{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T01:23:46Z","timestamp":1789176226534,"version":"build-2803163510"},"reference-count":23,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T00:00:00Z","timestamp":1722297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of Health with Current Research funds"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Myelin oligodendrocyte glycoprotein antibody disease (MOGAD) is characterized by multiple phenotypic conditions such as acute disseminated encephalomyelitis, optic neuritis, and myelitis. MOGAD\u2019s spectrum is expanding, with potential symptoms of increased intracranial pressure that are similar to idiopathic intracranial hypertension (IIH). We report a boy with new-onset continuous headache and a brain MRI at onset suggesting idiopathic intracranial hypertension (IIH). The patient showed resistance to treatment with acetazolamide and, after one month, developed optic neuritis in the left eye. Laboratory tests documented positive MOG antibodies (anti-MOG) in the serum. The final diagnosis was MOGAD, with the initial symptoms resembling IIH.<\/jats:p>","DOI":"10.3390\/jcm13154468","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T17:08:34Z","timestamp":1722359314000},"page":"4468","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Isolated Intracranial Hypertensions as Onset of Myelin Oligodendrocyte Glycoprotein Antibody Disease"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3336-9205","authenticated-orcid":false,"given":"Laura","family":"Papetti","sequence":"first","affiliation":[{"name":"Developmental Neurology Unit, Bambino Ges\u00f9 Children\u2019s Hospital IRCCS, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Moltoni","sequence":"additional","affiliation":[{"name":"Functional and Interventional Neuroradiology Unit, Bambino Ges\u00f9 Children\u2019s Hospital IRCCS, 00165 Rome, Italy"},{"name":"Neuroradiology Unit, NESMOS Department Sant\u2019Andrea Hospital, La Sapienza University, Via di Grottarossa, 1035-1039, 00189 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Longo","sequence":"additional","affiliation":[{"name":"Functional and Interventional Neuroradiology Unit, Bambino Ges\u00f9 Children\u2019s Hospital IRCCS, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Monte","sequence":"additional","affiliation":[{"name":"Developmental Neurology Unit, Bambino Ges\u00f9 Children\u2019s Hospital IRCCS, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4435-5826","authenticated-orcid":false,"given":"Francesco","family":"Dellepiane","sequence":"additional","affiliation":[{"name":"Functional and Interventional Neuroradiology Unit, Bambino Ges\u00f9 Children\u2019s Hospital IRCCS, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6486-5201","authenticated-orcid":false,"given":"Stefano","family":"Pro","sequence":"additional","affiliation":[{"name":"Developmental Neurology Unit, Bambino Ges\u00f9 Children\u2019s Hospital IRCCS, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Bracaglia","sequence":"additional","affiliation":[{"name":"Department of Diagnostics and Laboratory Medicine, Medical Laboratory Unit, Unit of Allergy and Autoimmunity, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Ruscitto","sequence":"additional","affiliation":[{"name":"Developmental Neurology Unit, Bambino Ges\u00f9 Children\u2019s Hospital IRCCS, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Verrotti","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Perugia, 06123 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6602-103X","authenticated-orcid":false,"given":"Massimiliano","family":"Valeriani","sequence":"additional","affiliation":[{"name":"Developmental Neurology Unit, Bambino Ges\u00f9 Children\u2019s Hospital IRCCS, 00165 Rome, Italy"},{"name":"Systems Medicine Department, Hospital of Rome, Tor Vergata University, 00133 Rome, Italy"},{"name":"Center for Sensory Motor Interaction, Aalborg University, DK-9220 Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/S1474-4422(22)00431-8","article-title":"Diagnosis of myelin oligodendrocyte glycoprotein antibody-associated disease: International MOGAD Panel proposed criteria","volume":"22","author":"Banwell","year":"2023","journal-title":"Lancet Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Mao, L., Yang, L., Kessi, M., He, F., Zhang, C., Wu, L., Yin, F., and Peng, J. (2019). Myelin Oligodendrocyte Glycoprotein (MOG) Antibody Diseases in Children in Central South China: Clinical Features, Treatments, Influencing Factors, and Outcomes. Front. Neurol., 10.","DOI":"10.3389\/fneur.2019.00868"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.pediatrneurol.2019.03.009","article-title":"Acute Disseminated Encephalomyelitis (ADEM) and Increased Intracranial Pressure Associated with Anti-Myelin Oligodendrocyte Glycoprotein Antibodies","volume":"99","author":"Narayan","year":"2019","journal-title":"Pediatr. Neurol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/s41433-018-0238-5","article-title":"The expanding burden of idiopathic intracranial hypertension","volume":"33","author":"Mollan","year":"2019","journal-title":"Eye"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Headache Classification Committee of the International Headache Society (IHS) (2013). The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia, 33, 629\u2013808.","DOI":"10.1177\/0333102413485658"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1177\/19418744231192159","article-title":"Perplexing Initial Presentations of MOGAD in Two Children: Intracranial Hypertension and New-Onset Seizure","volume":"13","author":"Zhou","year":"2023","journal-title":"Neurohospitalist"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e32986","DOI":"10.1097\/MD.0000000000032986","article-title":"Pediatric myelin oligodendrocyte glycoprotein antibody associated diseaseasymmetric papilledema and elevated ICP are two of the chameleons: A case report","volume":"102","author":"Alqahtani","year":"2023","journal-title":"Medicine"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"100028","DOI":"10.1016\/j.nerep.2021.100028","article-title":"Atypical myelin oligodendrocyte glycoprotein antibody disease presenting with isolated elevated intracranial pressure","volume":"1","author":"Valdrighi","year":"2021","journal-title":"Neuroimmunol. Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"578083","DOI":"10.1016\/j.jneuroim.2023.578083","article-title":"Paediatric MOG-antibody disease presenting with intracranial hypertension and unilateral vision loss without radiological evidence of optic neuritis","volume":"15","author":"Maran","year":"2023","journal-title":"J. Neuroimmunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1007\/s00415-018-8956-y","article-title":"Myelin oligodendrocyte glycoprotein-positive optic neuritis masquerading as pseudotumor cerebri at presentation","volume":"265","author":"Lotan","year":"2018","journal-title":"J. Neurol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.pediatrneurol.2015.01.002","article-title":"Elevated cerebrospinal fluid opening pressure in a pediatric demyelinating disease cohort","volume":"52","author":"Narula","year":"2015","journal-title":"Pediatr. Neurol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"5647","DOI":"10.1007\/s00415-022-11130-x","article-title":"Anti-MOG associated disease with intracranial hypertension after COVID-19 vaccination","volume":"269","author":"Jeantin","year":"2022","journal-title":"J. Neurol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.msard.2018.10.003","article-title":"Atypical Anti-MOG syndrome with aseptic meningoencephalitis and pseudotumor cerebri-like presentations","volume":"27","author":"Narayan","year":"2019","journal-title":"Mult. Scler. Relat. Disord."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e200020","DOI":"10.1212\/NXI.0000000000200020","article-title":"Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease Presenting as Intracranial Hypertension: A Case Report","volume":"9","author":"Chaudhuri","year":"2022","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Papetti, L., Panella, E., Monte, G., Ferilli, M.A.N., Tarantino, S., Checchi, M.P., and Valeriani, M. (2023). Pediatric Onset Multiple Sclerosis and Obesity: Defining the Silhouette of Disease Features in Overweight Patients. Nutrients, 15.","DOI":"10.3390\/nu15234880"},{"key":"ref_16","first-page":"e28071","article-title":"A Systematic Review on Whether an Association Exists between Adolescent Obesity and Idiopathic Intracranial Hypertension","volume":"8","author":"Zafar","year":"2022","journal-title":"Cureus"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.4103\/ijo.IJO_252_21","article-title":"Commentary: The role of inflammation in idiopathic intracranial hypertension","volume":"6","author":"Sudhakar","year":"2021","journal-title":"Indian J. Ophthalmol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"5348","DOI":"10.1210\/jc.2010-0729","article-title":"Cerebrospinal fluid corticosteroid levels and cortisol metabolism in patients with idiopathic intracranial hypertension: A link between 11beta-HSD1 and intracranial pressure regulation?","volume":"95","author":"Sinclair","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.bbi.2017.11.015","article-title":"11beta-hydroxysteroid dehydrogenase-1 deficiency alters brain energy metabolism in acute systemic inflammation","volume":"69","author":"Verma","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"ref_20","first-page":"234","article-title":"Increased levels of interleukins 2 and 17 in the cerebrospinal fluid of patients with idiopathic intracranial hypertension","volume":"2","author":"Edwards","year":"2013","journal-title":"Am. J. Clin. Exp. Immunol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/j.1526-4610.2008.001329.x","article-title":"Cytokines and chemokines in idiopathic intracranial hypertension","volume":"49","author":"Dhungana","year":"2009","journal-title":"Headache"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1177\/0333102415570762","article-title":"Oligoclonal bands and increased cytokine levels in idiopathic intracranial hypertension","volume":"35","author":"Ulusoy","year":"2015","journal-title":"Cephalalgia"},{"key":"ref_23","first-page":"21312","article-title":"Obesity is associated with myelin oligodendrocyte glycoprotein antibody-associated disease in acute optic neuritis","volume":"1","author":"Rubarth","year":"2022","journal-title":"Sci. Rep."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/15\/4468\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:26:48Z","timestamp":1760110008000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/15\/4468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,30]]},"references-count":23,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["jcm13154468"],"URL":"https:\/\/doi.org\/10.3390\/jcm13154468","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,30]]}}}