{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T23:48:13Z","timestamp":1778284093617,"version":"3.51.4"},"reference-count":54,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cH\u00f4pital Nord Franche-Comt\u00e9\u201d (HNFC)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: There is a gap between the very positive opinion of patients and doctors regarding knee viscosupplementation (VS) and the contrasting results of controlled studies. The objective of this study was to evaluate the overall satisfaction and predictors of satisfaction with VS in patients with knee osteoarthritis treated with VS. Methods: Post-hoc analysis of a cross-sectional study in patients with knee OA treated with one injection of a mannitol-modified cross-linked HA (HANOX-M-XL). The primary outcome was satisfaction, self-assessed semi-quantitatively by the patients. Demographics, radiological features, comorbidities, OA and comorbidities treatments, and lifestyle associated with satisfaction were studied in bivariate and multivariate analysis. Results: 89 patients (124 knees) were analyzed. A total of 88.7% were satisfied with the treatment. Satisfaction was correlated with duration of effectiveness (DoE) and negatively correlated with BMI. Satisfaction was higher in active versus sedentary patients, in tibiofemoral involvement, in Kellgren-Lawrence grade 1\u20133 versus 4, and in subjects not requiring intraarticular corticosteroid (IACS) concomitantly to VS. Satisfied subjects were older than dissatisfied ones. In multivariate analysis, older age, K\u2013L grade &lt; 4, absence of IACS, and longer DoE were associated with higher rates of satisfaction. Conclusions: We identified several predictive factors of patient satisfaction after VS of the knee. Alongside these objective factors, there are probably subjective factors linked to patient beliefs, fears, and expectations impacting satisfaction.<\/jats:p>","DOI":"10.3390\/jcm13185372","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T02:34:49Z","timestamp":1726022089000},"page":"5372","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Predictors of Satisfaction in Patients with Knee Osteoarthritis Treated with a Single Injection of Mannitol-Modified Crosslinked Hyaluronate Derivative"],"prefix":"10.3390","volume":"13","author":[{"given":"Martin","family":"Balblanc","sequence":"first","affiliation":[{"name":"General Medicine, Paris-Saclay University, 90014 Le Kremelin-Bic\u00eatre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Lohse","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, H\u00f4pital Nord Franche-Comt\u00e9, 90015 Belfort, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederic","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, H\u00f4pital Nord Franche-Comt\u00e9, 90015 Belfort, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Rapp","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, H\u00f4pital Nord Franche-Comt\u00e9, 90015 Belfort, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Bourgoin","sequence":"additional","affiliation":[{"name":"Clinical Research Unit, H\u00f4pital Nord Franche-Comt\u00e9, 90014 Belfort, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Charles","family":"Balblanc","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, H\u00f4pital Nord Franche-Comt\u00e9, 90015 Belfort, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0353-6292","authenticated-orcid":false,"given":"Thierry","family":"Conrozier","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, H\u00f4pital Nord Franche-Comt\u00e9, 90015 Belfort, France"},{"name":"Clinical Research Unit, H\u00f4pital Nord Franche-Comt\u00e9, 90014 Belfort, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1097\/BOR.0000000000000479","article-title":"Epidemiology of osteoarthritis: Literature update","volume":"30","author":"Vina","year":"2018","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1056\/NEJMcp1903768","article-title":"Osteoarthritis of the Knee","volume":"384","author":"Sharma","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.berh.2014.01.004","article-title":"The epidemiology of osteoarthritis","volume":"28","author":"Johnson","year":"2014","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s10787-011-0118-0","article-title":"Obesity and knee osteoarthritis","volume":"20","author":"Lee","year":"2012","journal-title":"Inflammopharmacology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/s41584-024-01102-y","article-title":"Molecular biomarker approaches to prevention of post-traumatic osteoarthritis","volume":"20","author":"Kraus","year":"2024","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1097\/PHM.0000000000001899","article-title":"Longitudinal Relationship Between Tibiofemoral Contact Stress at Baseline and Worsening of Knee Pain Over 84 Months in the Multicenter Osteoarthritis Study","volume":"101","author":"Rabe","year":"2022","journal-title":"Am. J. Phys. Med. Rehabil."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Lv, X., Liang, F., Liu, S., Deng, X., Lai, R., Du, J., and Luo, J. (2024). Causal relationship between diet and knee osteoarthritis: A Mendelian randomization analysis. PLoS ONE, 19.","DOI":"10.1371\/journal.pone.0297269"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Kie\u0142bowski, K., Herian, M., Bakinowska, E., Banach, B., Sroczy\u0144ski, T., and Pawlik, A. (2023). The Role of Genetics and Epigenetic Regulation in the Pathogenesis of Osteoarthritis. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241411655"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.jbspin.2020.09.004","article-title":"Recommendations of the French Society of Rheumatology on pharmacological treatment of knee osteoarthritis","volume":"87","author":"Sellam","year":"2020","journal-title":"Jt. Bone Spine"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.semarthrit.2014.05.014","article-title":"An algorithm recommendation for the management of knee osteoarthritis in Europe and internationally: A report from a task force of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO)","volume":"44","author":"Cooper","year":"2014","journal-title":"Semin. Arthritis Rheum."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1136\/ard.2003.011742","article-title":"EULAR Recommendations 2003: An evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT)","volume":"62","author":"Jordan","year":"2003","journal-title":"Ann. Rheum. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"46","DOI":"10.7326\/M14-1231","article-title":"Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: A systematic review and network meta-analysis","volume":"162","author":"Bannuru","year":"2015","journal-title":"Ann. Intern. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1517\/14740338.2015.1056776","article-title":"Safety and efficacy of paracetamol and NSAIDs in osteoarthritis: Which drug to recommend?","volume":"14","author":"Richette","year":"2015","journal-title":"Expert Opin. Drug Saf."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"915","DOI":"10.2147\/PPA.S200892","article-title":"Predictive factors of adherence to an association of glucosamine sulfate, copper, and ginger extracts in patients with symptomatic osteoarthritis: A prospective open-label French noninterventional study (the PREDOA study)","volume":"13","author":"Conrozier","year":"2019","journal-title":"Patient Prefer. Adherence"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"546","DOI":"10.2174\/138945010791011866","article-title":"Intraarticular treatments for osteoarthritis: New perspectives","volume":"11","author":"Chevalier","year":"2010","journal-title":"Curr. Drug Targets"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1177\/19476035221138958","article-title":"EUROVISCO Good Practice Recommendations for a First Viscosupplementation in Patients with Knee Osteoarthritis","volume":"14","author":"Conrozier","year":"2023","journal-title":"Cartilage"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1136\/bjsports-2015-095683","article-title":"AMSSM scientific statement concerning viscosupplementation injections for knee osteoarthritis: Importance for individual patient outcomes","volume":"50","author":"Trojian","year":"2016","journal-title":"Br. J. Sports Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"i1-57","DOI":"10.1093\/ageing\/afs199","article-title":"Guidance on the management of pain in older people","volume":"42","author":"Abdulla","year":"2013","journal-title":"Age Ageing"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/RHU.0000000000000449","article-title":"PANLAR Consensus Recommendations for the Management in Osteoarthritis of Hand, Hip, and Knee","volume":"22","author":"Rillo","year":"2016","journal-title":"J. Clin. Rheumatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/acr.21596","article-title":"American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee","volume":"64","author":"Hochberg","year":"2012","journal-title":"Arthritis Care Res."},{"key":"ref_21","first-page":"e721","article-title":"AAOS Clinical Practice Guideline Summary: Management of Osteoarthritis of the Knee (Nonarthroplasty), Third Edition","volume":"30","author":"Brophy","year":"2022","journal-title":"J. Am. Acad. Orthop. Surg."},{"key":"ref_22","first-page":"1124","article-title":"The discrepancy between recommendations and clinical practice for viscosupplementation in osteoarthritis: Mind the gap!","volume":"19","author":"Migliore","year":"2015","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s00264-017-3731-8","article-title":"Hyaluronic acid injections for osteoarthritis of the knee: Predictors of successful treatment","volume":"42","author":"Bowman","year":"2018","journal-title":"Int. Orthop."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1177\/1947603515620890","article-title":"Analysis for Prognostic Factors from a Database for the Intra-Articular Hyaluronic Acid (Euflexxa) Treatment for Osteoarthritis of the Knee","volume":"7","author":"Altman","year":"2016","journal-title":"Cartilage"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1177\/1947603516662503","article-title":"Appropriate Use Criteria for Hyaluronic Acid in the Treatment of Knee Osteoarthritis in the United States","volume":"8","author":"Bhadra","year":"2017","journal-title":"Cartilage"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1177\/1947603518783455","article-title":"EUROVISCO Recommendations for Optimizing the Clinical Results of Viscosupplementation in Osteoarthritis","volume":"11","author":"Conrozier","year":"2020","journal-title":"Cartilage"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1055\/s-0035-1568992","article-title":"Association between Hyaluronic Acid Injections and Time-to-Total Knee Replacement Surgery","volume":"29","author":"Altman","year":"2016","journal-title":"J. Knee Surg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1179544121994092","DOI":"10.1177\/1179544121994092","article-title":"Delay to TKA and Costs Associated with Knee Osteoarthritis Care Using Intra-Articular Hyaluronic Acid: Analysis of an Administrative Database","volume":"14","author":"Concoff","year":"2021","journal-title":"Clin. Med. Insights Arthritis Musculoskelet. Disord."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Altman, R., Lim, S., Steen, R.G., and Dasa, V. (2015). Hyaluronic acid injections are associated with delay of total knee replacement surgery in patients with knee osteoarthritis: Evidence from a large U.S. health claims database. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0145776"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Fallacara, A., Baldini, E., Manfredini, S., and Vertuani, S. (2018). Hyaluronic Acid in the Third Millennium. Polymers, 10.","DOI":"10.3390\/polym10070701"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.carres.2006.10.027","article-title":"Inhibitory effects of different antioxidants on hyaluronan depolymerization","volume":"342","author":"Mendoza","year":"2007","journal-title":"Carbohydr. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.3390\/polym6071948","article-title":"Effect of mannitol on hyaluronic acid stability in two in vitro models of oxidative stress","volume":"6","author":"Rinaudo","year":"2014","journal-title":"Polymers"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1177\/19476035221109230","article-title":"The Association between Radiographic Features and the Duration of Effectiveness of a Single Injection of Extended-Release Hyaluronic Acid (HANOX-M-XL) in Patients with Knee Osteoarthritis: Preliminary Results of a Prospective Trial","volume":"14","author":"Perruchet","year":"2023","journal-title":"Cartilage"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Darsy, G., Patarin, J., and Conrozier, T. (2023). Large Variations in Resistance to Degradation between Hyaluronic Acid Viscosupplements: A Comparative Rheological Study. Cartilage, 19476035231205696.","DOI":"10.1177\/19476035231205696"},{"key":"ref_35","unstructured":"(2024, September 04). Available online: https:\/\/www.profilmedecin.fr\/contenu\/chiffres-cles-rhumatologue\/."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Rapp, C., Boudif, F., Bourgoin, C., Lohse, A., and Conrozier, T. (2024). A Cross-Sectional Study of Factors Predicting the Duration of the Efficacy of Viscosupplementation in Knee Osteoarthritis. J. Clin. Med., 13.","DOI":"10.20944\/preprints202402.1442.v1"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1136\/ard.2011.155119","article-title":"Defining radiographic incidence and progression of knee osteoarthritis: Suggested modifications of the Kellgren and Lawrence scale","volume":"70","author":"Felson","year":"2011","journal-title":"Ann. Rheum. Dis."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1002\/jor.23529","article-title":"Obesity and radiological severity are associated with viscosupplementation failure in patients with knee osteoarthritis","volume":"35","author":"Eymard","year":"2017","journal-title":"J. Orthop. Res."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Conrozier, T., Eymard, F., Chouk, M., and Chevalier, X. (2019). Impact of obesity, structural severity and their combination on the efficacy of viscosupplementation in patients with knee osteoarthritis. BMC Musculoskelet. Disord., 20.","DOI":"10.1186\/s12891-019-2748-0"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1742-1241.2003.tb10535.x","article-title":"A one-year, randomised, placebo (saline) controlled clinical trial of 500\u2013730 kDa sodium hyaluronate (Hyalgan) on the radiological change in osteoarthritis of the knee","volume":"57","author":"Jubb","year":"2003","journal-title":"Int. J. Clin. Pract."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1515\/sjpain-2019-0079","article-title":"Altered pain processing and sensitisation is evident in adults with patellofemoral pain: A systematic review including meta-analysis and meta-regression","volume":"20","author":"Bartholomew","year":"2019","journal-title":"Scand. J. Pain."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"132","DOI":"10.26603\/001c.57603","article-title":"Signs of Nervous System Sensitization in Female Runners with Chronic Patellofemoral Pain","volume":"18","author":"Eckenrode","year":"2023","journal-title":"Int. J. Sports Phys. Ther."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"604","DOI":"10.2340\/16501977-0372","article-title":"Predictors of pain and function outcome after rehabilitation in patients with patellofemoral pain syndrome","volume":"41","author":"Piva","year":"2009","journal-title":"J. Rehabil. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e018624","DOI":"10.1136\/bmjopen-2017-018624","article-title":"The experience of living with patellofemoral pain-loss, confusion and fear-avoidance: A UK qualitative study","volume":"8","author":"Smith","year":"2018","journal-title":"BMJ Open"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1007\/s00402-016-2432-x","article-title":"Characteristics and associated factors of Klee cartilage lesions: Preliminary baseline-data of more than 1000 patients from the German cartilage registry (KnorpelRegister DGOU)","volume":"136","author":"Spahn","year":"2016","journal-title":"Arch. Orthop. Trauma Surg."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Restuccia, R., Ruggieri, D., Magaudda, L., and Talotta, R. (2022). The preventive and therapeutic role of physical activity in knee osteoarthritis. Reumatismo, 74.","DOI":"10.4081\/reumatismo.2022.1466"},{"key":"ref_47","first-page":"112","article-title":"Physical therapy for patients with knee and hip osteoarthritis: Supervised, active treatment is current best practice","volume":"37","author":"Skou","year":"2019","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s11999-012-2659-y","article-title":"Adding triamcinolone improves viscosupplementation: A randomized clinical trial","volume":"471","author":"Rezende","year":"2013","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1177\/1947603517703732","article-title":"Intraarticular Injection of a Cross-Linked Sodium Hyaluronate Combined with Triamcinolone Hexacetonide (Cingal) to Provide Symptomatic Relief of Osteoarthritis of the Knee: A Randomized, Double-Blind, Placebo-Controlled Multicenter Clinical Trial","volume":"9","author":"Hangody","year":"2018","journal-title":"Cartilage"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Power, J.D., Trifoi, F., Canizares, M., Perruccio, A.V., Shanmugaraj, A., Gandhi, R., Davey, J.R., Syed, K., Mahomed, N.N., and Veillette, C. (2024). The impact of diabetes on physical and mental health status and patient satisfaction after total hip and knee arthroplasty. PLoS ONE, 19.","DOI":"10.1371\/journal.pone.0302315"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/BF01349873","article-title":"Factors related to patients\u2019 satisfaction with their medical care","volume":"9","author":"Lochman","year":"1983","journal-title":"J. Community Health"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0140-6736(04)17670-8","article-title":"External validity of randomised controlled trials: \u201cto whom do the results of this trial apply\u201d?","volume":"365","author":"Rothwell","year":"2005","journal-title":"Lancet"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Leininger, B.D., Johnson, P.J., Bronfort, G., Kuntz, K.M., Enns, E., Hodges, J.S., and Evans, R. (2024). How well do participants in clinical trials represent the U.S. population with chronic neck or back pain?. BMC Musculoskelet. Disord., 25.","DOI":"10.1186\/s12891-024-07524-9"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.semarthrit.2015.04.011","article-title":"Consensus statement on viscosupplementation with hyaluronic acid for the management of osteoarthritis","volume":"45","author":"Henrotin","year":"2015","journal-title":"Semin. Arthritis Rheum."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/18\/5372\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:53:28Z","timestamp":1760111608000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/18\/5372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,11]]},"references-count":54,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["jcm13185372"],"URL":"https:\/\/doi.org\/10.3390\/jcm13185372","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,11]]}}}