{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T06:31:36Z","timestamp":1787985096373,"version":"build-2784847793"},"reference-count":51,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T00:00:00Z","timestamp":1720915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Pulmonary tuberculosis (TB) remains a major public health issue in India, with high incidence and mortality. The current literature on post-TB sequelae functional defects focuses heavily on spirometry, with conflicting obstruction vs. restriction data, lacks advanced statistical analysis, and has insufficient data on diffusion limitation and functional impairment. Objective: This study aimed to thoroughly evaluate post-tubercular sequelae after treatment, assessing chest radiology, spirometry, diffusing capacity, and exercise capacity. Methods: A total of 85 patients were studied at a university teaching hospital in Mysuru. The data collected included characteristics, comorbidities, smoking history, and respiratory symptoms. The investigations included spirometry, DLCO, chest X-rays with scoring, and 6MWT. Results: Of the patients, 70% had abnormal X-rays post-treatment, correlating with reduced lung function. Additionally, 70% had impaired spirometry with obstructive\/restrictive patterns, and 62.2% had reduced DLCO, with females at higher risk. Smoking increased the risk of sequelae. Conclusions: Most patients had residual radiological\/lung function abnormalities post-treatment. Advanced analyses provide insights into obstructive vs. restrictive defects. Ongoing research should explore pathogenetic mechanisms and therapeutic modalities to minimize long-term post-TB disability.<\/jats:p>","DOI":"10.3390\/jcm13144115","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T14:15:49Z","timestamp":1721052949000},"page":"4115","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Unveiling Silent Consequences: Impact of Pulmonary Tuberculosis on Lung Health and Functional Wellbeing after Treatment"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8665-1313","authenticated-orcid":false,"given":"Nidhi","family":"Bansal","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru 570015, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5858-8298","authenticated-orcid":false,"given":"Sumalatha","family":"Arunachala","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru 570015, India"},{"name":"Department of Critical Care Medicine, Adichunchanagiri Institute of Medical Sciences, Bellur 571448, India"},{"name":"Department of Critical Care, ClearMedi Multispecialty Hospital, Mysuru 570017, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8470-3114","authenticated-orcid":false,"given":"Mohammed","family":"Kaleem Ullah","sequence":"additional","affiliation":[{"name":"Centre for Excellence in Molecular Biology and Regenerative Medicine (A DST-FIST Supported Center), Department of Biochemistry (A DST-FIST Supported Department), JSS Medical College, JSS Academy of Higher Education and Research, Mysuru 570015, India"},{"name":"Division of Infectious Disease and Vaccinology, School of Public Health, University of California, Berkeley, CA 94720, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0147-8376","authenticated-orcid":false,"given":"Shreedhar","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru 570015, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6507-8098","authenticated-orcid":false,"given":"Sukanya","family":"Ravindran","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru 570015, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6781-3627","authenticated-orcid":false,"given":"Rekha Vaddarahalli","family":"ShankaraSetty","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru 570015, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sowmya","family":"Malamardi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru 570015, India"},{"name":"School of Psychology & Public Health, College of Science Health and Engineering, La Trobe University, Melbourne 3086, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4898-9466","authenticated-orcid":false,"given":"Sindaghatta Krishnarao","family":"Chaya","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru 570015, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5651-1123","authenticated-orcid":false,"given":"Komarla Sundararaja","family":"Lokesh","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru 570015, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7270-0247","authenticated-orcid":false,"given":"Ashwaghosha","family":"Parthasarathi","sequence":"additional","affiliation":[{"name":"Rutgers University Institute for Health, Healthcare Policy, and Aging Research, The State University of New Jersey, 112 Paterson Street, New Brunswick, NJ 08901, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3920-7570","authenticated-orcid":false,"given":"Bellipady","family":"Shyam Prasad Shetty","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic & Vascular Surgery, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru 570015, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashanth","family":"Chikkahonnaiah","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases, Princess Krishnajammanni Tuberculosis and Chest Diseases Hospital, Mysuru 570002, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant","family":"Vishwanath","sequence":"additional","affiliation":[{"name":"Centre for Excellence in Molecular Biology and Regenerative Medicine (A DST-FIST Supported Center), Department of Biochemistry (A DST-FIST Supported Department), JSS Medical College, JSS Academy of Higher Education and Research, Mysuru 570015, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayaraj Biligere","family":"Siddaiah","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru 570015, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1632-5945","authenticated-orcid":false,"given":"Padukudru Anand","family":"Mahesh","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru 570015, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,14]]},"reference":[{"key":"ref_1","unstructured":"(2023, April 24). 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