{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:36:41Z","timestamp":1790282201787,"version":"4.1.0"},"reference-count":55,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T00:00:00Z","timestamp":1723420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hungarian Research Network (HUN-REN-PTE Chronic Pain Research Group)","award":["TKP 2021 EGA-13"],"award-info":[{"award-number":["TKP 2021 EGA-13"]}]},{"name":"Hungarian Research Network (HUN-REN-PTE Chronic Pain Research Group)","award":["K-134214"],"award-info":[{"award-number":["K-134214"]}]},{"DOI":"10.13039\/501100018818","name":"National Research, Development and Innovation Office","doi-asserted-by":"publisher","award":["TKP 2021 EGA-13"],"award-info":[{"award-number":["TKP 2021 EGA-13"]}],"id":[{"id":"10.13039\/501100018818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018818","name":"National Research, Development and Innovation Office","doi-asserted-by":"publisher","award":["K-134214"],"award-info":[{"award-number":["K-134214"]}],"id":[{"id":"10.13039\/501100018818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Stimulated capsaicin-sensitive peptidergic sensory nerves release somatostatin (SST), which has systemic anti-inflammatory and analgesic effects, correlating with the severity of tissue injury. Previous studies suggest that SST release into the systemic circulation is likely to serve as a protective mechanism during thoracic and orthopedic surgeries, scoliosis operations, and septic conditions, all involving significant tissue damage, pain, and inflammation. In a severe systemic inflammation rat model, SST released from sensory nerves into the bloodstream enhanced innate defense, reducing mortality. Inflammation is the key pathophysiological process responsible for the formation, progression, instability, and healing of atherosclerotic plaques. Methods: We measured SST-like immunoreactivity (SST-LI) in the plasma of healthy volunteers in different age groups and also that of stable angina patients with coronary heart disease (CHD) using ELISA and tracked changes during invasive coronary interventions (coronarography) with and without stent implantation. Samples were collected at (1) pre-intervention, (2) after coronarography, (3) 2 h after coronarography initiation and coronary stent placement, and (4) the next morning. Results: There was a strong negative correlation between SST-LI concentrations and age; the plasma SST-LI of older healthy volunteers (47\u201373 years) was significantly lower than in young ones (24\u201327 years). Baseline SST-LI in CHD patients who needed stents was significantly reduced compared to those not requiring stents. Plasma SST-LI significantly increased two hours post stent insertion and the next morning compared to pre-intervention levels. Conclusions: Age-related SST decrease might be a consequence of lower gene expression within specific hypo-thalamic nuclei as has been previously demonstrated in rodent animals. Reperfusion of ischemic myocardium post-stent implantation may trigger SST release, potentially offering protective benefits in coronary heart disease. Investigating this SST-mediated mechanism could offer valuable insights for future therapies.<\/jats:p>","DOI":"10.3390\/jcm13164727","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T11:23:46Z","timestamp":1723461826000},"page":"4727","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Plasma Somatostatin Levels Are Lower in Patients with Coronary Stenosis and Significantly Increase after Stent Implantation"],"prefix":"10.3390","volume":"13","author":[{"given":"Bal\u00e1zs","family":"S\u00fct\u0151","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Intensive Therapy, Medical School, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f3zsef","family":"Kun","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy, Medical School, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"},{"name":"Hungarian Centre for Genomics and Bioinformatics, Szent\u00e1gothai Research Centre, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"},{"name":"National Laboratory for Drug Research and Development, 1117 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ter\u00e9z","family":"Bagoly","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy, Medical School, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4098-190X","authenticated-orcid":false,"given":"Timea","family":"N\u00e9meth","sequence":"additional","affiliation":[{"name":"Department of Languages for Biomedical Purposes and Communication, Medical School, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9898-632X","authenticated-orcid":false,"given":"Erika","family":"Pint\u00e9r","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy, Medical School, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"},{"name":"National Laboratory for Drug Research and Development, 1117 Budapest, Hungary"},{"name":"Hungarian Research Network (HUN-REN-PTE), Chronic Pain Research Group, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorottya","family":"Kardos","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Therapy, General District Hospital Szeksz\u00e1rd, 7100 Szeksz\u00e1rd, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsuzsanna","family":"Helyes","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy, Medical School, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"},{"name":"National Laboratory for Drug Research and Development, 1117 Budapest, Hungary"},{"name":"Hungarian Research Network (HUN-REN-PTE), Chronic Pain Research Group, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/S0024-3205(99)00374-4","article-title":"Calcitonin Gene-Related Peptide and Other Neuropeptides in the Plasma of Patients with Soft Tissue Injury","volume":"65","author":"Onuoha","year":"1999","journal-title":"Life Sci."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Sz\u0151ke, \u00c9., and Helyes, Z. 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