{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T16:17:55Z","timestamp":1773850675423,"version":"3.50.1"},"reference-count":27,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2024,7,28]],"date-time":"2024-07-28T00:00:00Z","timestamp":1722124800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Patients with cardiogenic shock (CS) and mitral regurgitation (MI) have a prohibitive risk that contraindicates surgical treatment. Although the feasibility of transcatheter edge-to-edge therapy (TEER) has been demonstrated in this setting, the benefit of the combined use of TEER with mechanical circulatory support devices (MCS) has not been studied. The aim of this study was to evaluate the clinical outcomes of TEER in patients with MCS. Methods: The MITRA-ASSIST study is a retrospective multicentre Spanish registry that included patients with MR and CS who underwent TEER in combination with MCS. The primary endpoint was death from any cause at 12 months. The secondary endpoint was a composite of death from any cause or hospitalisation for heart failure at 12 months. Results: A total of twenty-four patients in nine high-volume Spanish centres (66.2 (51\u201382) years, 70.8% female, EuroSCORE II 20.4 \u00b1 17.8) were included. Acute ST-elevation myocardial infarction was the main CS aetiology (56%), and the most implanted MCS was the intra-aortic balloon pump (82.6%), followed by ECMO (8.7%), IMPELLACP\u00ae (4.3%), or a combination of both (4.3%). Procedural success was 95.8%, with 87.5% in-hospital survival. At 12-month follow-up, 25.0% of patients died, and 33.3% had a composite event of death from any cause or hospitalisation for heart failure. Conclusions: TEER in patients with concomitant CS and MR who require MCS appears to be a promising therapeutic alternative with a high device procedural success rate and acceptable mortality and heart failure readmission rates at follow-up.<\/jats:p>","DOI":"10.3390\/jcm13154408","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T09:50:05Z","timestamp":1722246605000},"page":"4408","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Combined Use of MITRACLIP and Ventricular ASSIST Devices in Cardiogenic Shock: MITRA-ASSIST Registry"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5018-4392","authenticated-orcid":false,"given":"Borja","family":"Rivero-Santana","sequence":"first","affiliation":[{"name":"Cardiology Department, La Paz University Hospital, 28046 Madrid, Spain"},{"name":"Hospital La Paz Institute for Health Research, IdiPAZ, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6362-7618","authenticated-orcid":false,"given":"Alfonso","family":"Jurado-Roman","sequence":"additional","affiliation":[{"name":"Cardiology Department, La Paz University Hospital, 28046 Madrid, Spain"},{"name":"Hospital La Paz Institute for Health Research, IdiPAZ, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5433-1364","authenticated-orcid":false,"given":"Isaac","family":"Pascual","sequence":"additional","affiliation":[{"name":"Hospital Universitario Central de Asturias, 33011 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7556-3711","authenticated-orcid":false,"given":"Chi Hion","family":"Li","sequence":"additional","affiliation":[{"name":"Hospital de la Santa Creu i Sant Pau, 08025 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7562-8677","authenticated-orcid":false,"given":"Pilar","family":"Jimenez","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Estevez-Loureiro","sequence":"additional","affiliation":[{"name":"Complexo Hospitalario Universitario de Vigo, 36312 Vigo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Cepas-Guill\u00e9n","sequence":"additional","affiliation":[{"name":"Hospital Clinic, 08036 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8428-9248","authenticated-orcid":false,"given":"Tom\u00e1s","family":"Benito-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Le\u00f3n, 24008 Le\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Serrador","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico de Valladolid, 47003 Valladolid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Maria","family":"De La Torre-Hernandez","sequence":"additional","affiliation":[{"name":"Hospital Universitario Marqu\u00e9s de Valdecilla, 39008 Santander, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4958-6108","authenticated-orcid":false,"given":"Pablo","family":"Avanzas","sequence":"additional","affiliation":[{"name":"Hospital Universitario Central de Asturias, 33011 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3025-8251","authenticated-orcid":false,"given":"Estefania","family":"Fernandez-Peregrina","sequence":"additional","affiliation":[{"name":"Hospital de la Santa Creu i Sant Pau, 08025 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Nombela","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berenice","family":"Caneiro-Queija","sequence":"additional","affiliation":[{"name":"Complexo Hospitalario Universitario de Vigo, 36312 Vigo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Freixas","sequence":"additional","affiliation":[{"name":"Hospital Clinic, 08036 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe","family":"Fernandez-Vazquez","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Le\u00f3n, 24008 Le\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2311-4129","authenticated-orcid":false,"given":"Ignacio","family":"Amat-Santos","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico de Valladolid, 47003 Valladolid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae-Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Hospital Universitario Marqu\u00e9s de Valdecilla, 39008 Santander, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Leon","sequence":"additional","affiliation":[{"name":"Hospital Universitario Central de Asturias, 33011 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dabit","family":"Arzamendi","sequence":"additional","affiliation":[{"name":"Hospital de la Santa Creu i Sant Pau, 08025 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raul","family":"Moreno","sequence":"additional","affiliation":[{"name":"Cardiology Department, La Paz University Hospital, 28046 Madrid, Spain"},{"name":"Hospital La Paz Institute for Health Research, IdiPAZ, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Galeote","sequence":"additional","affiliation":[{"name":"Cardiology Department, La Paz University Hospital, 28046 Madrid, Spain"},{"name":"Hospital La Paz Institute for Health Research, IdiPAZ, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1001\/jama.2021.18323","article-title":"Cardiogenic Shock after Acute Myocardial Infarction: A 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