{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T23:41:27Z","timestamp":1782776487245,"version":"3.54.5"},"reference-count":48,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T00:00:00Z","timestamp":1720915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Refractory end-stage pulmonary failure may benefit from extracorporeal life support (ECLS) as a bridge to lung transplantation. Veno-venous (VV) extracorporeal membrane oxygenation (ECMO) has been recommended for patients who have failed conventional medical therapy and mechanical ventilation. Veno-arterial (VA) ECMO may be used in patients with acute right ventricular (RV) failure, haemodynamic instability, or refractory respiratory failure. Peripheral percutaneous approaches, either dual-site single-lumen cannulation for veno-pulmonary (VP) ECMO or single-site dual-lumen (dl)VP ECMO, using the ProtekDuo right ventricular assist device (RVAD) cannula, has made this configuration a desirable option as a bridge to transplantation. These configurations support the right ventricle, prevent recirculation by placing the tricuspid and pulmonary valve between the drainage and return cannulas, provide the direct introduction of oxygenated blood into the pulmonary artery, and have been shown to decrease the incidence of acute kidney injury (AKI), requiring continuous renal replacement therapy (CRRT) in certain disease states. This promotes haemodynamic stability, potential sedation-weaning trials, extubation, mobilisation, and pre-transplant rehabilitation. Methods: A web-based literature search in PubMed and EMBASE was undertaken based on a combination of keywords. The PICOS and PRISMA approaches were used. Results: Four case series were identified out of 323 articles, with a total of 34 patients placed on VP ECMO as a bridge to lung transplantation. All relevant data are reviewed and integrated into the Discussion. Conclusions: Despite the limited available evidence, the use of ProtekDuo has become very promising for the management of end-stage lung disease as a bridge to lung transplantation.<\/jats:p>","DOI":"10.3390\/jcm13144111","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T14:15:49Z","timestamp":1721052949000},"page":"4111","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Outcome of Veno-Pulmonary Extracorporeal Life Support in Lung Transplantation Using ProtekDuo Cannula: A Systematic Review and Description of Configurations"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2351-9994","authenticated-orcid":false,"given":"Massimo","family":"Capoccia","sequence":"first","affiliation":[{"name":"South Yorkshire Cardiothoracic Centre, Northern General Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield S5 7AU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9323-0547","authenticated-orcid":false,"given":"Joseph M.","family":"Brewer","sequence":"additional","affiliation":[{"name":"Nazih Zuhdi Transplant Institute, Specialty Critical Care and Acute Circulatory Support Service, INTEGRIS Baptist Medical Center, Oklahoma City, OK 73112, USA"},{"name":"Queen\u2019s University Health Quality Programs, Kingston, ON K7L 3N6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2030-619X","authenticated-orcid":false,"given":"Mindaugas","family":"Rackauskas","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Thoracic Surgery, University of Florida College of Medicine, Gainesville, FL 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torben K.","family":"Becker","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Division of Critical Care Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk M.","family":"Maybauer","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine, Philipps University, 35032 Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5791-4554","authenticated-orcid":false,"given":"Yuriy","family":"Stukov","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Thoracic Surgery, University of Florida College of Medicine, Gainesville, FL 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1777-2045","authenticated-orcid":false,"given":"Roberto","family":"Lorusso","sequence":"additional","affiliation":[{"name":"Extracorporeal Life Support (ECLS) Centrum, Cardio-Thoracic Surgery and Cardiology Department, Heart & Vascular Center, Maastricht University Medical Center (MUMC), 6229 ER Maastricht, The Netherlands"},{"name":"Cardiovascular Research Institute (CARIM), 6229 ER Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc O.","family":"Maybauer","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine, Philipps University, 35032 Marburg, Germany"},{"name":"Department of Anesthesiology, Division of Critical Care Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA"},{"name":"Critical Care Research Group, The Prince Charles Hospital, University of Queensland, Brisbane 4032, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/ajt.16759","article-title":"Lung transplantation for acute respiratory distress syndrome: A multicentre experience","volume":"22","author":"Frick","year":"2022","journal-title":"Am. J. Transplant."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.thorsurg.2022.01.005","article-title":"Lung Transplantation for Acute Respiratory Distress Syndrome","volume":"32","author":"Bharat","year":"2022","journal-title":"Thorac. Surg. Clin."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41572-019-0069-0","article-title":"Acute respiratory distress syndrome","volume":"5","author":"Matthay","year":"2019","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1042\/bse0430061","article-title":"Hypoxic pulmonary vasoconstriction","volume":"43","author":"Mark","year":"2007","journal-title":"Essays Biochem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1093\/bjaed\/mkw076","article-title":"Hypoxic pulmonary vasoconstriction","volume":"17","author":"Tarry","year":"2017","journal-title":"BJA Educ."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.21037\/jtd.2017.05.69","article-title":"Hypercapnia during acute respiratory distress syndrome: The tree that hides the forest!","volume":"9","year":"2017","journal-title":"J. Thorac. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.chest.2017.02.019","article-title":"The Right Ventricle in ARDS","volume":"152","author":"Zochios","year":"2017","journal-title":"Chest"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s00134-022-06904-w","article-title":"Acute right ventricular injury phenotyping in ARDS","volume":"49","author":"Zochios","year":"2023","journal-title":"Intensive Care Med."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Petit, M., Jullien, E., and Vieillard-Baron, A. (2022). Right Ventricular Function in Acute Respiratory Distress Syndrome: Impact on Outcome, Respiratory Strategy and Use of Veno-Venous Extracorporeal Membrane Oxygenation. Front. Physiol., 12.","DOI":"10.3389\/fphys.2021.797252"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s40560-023-00689-w","article-title":"High driving pressure ventilation induces pulmonary hypertension in a rabbit model of acute lung injury","volume":"11","author":"Xu","year":"2023","journal-title":"J. Intensive Care"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1177\/03913988221142904","article-title":"The ProtekDuo in ECMO configuration for ARDS secondary to COVID-19: A systematic review","volume":"46","author":"Maybauer","year":"2023","journal-title":"Int. J. Artif. Organs"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1016\/j.jtcvs.2017.06.063","article-title":"Extracorporeal membrane oxygenation as a bridge to lung transplantation: A single-center experience in the present era","volume":"154","author":"Todd","year":"2017","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.athoracsur.2016.11.056","article-title":"Awake Extracorporeal Membrane Oxygenation as Bridge to Lung Transplantation: A 9-Year Experience","volume":"104","author":"Biscotti","year":"2017","journal-title":"Ann. Thorac. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1093\/ejcts\/ezy036","article-title":"Extracorporeal membrane oxygenation as bridge to lung transplantation may not impact overall mortality risk after transplantation: Results from a 7-year single-centre experience","volume":"54","author":"Ius","year":"2018","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.jtcvs.2017.09.161","article-title":"Extracorporeal life support as a bridge to lung transplantation-experience of a high-volume transplant center","volume":"155","author":"Hoetzenecker","year":"2018","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.athoracsur.2018.02.036","article-title":"Contemporary Outcomes of Extracorporeal Membrane Oxygenation Used as Bridge to Lung Transplantation","volume":"106","author":"Hakim","year":"2018","journal-title":"Ann. Thorac. Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/ccd.26348","article-title":"Current status of percutaneous right ventricular assist devices: First-in-man use of a novel dual lumen cannula","volume":"88","author":"Aggarwal","year":"2016","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"A1314","DOI":"10.1016\/S0735-1097(18)31855-2","article-title":"Use of Protek Duo Tandem Heart for Percutaneous Right Ventricular Support in Various Clinical Settings: A Case Series","volume":"71","author":"Nicolais","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"S674","DOI":"10.21037\/jtd.2017.10.75","article-title":"Right ventricular dysfunction during acute respiratory distress syndrome and veno-venous extracorporeal membrane oxygenation","volume":"10","author":"Bunge","year":"2018","journal-title":"J. Thorac. Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e0268","DOI":"10.1097\/CCE.0000000000000268","article-title":"Right Ventricular Dysfunction and Mortality After Cannulation for Venovenous Extracorporeal Membrane Oxygenation","volume":"2","author":"Ortiz","year":"2020","journal-title":"Crit. Care Explor."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1097\/MAT.0000000000001666","article-title":"Right Ventricular Dysfunction is Associated with Increased Mortality in Patients Requiring Venovenous Extracorporeal Membrane Oxygenation for Coronavirus Disease 2019","volume":"68","author":"Maharaj","year":"2022","journal-title":"ASAIO J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1016\/j.jtcvs.2022.12.013","article-title":"Worse survival in patients with right ventricular dysfunction and COVID-19-associated acute respiratory distress requiring extracorporeal membrane oxygenation: A multicentre study from the ORACLE group","volume":"167","author":"Cain","year":"2024","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Bagate, F., Masi, P., Boukantar, M., Radu, C., Saiydoun, G., Fiore, A., Chiaroni, P.-M., Teiger, E., Folliguet, T., and Gallet, R. (2024). Refractory cor pulmonale under extracorporeal membrane oxygenation for acute respiratory distress syndrome: The role of conversion to veno-pulmonary arterial assist\u2014A case series. Front. Med., 11.","DOI":"10.3389\/fmed.2024.1348077"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1177\/02676591221149859","article-title":"The ProtekDuo dual-lumen cannula for temporary acute mechanical circulatory support in right heart failure: A systematic review","volume":"38","author":"Brewer","year":"2023","journal-title":"Perfusion"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1177\/02676591221090607","article-title":"The novel ProtekDuo ventricular assist device: Configurations, technical aspects, and present evidence","volume":"38","author":"Maybauer","year":"2023","journal-title":"Perfusion"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1164\/rccm.201109-1599OC","article-title":"Extracorporeal membrane oxygenation in awake patients as bridge to lung transplantation","volume":"185","author":"Fuehner","year":"2012","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jclinepi.2009.06.006","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: Explanation and elaboration","volume":"62","author":"Liberati","year":"2009","journal-title":"J. Clin. Epidemiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"777","DOI":"10.7326\/M14-2385","article-title":"The PRISMA Extension Statement for Reporting of Systematic Reviews Incorporating Network Meta-analyses of Health Care Interventions: Checklist and Explanations","volume":"162","author":"Hutton","year":"2015","journal-title":"Ann. Intern. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2046-4053-4-1","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement","volume":"4","author":"Moher","year":"2015","journal-title":"Syst. Rev."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Brewer, J.M., Broman, L.M., Swol, J., Lorusso, R., Conrad, S.A., and Maybauer, M.O. (2023). Standardized nomenclature for peripheral percutaneous cannulation of the pulmonary artery in extracorporeal membrane oxygenation: Current uptake and recommendations for improvement. Perfusion, online ahead of print.","DOI":"10.1177\/02676591231210457"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1097\/MAT.0000000000002040","article-title":"A Plea for Adoption of the Common ECLS Nomenclature","volume":"70","author":"Brewer","year":"2024","journal-title":"ASAIO J."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Usman, A.A., Spelde, A.E., Lutfi, W., Gutsche, J.T., Vernick, W.J., Toubat, O., Olia, S.E., Cantu, E., Courtright, A., and Crespo, M.M. (2024). Percutaneous Venopulmonary Extracorporeal Membrane Oxygenation as Bridge to Lung Transplantation. ASAIO J., online ahead of print.","DOI":"10.1097\/MAT.0000000000002179"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"832","DOI":"10.21037\/jtd-21-1199","article-title":"Oxygenated right ventricular assist device with a percutaneous dual-lumen cannula as a bridge to lung transplantation","volume":"14","author":"Harano","year":"2022","journal-title":"J. Thorac. Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1053\/j.jvca.2021.07.010","article-title":"Right Ventricular Assist Device With Extracorporeal Membrane Oxygenation for Bridging Right Ventricular Heart Failure to Lung Transplantation: A Single-Center Case Series and Literature Review","volume":"36","author":"Lee","year":"2022","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1097\/TP.0000000000003459","article-title":"Oxy-right Ventricular Assist Device for Bridging of Right Heart Failure to Lung Transplantation","volume":"105","author":"Lee","year":"2021","journal-title":"Transplantation"},{"key":"ref_36","first-page":"1070","article-title":"Bridge to lung transplantation and rescue post-transplant: The expanding role of extracorporeal membrane oxygenation","volume":"6","author":"Gulack","year":"2014","journal-title":"J. Thorac. Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.thorsurg.2014.09.010","article-title":"ECMO as bridge to lung transplant","volume":"25","author":"Biscotti","year":"2015","journal-title":"Thorac. Surg. Clin."},{"key":"ref_38","unstructured":"Ricks, W.A., Rackauskas, M., Weir, W., Emtiazjoo, A., Saha, B.K., Gries, C.J., and Maybauer, M.O. The ProtekDuo Cannula for Pre-, Intra-, and Postoperative Lung Transplantation Management. Ann. Card. Anaesth., in press."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.ccm.2015.05.014","article-title":"Novel Uses of Extracorporeal Membrane Oxygenation in Adults","volume":"36","author":"Abrams","year":"2015","journal-title":"Clin. Chest Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1016\/j.transproceed.2013.07.005","article-title":"Extracorporeal membrane oxygenation as bridge to lung transplantation","volume":"45","author":"Anile","year":"2013","journal-title":"Transplant. Proc."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13054-014-0686-7","article-title":"Extracorporeal life support as bridge to lung transplantation: A systematic review","volume":"19","author":"Chiumello","year":"2015","journal-title":"Crit. Care"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1097\/EJA.0000000000000291","article-title":"How to minimise ventilator-induced lung injury in transplanted lungs: The role of protective ventilation and other strategies","volume":"32","author":"Sutherasan","year":"2015","journal-title":"Eur. J. Anaesthesiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/j.healun.2012.07.001","article-title":"Outcomes and temporal trends among high-risk patients after lung transplantation in the United States","volume":"31","author":"George","year":"2012","journal-title":"J. Heart Lung Transplant."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"4090","DOI":"10.21037\/jtd-22-1387","article-title":"Management of primary graft dysfunction after lung transplantation with extracorporeal life support: An evidence-based review","volume":"15","author":"Luu","year":"2023","journal-title":"J. Thorac. Dis."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"217","DOI":"10.4103\/aca.aca_49_21","article-title":"The ProtekDuo as Double Lumen Return Cannula in V-VP ECMO Configuration: A First-in-Man Method Description","volume":"25","author":"Maybauer","year":"2022","journal-title":"Ann. Card. Anaesth."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Landolt, L., Janelle, G.M., Ricks, W., Rackauskas, M., and Maybauer, M.O. (2024). Transesophageal Echocardiography Guided Veno-Pulmonary Extracorporeal Membrane Oxygenation Cannula Insertion Technique. ASAIO J., online ahead of print.","DOI":"10.1097\/MAT.0000000000002147"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Brewer, M., Dacey, C., and Maybauer, M.O. (2024). Adaptive ECMO Therapeutics: The Integral Role of the ProtekDuo\u00ae Cannula. From: Firstenberg MS Editor, Evolving Therapies and Technologies in Extracorporeal Membrane Oxygenation, Intechopen.","DOI":"10.5772\/intechopen.1005327"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Purevjav, E., Martinez, H., Towbin, J.A., and Boston, U. (2023). The ProtekDuo\u00ae Cannula for Acute Mechanical Circulatory Support, Intechopen. Ventricular Assist Devices\u2014Advances and Applications in Heart Failure.","DOI":"10.5772\/intechopen.102242"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/14\/4111\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:16:34Z","timestamp":1760109394000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/14\/4111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,14]]},"references-count":48,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["jcm13144111"],"URL":"https:\/\/doi.org\/10.3390\/jcm13144111","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,14]]}}}