{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T21:30:04Z","timestamp":1788471004887,"version":"build-2803163510"},"reference-count":33,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T00:00:00Z","timestamp":1723420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Radiation-induced hemorrhagic cystitis (RHC) is a chronic inflammatory disease in patients undergoing radiation therapy that causes a cluster of symptoms which may have a latent period of months to years. The current non-invasive treatments include drug treatment and hyperbaric oxygen therapy (HBOT), which has been widely applied for RHC so far but with limited evidence. Thus, we conducted a systematic review and meta-analysis to clarify the effects and safety of HBOT for RHC. Methods: A systematic review and meta-analysis were utilized, searching in the databases of Embase, Pubmed, and Web of Science. The primary endpoint of the present study was complete remission of hematuria. The meta-analysis was conducted using a random effects model, and a pooled odds ratio with 95% CI was calculated. Results: A total of 317 studies were searched and fourteen articles with 556 patients were collected. The results showed that a total of 500 patients (89.9%) had symptom improvement, and the pooled results demonstrated that 55% of patients with HBOT had complete remission of hematuria (95% CI 51\u201359%). Conclusions: A significant improvement of symptoms when treated with HBOT was shown in this meta-analysis for patients with RHC.<\/jats:p>","DOI":"10.3390\/jcm13164724","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T11:23:46Z","timestamp":1723461826000},"page":"4724","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Efficacy and Safety of Hyperbaric Oxygen Therapy for Radiation-Induced Hemorrhagic Cystitis: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"13","author":[{"given":"Teng-Kai","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Surgery, Yonghe Cardinal Tien Hospital, New Taipei City 23445, Taiwan"},{"name":"School of Medicine, College of Medicine, Fu-Jen Catholic University, New Taipei City 242062, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Jen","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine, Fu-Jen Catholic University, New Taipei City 242062, Taiwan"},{"name":"Division of Radiation Oncology, Department of Oncology, National Taiwan University Hospital, Taipei 100225, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsing-Ju","family":"Li","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei 100225, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Fang","family":"Yu","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei 100225, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6375-8714","authenticated-orcid":false,"given":"Kai-Wen","family":"Huang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei 100225, Taiwan"},{"name":"Department of Surgery, National Taiwan University Hospital, Taipei 100225, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2007-0220","authenticated-orcid":false,"given":"Jason Chia-Hsien","family":"Cheng","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Department of Oncology, National Taiwan University Hospital, Taipei 100225, Taiwan"},{"name":"Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei 100225, Taiwan"},{"name":"Graduate Institute of Oncology, National Taiwan University College of Medicine, Taipei 100225, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1136\/gut.2004.062596","article-title":"Gastrointestinal complications of pelvic radiotherapy: Are they of any importance?","volume":"54","author":"Andreyev","year":"2005","journal-title":"Gut"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1200\/EDBK_320999","article-title":"Strategies to Minimize Late Effects From Pelvic Radiotherapy","volume":"41","author":"Dohm","year":"2021","journal-title":"Am. Soc. Clin. Oncol. Educ. Book"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.clon.2020.09.010","article-title":"Image-Guided Radiotherapy for Pelvic Cancers: A Review of Current Evidence and Clinical Utilisation","volume":"32","author":"Webster","year":"2020","journal-title":"Clin. Oncol. (R. Coll. Radiol.)"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s11934-018-0790-3","article-title":"Scoping Review and Meta-analysis of Hyperbaric Oxygen Therapy for Radiation-Induced Hemorrhagic Cystitis","volume":"19","author":"Cardinal","year":"2018","journal-title":"Curr. Urol. Rep."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Helissey, C., Cavallero, S., Brossard, C., Dusaud, M., Chargari, C., and Fran\u00e7ois, S. (2020). Chronic Inflammation and Radiation-Induced Cystitis: Molecular Background and Therapeutic Perspectives. Cells, 10.","DOI":"10.3390\/cells10010021"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1007\/s00120-022-01844-1","article-title":"[Radiation-induced hemorrhagic cystitis-possible treatment options!]","volume":"61","author":"Nuhn","year":"2022","journal-title":"Urologie"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/bju.14516","article-title":"Current management of radiation cystitis: A review and practical guide to clinical management","volume":"123","author":"Pascoe","year":"2019","journal-title":"BJU Int."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1016\/j.juro.2014.06.030","article-title":"Cystectomy for refractory hemorrhagic cystitis: Contemporary etiology, presentation and outcomes","volume":"192","author":"Linder","year":"2014","journal-title":"J. Urol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1080\/09553002.2023.2181996","article-title":"Advances in the management of radiation-induced cystitis in patients with pelvic malignancies","volume":"99","author":"Wang","year":"2023","journal-title":"Int. J. Radiat. Biol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Crocetto, F., Balsamo, R., Amicuzi, U., De Luca, L., Falcone, A., Mirto, B.F., Giampaglia, G., Ferretti, G., Capone, F., and Machiella, F. (2023). Novel Key Ingredients in Urinary Tract Health-The Role of D-mannose, Chondroitin Sulphate, Hyaluronic Acid, and N-acetylcysteine in Urinary Tract Infections (Uroial PLUS((R))). Nutrients, 15.","DOI":"10.3390\/nu15163573"},{"key":"ref_12","first-page":"CD005005","article-title":"Hyperbaric oxygen therapy for late radiation tissue injury","volume":"8","author":"Lin","year":"2023","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1126\/science.6612342","article-title":"Oxygen tension regulates the expression of angiogenesis factor by macrophages","volume":"221","author":"Knighton","year":"1983","journal-title":"Science"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration\u2019s tool for assessing risk of bias in randomised trials","volume":"343","author":"Higgins","year":"2011","journal-title":"BMJ"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1111\/j.1464-410X.2011.10550.x","article-title":"Comparison of intravesical hyaluronic acid instillation and hyperbaric oxygen in the treatment of radiation-induced hemorrhagic cystitis","volume":"109","author":"Shao","year":"2012","journal-title":"BJU Int."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1016\/S1470-2045(19)30494-2","article-title":"Radiation-induced cystitis treated with hyperbaric oxygen therapy (RICH-ART): A randomised, controlled, phase 2-3 trial","volume":"20","author":"Oscarsson","year":"2019","journal-title":"Lancet Oncol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0022-5347(01)61914-1","article-title":"Hyperbaric oxygen therapy for radiation induced hemorrhagic cystitis","volume":"161","author":"Mathews","year":"1999","journal-title":"J. Urol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1590\/S1677-5538.IBJU.2014.03.02","article-title":"Is there a role for hyberbaric oxygen as primary treatment for grade IV radiation-induced haemorrhagic cystitis? A prospective pilot-feasibility study and review of literature","volume":"40","author":"Dellis","year":"2014","journal-title":"Int. Braz. J. Urol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1590\/s1677-5538.ibju.2016.0451","article-title":"Hyberbaric oxygen as sole treatment for severe radiation-induced haemorrhagic cystitis","volume":"43","author":"Dellis","year":"2017","journal-title":"Int. Braz. J. Urol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/j.1442-2042.2008.02053.x","article-title":"Hyperbaric oxygen therapy for radiation-induced hemorrhagic cystitis","volume":"15","author":"Yoshida","year":"2008","journal-title":"Int. J. Urol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"200","DOI":"10.5173\/ceju.2012.04.art4","article-title":"Hyperbaric oxygen therapy (HBOT) in case of hemorrhagic cystitis after radiotherapy","volume":"65","author":"Polom","year":"2012","journal-title":"Cent. Eur. J. Urol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.acuro.2020.03.010","article-title":"Hyperbaric oxygen for radiation-induced cystitis: A long-term follow-up","volume":"44","author":"Pereira","year":"2020","journal-title":"Actas Urol. Esp. (Engl. Ed.)"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Degener, S., Pohle, A., Strelow, H., Mathers, M.J., Zumb\u00e9, J., Roth, S., and Brandt, A.S. (2015). Long-term experience of hyperbaric oxygen therapy for refractory radio- or chemotherapy-induced haemorrhagic cystitis. BMC Urol., 15.","DOI":"10.1186\/s12894-015-0035-4"},{"key":"ref_25","first-page":"79","article-title":"The effectiveness of hyperbaric oxygen therapy (HBOT) in radiation-induced haemorrhagic cystitis","volume":"129","author":"Chong","year":"2016","journal-title":"N. Z. Med. J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1111\/iju.12857","article-title":"Hyperbaric oxygen therapy for refractory radiation-induced hemorrhagic cystitis","volume":"22","year":"2015","journal-title":"Int. J. Urol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.urology.2004.10.050","article-title":"Early hyperbaric oxygen therapy improves outcome for radiation-induced hemorrhagic cystitis","volume":"65","author":"Chong","year":"2005","journal-title":"Urology"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"S518","DOI":"10.1016\/j.ijrobp.2009.07.1182","article-title":"Hyperbaric Oxygen-therapy for Radiation-induced Hemorrhagic Cystitis","volume":"75","author":"Wong","year":"2009","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1007\/s12094-022-02892-x","article-title":"The role of hyperbaric oxygen therapy in the treatment of radiation lesions","volume":"24","author":"Castedo","year":"2022","journal-title":"Clin. Transl. Oncol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"101014","DOI":"10.1016\/j.imr.2023.101014","article-title":"How to understand and report heterogeneity in a meta-analysis: The difference between I-squared and prediction intervals","volume":"12","author":"Borenstein","year":"2023","journal-title":"Integr. Med. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/iju.14130","article-title":"Hyperbaric oxygen therapy for radiation cystitis after pelvic radiotherapy: Systematic review of the recent literature","volume":"27","author":"Villeirs","year":"2020","journal-title":"Int. J. Urol."},{"key":"ref_32","first-page":"479","article-title":"Quality of life--the effect of hyperbaric oxygen treatment on radiation injury","volume":"40","author":"Irgens","year":"2013","journal-title":"Undersea Hyperb. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1111\/j.1464-410X.2009.08471.x","article-title":"Acute urinary retention and subsequent catheterization cause lipid peroxidation and oxidative DNA damage in the bladder: Preventive effect of edaravone, a free-radical scavenger","volume":"104","author":"Shimizu","year":"2009","journal-title":"BJU Int."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/16\/4724\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:35:17Z","timestamp":1760110517000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/16\/4724"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,12]]},"references-count":33,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["jcm13164724"],"URL":"https:\/\/doi.org\/10.3390\/jcm13164724","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,12]]}}}