{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:34:26Z","timestamp":1787225666441,"version":"build-2736575974"},"reference-count":37,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2024,8,11]],"date-time":"2024-08-11T00:00:00Z","timestamp":1723334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>(1) Background: The three factors within the Virchow triad play the leading role in the development of deep vein thrombosis (DVT) during pregnancy. (2) Methods: This research approaches the various risk factors associated with DVT and its most representative complications, pulmonary thromboembolism and cerebral venous thrombosis, in pregnant and postpartum women across a 15-year period (2007\u20132021). (3) Results: A total of 201 out of 287 patients with DVT had associated risk factors, while 86 did not present with any. Out of the 201 patients with risk factors, 47 developed pulmonary thromboembolism, while 12 experienced cerebral thrombosis. The statistical analysis of risk factors involved in DVT revealed high significance for obesity (OR 3.676; CI 2.484\u20135.439), gestational diabetes (OR 3.394; CI 2.101\u20135.483), hypertension (OR 2.325; CI 1.591\u20133.397), preeclampsia (OR 4.753; CI 2.342\u20139.645), thrombophilia (OR 12.138; CI 8.973\u201316.417), and varicose veins (OR 9.678; CI 7.321\u201312.793); for pulmonary thromboembolism, there was high significance for obesity (OR 7.867; CI 4.297\u201314.401), hypertension (OR 2.605; CI 1.246\u20135.446), preeclampsia (OR 7.483; CI 2.346\u201323.872), thrombophilia (OR 11.035; CI 5.910\u201320.602), and varicose veins (OR 6.837; CI 3.665\u201312.757); and for cerebral thromboembolism (CTE), the risk factors identified were obesity (OR 6.755; CI 1.954\u201323.347), hypertension (OR 1.167; CI 0.155\u20138.770), preeclampsia (OR 9.655; CI 1.283\u201372.672), and thrombophilia (OR 33.275; CI 12.884\u201385.939). (4) Conclusions:\u00a0Obesity was the only significant factor found to influence DVT, pulmonary embolism and CTE risks, and hereditary thrombophilia was the main factor influencing the risk for pulmonary thromboembolism and CTE. Systemic lupus erythematosus and gestational diabetes revealed conflicting results that require further investigation.<\/jats:p>","DOI":"10.3390\/jcm13164705","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T11:23:46Z","timestamp":1723461826000},"page":"4705","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Burden of Deep Vein Thrombosis and Risk Factors in Pregnancy and Postpartum\u2014Mirroring Our Region\u2019s Particularities"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2132-6742","authenticated-orcid":false,"given":"Catalina","family":"Filip","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery, University of Medicine and Pharmacy \u2018Gr. T. Popa\u2019, 700115 Iasi, Romania"},{"name":"CHU \u201cGabriel Montpied\u201d, 63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia Alexandra","family":"Socolov","sequence":"additional","affiliation":[{"name":"Department of Neurology, Emergency Hospital \u2018Professor Doctor Nicolae Oblu\u2019, 700309 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2862-2069","authenticated-orcid":false,"given":"Daniela Roxana","family":"Matasariu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Medicine and Pharmacy \u2018Gr. T. Popa\u2019, 700115 Iasi, Romania"},{"name":"Department of Obstetrics and Gynecology, Cuza Voda Hospital, 700038 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8207-7655","authenticated-orcid":false,"given":"Alexandra","family":"Ursache","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Medicine and Pharmacy \u2018Gr. T. Popa\u2019, 700115 Iasi, Romania"},{"name":"Department of Obstetrics and Gynecology, Cuza Voda Hospital, 700038 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina Delia","family":"Pisla","sequence":"additional","affiliation":[{"name":"Faculty of General Medicine, University of Medicine and Pharmacy \u2018Gr. T. Popa\u2019, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tudor Catalin","family":"Gisca","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Medicine and Pharmacy \u2018Gr. T. Popa\u2019, 700115 Iasi, Romania"},{"name":"Department of Obstetrics and Gynecology, Cuza Voda Hospital, 700038 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Mihalceanu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Medicine and Pharmacy \u2018Gr. T. Popa\u2019, 700115 Iasi, Romania"},{"name":"Department of Obstetrics and Gynecology, Cuza Voda Hospital, 700038 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5825-6189","authenticated-orcid":false,"given":"Vasile Lucian","family":"Boiculese","sequence":"additional","affiliation":[{"name":"Biostatistics, Department of Preventive Medicine and Interdisciplinarity, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demetra","family":"Socolov","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Medicine and Pharmacy \u2018Gr. T. Popa\u2019, 700115 Iasi, Romania"},{"name":"Department of Obstetrics and Gynecology, Cuza Voda Hospital, 700038 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1515\/jpm-2022-0008","article-title":"Venous thrombosis risk factors in pregnant women","volume":"50","author":"Bitsadze","year":"2022","journal-title":"J. Perinat. 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