{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:20:45Z","timestamp":1760145645597,"version":"build-2065373602"},"reference-count":59,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Catholic University of Valencia San Vicente M\u00e1rtir"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Although articles and reviews have been published on the effect of SARS-CoV-2 infection on pregnancy outcomes, they show mixed results with different hypotheses, and no work has focused specifically on the prevalence of thrombocytopenia. The objective of this systematic review and meta-analysis was to synthesize previous evidence and estimate the prevalence of thrombocytopenia in pregnant women with COVID-19. Methods: This systematic review was conducted according to the PRISMA-2020 and MOOSE guidelines. The Medline and Web of Science databases were searched in February 2024, and a meta-analysis of the overall prevalence of thrombocytopenia in pregnant women with COVID-19 was performed. The risk of bias was assessed using the Joanna Briggs Institute checklists. A leave-1-out sensitivity analysis was performed to test for disproportionate effect. Publication bias was assessed by visual inspection of funnel plots and Egger\u2019s test. Results: A total of 23 studies met the inclusion criteria, of which 8 were included in the meta-analysis. There was significant (Q = 101.04) and substantial heterogeneity among the studies (I2 = 93.07%). There were no quality-based exclusions from the review of eligible studies. The combined effect of the studies showed a prevalence of thrombocytopenia of 22.9% (95%CI 4.8\u201341.0%). Subgroup analysis revealed no statistically significant difference in the pooled prevalence of thrombocytopenia ([16.5%; 30.3%]; p = 0.375. Egger\u2019s test for bias was not significant, indicating that smaller studies did not report larger estimates of prevalence (t = 1.01, p = 0.353). Moreover, no potential publication bias was found. Our results are consistent with those obtained in pregnant women without COVID-19 infection and extend those of previous reviews of the effect of COVID-19 infection on pregnancy outcomes. Conclusions: Infection during pregnancy does not seem to be an additional risk factor for platelet count, although monitoring platelet count in pregnant women with COVID-19 may be of great importance to determine possible therapeutic strategies, especially in emergency cases.<\/jats:p>","DOI":"10.3390\/jcm13174980","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T12:53:19Z","timestamp":1724417599000},"page":"4980","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence of Thrombocytopenia in Pregnant Women with COVID-19: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9905-0443","authenticated-orcid":false,"given":"Mar\u00eda Teresa","family":"Murillo-Llorente","sequence":"first","affiliation":[{"name":"School of Medicine and Health Sciences, Catholic University of Valencia, C\/Quevedo n\u00ba 2, 46001 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6426-2999","authenticated-orcid":false,"given":"Ignacio","family":"Ventura","sequence":"additional","affiliation":[{"name":"Molecular and Mitochondrial Medicine Research Group, School of Medicine and Health Sciences, Catholic University of Valencia, C\/Quevedo n\u00ba 2, 46001 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9515-180X","authenticated-orcid":false,"given":"Francisco","family":"Tom\u00e1s-Aguirre","sequence":"additional","affiliation":[{"name":"School of Medicine and Health Sciences, Catholic University of Valencia, C\/Quevedo n\u00ba 2, 46001 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Defez-Martin","sequence":"additional","affiliation":[{"name":"General and Digestive System Surgery, Joan XXIII University Hospital, C\/Dr. Mallafr\u00e9 Guasch, 4, 43005 Tarragona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Inmaculada","family":"Mart\u00edn-D\u00edaz","sequence":"additional","affiliation":[{"name":"Primary Health Care Center Massamagrell, C\/Metge Miquel Servet, 48, 46130 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Atienza-Ramirez","sequence":"additional","affiliation":[{"name":"Hospital Universitario Dr. Peset, Av. Gaspar Aguilar, 90, 46017 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4818-9546","authenticated-orcid":false,"given":"Francisco","family":"Llorca-Colomer","sequence":"additional","affiliation":[{"name":"School of Medicine and Health Sciences, Catholic University of Valencia, C\/Quevedo n\u00ba 2, 46001 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adalberto","family":"Asins-Cubells","sequence":"additional","affiliation":[{"name":"Centro de Salud de L\u2019Eliana, Departamento Arnau de Vilanova-Lliria, C\/Rosales, 23, L\u2019Eliana, 46183 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5468-4434","authenticated-orcid":false,"given":"Mar\u00eda Ester","family":"Legidos-Garc\u00eda","sequence":"additional","affiliation":[{"name":"School of Medicine and Health Sciences, Catholic University of Valencia, C\/Quevedo n\u00ba 2, 46001 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5027-4785","authenticated-orcid":false,"given":"Marcelino","family":"P\u00e9rez-Bermejo","sequence":"additional","affiliation":[{"name":"School of Medicine and Health Sciences, Catholic University of Valencia, C\/Quevedo n\u00ba 2, 46001 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,23]]},"reference":[{"key":"ref_1","unstructured":"(2024, February 28). 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