{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T16:11:00Z","timestamp":1772122260597,"version":"3.50.1"},"reference-count":55,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:00:00Z","timestamp":1723161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Acute low back pain has a high prevalence, and when persisting into chronicity, it results in enormous socio-economic consequences. Sensory preferences may be key factors in predicting central sensitization as the main mechanism of nociplastic pain and chronicity. Objectives: Build a model to predict central sensitization symptoms using sensory profiles based on the PROGRESS framework. Methods: A Prognostic Model Research study was carried out to predict central sensitization symptoms at 12 weeks, using baseline sensory profiles, based on 114 patients with acute low back pain. Independent variables were sensory profiles, state and trait anxiety, age, duration, pain severity, depressive symptoms, and pain catastrophizing. Results: This model, based on continuous data, significantly predicts central sensitization symptoms at 12 weeks. It contains two significantly contributing variables: sensory profile Sensory Sensitive (unstandardized B-value = 0.42; p = 0.01) and trait anxiety (unstandardized B-value = 0.53; p \u2264 0.001). The model has a predictive value of R2 = 0.38. Conclusions: This model significantly predicts central sensitization symptoms based on sensory profile Sensory Sensitive and trait anxiety. This model may be a useful tool to intervene in a bottom\u2013up and top\u2013down approaches to prevent chronicity in clinical practice, including individual sensory preferences and behavioral responses to sensory stimulation in rehabilitation strategies.<\/jats:p>","DOI":"10.3390\/jcm13164677","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T09:48:54Z","timestamp":1723196934000},"page":"4677","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Sensory Profiles Predict Symptoms of Central Sensitization in Low Back Pain: A Predictive Model Research Study"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6993-3832","authenticated-orcid":false,"given":"Pieter J.","family":"Gr\u00e4per","sequence":"first","affiliation":[{"name":"Experimental Anatomy Research Group, Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education and Physiotherapy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9692-9513","authenticated-orcid":false,"given":"Aldo","family":"Scafoglieri","sequence":"additional","affiliation":[{"name":"Experimental Anatomy Research Group, Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education and Physiotherapy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium"},{"name":"Department of Master Education, SOMT University of Physiotherapy, Softwareweg 5, 3821 BN Amersfoort, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline R.","family":"Clark","sequence":"additional","affiliation":[{"name":"Pains & Brains, 8 Beach Grove, Omokoroa 3114, New Zealand"},{"name":"Pain in Motion Research Group, Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education and Physiotherapy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2924-1209","authenticated-orcid":false,"given":"Joannes M.","family":"Hallegraeff","sequence":"additional","affiliation":[{"name":"Experimental Anatomy Research Group, Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education and Physiotherapy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,9]]},"reference":[{"key":"ref_1","unstructured":"GBD 2021 Low Back Pain Collaborators (2023). Global, regional, and national burden of low back pain, 1990\u20132020, its attributable risk factors, and projections to 2050: A systematic analysis of the global burden of disease study 2021. Lancet Rheumatol., 22, e316\u2013e329."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"204","DOI":"10.2519\/jospt.2021.10340","article-title":"Stuck in the Middle With You: Why a Broad-Brush Approach to Defining Central Sensitization Does Not Help Clinicians and Patients","volume":"51","author":"Cayrol","year":"2021","journal-title":"J. Orthop. Sports Phys. Ther."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"100518","DOI":"10.1016\/j.bjpt.2023.100518","article-title":"Nociplastic pain and central sensitization in patients with chronic pain conditions: A terminology update for clinicians","volume":"27","author":"Nijs","year":"2023","journal-title":"Braz. J. Phys. Ther."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"343","DOI":"10.3233\/NRE-208007","article-title":"Functional pain disorders-more than nociplastic pain","volume":"47","author":"Popkirov","year":"2020","journal-title":"NeuroRehabilitation"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.jpain.2019.03.001","article-title":"Are signs of central sensitization in acute low back pain a precursor to poor outcome?","volume":"20","author":"Klyne","year":"2019","journal-title":"J. Pain"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1016\/S0140-6736(21)00392-5","article-title":"Nociplastic pain: Towards an understanding of prevalent pain conditions","volume":"397","author":"Fitzcharles","year":"2021","journal-title":"Lancet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e178","DOI":"10.1016\/S2665-9913(23)00324-7","article-title":"Nociceptive, neuropathic, or nociplastic low back pain? The low back pain phenotyping (BACPAP) consortium\u2019s international and multidisciplinary consensus recommendations","volume":"6","author":"Nijs","year":"2024","journal-title":"Lancet Rheumatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/00001163-199704000-00005","article-title":"The Impact of Sensory Processing Abilities on the Daily Lives of Young Children and Their Families: A Conceptual Model","volume":"9","author":"Dunn","year":"1997","journal-title":"Inf. Young Child."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"75","DOI":"10.5014\/ajot.55.1.75","article-title":"The adult sensory profile: Measuring patterns of sensory processing","volume":"55","author":"Brown","year":"2001","journal-title":"Am. J. Occup. Ther."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"181","DOI":"10.36076\/ppj\/2019.22.E181","article-title":"Prevalence of extreme trait sensory profiles and personality types in nonspecific chronic low back pain with predominant central sensitization: Secondary analysis of an international observational study","volume":"22","author":"Clark","year":"2019","journal-title":"Pain Physician"},{"key":"ref_11","first-page":"1508","article-title":"Evaluating sensory profiles in nociplastic chronic low back pain: A cross-sectional validation study","volume":"29","author":"Clark","year":"2022","journal-title":"Physiother. Theory Pract."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"487","DOI":"10.36076\/ppj.2017.20.5.487","article-title":"What Are the Predictors of Altered Central Pain Modulation in Chronic Musculoskeletal Pain Populations? A Systematic Review","volume":"20","author":"Clark","year":"2017","journal-title":"Pain Physician"},{"key":"ref_13","first-page":"1","article-title":"Sensory profiles and their role in the persistence of central sensitization symptoms in low back pain. A prospective cohort study","volume":"11","author":"Hartvigsen","year":"2024","journal-title":"Physiother. Theory Pract."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Riley, R.D., van der Windt, D.A., Croft, P., and Moons, K.G.M. (2019). Prognosis Research in Health Care, Concepts, Methods, and Impact, Oxford University Press. [1st ed.].","DOI":"10.1093\/med\/9780198796619.001.0001"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1097\/EDE.0b013e3181577511","article-title":"STROBE Initiative. Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and elaboration","volume":"18","author":"Vandenbroucke","year":"2007","journal-title":"Epidemiology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"W1","DOI":"10.7326\/M14-0698","article-title":"Transparent Reporting of a multivariable prediction model for Individual Prognosis or Diagnosis (TRIPOD): Explanation and elaboration","volume":"162","author":"Moons","year":"2015","journal-title":"Ann. Intern. Med."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"von Elm, E., Altman, D.G., Egger, M., Pocock, S.J., G\u00f8tzsche, P.C., and Vandenbroucke, J.P. (2007). STROBE Initiative. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: Guidelines for reporting observational studies. PLoS Med., 4.","DOI":"10.1371\/journal.pmed.0040296"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"World Medical Association (2013). World Medical Association Declaration of Helsinki: Ethical principles for medical research involving human subjects. J. Am. Med. Assoc., 310, 2191\u20132194.","DOI":"10.1001\/jama.2013.281053"},{"key":"ref_19","unstructured":"(2024, June 13). WHO Guideline for Non-Surgical Management of Chronic Primary Low Back Pain in Adults in Primary and Community Care Settings. Available online: https:\/\/www.who.int\/publications\/i\/item\/9789240081789."},{"key":"ref_20","unstructured":"(2014, June 13). KNGF Guideline on Low Back Pain and Lumbosacral Radicular Syndrome. Available online: https:\/\/www.kngf.nl\/binaries\/content\/assets\/kennisplatform\/onbeveiligd\/guidelines\/low-back-pain-2021\/kngf_guide_on_low_back_pain_practice_guideline.pdf."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Brown, C., and Dunn, W. (2002). Adolescent\/Adult Sensory Profile, Pearson Education.","DOI":"10.1037\/t56705-000"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"7305205040p1","DOI":"10.5014\/ajot.2019.028712","article-title":"Reference values for the adolescent\/adult sensory profile in Spain","volume":"73","year":"2019","journal-title":"Am. J. Occup. Ther."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e919","DOI":"10.1097\/PR9.0000000000000919","article-title":"Prognostic factors for pain chronicity in low back pain: A systematic review","volume":"6","author":"Nieminen","year":"2021","journal-title":"Pain Rep."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1097\/01.brs.0000164099.92112.29","article-title":"Responsiveness of the numeric pain rating scale in patients with low back pain","volume":"30","author":"Childs","year":"2005","journal-title":"Spine"},{"key":"ref_25","unstructured":"Spielberger, C.D., Gorsuch, R.L., Lushene, R., Vagg, P.R., and Jacobs, G.A. (1983). Manual for the State-Trait Anxiety Inventory, Consulting Psychologists Press."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1001\/archpsyc.1961.01710120031004","article-title":"An inventory for measuring depression","volume":"4","author":"Beck","year":"1961","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1176\/appi.psy.48.3.185","article-title":"Performance characteristics of depression screening instruments in survivors of acute myocardial infarction: Review of the evidence","volume":"48","author":"Thombs","year":"2007","journal-title":"Psychosmatics"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"S454","DOI":"10.1002\/acr.20556","article-title":"Measures of depression and depressive symptoms: Beck Depression Inventory-II (BDI-II), Center for Epidemiologic Studies Depression Scale (CES-D), Geriatric Depression Scale (GDS), Hospital Anxiety and Depression Scale (HADS), and Patient Health Questionnaire-9 (PHQ-9)","volume":"63","author":"Smarr","year":"2011","journal-title":"Arthritis Care Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1037\/0278-6133.20.2.112","article-title":"Psychometric evaluation of the Beck Depression Inventory-II with primary care medical patients","volume":"20","author":"Arnau","year":"2001","journal-title":"Health Psychol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.pain.2007.10.022","article-title":"Psychometric properties of the Beck Depression Inventory--second edition (BDI-II) in individuals with chronic pain","volume":"137","author":"Harris","year":"2008","journal-title":"Pain"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.jad.2013.02.009","article-title":"Reference values for major depression questionnaires: The Leiden Routine Outcome Monitoring Study","volume":"149","author":"Carlier","year":"2013","journal-title":"J. Affect. Disord."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.pain.2008.10.017","article-title":"Psychological influences on repetition-induced summation of activity-related pain in patients with chronic low back pain","volume":"141","author":"Sullivan","year":"2009","journal-title":"Pain"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1177\/1359105308093866","article-title":"Test-retest stability of the Pain Catastrophizing Scale and the Tampa Scale for Kinesiophobia in chronic pain over a longer period of time","volume":"13","author":"Peters","year":"2008","journal-title":"J. Health Psychol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1097\/AJP.0000000000000306","article-title":"The Dutch Central Sensitization Inventory (CSI): Factor analysis, discriminative power, and test-retest reliability","volume":"32","author":"Kregel","year":"2016","journal-title":"Clin. J. Pain"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.jpain.2012.11.012","article-title":"The Central Sensitization Inventory (CSI): Establishing clinically significant values for identifying central sensitivity syndromes in an outpatient chronic pain sample","volume":"14","author":"Neblett","year":"2013","journal-title":"J. Pain"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/j.1533-2500.2011.00493.x","article-title":"The development and psychometric validation of the central sensitization inventory","volume":"12","author":"Mayer","year":"2012","journal-title":"Pain Pract."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/papr.12440","article-title":"Establishing clinically relevant severity levels for the central sensitization inventory","volume":"17","author":"Neblett","year":"2017","journal-title":"Pain Pract."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1111\/papr.12636","article-title":"Measurement properties of the central sensitization inventory: A systematic review","volume":"18","author":"Scerbo","year":"2018","journal-title":"Pain Pract."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3758\/BF03193146","article-title":"G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences","volume":"39","author":"Faul","year":"2007","journal-title":"Behav. Res. Methods"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13167-015-0028-0","article-title":"Reporting and handling of missing data in predictive research for prevalent undiagnosed type 2 diabetes mellitus: A systematic review","volume":"6","author":"Masconi","year":"2015","journal-title":"EPMA J."},{"key":"ref_41","unstructured":"Field, A. (2018). Discovering Statistics Using SPSS, SAGE Publications. [3rd ed.]."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1302\/2046-3758.49.2000571","article-title":"Interpreting regression models in clinical outcome studies","volume":"4","author":"Hamilton","year":"2015","journal-title":"Bone Jt. Res."},{"key":"ref_43","unstructured":"Cohen, J. (1988). Statistical Power Analysis for the Behavioral Sciences, Routledge. [2nd ed.]."},{"key":"ref_44","first-page":"e383","article-title":"Central sensitization in chronic pain conditions: Latest discoveries and their potential for precision medicine","volume":"3","author":"Nijs","year":"2021","journal-title":"Lancet"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Schuttert, I., Wolff, A.P., Schiphorst Preuper, R.H.R., Malmberg, A.G.G.A., Reneman, M.F., and Timmerman, H. (2023). Validity of the Central Sensitization Inventory to Address Human Assumed Central Sensitization: Newly Proposed Clinically Relevant Values and Associations. J. Clin. Med., 23.","DOI":"10.3390\/jcm12144849"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"447","DOI":"10.36076\/ppj.2014\/17\/447","article-title":"Applying modern pain neuroscience in clinical practice: Criteria for the classification of central sensitization pain","volume":"17","author":"Nijs","year":"2014","journal-title":"Pain Physician"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1093\/aje\/kwi187","article-title":"When is baseline adjustment useful in analyses of change? An example with education and cognitive change","volume":"162","author":"Glymour","year":"2005","journal-title":"Am. J. Epidemiol."},{"key":"ref_48","first-page":"55","article-title":"Confounding and effect modification: Distribution and measure","volume":"1","year":"2012","journal-title":"Epidemiol. Methods"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.pmn.2016.05.008","article-title":"Central Sensitization in Functional Chronic Pain Syndromes: Overview and Clinical Application","volume":"17","author":"Bettini","year":"2016","journal-title":"Pain Manag. Nurs."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/sim.2331","article-title":"Dichotomizing continuous predictors in multiple regression: A bad idea","volume":"25","author":"Royston","year":"2006","journal-title":"Stat. Med."},{"key":"ref_51","unstructured":"Australian Commission on Safety and Quality in Health Care 2022 Low Back Pain Clinical Care Standard (2024, June 13). Clinical Care Standards, Australia, Available online: https:\/\/www.safetyandquality.gov.au\/standards\/clinical-care-standards\/low-back-pain-clinical-care-standard\/information-clinicians#what-clinicians-need-to-know."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"CPG1","DOI":"10.2519\/jospt.2021.0304","article-title":"Interventions for the management of acute and chronic low back pain: Revision 2021","volume":"51","author":"George","year":"2021","journal-title":"J. Orthop. Sports Phys. Ther."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1080\/14728222.2017.1353603","article-title":"Sleep disturbances and severe stress as glial activators: Key targets for treating central sensitization in chronic pain patients?","volume":"21","author":"Nijs","year":"2017","journal-title":"Expert Opin. Ther. Targets"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.2147\/JPR.S131479","article-title":"The central sensitization inventory validated and adapted for a Brazilian population: Psychometric properties and its relationship with brain-derived neurotrophic factor","volume":"10","author":"Caumo","year":"2017","journal-title":"J. Pain Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s40945-020-00095-7","article-title":"Diagnostic accuracy of the clinical indicators to identify central sensitization pain in patients with musculoskeletal pain","volume":"11","author":"Bittencourt","year":"2021","journal-title":"Arch. Physiother."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/16\/4677\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:32:52Z","timestamp":1760110372000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/16\/4677"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,9]]},"references-count":55,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["jcm13164677"],"URL":"https:\/\/doi.org\/10.3390\/jcm13164677","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,9]]}}}