{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:22:47Z","timestamp":1760145767385,"version":"build-2065373602"},"reference-count":25,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2024,8,25]],"date-time":"2024-08-25T00:00:00Z","timestamp":1724544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/objectives: An increase in the incidence of eosinophilic esophagitis (EoE) in children has been reported worldwide in the last decade. We conducted a study in a tertiary pediatric gastroenterology unit aimed at analyzing the clinical manifestations, biochemical markers, and endoscopic features of children with EoE in comparison to patients with non-eosinophilic esophagitis. Methods: This is a prospective analysis involving children with symptoms related to esophageal dysfunction, who had esophagogastroduodenoscopies with esophageal biopsies between January 2021 and April 2024 at \u201cDr. Victor Gomoiu\u201d Clinical Children\u2019s Hospital, in Bucharest, Romania. For the analysis, patients were considered in either Group 1, classified as EoE, or in Group 2, classified as reflux esophagitis. Results: Among the total of 72 patients diagnosed with esophagitis, 17 patients (Group 1\u2014study group) were classified as EoE and 55 were classified as reflux esophagitis (Group 2\u2014control group). The sex ratio analysis showed a male predominance in the study group (71% vs. 32%, p = 0.002). The main symptoms were regurgitation, eructation, and nausea. Dysphagia was present in two (11.76%) patients from Group 1. Eosinophilia was more prevalent in the EoE group than in the individuals with gastroesophageal reflux disease (GERD) (10 (58.85%) vs. 10 (18.18%, p = 0.001)), as well as the total IgE (11 (64.70%) vs. 6 (10.9%, p = 0.001)). Conclusions: Pediatric gastroenterologists need to be aware of EoE atypical presentation and perform adequate biopsies, mainly in children with refractory GERD-like symptoms, dysphagia, and food bolus impaction. Further analyses in terms of prognosis and treatment response should be addressed in longitudinal studies.<\/jats:p>","DOI":"10.3390\/jcm13175041","type":"journal-article","created":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T03:32:01Z","timestamp":1724643121000},"page":"5041","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Characterization of a Romanian Pediatric Population with Eosinophilic Esophagitis"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4133-5726","authenticated-orcid":false,"given":"Iulia Florentina","family":"Tincu","sequence":"first","affiliation":[{"name":"Department of Paediatrics, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Gastroenterology Department, \u201cDr. Victor Gomoiu\u201d Clinical Children Hospital, 022102 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiza Elena","family":"Bordei","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Gastroenterology Department, \u201cDr. Victor Gomoiu\u201d Clinical Children Hospital, 022102 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucica Luminita","family":"Gales","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, \u201cDr. Victor Gomoiu\u201d Clinical Children Hospital, 022102 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larisa Alexandra","family":"Duchi","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, \u201cDr. Victor Gomoiu\u201d Clinical Children Hospital, 022102 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loredana","family":"Dobrescu","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, \u201cDr. Victor Gomoiu\u201d Clinical Children Hospital, 022102 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca Teodora","family":"Chenescu","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, \u201cDr. Victor Gomoiu\u201d Clinical Children Hospital, 022102 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Zdanowicz, K., Kucharska, M., Sobaniec-Lotowska, M.E., Lebensztejn, D.M., and Daniluk, U. 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