{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:19:43Z","timestamp":1760145583343,"version":"build-2065373602"},"reference-count":35,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Taichung Veterans General Hospital","award":["TCVGH-1103602C","TCVGH-1103601D","TCVGH-1113602D","TCVGH-1113603C","TCVGH 1123601C","TCVGH-CTUST1117701","TCVGH-VHCY1108602","TCVGHVHCY1118602","VTA111-V2-2-1","VTA112-V2-1-1","VTA113-V2-2-1"],"award-info":[{"award-number":["TCVGH-1103602C","TCVGH-1103601D","TCVGH-1113602D","TCVGH-1113603C","TCVGH 1123601C","TCVGH-CTUST1117701","TCVGH-VHCY1108602","TCVGHVHCY1118602","VTA111-V2-2-1","VTA112-V2-1-1","VTA113-V2-2-1"]}]},{"name":"Taichung Veterans General Hospital\u2019s Chia-Yi Branch","award":["TCVGH-1103602C","TCVGH-1103601D","TCVGH-1113602D","TCVGH-1113603C","TCVGH 1123601C","TCVGH-CTUST1117701","TCVGH-VHCY1108602","TCVGHVHCY1118602","VTA111-V2-2-1","VTA112-V2-1-1","VTA113-V2-2-1"],"award-info":[{"award-number":["TCVGH-1103602C","TCVGH-1103601D","TCVGH-1113602D","TCVGH-1113603C","TCVGH 1123601C","TCVGH-CTUST1117701","TCVGH-VHCY1108602","TCVGHVHCY1118602","VTA111-V2-2-1","VTA112-V2-1-1","VTA113-V2-2-1"]}]},{"name":"VGH, TSGH, AS Joint Research Program","award":["TCVGH-1103602C","TCVGH-1103601D","TCVGH-1113602D","TCVGH-1113603C","TCVGH 1123601C","TCVGH-CTUST1117701","TCVGH-VHCY1108602","TCVGHVHCY1118602","VTA111-V2-2-1","VTA112-V2-1-1","VTA113-V2-2-1"],"award-info":[{"award-number":["TCVGH-1103602C","TCVGH-1103601D","TCVGH-1113602D","TCVGH-1113603C","TCVGH 1123601C","TCVGH-CTUST1117701","TCVGH-VHCY1108602","TCVGHVHCY1118602","VTA111-V2-2-1","VTA112-V2-1-1","VTA113-V2-2-1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: There is still no consensus about the coronavirus disease 2019 (COVID-19) vaccine-associated glomerular disease (CVAGD). Given the large number of vaccinations administered and the variations in glomerulopathy observed across different countries and regional environments, CVAGD remains an important area of concern. Aim of study: We aimed to elucidate the findings of CVAGD within a Taiwanese cohort using biopsy data. Additionally, we endeavored to clarify the presentation of CVAGD. Methods: We collected data from patients who underwent renal biopsy from June 2021 to October 2022 at Taichung Veterans General Hospital. Two independent nephrologists meticulously reviewed the charts to exclude cases unrelated to vaccination. Results: Initially, a total of 286 patients underwent renal biopsy at our institute. Ultimately, we identified 14 patients with highly suspected CVAGD. All 14 patients exhibited proteinuria and hematuria. The urinary protein-to-creatinine ratio was elevated (median of 2012.1 mg\/g; interquartile range (IQR) 25%\u2013IQR 75%: 941.85\u20133884.1 mg\/g) with a median serum creatinine level of 1.71 mg\/dL (0.79\u20135.35). The majority of CVAGD cases were diagnosed as immunoglobulin A (IgA) nephropathy (n = 5, 35.7%), followed by antineutrophil cytoplasmic antibody (ANCA)-related rapidly progressive glomerulonephritis (RPGN) (n = 4, 28.6%). There were only three cases of minimal change disease each: one case of focal segmental glomerulosclerosis, one of membranous glomerulonephritis, and one of lupus nephritis. The culprit of COVID-19 vaccinations was 35.7% (n = 5) of Oxford-AstraZeneca (ChAdOx1-S), 42.9% (n = 6) of Moderna, and 21.4% (n = 3) of BNT162b2. Most patients experienced improvements in renal function. Only two cases of P-ANCA RPGN and one case of IgA nephropathy did not recover. Eighty percent of IgA nephropathy cases had favorable outcomes, but none of the patients with P-ANCA RPGN achieved full recovery. Conclusions: IgA nephropathy and ANCA-related RPGN were the most common CVAGD, and all types of COVID-19 vaccines posed a risk for CVAGD. However, further studies are required to confirm causality.<\/jats:p>","DOI":"10.3390\/jcm13154494","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T08:14:46Z","timestamp":1722500086000},"page":"4494","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["De Novo Biopsy-Proven Glomerular Disease Following COVID-19 Vaccination"],"prefix":"10.3390","volume":"13","author":[{"given":"Cheng-Hsu","family":"Chen","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, 160, Sec. 3, Taiwan Boulevard, Taichung 407, Taiwan"},{"name":"Department of Life Science, Tunghai University, Taichung 407, Taiwan"},{"name":"Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung 402, Taiwan"},{"name":"PhD Program, Tissue Engineering and Regenerative Medicine, College of Medicine, National Chung Hsing University, Taichung 402, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Wei","family":"Chiu","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, 160, Sec. 3, Taiwan Boulevard, Taichung 407, Taiwan"},{"name":"Shinfu Clinic, Taichung 411, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo-Ding","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, 160, Sec. 3, Taiwan Boulevard, Taichung 407, Taiwan"},{"name":"Guomao Clinic, Taichung 436, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8585-4392","authenticated-orcid":false,"given":"Ming-Ju","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, 160, Sec. 3, Taiwan Boulevard, Taichung 407, Taiwan"},{"name":"Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung 402, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shang-Feng","family":"Tsai","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, 160, Sec. 3, Taiwan Boulevard, Taichung 407, Taiwan"},{"name":"Department of Life Science, Tunghai University, Taichung 407, Taiwan"},{"name":"Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung 402, Taiwan"},{"name":"Department of Medicine, National Yang-Ming University, Taipei 112, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/j.kint.2022.08.021","article-title":"Incidence of new onset glomerulonephritis after SARS-CoV-2 mRNA vaccination is not increased","volume":"102","author":"Diebold","year":"2022","journal-title":"Kidney Int."},{"key":"ref_2","first-page":"129","article-title":"Risk of glomerular diseases, proteinuria and hematuria following mRNA (BNT162b2) and inactivated (CoronaVac) SARS-CoV-2 vaccines","volume":"38","author":"Cheng","year":"2023","journal-title":"Nephrol. 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