{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T23:16:11Z","timestamp":1788131771525,"version":"build-2803163510"},"reference-count":45,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T00:00:00Z","timestamp":1723420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI22\/00594"],"award-info":[{"award-number":["PI22\/00594"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FI20\/00022"],"award-info":[{"award-number":["FI20\/00022"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CPII21\/00006"],"award-info":[{"award-number":["CPII21\/00006"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["007-0047"],"award-info":[{"award-number":["007-0047"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Instituto de Salud Carlos III","award":["PI22\/00594"],"award-info":[{"award-number":["PI22\/00594"]}]},{"name":"Instituto de Salud Carlos III","award":["FI20\/00022"],"award-info":[{"award-number":["FI20\/00022"]}]},{"name":"Instituto de Salud Carlos III","award":["CPII21\/00006"],"award-info":[{"award-number":["CPII21\/00006"]}]},{"name":"Instituto de Salud Carlos III","award":["007-0047"],"award-info":[{"award-number":["007-0047"]}]},{"name":"Instituto de Investigaci\u00f3n Sanitaria La Fe","award":["PI22\/00594"],"award-info":[{"award-number":["PI22\/00594"]}]},{"name":"Instituto de Investigaci\u00f3n Sanitaria La Fe","award":["FI20\/00022"],"award-info":[{"award-number":["FI20\/00022"]}]},{"name":"Instituto de Investigaci\u00f3n Sanitaria La Fe","award":["CPII21\/00006"],"award-info":[{"award-number":["CPII21\/00006"]}]},{"name":"Instituto de Investigaci\u00f3n Sanitaria La Fe","award":["007-0047"],"award-info":[{"award-number":["007-0047"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: The VALCODIS (Valencian Cognitive Diseases Study) cohort was designed and studied at the Hospital Universitari i Polit\u00e8cnic La Fe (Valencia, Spain) for the research of cognitive diseases, especially in the search for new biomarkers of Alzheimer\u2019s disease (AD). Methods: Participants in the VALCODIS cohort had cerebrospinal fluid (CSF) and blood samples, neuroimaging, and neuropsychological tests. The ApoE genotype was evaluated to identify its relationship with CSF biomarkers and neuropsychological tests in AD and non-AD participants. Results: A total of 1249 participants were included. They were mainly AD patients (n = 547) but also patients with other dementias (frontotemporal lobar dementia (n = 61), Lewy body dementia without AD CSF signature (n = 10), vascular dementia (n = 24) and other specific causes of cognitive impairment (n = 442), and patients with subjective memory complaints (n = 165)). In the ApoE genotype evaluation, significant differences were found for A\u03b242 levels between genotypes in both AD and non-AD patients, as well as a negative correlation between tau values and a cognitive test in non-carriers and \u03b54 heterozygous. Conclusions: The VALCODIS cohort provides biologically diagnosed patients with demographical, clinical and biochemical data, and biological samples for further studies on early AD diagnosis. Also, the ApoE genotype evaluation showed correlations between CSF biomarkers and neuropsychological tests.<\/jats:p>","DOI":"10.3390\/jcm13164735","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T11:23:46Z","timestamp":1723461826000},"page":"4735","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Insights from a 7-Year Dementia Cohort (VALCODIS): ApoE Genotype Evaluation"],"prefix":"10.3390","volume":"13","author":[{"given":"Miguel","family":"Baquero","sequence":"first","affiliation":[{"name":"Research Group in Alzheimer\u2019s Disease, Instituto de Investigaci\u00f3n Sanitaria La Fe, Avda. Fernando Abril Martorell, 106, 46026 Valencia, Spain"},{"name":"Neurology Unit, University and Polytechnic Hospital La Fe, Avda. Fernando Abril Martorell, 106, 46026 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4631-4761","authenticated-orcid":false,"given":"Laura","family":"Ferr\u00e9-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Research Group in Alzheimer\u2019s Disease, Instituto de Investigaci\u00f3n Sanitaria La Fe, Avda. Fernando Abril Martorell, 106, 46026 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7016-9739","authenticated-orcid":false,"given":"Lourdes","family":"\u00c1lvarez-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Research Group in Alzheimer\u2019s Disease, Instituto de Investigaci\u00f3n Sanitaria La Fe, Avda. Fernando Abril Martorell, 106, 46026 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00e9s","family":"Ferrer-Cairols","sequence":"additional","affiliation":[{"name":"Research Group in Alzheimer\u2019s Disease, Instituto de Investigaci\u00f3n Sanitaria La Fe, Avda. Fernando Abril Martorell, 106, 46026 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Garc\u00eda-Vall\u00e9s","sequence":"additional","affiliation":[{"name":"Research Group in Alzheimer\u2019s Disease, Instituto de Investigaci\u00f3n Sanitaria La Fe, Avda. Fernando Abril Martorell, 106, 46026 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar","family":"Peret\u00f3","sequence":"additional","affiliation":[{"name":"Research Group in Alzheimer\u2019s Disease, Instituto de Investigaci\u00f3n Sanitaria La Fe, Avda. Fernando Abril Martorell, 106, 46026 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Raga","sequence":"additional","affiliation":[{"name":"Research Group in Alzheimer\u2019s Disease, Instituto de Investigaci\u00f3n Sanitaria La Fe, Avda. Fernando Abril Martorell, 106, 46026 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0596-5613","authenticated-orcid":false,"given":"Gemma","family":"Garc\u00eda-Lluch","sequence":"additional","affiliation":[{"name":"Research Group in Alzheimer\u2019s Disease, Instituto de Investigaci\u00f3n Sanitaria La Fe, Avda. Fernando Abril Martorell, 106, 46026 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Pe\u00f1a-Bautista","sequence":"additional","affiliation":[{"name":"Research Group in Alzheimer\u2019s Disease, Instituto de Investigaci\u00f3n Sanitaria La Fe, Avda. 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