{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T03:55:40Z","timestamp":1776916540791,"version":"3.51.2"},"reference-count":51,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2024,8,18]],"date-time":"2024-08-18T00:00:00Z","timestamp":1723939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Alicia Koplowitz Foundation, Fundaci\u00f3n Alicia KoplowitzKoplowitz"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Young children with spinal muscular atrophy type 1 (SMA1) have limited independent mobility and participation that may lead to cognitive development delays. Implementing early powered mobility in interventions may help them to learn self-initiated movement, play, and having fun to participate in natural settings. The aim of this study is to evaluate the effectiveness of an early power mobility intervention for increasing participation, functional ability, and quality of life in young children with SMA1. Methods: AMEsobreRuedas is a randomized waiting list controlled clinical trial. A sample of 24 children (10 months-5 years old, with SMA1) will be randomly allocated to two groups. The experimental group will perform a family-centered intervention with powered mobility for 16 weeks in their natural environment: a 12-week-structured program three times a week; and a 4-week follow-up with free use of the powered mobility device. The control group (waiting list) will keep their routine and will receive the same intervention after the experimental group. Five assessments will be carried out at baseline and weeks 4, 8, 12, and 16. Primary outcomes are participation (YC-PEM); functional ability (PEDI-CAT); and quality of life (PedsQL-Neuromuscular module). Results: It is expected that this study will provide further knowledge about the positive impact of powered mobility for the analyzed variables. Moreover, family engagement in the intervention and establishment of functional goals may help to add valuable information about real needs in future research. Conclusions: Early powered mobility could increase the opportunities for children with SMA1 to learn to move independently and participate in their natural environment.<\/jats:p>","DOI":"10.3390\/jcm13164875","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T06:41:31Z","timestamp":1724049691000},"page":"4875","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["AMEsobreRuedas Early Powered Mobility in Children with Spinal Muscular Atrophy Type I: Protocol of a Randomized Controlled Trial"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4034-2585","authenticated-orcid":false,"given":"Roc\u00edo","family":"Palomo-Carri\u00f3n","sequence":"first","affiliation":[{"name":"Department of Nursing, Physiotherapy and Occupational Therapy, Faculty of Physiotherapy and Nursing, Universidad de Castilla-La Mancha, Avda. Carlos III, s\/n, 45071 Toledo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4308-7340","authenticated-orcid":false,"given":"Purificaci\u00f3n","family":"L\u00f3pez-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Department of Nursing, Physiotherapy and Occupational Therapy, Faculty of Physiotherapy and Nursing, Universidad de Castilla-La Mancha, Avda. Carlos III, s\/n, 45071 Toledo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6263-1818","authenticated-orcid":false,"given":"Egmar","family":"Longo","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Federal University of Paraiba, Jo\u00e3o Pessoa 58051-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2388-2213","authenticated-orcid":false,"given":"Helena","family":"Romay-Barrero","sequence":"additional","affiliation":[{"name":"Department of Nursing, Physiotherapy and Occupational Therapy, Faculty of Physiotherapy and Nursing, Universidad de Castilla-La Mancha, Avda. Carlos III, s\/n, 45071 Toledo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5322-0576","authenticated-orcid":false,"given":"Maribel","family":"R\u00f3denas-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Centro de Desarrollo Infantil y Atenci\u00f3n Temprana, Asociaci\u00f3n APSA, 03005 Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Plasencia-Robledo","sequence":"additional","affiliation":[{"name":"Centro Atenci\u00f3n Temprana El Grao, Hermanas Hospitalarias, 46024 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"de Andr\u00e9s-Beltr\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Centro RIE (Rehabilitaci\u00f3n Infantil Especializada), 28050 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Coello-Villal\u00f3n","sequence":"additional","affiliation":[{"name":"Hemichild-Research-Unit, Faculty of Physiotherapy and Nursing, Universidad de Castilla-La Mancha, 45071 Toledo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"D\u00edaz-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Asociaci\u00f3n de Padres de Ni\u00f1os con Dificultades en el Desarrollo\u2014APANDID, 45500 Toledo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2226-3560","authenticated-orcid":false,"given":"Soraya","family":"Pacheco-da-Costa","sequence":"additional","affiliation":[{"name":"Neuromusculoskeletal Physical Therapy in Stages of Life Research Group (FINEMEV), Physical Therapy Degree, Department of Nursing and Physical Therapy, Faculty of Medicine and Health Sciences, Universidad de Alcal\u00e1, Autov\u00eda A2, km 33.200, Alcal\u00e1 de Henares, 28805 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/s41572-022-00380-8","article-title":"Spinal muscular atrophy","volume":"8","author":"Chiriboga","year":"2022","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Day, J.W., Howell, K., Place, A., Long, K., Rossello, J., Kertesz, N., and Nomikos, G. (2022). Advances and limitations for the treatment of spinal muscular atrophy. BMC Pediatr., 22.","DOI":"10.1186\/s12887-022-03671-x"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Angilletta, I., Ferrante, R., Giansante, R., Lombardi, L., Babore, A., Dell\u2019Elice, A., Alessandrelli, E., Notarangelo, S., Ranaudo, M., and Palmarini, C. (2023). Spinal Muscular Atrophy: An Evolving Scenario through New Perspectives in Diagnosis and Advances in Therapies. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241914873"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Lejman, J., Zieli\u0144ski, G., Gawda, P., and Lejman, M. (2021). Alternative Splicing Role in New Therapies of Spinal Muscular Atrophy. Genes, 12.","DOI":"10.3390\/genes12091346"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1177\/0883073807305788","article-title":"Consensus Statement for Standard of Care in Spinal Muscular Atrophy","volume":"22","author":"Wang","year":"2007","journal-title":"J. Child Neurol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.nmd.2017.11.005","article-title":"Diagnosis and management of spinal muscular atrophy: Part 1: Recommendations for diagnosis, rehabilitation, orthopedic and nutritional care","volume":"28","author":"Mercuri","year":"2018","journal-title":"Neuromuscul. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.nmd.2017.11.004","article-title":"Diagnosis and management of spinal muscular atrophy: Part 2: Pulmonary and acute care; medications, supplements and immunizations; other organ systems; and ethics","volume":"28","author":"Finkel","year":"2018","journal-title":"Neuromuscul. Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e200310","DOI":"10.1212\/CPJ.0000000000200310","article-title":"Spinal Muscular Atrophy Update in Best Practices: Recommendations for Diagnosis Considerations","volume":"14","author":"Schroth","year":"2024","journal-title":"Neurol. Clin. Pract."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1097\/PHM.0000000000001045","article-title":"Evidence-Based Physiatry: Pediatric Neuromuscular Rehabilitation in the Era of Precision Medicine","volume":"97","author":"Paganoni","year":"2018","journal-title":"Am. J. Phys. Med. Rehab."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1212\/WNL.0000000000000741","article-title":"Observational study of spinal muscular atrophy type I and implications for clinical trials","volume":"83","author":"Finkel","year":"2014","journal-title":"Neurology"},{"key":"ref_11","first-page":"3","article-title":"New and developing therapies in spinal muscular atrophy","volume":"28","author":"Kariyawasam","year":"2018","journal-title":"Paediatr. Respir. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/dmcn.14798","article-title":"Brain, cognition, and language development in spinal muscular atrophy type 1: A scoping review","volume":"63","author":"Masson","year":"2021","journal-title":"Dev. Med. Child Neurol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Bitetti, I., Manna, M.R., Stella, R., and Varone, A. (2024). Motor and neurocognitive profiles of children with symptomatic spinal muscular atrophy type 1 with two copies of SMN2 before and after treatment: A longitudinal observational study. Front. Neurol., 15.","DOI":"10.3389\/fneur.2024.1326528"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1177\/0883073812449383","article-title":"Independent Mobility After Early Introduction of a Power Wheelchair in Spinal Muscular Atrophy","volume":"28","author":"Dunaway","year":"2013","journal-title":"J. Child Neurol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1016\/j.apmr.2017.05.028","article-title":"Retrospective Analysis of Predictors of Proficient Power Mobility in Young Children with Severe Motor Impairments","volume":"98","author":"Mockler","year":"2017","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1093\/ptj\/83.3.253","article-title":"Use of Power Mobility for a Young Child with Spinal Muscular Atrophy","volume":"83","author":"Jones","year":"2003","journal-title":"Phys. Ther."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Logan, S.W., Sloane, B.M., Kenyon, L.K., and Feldner, H.A. (2023). Powered Mobility Device Use and Developmental Change of Young Children with Cerebral Palsy. Behav. Sci., 13.","DOI":"10.3390\/bs13050399"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1080\/10400435.2012.685824","article-title":"The Positive Effects of Early Powered Mobility on Children\u2019s Psychosocial and Play Skills","volume":"25","author":"Guerette","year":"2013","journal-title":"Assist. Technol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1177\/0308022620973935","article-title":"Exploring young children\u2019s activity and participation change following 6 months\u2019 power mobility experience","volume":"84","author":"Livingstone","year":"2021","journal-title":"Br. J. Occup. Ther."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1080\/17483107.2021.1963330","article-title":"Active mobility, active participation: A systematic review of modified ride-on car use by children with disabilities","volume":"18","author":"Hospodar","year":"2023","journal-title":"Disabil. Rehabil. Assist. Technol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/disabilities1010001","article-title":"Enhancing Function, Fun and Participation with Assistive Devices, Adaptive Positioning, and Augmented Mobility for Young Children with Infantile-Onset Spinal Muscular Atrophy: A Scoping Review and Illustrative Case Report","volume":"1","author":"Livingstone","year":"2021","journal-title":"Disabilities"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ridd.2018.08.001","article-title":"Modified ride-on cars and mastery motivation in young children with disabilities: Effects of environmental modifications","volume":"83","author":"Huang","year":"2018","journal-title":"Res. Dev. Disabil."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Huang, H., Chen, Y., Huang, H., Shih, M., Hsieh, Y., and Chen, C. (2018). Modified Ride-On Cars and Young Children with Disabilities: Effects of Combining Mobility and Social Training. Front. Pediatr., 5.","DOI":"10.3389\/fped.2017.00299"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/PEP.0000000000000468","article-title":"Modified Ride-on Car Use by Young Children with Disabilities","volume":"30","author":"Logan","year":"2018","journal-title":"Pediatr. Phys. Ther."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/dmcn.12633","article-title":"The child and family experience of power mobility: A qualitative synthesis","volume":"57","author":"Livingstone","year":"2015","journal-title":"Dev. Med. Child Neurol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/PEP.0000000000000458","article-title":"Power Mobility Training Methods for Children: A Systematic Review","volume":"30","author":"Kenyon","year":"2018","journal-title":"Pediatr. Phys. Ther."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"World Medical Association (2013). Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects. JAMA, 310, 2191\u20132194.","DOI":"10.1001\/jama.2013.281053"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Burzaco-Samper, M. (2020). Ley Org\u00e1nica 3\/2018, de 5 de diciembre, de protecci\u00f3n de datos personales y garant\u00eda de los derechos digitales. Protecci\u00f3n de Datos Personales, Dykinson. [1st ed.].","DOI":"10.2307\/j.ctv17hm980"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1111\/dmcn.13709","article-title":"Power mobility skill progression for children and adolescents: A systematic review of measures and their clinical application","volume":"60","author":"Field","year":"2018","journal-title":"Dev. Med. Child Neurol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.apmr.2014.09.031","article-title":"Psychometric Properties of the Young Children\u2019s Participation and Environment Measure","volume":"96","author":"Khetani","year":"2015","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3109\/09638288.2011.607217","article-title":"Computer adaptive test performance in children with and without disabilities: Prospective field study of the PEDI-CAT","volume":"34","author":"Dumas","year":"2012","journal-title":"Disabil. Rehabil."},{"key":"ref_32","first-page":"81","article-title":"Spanish translation and validation of the neuromuscular module of the Pediatric Quality of Life Inventory (PedsQL): Evaluation of the quality of life perceived by the parents of 2\u20134-year-old children with neuromuscular diseases","volume":"66","author":"Fagoaga","year":"2018","journal-title":"Neurologia"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1682\/JRRD.2013.11.0237","article-title":"Assessment of learning powered mobility use\u2014Applying grounded theory to occupational performance","volume":"51","author":"Nilsson","year":"2014","journal-title":"J. Rehabil. Res. Dev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/1440-1630.12709","article-title":"Inter-rater reliability of the assessment of learning powered mobility use, version 2.0, when applied with children and adults engaged in Driving to Learn in a powered wheelchair","volume":"68","author":"Svensson","year":"2021","journal-title":"Aust. Occup. Ther. J."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.apmr.2015.08.424","article-title":"Proposed Criteria for Appraising Goal Attainment Scales Used as Outcome Measures in Rehabilitation Research","volume":"97","author":"Evans","year":"2016","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1037\/pas0000257","article-title":"Psychometric Properties of the Parenting Stress Index-Short Form (PSI-SF) in a High-Risk Sample of Mothers and Their Infants","volume":"28","author":"Barroso","year":"2016","journal-title":"Psychol. Assess."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1007\/s12144-017-9659-8","article-title":"Psychometric Properties of the Castilian Spanish Version of the Client Satisfaction Questionnaire (CSQ-8)","volume":"38","author":"Torres","year":"2019","journal-title":"Curr. Psychol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Guerreiro, J., Jim\u00e9nez-Arberas, E., Porto-Trillo, P., Vilar-Figueira, O., Sa\u00e9nz-L\u00f3pez-Bu\u00f1uel, P., Pais, S., Tierra Orta, J., and Pousada Garc\u00eda, T. (2022). Cross-Cultural Validation of Quebec User Satisfaction with Assistive Technology 2.0 for Spanish Population (QUEST-2.0 ES). Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19159349"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Aceros, J., and Lundy, M. (2020). Enhanced Steering and Drive Adaptations of Modified Ride-On Toy Cars for Improved Directional Control in Very Young Children with Severe Multiple Developmental Impairments. Front. Pediatr., 8.","DOI":"10.3389\/fped.2020.00567"},{"key":"ref_40","first-page":"2055668320926046","article-title":"Beginning power mobility: An exploration of factors associated with child use of early power mobility devices and parent device preference","volume":"7","author":"Livingstone","year":"2020","journal-title":"J. Rehabil. Assist. Technol. Eng."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.apmr.2022.09.021","article-title":"Rehabilitation Treatment Specification System: Identifying Barriers, Facilitators, and Strategies for Implementation in Research, Education, and Clinical Care","volume":"104","author":"Holmes","year":"2023","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.apmr.2018.09.112","article-title":"The Rehabilitation Treatment Specification System: Implications for Improvements in Research Design, Reporting, Replication, and Synthesis","volume":"100","author":"Dijkers","year":"2019","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"7703070010","DOI":"10.5014\/ajot.2023.077301","article-title":"Improving Standards of Research Reporting in Intervention Research: Considerations for the Rehabilitation Treatment Specification System Model","volume":"77","author":"Reynolds","year":"2023","journal-title":"Am. J. Occup. Ther."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"160940691875763","DOI":"10.1177\/1609406918757631","article-title":"Thinking Critically About Photovoice: Achieving Empowerment and Social Change","volume":"17","author":"Liebenberg","year":"2018","journal-title":"Int. J. Qual. Methods"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/s43586-023-00214-1","article-title":"Participatory action research","volume":"3","author":"Cornish","year":"2023","journal-title":"Nat. Rev. Methods Primers"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1111\/hex.12486","article-title":"Evaluating patient and public involvement in health research: From theoretical model to practical workshop","volume":"20","author":"Gibson","year":"2017","journal-title":"Health Expect."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Arumugam, A., Phillips, L.R., Moore, A., Kumaran, S.D., Sampath, K.K., Migliorini, F., Maffulli, N., Ranganadhababu, B.N., Hegazy, F., and Botto-van Bemden, A. (2023). Patient and public involvement in research: A review of practical resources for young investigators. BMC Rheumatol., 7.","DOI":"10.1186\/s41927-023-00327-w"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1177\/0741713604263057","article-title":"Qualitative Research in Practice: Examples for Discussion and Analysis","volume":"54","author":"Hansman","year":"2004","journal-title":"Adult Educ. Q."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1080\/2159676X.2019.1628806","article-title":"Reflecting on reflexive thematic analysis","volume":"11","author":"Braun","year":"2019","journal-title":"Qual. Res. Sport Exerc. Health"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Huang, H. (2018). Perspectives on Early Power Mobility Training, Motivation, and Social Participation in Young Children with Motor Disabilities. Front. Psychol., 8.","DOI":"10.3389\/fpsyg.2017.02330"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.acap.2010.12.014","article-title":"Evidence for Family-Centered Care for Children with Special Health Care Needs: A Systematic Review","volume":"11","author":"Kuhlthau","year":"2011","journal-title":"Acad. Pediatr."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/16\/4875\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:38:32Z","timestamp":1760110712000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/16\/4875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,18]]},"references-count":51,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["jcm13164875"],"URL":"https:\/\/doi.org\/10.3390\/jcm13164875","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,18]]}}}