{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T07:27:46Z","timestamp":1784618866949,"version":"3.55.0"},"reference-count":26,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T00:00:00Z","timestamp":1725926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Diabetic cardiac muscle disease or diabetic cardiomyopathy (DbCM) comprises a set of myocardial lesions that are not associated with coronary atherosclerosis or high blood pressure. It is characterized by fibrosis and hypertrophy, which ultimately results in heart failure. Diastolic dysfunction (DD) has been shown to be the first manifestation of diabetic cardiomyopathy. Currently, there are few studies on the prevalence of diabetic cardiomyopathy in adult patients diagnosed with type 1 diabetes mellitus (T1D). Methods: The study included 75 adult participants who underwent an echocardiogram. Data on their comorbidities were collected from their medical records and biochemical parameters were analyzed in blood and urine samples. Results: We found that the prevalence of DbCM in our T1D population was more than one-third (34%), which exceeded the prevalence reported in studies with adolescents and that reported in the population without diabetes. Also, we found that the probability of developing DD after 20 years of T1D diagnosis was 78%. Conclusions: Recommendations need to be issued in relation to diabetic cardiomyopathy to carry out secondary prevention in adult patients with T1D. More multicenter studies, which include a larger population, from different regions of the world need to be performed.<\/jats:p>","DOI":"10.3390\/jcm13185351","type":"journal-article","created":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T05:53:03Z","timestamp":1725947583000},"page":"5351","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prevalence of Cardiomyopathy in Patients with Type 1 Diabetes Mellitus"],"prefix":"10.3390","volume":"13","author":[{"given":"Oscar Daniel","family":"Fabila-de la Cruz","sequence":"first","affiliation":[{"name":"Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Salif","family":"Luna-Avila","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4132-5093","authenticated-orcid":false,"given":"Mar\u00eda del Pilar","family":"Sotelo-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Servicio de Endocrinolog\u00eda, Hospital de Especialidades \u201cDr. Bernardo Sep\u00falveda\u201d, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4561-5908","authenticated-orcid":false,"given":"Andr\u00e9s D.","family":"Litardo-Mosquera","sequence":"additional","affiliation":[{"name":"Endocrinolog\u00eda, Hospital Cl\u00ednica San Francisco, Guayaquil 090511, Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Orihuela","sequence":"additional","affiliation":[{"name":"Servicio de Cardiolog\u00eda, Hospital de Especialidades \u201cDr. Bernardo Sep\u00falveda\u201d, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5159-9856","authenticated-orcid":false,"given":"Aldo","family":"Ferreira-Hermosillo","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Endocrinas, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1056\/NEJMoa1008862","article-title":"Diabetes Mellitus, Fasting Glucose, and Risk of Cause-Specific Death","volume":"364","author":"Kaptoge","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.medcli.2013.04.024","article-title":"Enfermedad cardiovascular en la diabetes mellitus tipo 1. M\u00e1s que mera coincidencia","volume":"141","author":"Donlo","year":"2013","journal-title":"Med. Cl\u00edn."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S1262-3636(07)70059-9","article-title":"Left ventricular diastolic dysfunction: An early sign of diabetic cardiomyopathy?","volume":"29","author":"Cosson","year":"2003","journal-title":"Diabetes Metab."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"R225","DOI":"10.1530\/JME-16-0249","article-title":"Lipid metabolism and its implications for type 1 diabetes-associated cardiomyopathy","volume":"58","author":"Ritchie","year":"2017","journal-title":"J. Mol. Endocrinol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00592-017-1062-2","article-title":"Arterial-ventricular coupling in type 1 diabetes: Arterial stiffness is associated with impaired global longitudinal strain in type 1 diabetes patients\u2014The Thousand & 1 Study","volume":"55","author":"Theilade","year":"2017","journal-title":"Acta Diabetol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.amjcard.2006.07.063","article-title":"Left ventricular function in normotensive young adults with Well-Controlled Type 1 Diabetes Mellitus","volume":"99","author":"Miccoli","year":"2007","journal-title":"Am. J. Cardiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"R127","DOI":"10.1530\/EJE-17-0724","article-title":"MECHANISMS IN ENDOCRINOLOGY: Diabetic cardiomyopathy: Pathophysiology and potential metabolic interventions state of the art review","volume":"178","author":"Levelt","year":"2018","journal-title":"Eur. J. Endocrinol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.jcmg.2014.12.020","article-title":"Global longitudinal strain is not impaired in Type 1 diabetes patients without albuminuria","volume":"8","author":"Jensen","year":"2015","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/ejechocard\/jep086","article-title":"Tissue Doppler imaging must be performed to detect early left ventricular dysfunction in patients with type 1 diabetes mellitus","volume":"10","author":"Gul","year":"2009","journal-title":"Eur. J. Echocardiogr."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1007\/s00125-014-3164-5","article-title":"Prevalence of systolic and diastolic dysfunction in patients with type 1 diabetes without known heart disease: The Thousand & 1 Study","volume":"57","author":"Jensen","year":"2014","journal-title":"Diabetologia"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.diabres.2007.09.014","article-title":"Uncomplicated type 1 diabetes and preclinical left ventricular myocardial dysfunction: Insights from echocardiography and exercise cardiac performance evaluation","volume":"79","author":"Palmieri","year":"2008","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/mrm.10372","article-title":"Myocardial triglycerides and systolic function in humans: In vivo evaluation by localized proton spectroscopy and cardiac imaging","volume":"49","author":"Szczepaniak","year":"2003","journal-title":"Magn. Reson. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1016\/j.jacc.2008.07.062","article-title":"Myocardial steatosis is an independent predictor of diastolic dysfunction in type 2 diabetes mellitus","volume":"52","author":"Rijzewijk","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1210\/endrev\/bnaa025","article-title":"Microvascular dysfunction in diabetes mellitus and cardiometabolic disease","volume":"42","author":"Horton","year":"2020","journal-title":"Endocr. Rev."},{"key":"ref_15","unstructured":"Herrera-M\u00e1rquez, R., Peralta-Cort\u00e1zar, C., Contreras-Rodr\u00edguez, A., Hern\u00e1ndez-Rodr\u00edguez, J., and Manjarrez-Guti\u00e9rrez, G. (2024, July 16). Subclinical Left Ventricular Diastolic Dysfunction in Adolescents with Type 1 Diabetes. Bolet\u00edn M\u00e9dico Del Hospital Infantil De M\u00e9xico (English Edition). Available online: https:\/\/www.elsevier.es\/en-revista-boletin-medico-del-hospital-infantil-201-articulo-subclinical-left-ventricular-diastolic-dysfunction-X2444340914395327."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jdiacomp.2013.09.013","article-title":"Prevalence, predictors and evolution of echocardiographically defined cardiac abnormalities in adults with type 1 diabetes: An observational cohort study","volume":"28","author":"Wai","year":"2014","journal-title":"J. Diabetes Complicat."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.echo.2016.01.011","article-title":"Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"29","author":"Nagueh","year":"2016","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0300-8932(00)75137-2","article-title":"Insuficiencia card\u00edaca\/trasplante card\u00edaco","volume":"53","author":"Cabrera","year":"2000","journal-title":"Rev. Esp. Cardiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1080\/14017430601156384","article-title":"Changes in glycaemic control are related to the systolic function in type 1 diabetes mellitus","volume":"41","author":"Andersen","year":"2007","journal-title":"Scand. Cardiovasc. J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"353","DOI":"10.2337\/diacare.18.3.353","article-title":"Impaired Left Ventricular Diastolic Function and Vascular Postischemic Vasodilation Associated with Microalbuminuria in IDDM Patients","volume":"18","author":"Guglielmi","year":"1995","journal-title":"Diabetes Care"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.amjcard.2003.12.026","article-title":"Prevalence of ventricular diastolic dysfunction in asymptomatic, normotensive patients with diabetes mellitus","volume":"93","author":"Boyer","year":"2004","journal-title":"Am. J. Cardiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1177\/1479164118787415","article-title":"The prevalence of left ventricular diastolic dysfunction and heart failure with preserved ejection fraction in men and women with type 2 diabetes: A systematic review and meta-analysis","volume":"15","author":"Bouthoorn","year":"2018","journal-title":"Diab Vasc. Dis. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/S0188-4409(00)00264-2","article-title":"Left Ventricular Diastolic Dysfunction Secondary to Hyperglycemia in Patients with Type II Diabetes","volume":"32","author":"Rangel","year":"2001","journal-title":"Arch. Med. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e025578","DOI":"10.1161\/JAHA.122.025578","article-title":"Genetic determinants of body mass index and fasting glucose are mediators of Grade 1 diastolic dysfunction","volume":"11","author":"Vaitinadin","year":"2022","journal-title":"J. Am. Heart Assoc."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.repc.2020.11.012","article-title":"Echocardiographic evaluation in type 1 diabetes mellitus","volume":"40","author":"Weber","year":"2021","journal-title":"Rev. Port. Cardiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1007\/s00125-019-05009-2","article-title":"Echocardiography improves prediction of major adverse cardiovascular events in a population with type 1 diabetes and without known heart disease: The Thousand & 1 Study","volume":"62","author":"Jensen","year":"2019","journal-title":"Diabetologia"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/18\/5351\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:52:49Z","timestamp":1760111569000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/18\/5351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,10]]},"references-count":26,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["jcm13185351"],"URL":"https:\/\/doi.org\/10.3390\/jcm13185351","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,10]]}}}