{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:17:29Z","timestamp":1760145449630,"version":"build-2065373602"},"reference-count":29,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research, Development, and Innovation Office, Hungary","award":["NKFI-FK19-132499","5S 724 (A202)"],"award-info":[{"award-number":["NKFI-FK19-132499","5S 724 (A202)"]}]},{"name":"\u201cGeza Hetenyi\u201d Grant, University of Szeged","award":["NKFI-FK19-132499","5S 724 (A202)"],"award-info":[{"award-number":["NKFI-FK19-132499","5S 724 (A202)"]}]},{"name":"\u00daNKP-23-3-SZTE-183 New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development, and Innovation Fund","award":["NKFI-FK19-132499","5S 724 (A202)"],"award-info":[{"award-number":["NKFI-FK19-132499","5S 724 (A202)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Obesity and overweight are also becoming more prevalent among women of childbearing age and pregnant women. In maternal obesity, the activation of metabolic, inflammatory, and oxidative stress pathways is proven, which appears to be a key step in the pathological changes observed in placental and uterine function. Several recent studies have evidenced that aquaporins (AQPs) are critical players in adipose tissue biology and are involved in the onset of obesity. Methods: Our studies aimed to investigate the changes in placental volume and vascularization and measure the AQP5 expression and total antioxidant capacity (TAC) in the placenta and uterus tissues in obese and typical-weight mothers. We also aim to measure the AQP5 plasma concentration. Results: We found AQP5 dominance in the uterus and plasma at 34 weeks of normal pregnancy. The placental volume increased and the vascularization decreased in obese mothers compared to the control. The AQP5 expression increased in the uterus of the obese group and did not change in the placenta. The TAC decreased in the plasma of overweight mothers. Conclusions: We hypothesize that increased AQP5 expression prolongs the length of pregnancy and inhibits the onset of contractions. Based on our findings, we can develop diagnostic tests and provide new targets for tocolytic drug development.<\/jats:p>","DOI":"10.3390\/jcm13154490","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T17:16:49Z","timestamp":1722446209000},"page":"4490","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Obesity on Aquaporin5 Expression in Human Placental and Uterus Tissues"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2746-5372","authenticated-orcid":false,"given":"Kata Kira","family":"Kem\u00e9ny","sequence":"first","affiliation":[{"name":"Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, H-6726 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7485-9895","authenticated-orcid":false,"given":"Zoltan","family":"Kozinszky","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Albert Szent-Gy\u00f6rgyi Medical School, University of Szeged, H-6725 Szeged, Hungary"},{"name":"Capio Specialized Center for Gynecology, Solna, 171 45 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1bel T.","family":"Altorjay","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Albert Szent-Gy\u00f6rgyi Medical School, University of Szeged, H-6725 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e1lint","family":"Kolcs\u00e1r","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Albert Szent-Gy\u00f6rgyi Medical School, University of Szeged, H-6725 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1168-7261","authenticated-orcid":false,"given":"Andrea","family":"Sur\u00e1nyi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Albert Szent-Gy\u00f6rgyi Medical School, University of Szeged, H-6725 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eszter","family":"Ducza","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, H-6726 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"155217","DOI":"10.1016\/j.metabol.2022.155217","article-title":"A 2022 Update on the Epidemiology of Obesity and a Call to Action: As Its Twin COVID-19 Pandemic Appears to Be Receding, the Obesity and Dysmetabolism Pandemic Continues to Rage On","volume":"133","author":"Boutari","year":"2022","journal-title":"Metabolism"},{"unstructured":"(2024, July 09). 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