{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:18:10Z","timestamp":1760145490902,"version":"build-2065373602"},"reference-count":27,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T00:00:00Z","timestamp":1722297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: The objective of our study was to assess the prenatal course, associated anomalies and postnatal outcome and the predictive value of various prenatal parameters for survival in prenatally diagnosed cases of truncus arteriosus communis (TAC). Methods: We evaluated cases from four centers between 2008 and 2021. Results: In 37\/47 cases (78.7%), classification into a Van Praagh sbtype was possible, most had TAC type A1 (18\/37 = 48.6%). In 33\/47 (70.2%) with available valve details on common trunk valve, most presented with tricuspid valves (13\/33 = 39.4%). In the overall sample, 14\/47 (29.8%) had relevant insufficiency, and 8\/47 (17%) had stenosis. In total, 37\/47 (78.7%) underwent karyotyping, with 15\/37 (40.5%) showing abnormal results, mainly 22q11.2 microdeletion (9\/37 = 24.3%). Overall, 17\/47 (36.2%) had additional extracardiac anomalies (17\/47 = 36.2%). Additional intracardiac anomalies were present in 30\/47 (63.8%), or 32\/47 (68.1%) if coronary anomalies were included. Four (8.5%) had major defects. Two (4.3%) intrauterine deaths occurred, in 10 (21.3%) cases, the parents opted for termination, predominantly in non-isolated cases (8\/10 = 80.0%). A total of 35\/47 (74.5%) were born alive at 39 (35\u201341) weeks. Three (8.6%) pre-surgical deaths occurred in non-isolated cases. In 32\/35 (91.4%), correction surgery was performed. The postoperative survival rate was 84.4% (27\/32) over a median follow-up of 51.5 months. Initial intervention was performed 16 (1\u201371) days postpartum, and 22\/32 (68.8%) required re-intervention. Regarding prenatal outcome-predicting parameters, no significant differences were identified between the survivor and non-survivor groups. Conclusions: There exist limited outcome data for TAC. To our knowledge, this is the largest multicenter, prenatal cohort with an intention-to-treat survival rate of almost 85%.<\/jats:p>","DOI":"10.3390\/jcm13154465","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T15:25:23Z","timestamp":1722353123000},"page":"4465","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prenatal Diagnosis, Course and Outcome of Patients with Truncus Arteriosus Communis"],"prefix":"10.3390","volume":"13","author":[{"given":"Aline","family":"Wolter","sequence":"first","affiliation":[{"name":"Division of Prenatal Medicine, Department of Obstetrics and Gynecology, Justus-Liebig University and University Hospital UKGM Giessen, 35392 Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annika","family":"Haessig","sequence":"additional","affiliation":[{"name":"Division of Prenatal Medicine, Department of Obstetrics and Gynecology, Justus-Liebig University and University Hospital UKGM Giessen, 35392 Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5654-9559","authenticated-orcid":false,"given":"Andrii","family":"Kurkevych","sequence":"additional","affiliation":[{"name":"Pediatric Heart Centre, 04050 Kiew, Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3388-0636","authenticated-orcid":false,"given":"Jan","family":"Weichert","sequence":"additional","affiliation":[{"name":"Division of Prenatal Medicine, Department of Obstetrics and Gynecology, University Hospital of Schleswig-Holstein, Campus L\u00fcbeck, 23538 L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Bosselmann","sequence":"additional","affiliation":[{"name":"Prenatal Medicine, Prenatal Care Center Stuttgart, 70184 Stuttgart, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunther","family":"Mielke","sequence":"additional","affiliation":[{"name":"Prenatal Medicine, Prenatal Care Center Stuttgart, 70184 Stuttgart, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7688-5357","authenticated-orcid":false,"given":"Ivonne Alexandra","family":"Bedei","sequence":"additional","affiliation":[{"name":"Division of Prenatal Medicine, Department of Obstetrics and Gynecology, Justus-Liebig University and University Hospital UKGM Giessen, 35392 Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Schenk","sequence":"additional","affiliation":[{"name":"Division of Prenatal Medicine, Department of Obstetrics and Gynecology, Justus-Liebig University and University Hospital UKGM Giessen, 35392 Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellydda","family":"Widriani","sequence":"additional","affiliation":[{"name":"Division of Prenatal Medicine, Department of Obstetrics and Gynecology, Justus-Liebig University and University Hospital UKGM Giessen, 35392 Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Axt-Fliedner","sequence":"additional","affiliation":[{"name":"Division of Prenatal Medicine, Department of Obstetrics and Gynecology, Justus-Liebig University and University Hospital UKGM Giessen, 35392 Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1046\/j.1469-7580.2003.00168.x","article-title":"Septation and separation within the outflow tract of the developing heart","volume":"202","author":"Webb","year":"2003","journal-title":"J. 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Anesth."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/15\/4465\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:26:45Z","timestamp":1760110005000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/15\/4465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,30]]},"references-count":27,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["jcm13154465"],"URL":"https:\/\/doi.org\/10.3390\/jcm13154465","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2024,7,30]]}}}