{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T23:04:48Z","timestamp":1784675088706,"version":"3.55.0"},"reference-count":22,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T00:00:00Z","timestamp":1723593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002642","name":"Korea University","doi-asserted-by":"publisher","award":["K2125911"],"award-info":[{"award-number":["K2125911"]}],"id":[{"id":"10.13039\/501100002642","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Although advancements in desensitization protocols have led to increased ABO-incompatible (ABOi) living-donor liver transplantation (LDLT), a higher biliary complication rate remains a problem. This study evaluated the effect of baseline anti-ABO antibody titers before desensitization on biliary complications after ABOi LDLT. Methods: The study cohort comprised 116 patients in the ABO-compatible group (ABOc), 29 in the ABOi with the low titer (&lt;1:128) group (ABOi-L), and 14 in the high titer (\u22651:128) group (ABOi-H). Results: Biliary complications occurred more frequently in the ABOi-H group than in the ABOi-L and ABOc groups (7 [50.0%] vs. 8 [27.6%] and 24 [20.7%], respectively, p = 0.041). Biliary complication-free survival was significantly worse in the ABOi-H group than in the other groups (p = 0.043). Diffuse intrahepatic biliary strictures occurred more frequently in the ABOi-H group than in the other groups (p = 0.005). Multivariable analysis revealed that the high anti-ABO antibody titer (\u22651:128) is an independent risk factor for biliary complications (hazard ratio 3.943 [1.635\u20139.506]; p = 0.002). Conclusions: A high baseline anti-ABO antibody titer (\u22651:128), female sex, and hepatic artery complications are significant risk factors for biliary complications.<\/jats:p>","DOI":"10.3390\/jcm13164789","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T09:20:51Z","timestamp":1723627251000},"page":"4789","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Baseline Anti-ABO Antibody Titer on Biliary Complications in ABO-Incompatible Living-Donor Liver Transplantation"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6669-0460","authenticated-orcid":false,"given":"Se-Hyeon","family":"Yu","sequence":"first","affiliation":[{"name":"Division of HBP Surgery and Liver Transplantation, Department of Surgery, Korea University Anam Hospital, Korea University College of Medicine, Seoul 02841, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9253-8662","authenticated-orcid":false,"given":"Hye-Sung","family":"Jo","sequence":"additional","affiliation":[{"name":"Division of HBP Surgery and Liver Transplantation, Department of Surgery, Korea University Anam Hospital, Korea University College of Medicine, Seoul 02841, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Dong","family":"Yu","sequence":"additional","affiliation":[{"name":"Division of HBP Surgery and Liver Transplantation, Department of Surgery, Korea University Anam Hospital, Korea University College of Medicine, Seoul 02841, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pyoung-Jae","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Transplantation and Vascular Surgery, Department of Surgery, Korea University Guro Hospital, Korea University College of Medicine, Seoul 02841, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung-Joon","family":"Han","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliopancreas and Transplant Surgery, Korea University Ansan Hospital, Ansan-si 05505, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0080-176X","authenticated-orcid":false,"given":"Sang-Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliopancreas and Transplant Surgery, Korea University Ansan Hospital, Ansan-si 05505, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syahrul Hadi","family":"Kamarulzaman","sequence":"additional","affiliation":[{"name":"Division of HBP Surgery and Liver Transplantation, Department of Surgery, Korea University Anam Hospital, Korea University College of Medicine, Seoul 02841, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0608-1580","authenticated-orcid":false,"given":"Dong-Sik","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of HBP Surgery and Liver Transplantation, Department of Surgery, Korea University Anam Hospital, Korea University College of Medicine, Seoul 02841, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1097\/LVT.0000000000000303","article-title":"The incidence of adverse outcome in donors after living donor liver transplantation: A meta-analysis of 60,829 donors","volume":"30","author":"Xiao","year":"2024","journal-title":"Liver Transpl."},{"key":"ref_2","first-page":"231","article-title":"Human ABO-incompatible living donor renal homografts","volume":"28","author":"Alexandre","year":"1985","journal-title":"Neth. 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