{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T21:21:01Z","timestamp":1788729661079,"version":"build-2803163510"},"reference-count":131,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:00:00Z","timestamp":1721088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Aortic stenosis (AS) represents a notable paradigm for cardiovascular (CV) and geriatric disorders owing to comorbidity. Transcatheter aortic valve replacement (TAVR) was initially considered a therapeutic strategy in elderly individuals deemed unsuitable for or at high risk of surgical valve replacement. The progressive improvement in TAVR technology has led to the need to refine older patients\u2019 stratification, progressively incorporating the concept of frailty and other geriatric vulnerabilities. Recognizing the intricate nature of the aging process, reliance exclusively on chronological age for stratification resulted in an initial but inadequate tool to assess both CV and non-CV risks effectively. A comprehensive geriatric evaluation should be performed before TAVR procedures, taking into account both physical and cognitive capabilities and post-procedural outcomes through a multidisciplinary framework. This review adopts a multidisciplinary perspective to delve into the diagnosis and holistic management of AS in elderly populations in order to facilitate decision-making, thereby optimizing outcomes centered around patient well-being.<\/jats:p>","DOI":"10.3390\/jcm13144169","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T12:29:43Z","timestamp":1721219383000},"page":"4169","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["A Comprehensive Geriatric Workup and Frailty Assessment in Older Patients with Severe Aortic Stenosis"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2028-2319","authenticated-orcid":false,"given":"Enrico","family":"Brunetti","sequence":"first","affiliation":[{"name":"Geriatric Unit, Department of Medical Sciences, University of Turin, Hospital Citt\u00e0 della Salute e della Scienza di Torino, 10126 Turin, Italy"},{"name":"Department of Experimental and Clinical Medicine, University of Florence, Largo G. Brambilla 3, 50134 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5369-5382","authenticated-orcid":false,"given":"Fabiana","family":"Luc\u00e0","sequence":"additional","affiliation":[{"name":"Cardiology Department, Grande Ospedale Metropolitano di Reggio, 89124 Reggio Calabria, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6680-7681","authenticated-orcid":false,"given":"Roberto","family":"Presta","sequence":"additional","affiliation":[{"name":"Geriatric Unit, Department of Medical Sciences, University of Turin, Hospital Citt\u00e0 della Salute e della Scienza di Torino, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8101-4695","authenticated-orcid":false,"given":"Niccol\u00f2","family":"Marchionni","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, University of Florence, Largo G. Brambilla 3, 50134 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Boccanelli","sequence":"additional","affiliation":[{"name":"UniCamillus University, 00131 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Ungar","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, University of Florence, Largo G. Brambilla 3, 50134 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmelo Massimiliano","family":"Rao","sequence":"additional","affiliation":[{"name":"Cardiology Department, Grande Ospedale Metropolitano di Reggio, 89124 Reggio Calabria, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Ingianni","sequence":"additional","affiliation":[{"name":"Cardiology ASP, 91100 Trapani, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maddalena","family":"Lettino","sequence":"additional","affiliation":[{"name":"Department for Cardiac, Thoracic and Vascular Diseases, Fondazione IRCCS San Gerardo dei Tintori, 20900 Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donatella","family":"Del Sindaco","sequence":"additional","affiliation":[{"name":"UOC Santo Spirito-Nuova Regina Margherita-ASL Rome 1, 00153 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano","family":"Murrone","sequence":"additional","affiliation":[{"name":"S.C. 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De Gasperis\u201d, ASST Niguarda Hospital, 20162 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2945-0243","authenticated-orcid":false,"given":"Mario","family":"Bo","sequence":"additional","affiliation":[{"name":"Geriatric Unit, Department of Medical Sciences, University of Turin, Hospital Citt\u00e0 della Salute e della Scienza di Torino, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0038-9445","authenticated-orcid":false,"given":"Iris","family":"Parrini","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Mauriziano Hospital, 10128 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1136\/heartjnl-2021-319025","article-title":"Cumulative burden of clinically significant aortic stenosis in community-dwelling older adults","volume":"107","author":"Owens","year":"2021","journal-title":"Heart"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1136\/heartjnl-2021-319697","article-title":"Incident aortic stenosis in 49,449 men and 42,229 women investigated with routine echocardiography","volume":"108","author":"Stewart","year":"2022","journal-title":"Heart"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1136\/heartjnl-2020-316661","article-title":"Cochrane corner: Transcatheter aortic valve implantation versus surgical aortic valve replacement for severe aortic stenosis in people with low surgical risk","volume":"106","author":"Kolkailah","year":"2020","journal-title":"Heart"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1056\/NEJMoa1514616","article-title":"Transcatheter or Surgical Aortic-Valve Replacement in Intermediate-Risk Patients","volume":"374","author":"Leon","year":"2016","journal-title":"N. 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