{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T05:39:02Z","timestamp":1774935542393,"version":"3.50.1"},"reference-count":25,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Acute coronary syndrome (ACS) represents an important clinical manifestation of coronary artery disease (CAD) and is characterized by a particularly poor prognosis. Myocardial reperfusion through primary percutaneous coronary intervention (PPCI) is imperative in the event of acute ST elevation myocardial infarction (STEMI). Interleukin-22 (IL-22) regulates immune and inflammatory responses. This interleukin has been described in the scenario of the CAD, but there are no data in patients with STEMI undergoing PPCI. Objectives: The goals of this study were to investigate the differences in circulating IL-22 levels between patients with STEMI undergoing PPCI and healthy controls and to determine whether these differences were associated with the culprit coronary artery, door-to-balloon time (DBT), final angiographic result, CAD classification, and presence of diabetes mellitus (DM). Methods: A total of 280 participants were recruited, comprising 210 STEMI cases and 70 healthy controls. Participants underwent clinical and angiographic evaluations, and serum IL-22 levels were measured using an enzyme-linked immunosorbent assay (ELISA). Data analysis was performed using the Mann\u2013Whitney and Fisher tests, with p &lt; 0.05 indicating significance. Results: Serum IL-22 levels were lower in cases (149.63, 84.99\u2013294.56) than in the controls (482.67, 344.33\u2013641.00); p &lt; 0.001. Lower IL-22 levels were associated with the right coronary artery (RCA) (144.57, 70.84\u2013242.43; 146.00, 63.60\u2013279.67; 191.71, 121.80\u2013388.97); p = 0.033. IL-22 was lower with shorter DBT (\u226460 min, 106.00, 49.60\u2013171.71; &gt;60 min, 153.00, 88.86\u2013313.60); p = 0.043. Conclusions: IL-22 levels were significantly lower in patients with STEMI than in healthy controls.<\/jats:p>","DOI":"10.3390\/jcm13174971","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T12:53:19Z","timestamp":1724417599000},"page":"4971","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Circulating Interleukin-22 in Patients with Acute Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention"],"prefix":"10.3390","volume":"13","author":[{"given":"Augusto Ferreira","family":"Correia","sequence":"first","affiliation":[{"name":"Internal Medicine Department, Cardiology Division, Federal University of Pernambuco, Recife 50670-901, Brazil"},{"name":"Cardiology Emergency Room of Pernambuco, University of Pernambuco, Recife 52010-010, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina Gomes Cavalcanti de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Maur\u00edcio de Nassau University, Recife 51021-140, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Dinaldo Cavalcanti de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Faculty of Medicine of Sert\u00e3o, Arcoverde 56512-670, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelly Cristina","family":"Pereira","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Cardiology Division, Federal University of Pernambuco, Recife 50670-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavio Alisson","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Mestre Vitalino Hospital, Caruaru 55015-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estev\u00e3o Campos Carvalho","family":"Martins","sequence":"additional","affiliation":[{"name":"Gale\u00e3o Air Force Hospital, Rio de Janeiro 21941-353, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dinaldo Cavalcanti de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Cardiology Division, Federal University of Pernambuco, Recife 50670-901, Brazil"},{"name":"Cardiology Emergency Room of Pernambuco, University of Pernambuco, Recife 52010-010, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,23]]},"reference":[{"key":"ref_1","first-page":"e21","article-title":"Heart disease and stroke statistics -2009 update: A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee","volume":"119","author":"Adams","year":"2009","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1056\/NEJMra1216063","article-title":"Mechanisms of acute coronary syndromes and their implications for therapy","volume":"368","author":"Libby","year":"2013","journal-title":"N. 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