{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T02:03:40Z","timestamp":1788228220818,"version":"build-2803163510"},"reference-count":33,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T00:00:00Z","timestamp":1725840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objective: There is increasing evidence for the effect of inflammation on the etiology of febrile seizure (FS) patients. We aimed to investigate the role of easily accessible inflammatory markers such as the neutrophil\u2013lymphocyte ratio (NLR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), neutrophil\u2013lymphocyte\u2013platelet ratio (NLPR), and pan-immune-inflammation value (PIV) in febrile seizure. Methods: A total of 300 children, including 100 with febrile convulsions (FS), 100 febrile controls (FCs), and 100 healthy controls (HCs), were included in this retrospective study. The FS group was compared with the FC and HC groups in terms of these inflammatory indexes. Results: Between the FS group and the FC group, the neutrophil count was significantly higher in the FS group (p = 0.001) and the lymphocyte count was significantly lower (p &lt; 0.001). The NLR (p &lt; 0.001), SII (p &lt; 0.001), SIRI (p &lt; 0.001), NLPR (p &lt; 0.001), and PIV (p &lt; 0.001) were significantly higher in the FS group than in both the FC and healthy control groups. The optimal cut-off values for predicting FS in febrile conditions were 3.59&gt; for NLR, &gt;870.47 for SII, &gt;1.96 for SIRI, 0.96&gt; for NLPR, and &gt;532.75 for PIV. Conclusions: The inflammatory indices are inexpensive, easily accessible hematological markers that can contribute to the diagnosis of FS.<\/jats:p>","DOI":"10.3390\/jcm13175330","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T05:06:06Z","timestamp":1725858366000},"page":"5330","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Predictive Value of Neutrophil\u2013Lymphocyte Ratio and Other Inflammation Indices in Febrile Seizures in Children"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0411-6778","authenticated-orcid":false,"given":"Yakup","family":"S\u00f6\u011f\u00fctl\u00fc","sequence":"first","affiliation":[{"name":"\u00dcmraniye Training and Research Hospital, Department of Pediatrics, Pediatric Emergency Medicine Clinic, University of Health Sciences, 34764 \u0130stanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5871-2033","authenticated-orcid":false,"given":"U\u011fur","family":"Alta\u015f","sequence":"additional","affiliation":[{"name":"\u00dcmraniye Training and Research Hospital, Department of Pediatrics, Pediatric Allergy and Immunology Clinic, University of Health Sciences, 34764 \u0130stanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Han, M.J., Heo, J.H., Hwang, J.S., Jang, Y.-T., Lee, M., and Kim, S.J. 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