{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:41:47Z","timestamp":1782952907375,"version":"3.54.5"},"reference-count":34,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T00:00:00Z","timestamp":1722643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Primary sclerosing cholangitis (PSC) is an immune-mediated disease that has an unfavorable prognosis and needs a liver transplant (LT). The aim of this paper was to show the usefulness of the Majoie classification on magnetic resonance cholangiopancreatography (MRCP) images in assessing the prognosis in adult patients with PSC. Methods: Our work presents a retrospective monocentric study performed on 64 adult patients with PSC of the large bile ducts. Two radiologists evaluated the MRCP of diagnosis and calculated MRCP scores using the Majoie classification. Liver-related outcome (LT or liver-related death) was marked as a primary endpoint. Results: Univariate analysis showed that patients with more severe lesions (sum score of intrahepatic and extrahepatic ducts &gt; 3) had a lower age at diagnosis, of 37.2 years, complicated with liver cirrhosis (53.1% of patients) and recurrent cholangitis (28.1%) p &lt; 0.05, without significant differences in mortality, association with IBD or LT. Concordance analysis between MRCP prognostic scores and progression to a PSC-related event showed a moderate relationship (c-statistic 0.662), and a good AUROC was observed for the UKPSC score (0.893) and the MRS (0.936). Conclusions: In the study, we observed a good correlation between the imaging scores based on the Majoie classification and the evolution of the patients. These scores were outperformed by the UKPSC, MRS, and PREsTo clinical models. Their utility was best in predicting recurrent cholangitis.<\/jats:p>","DOI":"10.3390\/jcm13154548","type":"journal-article","created":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T13:57:28Z","timestamp":1722866248000},"page":"4548","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Quantitative Magnetic Resonance Cholangiopancreatography Scoring and Its Predictive Value for Outcomes in Adults with Primary Sclerosing Cholangitis"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2914-4191","authenticated-orcid":false,"given":"Matei","family":"Mandea","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Discipline of Gastroenterology and Hepatology, University of Medicine and Pharmacy Carol Davila, 050474 Bucharest, Romania"},{"name":"Department of Radiology, Medical Imaging and Interventional Radiology I, University of Medicine and Pharmacy Carol Davila, 050474 Bucharest, Romania"},{"name":"Digestive Diseases and Liver Transplant Center, Fundeni Clinical Institute, 022328 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7805-5920","authenticated-orcid":false,"given":"Speranta Maria","family":"Iacob","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Discipline of Gastroenterology and Hepatology, University of Medicine and Pharmacy Carol Davila, 050474 Bucharest, Romania"},{"name":"Department of Radiology, Medical Imaging and Interventional Radiology I, University of Medicine and Pharmacy Carol Davila, 050474 Bucharest, Romania"},{"name":"Digestive Diseases and Liver Transplant Center, Fundeni Clinical Institute, 022328 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8413-2307","authenticated-orcid":false,"given":"Mugur Cristian","family":"Grasu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Medical Imaging and Interventional Radiology I, University of Medicine and Pharmacy Carol Davila, 050474 Bucharest, Romania"},{"name":"Laboratory of Radiology and Medical Imaging, Fundeni Clinical Institute, 022328 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4602-7838","authenticated-orcid":false,"given":"Cristian","family":"Anghel","sequence":"additional","affiliation":[{"name":"Department of Radiology, Medical Imaging and Interventional Radiology I, University of Medicine and Pharmacy Carol Davila, 050474 Bucharest, Romania"},{"name":"Laboratory of Radiology and Medical Imaging, Fundeni Clinical Institute, 022328 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8545-310X","authenticated-orcid":false,"given":"Razvan Andrei","family":"Iacob","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Discipline of Gastroenterology and Hepatology, University of Medicine and Pharmacy Carol Davila, 050474 Bucharest, Romania"},{"name":"Department of Radiology, Medical Imaging and Interventional Radiology I, University of Medicine and Pharmacy Carol Davila, 050474 Bucharest, Romania"},{"name":"Digestive Diseases and Liver Transplant Center, Fundeni Clinical Institute, 022328 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela Corina","family":"Ghioca","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Discipline of Gastroenterology and Hepatology, University of Medicine and Pharmacy Carol Davila, 050474 Bucharest, Romania"},{"name":"Department of Radiology, Medical Imaging and Interventional Radiology I, University of Medicine and Pharmacy Carol Davila, 050474 Bucharest, Romania"},{"name":"Digestive Diseases and Liver Transplant Center, Fundeni Clinical Institute, 022328 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Gheorghe","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Discipline of Gastroenterology and Hepatology, University of Medicine and Pharmacy Carol Davila, 050474 Bucharest, Romania"},{"name":"Department of Radiology, Medical Imaging and Interventional Radiology I, University of Medicine and Pharmacy Carol Davila, 050474 Bucharest, Romania"},{"name":"Digestive Diseases and Liver Transplant Center, Fundeni Clinical Institute, 022328 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana Simona","family":"Gheorghe","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Discipline of Gastroenterology and Hepatology, University of Medicine and Pharmacy Carol Davila, 050474 Bucharest, Romania"},{"name":"Department of Radiology, Medical Imaging and Interventional Radiology I, University of Medicine and Pharmacy Carol Davila, 050474 Bucharest, Romania"},{"name":"Digestive Diseases and Liver Transplant Center, Fundeni Clinical Institute, 022328 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Vernero, M., Saibeni, S., Scalvini, D., Cicalini, C., Chiarello, L., Nardi, S., Ribaldone, D.G., and Bezzio, C. (2024). Prevalence and Clinical Impact of Immune-Mediated Inflammatory Diseases in Patients with Inflammatory Bowel Disease: Results from a Large Retrospective Observational Study. J. Clin. Med., 13.","DOI":"10.3390\/jcm13041019"},{"key":"ref_2","first-page":"293","article-title":"Primary Sclerosing Cholangitis, Part 1: Epidemiology, Etiopathogenesis, Clinical Features, and Treatment","volume":"14","author":"Tabibian","year":"2018","journal-title":"Gastroenterol. Hepatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1002\/hep.32771","article-title":"AASLD practice guidance on primary sclerosing cholangitis and cholangiocarcinoma","volume":"77","author":"Bowlus","year":"2022","journal-title":"Hepatology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.jhep.2022.05.011","article-title":"EASL Clinical Practice Guidelines on sclerosing cholangitis","volume":"77","author":"Chazouilleres","year":"2022","journal-title":"J. Hepatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1136\/gutjnl-2018-317993","article-title":"British Society of Gastroenterology and UK-PSC guidelines for the diagnosis and management of primary sclerosing cholangitis","volume":"68","author":"Chapman","year":"2019","journal-title":"Gut"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/liv.15286","article-title":"Impact on follow-up strategies in patients with primary sclerosing cholangitis","volume":"43","author":"Bergquist","year":"2022","journal-title":"Liver Int."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Schmeltzer, P.A., and Russo, M.W. (2021). Systematic Review of Prognostic Models Compared to the Mayo Risk Score for Primary Sclerosing Cholangitis. J. Clin. Med., 10.","DOI":"10.3390\/jcm10194476"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1055\/s-0039-1687853","article-title":"Magnetic Resonance Imaging in Primary Sclerosing Cholangitis\u2014Current State and Future Directions","volume":"39","author":"Zenouzi","year":"2019","journal-title":"Semin. Liver Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1148\/rg.2019180213","article-title":"Imaging Features of Primary Sclerosing Cholangitis: From Diagnosis to Liver Transplant Follow-up","volume":"39","author":"Khoshpouri","year":"2019","journal-title":"RadioGraphics"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Mesropyan, N., Kupczyk, P., Kukuk, G.M., Dold, L., Weismueller, T., Endler, C., Isaak, A., Faron, A., Sprinkart, A.M., and Pieper, C.C. (2021). Diagnostic value of magnetic resonance parametric mapping for non-invasive assessment of liver fibrosis in patients with primary sclerosing cholangitis. BMC Med. Imaging, 21.","DOI":"10.1186\/s12880-021-00598-0"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3390\/tomography10010005","article-title":"Primary Sclerosing Cholangitis: Diagnostic Criteria","volume":"10","author":"Cazzagon","year":"2024","journal-title":"Tomography"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Boicean, A., Birlutiu, V., Ichim, C., Todor, S.B., Hasegan, A., Bacila, C., Solomon, A., Cristian, A., and Dura, H. (2023). Predictors of Post-ERCP Pancreatitis (P.E.P.) in Choledochal Lithiasis Extraction. J. Pers. Med., 13.","DOI":"10.3390\/jpm13091356"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Vl\u0103du\u0163, C., Cioc\u00eerlan, M., Bilous, D., \u0218andru, V., Stan-Ilie, M., Panic, N., Becheanu, G., Jinga, M., Costache, R.S., and Costache, D.O. (2020). An Overview on Primary Sclerosing Cholangitis. J. Clin. Med., 9.","DOI":"10.3390\/jcm9030754"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s002610000098","article-title":"Evaluation of a modified cholangiographic classification system for primary sclerosing cholangitis","volume":"26","author":"Rajaram","year":"2001","journal-title":"Abdom. Imaging"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"495","DOI":"10.2214\/ajr.157.3.1651643","article-title":"Primary sclerosing cholangitis: A modified classification of cholangiographic findings","volume":"157","author":"Majoie","year":"1991","journal-title":"Am. J. Roentgenol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1055\/s-0030-1255527","article-title":"Validation of a cholangiographic prognostic model in primary sclerosing cholangitis","volume":"42","author":"Ponsioen","year":"2010","journal-title":"Endoscopy"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/hep4.1454","article-title":"Magnetic Resonance Cholangiopancreatography Severity Predicts Disease Outcomes in Pediatric Primary Sclerosing Cholangitis: A Reliability and Validity Study","volume":"4","author":"Patil","year":"2020","journal-title":"Hepatol. Commun."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s00247-001-0617-z","article-title":"Magnetic resonance cholangiopancreatography in primary sclerosing cholangitis in children","volume":"32","author":"Ferrara","year":"2002","journal-title":"Pediatr. Radiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1053\/jhep.2003.50346","article-title":"A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C","volume":"38","author":"Wai","year":"2003","journal-title":"Hepatology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1002\/hep.21178","article-title":"Development of a simple noninvasive index to predict significant fibrosis in patients with HIV\/HCV coinfection","volume":"43","author":"Sterling","year":"2006","journal-title":"Hepatology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/hep.30085","article-title":"Primary Sclerosing Cholangitis Risk Estimate Tool (PREsTo) Predicts Outcomes of the Disease: A Derivation and Validation Study Using Machine Learning","volume":"71","author":"Eaton","year":"2020","journal-title":"Hepatology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/S0025-6196(11)64614-4","article-title":"A Revised Natural History Model for Primary Sclerosing Cholangitis","volume":"75","author":"Kim","year":"2000","journal-title":"Mayo Clin. Proc."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1002\/hep.30479","article-title":"Factors Associated with Outcomes of Patients with Primary Sclerosing Cholangitis and Development and Validation of a Risk Scoring System","volume":"69","author":"Goode","year":"2019","journal-title":"Hepatology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3735","DOI":"10.1007\/s00330-020-06728-6","article-title":"Risk stratification in primary sclerosing cholangitis: Comparison of biliary stricture severity on MRCP versus liver stiffness by MR elastography and vibration-controlled transient elastography","volume":"30","author":"Tafur","year":"2020","journal-title":"Eur. Radiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1016\/j.cgh.2019.10.041","article-title":"Changes in Liver Stiffness, Measured by Magnetic Resonance Elastography, Associated with Hepatic Decompensation in Patients with Primary Sclerosing Cholangitis","volume":"18","author":"Eaton","year":"2019","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1016\/j.cgh.2019.03.013","article-title":"Simple Magnetic Resonance Scores Associate with Outcomes of Patients With Primary Sclerosing Cholangitis","volume":"17","author":"Lemoinne","year":"2019","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"109884","DOI":"10.1016\/j.ejrad.2021.109884","article-title":"Assessment of prognostic value and interreader agreement of ANALI scores in patients with primary sclerosing cholangitis","volume":"142","author":"Grigoriadis","year":"2021","journal-title":"Eur. J. Radiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1002\/hep4.1860","article-title":"A Quantitative Magnetic Resonance Cholangiopancreatography Metric of Intrahepatic Biliary Dilatation Severity Detects High-Risk Primary Sclerosing Cholangitis","volume":"6","author":"Selvaraj","year":"2022","journal-title":"Hepatol. Commun."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s00330-021-08142-y","article-title":"Evaluation of quantitative MRCP (MRCP+) for risk stratification of primary sclerosing cholangitis: Comparison with morphological MRCP, MR elastography, and biochemical risk scores","volume":"32","author":"Ismail","year":"2021","journal-title":"Eur. Radiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"100577","DOI":"10.1016\/j.jhepr.2022.100577","article-title":"Quantitative magnetic resonance cholangiopancreatography metrics are associated with disease severity and outcomes in people with primary sclerosing cholangitis","volume":"4","author":"Cazzagon","year":"2022","journal-title":"JHEP Rep."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"100834","DOI":"10.1016\/j.jhepr.2023.100834","article-title":"A composite score using quantitative magnetic resonance cholangiopancreatography predicts clinical outcomes in primary sclerosing cholangitis","volume":"5","author":"Vuppalanchi","year":"2023","journal-title":"JHEP Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.dld.2022.10.015","article-title":"A quantitative MRCP-derived score for medium-term outcome prediction in primary sclerosing cholangitis","volume":"55","author":"Cristoferi","year":"2023","journal-title":"Dig. Liver Dis."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"100595","DOI":"10.1016\/j.jhepr.2022.100595","article-title":"Development of a prognostic MRCP-score (DiStrict) for individuals with large-duct primary sclerosing cholangitis","volume":"4","author":"Grigoriadis","year":"2022","journal-title":"JHEP Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"11729","DOI":"10.3389\/ti.2023.11729","article-title":"Liver Transplantation for Primary Sclerosing Cholangitis (PSC) With or Without Inflammatory Bowel Disease (IBD)\u2014A European Society of Organ Transplantation (ESOT) Consensus Statement","volume":"36","author":"Carbone","year":"2023","journal-title":"Transpl. Int."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/15\/4548\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:29:41Z","timestamp":1760110181000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/15\/4548"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,3]]},"references-count":34,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["jcm13154548"],"URL":"https:\/\/doi.org\/10.3390\/jcm13154548","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,3]]}}}