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However, two marker rhythms of the circadian system, motor activity and distal temperature, are not evaluated. Methods: To determine the relationship between the functional status of the circadian system and the Child\u2013Pugh scale in patients awaiting liver transplantation, distal temperature, motor activity, and light exposure rhythms were monitored for a full week using a wrist device (Kronowise 6.0) in 63 patients (17 women, 46 men) aged between 20 and 76 years. Results: Circadian parameters (amplitude, regularity, and fragmentation) of motor activity rhythms, distal temperature, and light exposure worsen in close association with liver disease severity as assessed by using the Child\u2013Pugh score. Likewise, the worsening of rhythmic parameters and liver disease is associated with a deterioration in the markers of the red series: count, hemoglobin, and hematocrit. Conclusions: These results indicate the utility of ambulatory monitoring of marker rhythms to complement the clinical information provided by the Child\u2013Pugh scale and to help establish nutrition, physical exercise, and sleep guidelines that promote better survival and quality of life in these patients.<\/jats:p>","DOI":"10.3390\/jcm13154529","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T13:14:42Z","timestamp":1722604482000},"page":"4529","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Relationship between Circadian System Status, Child\u2013Pugh Score, and Clinical Outcome in Cirrhotic Patients on Waiting Lists for Liver Transplantation"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7497-6709","authenticated-orcid":false,"given":"Laura","family":"Mart\u00ednez-Alarc\u00f3n","sequence":"first","affiliation":[{"name":"Departamento de Producci\u00f3n Animal, Hospital Cl\u00ednico Universitario Virgen de la Arrixaca (UDICA), 30120 Murcia, Spain"},{"name":"Instituto Murciano de Investigaci\u00f3n Biosanitaria (IMIB), 30120 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8213-3370","authenticated-orcid":false,"given":"Antonio","family":"Mart\u00ednez-Nicol\u00e1s","sequence":"additional","affiliation":[{"name":"Instituto Murciano de Investigaci\u00f3n Biosanitaria (IMIB), 30120 Murcia, Spain"},{"name":"Chronobiology Laboratory, Department of Physiology, College of Biology, University of Murcia, Mare Nostrum Campus, 30100 Murcia, Spain"},{"name":"Human Physiology Area, Faculty of Sport Sciences, University of Murcia, Santiago de la Ribera-San Javier, 30720 Murcia, Spain"},{"name":"Ciber Fragilidad y Envejecimiento Saludable (CIBERFES), 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Jover-Aguilar","sequence":"additional","affiliation":[{"name":"Instituto Murciano de Investigaci\u00f3n Biosanitaria (IMIB), 30120 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00edctor","family":"L\u00f3pez-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Servicio de Cirug\u00eda, Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5483-0312","authenticated-orcid":false,"given":"Felipe","family":"Alconchel-Gago","sequence":"additional","affiliation":[{"name":"Servicio de Cirug\u00eda, Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5512-9010","authenticated-orcid":false,"given":"Antonio","family":"R\u00edos","sequence":"additional","affiliation":[{"name":"Servicio de Cirug\u00eda, Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Antonio","family":"Madrid","sequence":"additional","affiliation":[{"name":"Instituto Murciano de Investigaci\u00f3n Biosanitaria (IMIB), 30120 Murcia, Spain"},{"name":"Chronobiology Laboratory, Department of Physiology, College of Biology, University of Murcia, Mare Nostrum Campus, 30100 Murcia, Spain"},{"name":"Ciber Fragilidad y Envejecimiento Saludable (CIBERFES), 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9343-3918","authenticated-orcid":false,"given":"Mar\u00eda","family":"de los \u00c1ngeles Rol","sequence":"additional","affiliation":[{"name":"Instituto Murciano de Investigaci\u00f3n Biosanitaria (IMIB), 30120 Murcia, Spain"},{"name":"Chronobiology Laboratory, Department of Physiology, College of Biology, University of Murcia, Mare Nostrum Campus, 30100 Murcia, Spain"},{"name":"Ciber Fragilidad y Envejecimiento Saludable (CIBERFES), 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Servicio de Cirug\u00eda, Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5580-1612","authenticated-orcid":false,"given":"Guillermo","family":"Ramis","sequence":"additional","affiliation":[{"name":"Instituto Murciano de Investigaci\u00f3n Biosanitaria (IMIB), 30120 Murcia, Spain"},{"name":"Departamento de Producci\u00f3n Animal, Facultad de Veterinaria, 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