{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T11:04:13Z","timestamp":1780398253664,"version":"3.54.1"},"reference-count":42,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T00:00:00Z","timestamp":1723593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The number of solid organ transplant recipients (SOTRs) is growing as a consequence of an increase in transplantations and longer survival; these patients, thus, frequently suffer various comorbidities and are subjected to the detrimental effects of immunosuppressive agents, which expose them to a higher risk of developing malignancies. These drugs also complicate the surgical treatment of neoplasms, as they can hinder wound healing, especially when associated with other unfavorable factors (e.g., previous radiotherapy, diabetes, etc.). We herein present our experience with a 74-year-old SOTR who underwent a radical extended parotidectomy and reconstruction with a submental island flap for a persistent cutaneous squamous carcinoma after radiotherapy; his complicated clinical course was characterized by incredibly slow wound healing. The current literature was reviewed to provide a succinct overview of the main difficulties of head and neck surgery in SOTRs. In particular, the immunosuppressive regimen can be tapered considering the individual risk and other elements should be carefully assessed, possibly prior to surgery, to prevent cumulative harm. New developments, including intraoperative monitoring of flap vascularization through indocyanine green fluorescence video-angiography and the prophylactic application of negative pressure wound therapy, when feasible, may be particularly beneficial for high-risk patients.<\/jats:p>","DOI":"10.3390\/jcm13164790","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T09:20:51Z","timestamp":1723627251000},"page":"4790","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Reconstructive Surgery of the Head and Neck in Organ Transplant Recipients: A Case Report and a Review of the Literature"],"prefix":"10.3390","volume":"13","author":[{"given":"Andrea","family":"Rampi","sequence":"first","affiliation":[{"name":"Otorhinolaryngology Unit, Sondrio Hospital, ASST Valtellina e Alto Lario, 23100 Sondrio, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3639-1504","authenticated-orcid":false,"given":"Lara Valentina","family":"Comini","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology, Head and Neck Surgery, Candiolo Cancer Institute, FPO-IRCCS, 10060 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2677-8091","authenticated-orcid":false,"given":"Andrea","family":"Galli","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit, Division Head and Neck Department, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy"},{"name":"School of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bright Oworae","family":"Howardson","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit, Division Head and Neck Department, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy"},{"name":"School of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7260-9126","authenticated-orcid":false,"given":"Alberto","family":"Tettamanti","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit, Division Head and Neck Department, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy"},{"name":"School of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Luparello","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology, Head and Neck Surgery, Candiolo Cancer Institute, FPO-IRCCS, 10060 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Redaelli","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit, Sondrio Hospital, ASST Valtellina e Alto Lario, 23100 Sondrio, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Di Santo","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology, Head and Neck Surgery, Candiolo Cancer Institute, FPO-IRCCS, 10060 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9163-5540","authenticated-orcid":false,"given":"Stefano","family":"Bondi","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology, Head and Neck Surgery, Candiolo Cancer Institute, FPO-IRCCS, 10060 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4009","DOI":"10.1002\/hed.25937","article-title":"Elevated Incidence of Head and Neck Cancer in Solid Organ Transplant Recipients","volume":"41","author":"Mowery","year":"2019","journal-title":"Head Neck"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e13669","DOI":"10.1111\/ctr.13669","article-title":"Post-Transplant Malignancy in Solid Organ Transplant Recipients in Ireland, The Irish Transplant Cancer Group","volume":"33","author":"Sexton","year":"2019","journal-title":"Clin. 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