{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T12:53:16Z","timestamp":1787921596048,"version":"build-2784847793"},"reference-count":16,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:00:00Z","timestamp":1722902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background:\u00a0Mycoplasma pneumoniae (MP) is a significant respiratory pathogen leading to community-acquired pneumonia (CAP), especially in children. Up to 30% of confirmed MP cases can develop dermatological symptoms, with Mycoplasma pneumoniae-induced rash and mucositis (MIRM) being a distinct clinical entity marked by mucous membrane inflammation, with or without skin lesions. Methods: This case report describes a 7-year-old girl admitted with fever, stomatitis, conjunctivitis, and skin lesions. On the second day, a painful neck enlargement was observed, with ultrasound confirming bilateral submandibular salivary gland inflammation and elevated serum amylase levels. The patient later developed pneumonia, confirmed via chest X-ray and pleural ultrasound. MP infection was confirmed via specific IgM antibodies and PCR in a throat swab. Results: The patient was diagnosed with MIRM and was treated with clarithromycin, amoxicillin with clavulanic acid, and methylprednisolone, resulting in a full recovery. Conclusions: This case highlights a unique presentation of MIRM with salivary gland inflammation, not previously described in pediatric mycoplasmal infections.<\/jats:p>","DOI":"10.3390\/jcm13164587","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T08:07:59Z","timestamp":1722931679000},"page":"4587","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Unique Presentation of Mycoplasma pneumoniae-Induced Rash and Mucositis with Salivary Gland Inflammation in a Pediatric Patient: A Case Report"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0367-3548","authenticated-orcid":false,"given":"Izabela","family":"Kucharek","sequence":"first","affiliation":[{"name":"Clinical Department of Pediatrics and Allergology, National Medical Institute of the Ministry of the Interior and Administration, 02-507 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaudia","family":"Bednarz","sequence":"additional","affiliation":[{"name":"Clinical Department of Pediatrics and Allergology, National Medical Institute of the Ministry of the Interior and Administration, 02-507 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam Jerzy","family":"Sybilski","sequence":"additional","affiliation":[{"name":"Clinical Department of Pediatrics and Allergology, National Medical Institute of the Ministry of the Interior and Administration, 02-507 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"E205","DOI":"10.1097\/INF.0000000000001881","article-title":"Mycoplasma-induced Rash and Mucositis in a Father and Son: A Case Report","volume":"37","author":"Song","year":"2018","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1001\/jamadermatol.2019.3602","article-title":"Frequency and Clinical Presentation of Mucocutaneous Disease Due to Mycoplasma pneumoniae Infection in Children with Community-Acquired Pneumonia","volume":"156","author":"Theiler","year":"2020","journal-title":"JAMA Dermatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jaad.2014.06.026","article-title":"Mycoplasma pneumoniae-Induced Rash and Mucositis as a Syndrome Distinct from Stevens-Johnson Syndrome and Erythema Multiforme: A Systematic Review","volume":"72","author":"Canavan","year":"2015","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/ced.14404","article-title":"Reactive Infectious Mucocutaneous Eruption: Mycoplasma pneumoniae-Induced Rash and Mucositis and Other Parainfectious Eruptions","volume":"46","author":"Ramien","year":"2021","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1111\/pde.14419","article-title":"Adenoviral-Induced Rash and Mucositis: Expanding the Spectrum of Reactive Infectious Mucocutaneous Eruption","volume":"38","year":"2021","journal-title":"Pediatr. Dermatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1001\/jamadermatol.2021.0385","article-title":"Reactive Infectious Mucocutaneous Eruption Associated With SARS-CoV-2 Infection","volume":"157","author":"Holcomb","year":"2021","journal-title":"JAMA Dermatol."},{"key":"ref_7","unstructured":"Ramien, M.L., Bahubeshi, A., Pope, E., Eichenfield, L., Lara-Corrales, I., Nopper, A.J., and Shear, N. (2018, January 13). Redefining severe cutaneous reactions in children. Proceedings of the Society for Pediatric Dermatology Annual Meeting, Junior Faculty Forum, Lake Tahoe, CA, USA."},{"key":"ref_8","first-page":"e7449","article-title":"Mycoplasma pneumoniae Induced Rash and Mucositis with Bilateral Otitis Media and Sinusitis","volume":"12","author":"Lofgren","year":"2020","journal-title":"Cureus"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Lofgren, D., and Lenkeit, C. (2021). Mycoplasma pneumoniae-Induced Rash and Mucositis: A Systematic Review of the Literature. Spartan Med. Res. J., 6.","DOI":"10.51894\/001c.25284"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1128\/CMR.17.4.697-728.2004","article-title":"Mycoplasma pneumoniae and Its Role as a Human Pathogen","volume":"17","author":"Waites","year":"2004","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Wrotek, A., Robakiewicz, J., Pawlik, K., Rudzinski, P., Pilarska, I., Jaro\u0144, A., Imie\u0142owska, A., Jarz\u0119bowska, M., Zab\u0142ocka, K., and Jackowska, T. (2022). The Etiology of Community-Acquired Pneumonia Correlates with Serum Inflammatory Markers in Children. J. Clin. Med., 11.","DOI":"10.3390\/jcm11195506"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Liu, L., Wang, Y., Sun, J., Wang, W., Hou, J., and Wang, X. (2020). Case Report: Clinical and Immunological Features of a Chinese Cohort With Mycoplasma-Induced Rash and Mucositis. Front. Pediatr., 8.","DOI":"10.3389\/fped.2020.00402"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/s40136-022-00415-4","article-title":"Pediatric Sialendoscopy","volume":"10","author":"Brodie","year":"2022","journal-title":"Curr. Otorhinolaryngol. Rep."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1136\/bmj.280.6229.1421","article-title":"Major and Minor Salivary Gland Swelling in Mycoplasma pneumoniae Infection","volume":"1","author":"Wray","year":"1980","journal-title":"Br. Med. J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1177\/0009922820931802","article-title":"Severe Mycoplasma-Induced Rash and Mucositis Treated With IVIG","volume":"59","author":"Rollins","year":"2020","journal-title":"Clin. Pediatr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1177\/1203475419874444","article-title":"Treatment of Mycoplasma pneumoniae-Induced Rash and Mucositis With Cyclosporine","volume":"23","author":"Li","year":"2019","journal-title":"J. Cutan. Med. Surg."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/16\/4587\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:30:38Z","timestamp":1760110238000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/16\/4587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,6]]},"references-count":16,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["jcm13164587"],"URL":"https:\/\/doi.org\/10.3390\/jcm13164587","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,6]]}}}