{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:21:25Z","timestamp":1791908485189,"version":"4.3.4"},"reference-count":62,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T00:00:00Z","timestamp":1724198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Saudi Arabia Cultural Bureau in London"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Currently, the primary strategy for addressing polycystic ovarian syndrome (PCOS) involves lifestyle modifications, with a focus on weight loss. The purpose of this meta-analysis was to assess the impact of weight loss through dietary interventions on inflammatory status and hyperandrogenism in PCOS women. Methods: A comprehensive search was conducted to identify randomised controlled trials (RCTs) and cohort studies assessing the impact of diet-induced weight loss on circulating inflammatory markers (CRP, IL-6, IL-1\u03b2, TNF-\u03b1), androgens (testosterone, androstenedione), SHBG, and luteinising hormone (LH) in PCOS women. The quality and risk of bias of the included studies were assessed using the Cochrane Collaboration\u2019s tool for RCTs and the Newcastle\u2013Ottawa Scale for cohort studies. Data were entered into RevMan software v5.9 for the calculation of standard mean difference (SMD) and the 95% confidence interval (95%CI) of circulating inflammatory markers, androgens, and LH between baseline and post-weight loss values. Results: Eleven studies (n = 323) were eligible for the systematic review, of which nine (n = 286) were included in the meta-analysis. Pooled analysis of data revealed a statistically significant decrease in circulating CRP (SMD 0.39, 95%CI 0.22, 0.56; 9 studies, n = 286), IL-6 (SMD 0.37, 95%Cl, 0.12, 0.61; 3 Studies, n = 140), TNF-\u03b1 (SMD 0.30, 95%Cl, 0.07, 0.53; 4 Studies, n = 162), androstenedione (SMD 0.36, 95%Cl, 0.13, 0.60; 4 studies, n = 147) and LH (SMD 0.30, 95% Cl, 0.09, 0.51; 5 studies, n = 197) after weight loss compared to baseline levels among PCOS women. A meta-analysis of five studies (n = 173) showed a statistically significant increase in circulating SHBG after weight loss compared to baseline levels (SMD \u22120.43, 95%Cl, \u22120.65, \u22120.21). Conclusions: These findings suggest that weight loss induced by dietary interventions seems to improve PCOS-related chronic inflammation and hyperandrogenism. The possible causative relationship between the improvement in inflammation and hyperandrogenism remains to be determined.<\/jats:p>","DOI":"10.3390\/jcm13164934","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T11:14:41Z","timestamp":1724325281000},"page":"4934","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The Impact of Diet-Induced Weight Loss on Inflammatory Status and Hyperandrogenism in Women with Polycystic Ovarian Syndrome (PCOS)\u2014A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3058-7239","authenticated-orcid":false,"given":"Salih Atalah","family":"Alenezi","sequence":"first","affiliation":[{"name":"Division of Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham NG5 1PB, UK"},{"name":"Prince Mohammed Bin Abdulaziz Medical City, Ministry of Health, Riyadh 14214, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nusaiba","family":"Elkmeshi","sequence":"additional","affiliation":[{"name":"Division of Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham NG5 1PB, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Alanazi","sequence":"additional","affiliation":[{"name":"Health Sciences, Applied Sciences, Petaling Jaya 47301, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulaiman T.","family":"Alanazi","sequence":"additional","affiliation":[{"name":"Health Sciences, Applied Sciences, Petaling Jaya 47301, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raheela","family":"Khan","sequence":"additional","affiliation":[{"name":"Division of Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham NG5 1PB, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8321-1302","authenticated-orcid":false,"given":"Saad","family":"Amer","sequence":"additional","affiliation":[{"name":"Division of Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham NG5 1PB, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1177\/1933719114522525","article-title":"Prevalence of polycystic ovary syndrome phenotypes using updated criteria for polycystic ovarian morphology: An assessment of over 100 consecutive women self-reporting features of polycystic ovary syndrome","volume":"21","author":"Clark","year":"2014","journal-title":"Reprod. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.amjmed.2014.04.017","article-title":"Polycystic ovary syndrome: Update on diagnosis and treatment","volume":"127","author":"Setji","year":"2014","journal-title":"Am. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1093\/humupd\/dms030","article-title":"Overweight, obesity and central obesity in women with polycystic ovary syndrome: A systematic review and meta-analysis","volume":"18","author":"Lim","year":"2012","journal-title":"Hum. Reprod. Update"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1210\/er.2011-1034","article-title":"Insulin resistance and the polycystic ovary syndrome revisited: An update on mechanisms and implications","volume":"33","author":"Dunaif","year":"2012","journal-title":"Endocr. Rev."},{"key":"ref_5","first-page":"55","article-title":"Cardiometabolic aspects of polycystic ovarian syndrome","volume":"3","author":"Cho","year":"2007","journal-title":"Vasc. Health Risk Manag."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s00404-014-3199-3","article-title":"The effect of obesity on inflammatory markers in patients with PCOS: A BMI-matched case-control study","volume":"290","author":"Okyay","year":"2014","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_7","first-page":"409","article-title":"C-reactive protein: A new risk assessment tool for cardiovascular disease","volume":"105","author":"Clearfield","year":"2005","journal-title":"J. Osteopath. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1161\/01.HYP.0000130484.20501.df","article-title":"C-reactive protein: Risk marker or mediator in atherothrombosis?","volume":"44","author":"Jialal","year":"2004","journal-title":"Hypertension"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/90984","article-title":"The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity","volume":"7","author":"Yamauchi","year":"2001","journal-title":"Nat. Med."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Alenezi, S.A., Khan, R., Snell, L., Aboeldalyl, S., and Amer, S. (2023). The Role of NLRP3 Inflammasome in Obesity and PCOS\u2014A Systematic Review and Meta-Analysis. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241310976"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1161\/01.CIR.103.8.1057","article-title":"Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages","volume":"103","author":"Ouchi","year":"2001","journal-title":"Circulation"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.diabres.2005.10.025","article-title":"Serum CRP levels are equally elevated in newly diagnosed type 2 diabetes and impaired glucose tolerance and related to adiponectin levels and insulin sensitivity","volume":"72","author":"Yuan","year":"2006","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"5454","DOI":"10.1210\/jc.2003-032237","article-title":"Evidence for an association between metabolic cardiovascular syndrome and coronary and aortic calcification among women with polycystic ovary syndrome","volume":"89","author":"Talbott","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"5592","DOI":"10.1210\/jc.2004-0751","article-title":"Endothelial dysfunction in young women with polycystic ovary syndrome: Relationship with insulin resistance and low-grade chronic inflammation","volume":"89","author":"Tarkun","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_15","first-page":"1177","article-title":"Serum and follicular fluid cytokines in polycystic ovary syndrome during stimulated cycles","volume":"101","author":"Amato","year":"2003","journal-title":"Obstet. Gynecol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.metabol.2006.04.002","article-title":"Plasma interleukin 6 levels are elevated in polycystic ovary syndrome independently of obesity or sleep apnea","volume":"55","author":"Vgontzas","year":"2006","journal-title":"Metabolism"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"6014","DOI":"10.1210\/jc.2005-1002","article-title":"Central fat excess in polycystic ovary syndrome: Relation to low-grade inflammation and insulin resistance","volume":"90","author":"Puder","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"356.e351","DOI":"10.1016\/j.amjmed.2005.10.059","article-title":"Endothelial dysfunction in PCOS: Role of obesity and adipose hormones","volume":"119","author":"Carmina","year":"2006","journal-title":"Am. J. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1007\/BF03347474","article-title":"Serum adiponectin in women with polycystic ovarian syndrome and its relation to clinical, metabolic and endocrine parameters","volume":"27","author":"Sieminska","year":"2004","journal-title":"J. Endocrinol. Investig."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1055\/s-0031-1299765","article-title":"Differential diagnosis of hyperandrogenism in women with polycystic ovary syndrome","volume":"120","year":"2012","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3569","DOI":"10.1093\/humrep\/des335","article-title":"Common variants in the sex hormone-binding globulin gene (SHBG) and polycystic ovary syndrome (PCOS) in Mediterranean women","volume":"27","author":"Gambineri","year":"2012","journal-title":"Hum. Reprod."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/0002-9378(95)90147-7","article-title":"Ovarian control of follicle development","volume":"172","author":"Erickson","year":"1995","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1093\/humupd\/dmn015","article-title":"Follicle dynamics and anovulation in polycystic ovary syndrome","volume":"14","author":"Franks","year":"2008","journal-title":"Hum. Reprod. Update"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1093\/humupd\/dmw025","article-title":"The management of anovulatory infertility in women with polycystic ovary syndrome: An analysis of the evidence to support the development of global WHO guidance","volume":"22","author":"Balen","year":"2016","journal-title":"Hum. Reprod. Update"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Alenezi, S.A., Khan, R., and Amer, S. (2024). The Impact of High BMI on Pregnancy Outcomes and Complications in Women with PCOS Undergoing IVF\u2014A Systematic Review and Meta-Analysis. J. Clin. Med., 13.","DOI":"10.3390\/jcm13061578"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/ajcn\/84.1.77","article-title":"Short-term meal replacements followed by dietary macronutrient restriction enhance weight loss in polycystic ovary syndrome","volume":"84","author":"Moran","year":"2006","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_27","unstructured":"(1998). Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults: The Evidence Report, National Institutes of Health, National Heart, Lung, and Blood Institute."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1161\/01.CIR.102.18.2284","article-title":"AHA Dietary Guidelines: Revision 2000: A statement for healthcare professionals from the Nutrition Committee of the American Heart Association","volume":"102","author":"Krauss","year":"2000","journal-title":"Circulation"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3945\/ajcn.2010.29913","article-title":"Greater variety in fruit and vegetable intake is associated with lower inflammation in Puerto Rican adults","volume":"93","author":"Bhupathiraju","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1258\/ebm.2012.012157","article-title":"Serum metabolic variables associated with impaired glucose tolerance induced by high-fat-high-cholesterol diet in Macaca mulatta","volume":"237","author":"Li","year":"2012","journal-title":"Exp. Biol. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1080\/07315724.2012.10720017","article-title":"Beneficial effects of a high-protein, low-glycemic-load hypocaloric diet in overweight and obese women with polycystic ovary syndrome: A randomized controlled intervention study","volume":"31","author":"Mehrabani","year":"2012","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/s40519-021-01223-3","article-title":"Green cardamom plus low-calorie diet can decrease the expression of inflammatory genes among obese women with polycystic ovary syndrome: A double-blind randomized clinical trial","volume":"27","author":"Cheshmeh","year":"2021","journal-title":"Eat. Weight Disord. Stud. Anorex. Bulim. Obes."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3945\/ajcn.2010.29261","article-title":"Effect of a low glycemic index compared with a conventional healthy diet on polycystic ovary syndrome","volume":"92","author":"Marsh","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1111\/j.1447-0756.2012.02051.x","article-title":"Effect of M etformin compared with hypocaloric diet on serum C-reactive protein level and insulin resistance in obese and overweight women with polycystic ovary syndrome","volume":"39","author":"Esfahanian","year":"2012","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.jand.2012.11.018","article-title":"Dietary composition in the treatment of polycystic ovary syndrome: A systematic review to inform evidence-based guidelines","volume":"113","author":"Moran","year":"2013","journal-title":"J. Acad. Nutr. Diet."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"d5928","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration\u2019s tool for assessing risk of bias in randomised trials","volume":"343","author":"Higgins","year":"2011","journal-title":"Bmj"},{"key":"ref_37","unstructured":"Wells, G.A., Shea, B., O\u2019Connell, D., Peterson, J., Welch, V., Losos, M., and Tugwell, P. (2000). The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.1210\/jc.2012-1558","article-title":"The impact of excision of ovarian endometrioma on ovarian reserve: A systematic review and meta-analysis","volume":"97","author":"Raffi","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/aogs.13698","article-title":"The impact of uterine artery embolization on ovarian reserve: A systematic review and meta-analysis","volume":"99","author":"Amer","year":"2020","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1007\/s00384-019-03354-7","article-title":"An updated systematic review and meta-analysis about the safety and efficacy of infliximab biosimilar, CT-P13, for patients with inflammatory bowel disease","volume":"34","author":"Ebada","year":"2019","journal-title":"Int. J. Color. Dis."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1002\/sim.2589","article-title":"Inferences on standardized mean difference: The generalized variable approach","volume":"26","author":"Tian","year":"2007","journal-title":"Stat. Med."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Takeshima, N., Sozu, T., Tajika, A., Ogawa, Y., Hayasaka, Y., and Furukawa, T.A. (2014). Which is more generalizable, powerful and interpretable in meta-analyses, mean difference or standardized mean difference?. BMC Med. Res. Methodol., 14.","DOI":"10.1186\/1471-2288-14-30"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Cohen, J. (2013). Statistical Power Analysis for the Behavioral Sciences, Academic Press.","DOI":"10.4324\/9780203771587"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Deshmukh, H., Papageorgiou, M., Wells, L., Akbar, S., Strudwick, T., Deshmukh, K., Vitale, S.G., Rigby, A., Vince, R.V., and Reid, M. (2023). The Effect of a Very-Low-Calorie Diet (VLCD) vs. a Moderate Energy Deficit Diet in Obese Women with Polycystic Ovary Syndrome (PCOS)\u2014A Randomised Controlled Trial. Nutrients, 15.","DOI":"10.3390\/nu15183872"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"295","DOI":"10.5603\/GP.a2018.0051","article-title":"Changes in the IGF-1 and TNF-\u03b1 synthesis pathways before and after three-month reduction diet with low glicemic index in women with PCOS","volume":"89","author":"Szczuko","year":"2018","journal-title":"Ginekol. Pol."},{"key":"ref_46","first-page":"806","article-title":"Effects of Ramadan fasting on glucose homeostasis, lipid profiles, inflammation and oxidative stress in women with polycystic ovary syndrome in Kashan, Iran","volume":"18","author":"Asemi","year":"2015","journal-title":"Arch. Iran. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1016\/j.fertnstert.2010.02.057","article-title":"The effect of modifying dietary protein and carbohydrate in weight loss on arterial compliance and postprandial lipidemia in overweight women with polycystic ovary syndrome","volume":"94","author":"Moran","year":"2010","journal-title":"Fertil. Steril."},{"key":"ref_48","first-page":"13","article-title":"The effect of weight loss on inflammation in obese women with polycystic ovary syndrome","volume":"59","author":"Janowska","year":"2008","journal-title":"Endokrynol. Pol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1210\/jc.2006-2336","article-title":"C-reactive protein before and after weight loss in overweight women with and without polycystic ovary syndrome","volume":"92","author":"Moran","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_50","first-page":"ED000142","article-title":"Updated guidance for trusted systematic reviews: A new edition of the Cochrane Handbook for Systematic Reviews of Interventions","volume":"2019","author":"Cumpston","year":"2019","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/CCQF1608","article-title":"Oral nutritional interventions in frail older people who are malnourished or at risk of malnutrition: A systematic review","volume":"26","author":"Thomson","year":"2022","journal-title":"Health Technol. Assess."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1001\/jama.282.22.2131","article-title":"Elevated C-reactive protein levels in overweight and obese adults","volume":"282","author":"Visser","year":"1999","journal-title":"Jama"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Aboeldalyl, S., James, C., Seyam, E., Ibrahim, E.M., Shawki, H.E.-D., and Amer, S. (2021). The role of chronic inflammation in polycystic ovarian syndrome\u2014A systematic review and meta-analysis. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22052734"},{"key":"ref_54","first-page":"3924018","article-title":"The Effect of Exercise on Inflammatory Markers in PCOS Women: A Systematic Review and Meta-Analysis of Randomized Trials","volume":"2023","author":"Nosratabadi","year":"2023","journal-title":"Int. J. Clin. Pract."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1530\/EC-14-0010","article-title":"Effect of lifestyle intervention on the reproductive endocrine profile in women with polycystic ovarian syndrome: A systematic review and meta-analysis","volume":"3","author":"Haqq","year":"2014","journal-title":"Endocr. Connect."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1161\/01.RES.0000163635.62927.34","article-title":"Adipose tissue, inflammation, and cardiovascular disease","volume":"96","author":"Berg","year":"2005","journal-title":"Circ. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/joim.12044","article-title":"Effects of an isocaloric healthy N ordic diet on insulin sensitivity, lipid profile and inflammation markers in metabolic syndrome\u2014A randomized study (SYSDIET)","volume":"274","author":"Uusitupa","year":"2013","journal-title":"J. Intern. Med."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Rolland, C., Hession, M., and Broom, I. (2011). Effect of weight loss on adipokine levels in obese patients. Diabetes Metab. Syndr. Obes. Targets Ther., 315\u2013323.","DOI":"10.2147\/DMSO.S22788"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Malesza, I.J., Malesza, M., Walkowiak, J., Mussin, N., Walkowiak, D., Aringazina, R., Bartkowiak-Wieczorek, J., and M\u0105dry, E. (2021). High-fat, western-style diet, systemic inflammation, and gut microbiota: A narrative review. Cells, 10.","DOI":"10.3390\/cells10113164"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s11739-023-03374-w","article-title":"Gut microbiota, intestinal permeability, and systemic inflammation: A narrative review","volume":"19","author":"Petito","year":"2024","journal-title":"Intern. Emerg. Med."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"\u00c1vila-Escalante, M.L., Coop-Gamas, F., Cervantes-Rodr\u00edguez, M., M\u00e9ndez-Iturbide, D., and Aranda-Gonz\u00e1lez, I.I. (2020). The effect of diet on oxidative stress and metabolic diseases\u2014Clinically controlled trials. J. Food Biochem., 44.","DOI":"10.1111\/jfbc.13191"},{"key":"ref_62","first-page":"610950","article-title":"Nutritionally mediated oxidative stress and inflammation","volume":"2013","author":"Costa","year":"2013","journal-title":"Oxidative Med. Cell. Longev."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/16\/4934\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:40:34Z","timestamp":1760110834000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/16\/4934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,21]]},"references-count":62,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["jcm13164934"],"URL":"https:\/\/doi.org\/10.3390\/jcm13164934","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,21]]}}}