures","volume":"8","author":"Faulkner","year":"1993","journal-title":"J. Bone Miner. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00402-017-2857-x","article-title":"The nail-shaft-axis of the of proximal femoral nail antirotation (PFNA) is an important prognostic factor in the operative treatment of intertrochanteric fractures","volume":"138","author":"Jiamton","year":"2018","journal-title":"Arch. Orthop. Trauma Surg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2307\/2529310","article-title":"The measurement of observer agreement for categorical data","volume":"33","author":"Landis","year":"1977","journal-title":"Biometrics"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1093\/jhps\/hnu009","article-title":"Bony abnormalities of the hip joint: A new comprehensive, reliable and radiation-free measurement method using magnetic resonance imaging","volume":"1","author":"Commean","year":"2014","journal-title":"J. Hip Preserv. Surg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.bone.2009.08.059","article-title":"Analysis of hip geometry by clinical CT for the assessment of hip fracture risk in elderly Japanese women","volume":"46","author":"Ito","year":"2010","journal-title":"Bone"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1359\/jbmr.1997.12.11.1895","article-title":"Different morphometric and densitometric parameters predict cervical and trochanteric hip fracture: The EPIDOS Study","volume":"12","author":"Duboeuf","year":"1997","journal-title":"J. Bone Miner. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s00198-010-1301-7","article-title":"Proximal hip geometry and hip fracture risk assessment in a Korean population","volume":"22","author":"Im","year":"2011","journal-title":"Osteoporos. Int."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e33622","DOI":"10.1097\/MD.0000000000033622","article-title":"The effect of pre-fracture proximal femur geometry on hip fracture type in elderly patients","volume":"102","author":"Karagoz","year":"2023","journal-title":"Medicine"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Zhuang, H., Li, Y., Lin, J., Cai, D., Cai, S., Yan, L., and Yao, X. (2017). Cortical thickness in the intertrochanteric region may be relevant to hip fracture type. BMC Musculoskelet. Disord., 18.","DOI":"10.1186\/s12891-017-1669-z"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1016\/j.jbiomech.2010.02.032","article-title":"Assessment of the bilateral asymmetry of human femurs based on physical, densitometric, and structural rigidity characteristics","volume":"43","author":"Pierre","year":"2010","journal-title":"J. Biomech."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1007\/s00276-020-02676-4","article-title":"Morphological consistency of bilateral hip joints in adults based on the X-ray and CT data","volume":"43","author":"Zhao","year":"2021","journal-title":"Surg. Radiol. Anat."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1007\/s11999-012-2704-x","article-title":"Are the left and right proximal femurs symmetric?","volume":"471","author":"Young","year":"2013","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S8756-3282(00)00300-8","article-title":"Hip geometry, bone mineral distribution, and bone strength in European men and women: The EPOS study","volume":"27","author":"Crabtree","year":"2000","journal-title":"Bone"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s001980050059","article-title":"Bone mass and structure at the hip in men and women over the age of 60 years","volume":"8","author":"Peacock","year":"1998","journal-title":"Osteoporos. Int."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1080\/02841850510021562","article-title":"Geometry of the proximal femur in relation to age and sex: A cross-sectional study in healthy adult Danes","volume":"46","author":"Nissen","year":"2005","journal-title":"Acta Radiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.arthro.2012.07.008","article-title":"Sex differences of hip morphology in young adults with hip pain and labral tears","volume":"29","author":"Hetsroni","year":"2013","journal-title":"Arthroscopy"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1259\/bjr\/42380498","article-title":"Differences in bone mineral density and geometry in men and women: The Newcastle Thousand Families Study at 50 years old","volume":"78","author":"Tuck","year":"2005","journal-title":"Br. J. Radiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/jor.21265","article-title":"Gender differences in 3D morphology and bony impingement of human hips","volume":"29","author":"Nakahara","year":"2011","journal-title":"J. Orthop. Res."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/14\/4071\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:15:31Z","timestamp":1760109331000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/14\/4071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,12]]},"references-count":47,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["jcm13144071"],"URL":"https:\/\/doi.org\/10.3390\/jcm13144071","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,12]]}}}