{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:54:58Z","timestamp":1785894898017,"version":"3.56.0"},"reference-count":27,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Daiichi-Sankyo"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Oral anticoagulation (OAC) is pivotal in the clinical management of atrial fibrillation (AF) patients. Vitamin K antagonists (VKAs) and direct oral anticoagulants (DOACs) prevent thromboembolic events, but information about the quality of life (QoL) and patient satisfaction in relation with the anticoagulant treatment is limited. Methods: REGUEIFA is a prospective, observational, and multicentre study that included patients with AF treated by cardiologists. We included patients treated with VKAs or DOACs. The EuroQol-5D (EQ-5D) questionnaire evaluated QoL, and the Anti-Clot Treatment Scale (ACTS) questionnaire investigated patient satisfaction with OAC. Results: A total of 904 patients were included (532 on VKA and 372 on DOACs). A total of 846 patients completed the EQ-5D questionnaire, with results significantly worse in patients on VKAs than on DOACs: more mobility limitations (37.6% vs. 24.2%, p &lt; 0.001), more restriction in usual activities (24.7% vs. 18.3%, p = 0.026), more pain\/discomfort (31.8% vs. 24.2%, p = 0.015), a lower visual analogue scale (VAS) score (66.4 \u00b1 16.21 vs. 70.8 \u00b1 15.6), and a lower EQ-D5 index (0.79 \u00b1 0.21 vs. 0.85 \u00b1 0.2, p &lt; 0.001). After adjusting for baseline characteristics, VKA treatment was not an independent factor towards worse EQ-5D results. Also, 738 patients completed the ACTS questionnaire, and burden and profit scores were lower in patients on VKAs than for DOACs (52.1 \u00b1 8.4 vs. 55.5 \u00b1 6.8, p &lt; 0.001 and 11.1 \u00b1 2.4 vs. 11.8 \u00b1 2.6, p &lt; 0.001, respectively). The negative impact score was higher for VKAs than for DOACs (1.8 \u00b1 1.02 vs. 1.6 \u00b1 0.99, p &lt; 0.001), with a general positive impact score lower for VKAs than for DOACs (3.6 \u00b1 0.96 vs. 3.8 \u00b1 1.02, p &lt; 0.001). Conclusions: Patients on VKA have more comorbidity and worse EQ-5D and VAS scores than those on DOACs. VKA has a greater burden and higher negative impact on the patient\u2019s life than DOACs.<\/jats:p>","DOI":"10.3390\/jcm13175283","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T05:02:28Z","timestamp":1725598948000},"page":"5283","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Health-Related Quality of Life and Satisfaction in Atrial Fibrillation Patients on Anticoagulant Therapy: Differences between Vitamin K Antagonists and Direct Oral Anticoagulants; Results from the Multicentre REGUEIFA Registry"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2643-5198","authenticated-orcid":false,"given":"Pilar","family":"Cabanas-Grand\u00edo","sequence":"first","affiliation":[{"name":"Cardiology Department, Hospital \u00c1lvaro Cunqueiro, 36312 Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4065-221X","authenticated-orcid":false,"given":"Laila","family":"Gonz\u00e1lez-Melchor","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Cl\u00ednico de Santiago de Compostela, 15706 A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda V\u00e1zquez","family":"Caama\u00f1o","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Povisa, 36211 Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiliano Fern\u00e1ndez-Obanza","family":"Windcheid","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Arquitecto Marcide, 15405 Ferrol, A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva Gonz\u00e1lez","family":"Babarro","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital de Montecelo, 36071 Pontevedra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga Dur\u00e1n","family":"Bob\u00edn","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Universitario Lucus Augusti, 27002 Lugo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam Pi\u00f1eiro","family":"Portela","sequence":"additional","affiliation":[{"name":"Cardiology Department, Complexo Hospitalario Universitario de A Coru\u00f1a, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a (INIBIC), 15006 A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar Prada","family":"Delgado","sequence":"additional","affiliation":[{"name":"Cardiology Department, Complexo Hospitalario Universitario de A Coru\u00f1a, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a (INIBIC), 15006 A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Elices","family":"Teja","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Universitario Lucus Augusti, 27002 Lugo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario Guti\u00e9rrez","family":"Feijoo","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital de Ourense, 32005 Ourense, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evaristo","family":"Freire","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital de Ourense, 32005 Ourense, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar D\u00edaz","family":"Castro","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital \u00c1lvaro Cunqueiro, 36312 Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3087-2067","authenticated-orcid":false,"given":"Javier Mu\u00f1iz","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Odds S.L., 15005 A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Garc\u00eda-Seara","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Cl\u00ednico de Santiago de Compostela, 15706 A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4483-9778","authenticated-orcid":false,"given":"Carlos","family":"Gonz\u00e1lez-Juanatey","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Universitario Lucus Augusti, 27002 Lugo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1161\/CIRCULATIONAHA.113.005119","article-title":"Worldwide epidemiology of atrial fibrillation: A Global Burden of Disease 2010 Study","volume":"129","author":"Chugh","year":"2014","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1093\/eurheartj\/ehs469","article-title":"All-cause mortality in 272,186 patients hospitalized with incident atrial fibrillation 1995\u20132008: A Swedish nationwide long-term case control study","volume":"34","author":"Andersson","year":"2013","journal-title":"Eur. Heart J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1161\/01.STR.22.8.983","article-title":"Atrial fibrillation as an independent risk factor for stroke: The Framingham Study","volume":"22","author":"Wolf","year":"1991","journal-title":"Stroke"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"857","DOI":"10.7326\/0003-4819-146-12-200706190-00007","article-title":"Meta-analysis: Antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation","volume":"146","author":"Hart","year":"2007","journal-title":"Ann. Intern. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/S0140-6736(13)62343-0","article-title":"Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: A meta-analysis of randomised trials","volume":"383","author":"Ruff","year":"2014","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1056\/NEJMoa1107039","article-title":"Apixaban versus warfarin in patients with atrial fibrillation","volume":"365","author":"Granger","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"448.e1","DOI":"10.1016\/j.amjmed.2005.10.057","article-title":"Quality of life in patients with atrial fibrillation: A systematic review","volume":"119","author":"Thrall","year":"2006","journal-title":"Am. J. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1136\/heartjnl-2011-300550","article-title":"Symptoms, functional status and quality of life in patients with controlled and uncontrolled atrial fibrillation: Data from the RealiseAF cross-sectional international registry","volume":"98","author":"Steg","year":"2012","journal-title":"Heart"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ahj.2016.08.003","article-title":"Patients Factors Associated with Quality of Life in Atrial Fibrillation Randolph-Determinants of Quality of Life in Atrial Fibrillation","volume":"182","author":"Randolph","year":"2016","journal-title":"Am. Heart J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/clc.22108","article-title":"Influence of body mass index on recurrence and quality of life in atrial fibrillation patients after catheter ablation: A meta-analysis and systematic review","volume":"36","author":"Zhuang","year":"2013","journal-title":"Clin. Cardiol."},{"key":"ref_11","first-page":"197","article-title":"Rationale, design and basal characteristics of REGUEIFA study (Multicenter Registry of Atrial Fibrillation in Galicia)","volume":"56","author":"Seara","year":"2021","journal-title":"REC CardioClinics"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3109\/07853890109002087","article-title":"EQ-SD: A measure of health status from the EuroQol Group","volume":"33","author":"Rabin","year":"2001","journal-title":"Ann. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0212-6567(01)70406-4","article-title":"El EuroQol-5D: Una alternativa sencilla para la medici\u00f3n de la calidad de vida relacionada con la salud en atenci\u00f3n primaria","volume":"28","author":"Herdman","year":"2001","journal-title":"Atenci\u00f3n Primaria"},{"key":"ref_14","first-page":"192","article-title":"Validation of satisfaction questionnaire ACTS in outpatients with atrial fibrillation treated with oral anticoagulants in Spain","volume":"147","author":"Pose","year":"2016","journal-title":"ALADIN Study. Med. Clin."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1093\/europace\/eup421","article-title":"Validation of the AF-QoL, a disease-specific quality of life questionnaire for patients with atrial fibrillation","volume":"12","author":"Arribas","year":"2010","journal-title":"Europace"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1161\/CIRCEP.110.958033","article-title":"Development and validation of the Atrial Fibrillation Effect on Quality-of-Life (AFEQT) Questionnaire in patients with atrial fibrillation","volume":"4","author":"Spertus","year":"2011","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1007\/s11136-011-9903-x","article-title":"Development and preliminary testing of the new five-level version of EQ-5D (EQ-5D-5L)","volume":"20","author":"Herdman","year":"2011","journal-title":"Qual. Life Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e010992","DOI":"10.1161\/JAHA.118.010992","article-title":"Sex Differences in Quality of Life in Patients with Atrial Fibrillation: A Systematic Review","volume":"8","author":"Ree","year":"2019","journal-title":"J. Am. Heart Assoc."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1093\/eurheartj\/ehm358","article-title":"Outcome parameters for trials in atrial fibrillation: Executive summary","volume":"28","author":"Kirchhof","year":"2007","journal-title":"Eur. Heart J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1093\/europace\/eut395","article-title":"The European Heart Rhythm Association symptom classification for atrial fibrillation: Validation and improvement through a simple modification","volume":"16","author":"Wynn","year":"2014","journal-title":"Europace"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/j.jacc.2017.07.755","article-title":"Care Patterns and Outcomes in Atrial Fibrillation Patients with and without Diabetes ORBIT-AF Registry","volume":"70","author":"Shrader","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_22","unstructured":"(2018, January 10). Informe de Posicionamiento Terap\u00e9utico UT_ACOD\/V5\/21112016. Criterios y Recomendaciones Generales para el Uso de los Anticoagulantes Orales Directos (ACOD) en la Prevenci\u00f3n del Ictus y la Embolia Sist\u00e9mica en Pacientes con Fibrilaci\u00f3n Auricular no Valvular. Fecha de Publicaci\u00f3n 21 de Noviembre de 2016. Available online: https:\/\/www.aemps.gob.es\/medicamentosUsoHumano\/informesPublicos\/docs\/criterios-anticoagulantes-orales.pdf."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Lavalle, C., Pierucci, N., Mariani, M.V., Piro, A., Borrelli, A., Grimaldi, M., Rossillo, A., Notarstefano, P., Compagnucci, P., and Dello Russo, A. (2024). Italian Registry in the Setting of Atrial Fibrillation Ablation with Rivaroxaban-IRIS. Minerva Cardiol. Angiol., epub ahead of print.","DOI":"10.23736\/S2724-5683.24.06546-3"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1002\/clc.22565","article-title":"Impact of switching from a vitamin Kantagonist to rivaroxaban on satisfaction with anticoagulation therapy: The XANTUS-ACTS substudy","volume":"39","author":"Coleman","year":"2016","journal-title":"Clin. Cardiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"303","DOI":"10.2217\/cer-2016-0078","article-title":"Satisfaction, quality of life and perception of patients regarding burdens and benefits of vitamin K antagonists compared with direct oral anticoagulants in patients with nonvalvular atrial fibrillation","volume":"6","author":"Vivancos","year":"2017","journal-title":"J. Comp. Eff. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1056\/NEJMoa0708078","article-title":"Genetic determinants of response to warfarin during initial anticoagulation","volume":"358","author":"Schwarz","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1182\/asheducation-2013.1.464","article-title":"Pros and cons of new oral anticoagulants","volume":"2013","author":"Bauer","year":"2013","journal-title":"Hematol. Am. Soc. Hematol. Educ. Program"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/17\/5283\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:49:37Z","timestamp":1760111377000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/17\/5283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,6]]},"references-count":27,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["jcm13175283"],"URL":"https:\/\/doi.org\/10.3390\/jcm13175283","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,6]]}}}