{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T22:42:48Z","timestamp":1775083368338,"version":"3.50.1"},"reference-count":100,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T00:00:00Z","timestamp":1726099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>This article explores the pulmonary complications associated with inflammatory bowel disease (IBD). It presents a detailed case study of a 22-year-old male with Crohn\u2019s disease exhibiting pulmonary symptoms. The review delves into the spectrum of pulmonary involvement in IBD, covering clinical presentations, diagnostic challenges, underlying pathophysiology, and management strategies. It highlights the significance of these extraintestinal manifestations on patient outcomes and quality of life. The article underscores the need for heightened clinical awareness and a systematic approach to diagnosis and management, integrating the expertise of multiple specialists. The review identifies gaps in current research, suggesting avenues for future investigation to enhance the understanding and treatment of these complex manifestations.<\/jats:p>","DOI":"10.3390\/jcm13185401","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T06:31:40Z","timestamp":1726122700000},"page":"5401","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Pulmonary Manifestations of IBD: Case Report and Review of the Literature"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9597-1989","authenticated-orcid":false,"given":"Amit","family":"Herling","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Ben-Gurion University of the Negev, Be\u2032er Sheva 8410501, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tal Moshe","family":"Perluk","sequence":"additional","affiliation":[{"name":"Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6139001, Israel"},{"name":"The Pulmonary Institute, Tel Aviv Medical Center, Tel Aviv 6423906, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7272-5284","authenticated-orcid":false,"given":"Ophir","family":"Freund","sequence":"additional","affiliation":[{"name":"Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6139001, Israel"},{"name":"The Pulmonary Institute, Tel Aviv Medical Center, Tel Aviv 6423906, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nitsan","family":"Maharshak","sequence":"additional","affiliation":[{"name":"Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6139001, Israel"},{"name":"IBD Unit, Department of Gastroenterology and Liver Diseases, Tel Aviv Medical Center, Tel Aviv 6423906, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathaniel Aviv","family":"Cohen","sequence":"additional","affiliation":[{"name":"Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6139001, Israel"},{"name":"IBD Unit, Department of Gastroenterology and Liver Diseases, Tel Aviv Medical Center, Tel Aviv 6423906, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/nrgastro.2015.150","article-title":"The global burden of IBD: From 2015 to 2025","volume":"12","author":"Kaplan","year":"2015","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1093\/ecco-jcc\/jjx008","article-title":"Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 1: Definitions, Diagnosis, Extra-intestinal Manifestations, Pregnancy, Cancer Surveillance, Surgery, and Ileo-anal Pouch Disorders","volume":"11","author":"Magro","year":"2017","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"560","DOI":"10.4291\/wjgp.v5.i4.560","article-title":"Patterns of airway involvement in inflammatory bowel diseases","volume":"5","author":"Papanikolaou","year":"2014","journal-title":"World J. Gastrointest. Pathophysiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1183\/09031936.00079414","article-title":"Increased incidence of inflammatory bowel disease in Qu\u00e9bec residents with airway diseases","volume":"45","author":"Brassard","year":"2014","journal-title":"Eur. Respir. J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"200269","DOI":"10.1183\/20734735.0269-2020","article-title":"Inflammatory bowel disease and the lung in pediatric patients","volume":"17","author":"Jochmann","year":"2021","journal-title":"Breathe"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1053\/j.gastro.2021.07.042","article-title":"Extraintestinal Manifestations of Inflammatory Bowel Disease: Current Concepts, Treatment, and Implications for Disease Management","volume":"161","author":"Rogler","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1007\/s00384-006-0094-9","article-title":"Inflammatory bowel disease and the lung: Is there a link between surgery and bronchiectasis?","volume":"21","author":"Kelly","year":"2006","journal-title":"Int. J. Color. Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s12664-011-0129-1","article-title":"Pulmonary manifestations in inflammatory bowel disease: A prospective study","volume":"30","author":"Desai","year":"2011","journal-title":"Indian J. Gastroenterol. Off. J. Indian Soc. Gastroenterol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"5187","DOI":"10.1007\/s10620-022-07385-z","article-title":"Prevalence of Pulmonary Diseases in Association with Inflammatory Bowel Disease","volume":"67","author":"Pemmasani","year":"2022","journal-title":"Dig. Dis. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1378\/chest.06-1074","article-title":"Thoracic manifestations of inflammatory bowel disease","volume":"131","author":"Black","year":"2007","journal-title":"Chest"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3109\/07853890903559724","article-title":"Extraintestinal manifestations of inflammatory bowel disease: Epidemiology, diagnosis, and management","volume":"42","author":"Larsen","year":"2010","journal-title":"Ann. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"13501","DOI":"10.3748\/wjg.v20.i37.13501","article-title":"Pulmonary manifestations of inflammatory bowel disease","volume":"20","author":"Ji","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"6137","DOI":"10.3748\/wjg.v23.i33.6137","article-title":"Patients with inflammatory bowel disease have increased risk of autoimmune and inflammatory diseases","volume":"23","author":"Halling","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1093\/ibd\/izaa112","article-title":"Respiratory tract manifestations of inflammatory bowel disease","volume":"27","author":"Lee","year":"2021","journal-title":"Inflamm. Bowel. Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1097\/00054725-200303000-00004","article-title":"Pulmonary manifestations of inflammatory bowel disease","volume":"9","author":"Storch","year":"2003","journal-title":"Inflamm. Bowel. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/ecco-jcc\/jjv213","article-title":"The First European Evidence-based Consensus on Extra-intestinal Manifestations in Inflammatory Bowel Disease","volume":"10","author":"Harbord","year":"2016","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nrgastro.2013.117","article-title":"Extraintestinal manifestations and complications in IBD","volume":"10","author":"Ott","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1055\/s-0041-1730891","article-title":"Pathophysiology of Bronchiectasis","volume":"42","author":"Keir","year":"2021","journal-title":"Semin. Respir. Crit. Care Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.12968\/hmed.2020.0556","article-title":"An update on interstitial lung disease","volume":"82","author":"Mudawi","year":"2021","journal-title":"Br. J. Hosp. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1093\/ecco-jcc\/jjz165","article-title":"Interstitial and Granulomatous Lung Disease in Inflammatory Bowel Disease Patients","volume":"14","author":"Eliadou","year":"2020","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1378\/chest.10-0883","article-title":"Cryptogenic and secondary organizing pneumonia: Clinical presentation, radiographic findings, treatment response, and prognosis","volume":"139","author":"Drakopanagiotakis","year":"2011","journal-title":"Chest"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Cavalli, C.A.M., Gabbiadini, R., Dal Buono, A., Quadarella, A., De Marco, A., Repici, A., Bezzio, C., Simonetta, E., Aliberti, S., and Armuzzi, A. (2023). Lung Involvement in Inflammatory Bowel Diseases: Shared Pathways and Unwanted Connections. J. Clin. Med., 12.","DOI":"10.3390\/jcm12196419"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/00004836-199607000-00009","article-title":"Immune-Related Systemic Manifestations of Inflammatory Bowel Disease: A Prospective Study of 792 Patients","volume":"23","year":"1996","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.amjmed.2019.07.007","article-title":"Pulmonary Manifestations of Inflammatory Bowel Disease","volume":"133","author":"Massart","year":"2020","journal-title":"Am. J. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/mi.2011.55","article-title":"Pulmonary-intestinal cross-talk in mucosal inflammatory disease","volume":"5","author":"Keely","year":"2012","journal-title":"Mucosal. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/s41424-018-0054-z","article-title":"Co-occurrence of Asthma and the Inflammatory Bowel Diseases: A Systematic Review and Meta-analysis","volume":"9","author":"Kuenzig","year":"2018","journal-title":"Clin. Transl. Gastroenterol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"E1128","DOI":"10.1073\/pnas.1616783114","article-title":"Gene polymorphism linked to increased asthma and IBD risk alters gasdermin-B structure, a sulfatide and phosphoinositide binding protein","volume":"114","author":"Chao","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_28","first-page":"e6836","article-title":"Inflammatory bowel disease and obstructive pulmonary disease: A two-way association?","volume":"12","author":"Zergham","year":"2020","journal-title":"Cureus"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"7735","DOI":"10.3748\/wjg.v22.i34.7735","article-title":"Inflammatory bowel disease and airway diseases","volume":"22","author":"Vutcovici","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00408-008-9080-z","article-title":"Increased risk of both ulcerative colitis and Crohn\u2019s disease in a population suffering from COPD","volume":"186","author":"Ekbom","year":"2008","journal-title":"Lung"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Raftery, A.L., Tsantikos, E., Harris, N.L., and Hibbs, M.L. (2020). Links Between Inflammatory Bowel Disease and Chronic Obstructive Pulmonary Disease. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.02144"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"877","DOI":"10.3349\/ymj.2015.56.4.877","article-title":"Gene-Environment Interactions in Asthma: Genetic and Epigenetic Effects","volume":"56","author":"Lee","year":"2015","journal-title":"Yonsei Med. J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1093\/oxfordjournals.aje.a114550","article-title":"Nonspecific inflammatory bowel disease and smoking","volume":"125","author":"Franceschi","year":"1987","journal-title":"Am. J. Epidemiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.4065\/81.11.1462","article-title":"Smoking and inflammatory bowel disease: A meta-analysis","volume":"81","author":"Mahid","year":"2006","journal-title":"Mayo Clin. Proc."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1053\/gast.1996.v110.pm8566589","article-title":"Effects of cigarette smoking on the long-term course of Crohn\u2019s disease","volume":"110","author":"Cosnes","year":"1996","journal-title":"Gastroenterology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1136\/gut.33.6.779","article-title":"Smoking in Crohn\u2019s disease: Effect on localisation and clinical course","volume":"33","author":"Lindberg","year":"1992","journal-title":"Gut"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1172\/jci.insight.94040","article-title":"Chronic cigarette smoke exposure induces systemic hypoxia that drives intestinal dysfunction","volume":"3","author":"Fricker","year":"2018","journal-title":"JCI Insight"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1093\/ecco-jcc\/jjv238","article-title":"Smoking is Associated With Extra-intestinal Manifestations in Inflammatory Bowel Disease","volume":"10","author":"Severs","year":"2016","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"4819","DOI":"10.3748\/wjg.v12.i30.4819","article-title":"Extraintestinal manifestations and complications in inflammatory bowel diseases","volume":"12","author":"Rothfuss","year":"2006","journal-title":"World J. Gastroenterol. WJG"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2102776","DOI":"10.1183\/13993003.02776-2021","article-title":"Drug-induced interstitial lung disease","volume":"60","author":"Spagnolo","year":"2022","journal-title":"Eur. Respir. J."},{"key":"ref_41","first-page":"1","article-title":"British Thoracic Society Guideline for bronchiectasis in adults","volume":"74","author":"Hill","year":"2019","journal-title":"Thorax"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.crohns.2010.03.008","article-title":"Pulmonary manifestations of inflammatory bowel disease: Case presentations and review","volume":"4","author":"Basseri","year":"2010","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1183\/09031936.02.00267402","article-title":"Sulphasalazine and lung toxicity","volume":"19","author":"Parry","year":"2002","journal-title":"Eur. Respir. J."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1517\/14740338.4.4.723","article-title":"Methotrexate pulmonary toxicity","volume":"4","author":"Lateef","year":"2005","journal-title":"Expert Opin. Drug Saf."},{"key":"ref_45","first-page":"e29518","article-title":"Overview of Methotrexate Toxicity: A Comprehensive Literature Review","volume":"14","author":"Hamed","year":"2022","journal-title":"Cureus"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1056\/NEJMoa011110","article-title":"Tuberculosis associated with infliximab, a tumor necrosis factor \u03b1\u2013neutralizing agent","volume":"345","author":"Keane","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1002\/ibd.20027","article-title":"Safety of biologic therapy","volume":"13","author":"Blonski","year":"2007","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_48","first-page":"e1483","article-title":"Drug-Related Pneumonitis in Patients Receiving Vedolizumab Therapy for Inflammatory Bowel Disease","volume":"20","author":"Pugliese","year":"2022","journal-title":"Clin. Gastroenterol. Hepatol. Off. Clin. Pract. J. Am. Gastroenterol. Assoc."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1080\/14740338.2020.1773430","article-title":"Long-term safety of approved biologics for ulcerative colitis","volume":"19","author":"Parigi","year":"2020","journal-title":"Expert Opin. Drug Saf."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"210075","DOI":"10.1183\/16000617.0075-2021","article-title":"Systematic review on long-term adverse effects of inhaled corticosteroids in the treatment of COPD","volume":"30","author":"Miravitlles","year":"2021","journal-title":"Eur. Respir. Rev."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.semarthrit.2015.07.006","article-title":"Vasculitis in patients with inflammatory bowel diseases: A study of 32 patients and systematic review of the literature","volume":"45","author":"Sy","year":"2016","journal-title":"Semin. Arthritis Rheum."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s10620-009-0763-y","article-title":"The vasculitis in IBD is associated with the degree of inflammation","volume":"55","author":"Kruschewski","year":"2010","journal-title":"Dig. Dis. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1093\/rheumatology\/keab662","article-title":"IgA vasculitis in patients with inflammatory bowel disease: New insights into the role of TNF-\u03b1 blockers","volume":"61","author":"Rasmussen","year":"2022","journal-title":"Rheumatology"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.mayocp.2012.04.011","article-title":"Vasculitis associated with tumor necrosis factor-\u03b1 inhibitors","volume":"87","author":"Sokumbi","year":"2012","journal-title":"Mayo Clin. Proc."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1055\/s-0037-1615600","article-title":"The incidence of deep venous thrombosis and pulmonary embolism among patients with inflammatory bowel disease: A population-based cohort study","volume":"85","author":"Bernstein","year":"2001","journal-title":"Thromb. Haemost."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12959-015-0044-2","article-title":"Thrombosis in inflammatory bowel diseases: What\u2019s the link?","volume":"13","author":"Giannotta","year":"2015","journal-title":"Thromb. J."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.thromres.2014.12.025","article-title":"Inflammatory bowel disease increases the risks of deep vein thrombosis and pulmonary embolism in the hospitalized patients: A nationwide cohort study","volume":"135","author":"Chung","year":"2015","journal-title":"Thromb. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"13863","DOI":"10.3748\/wjg.v20.i38.13863","article-title":"Inflammatory bowel disease and thromboembolism","volume":"20","author":"Zezos","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_59","first-page":"617","article-title":"Thrombosis and inflammatory bowel disease","volume":"3","author":"Irving","year":"2005","journal-title":"Clin. Gastroenterol. Hepatol. Off. Clin. Pract. J. Am. Gastroenterol. Assoc."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1053\/gast.2002.32362","article-title":"The natural history of fistulizing Crohn\u2019s disease in Olmsted County, Minnesota","volume":"122","author":"Schwartz","year":"2002","journal-title":"Gastroenterology"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/0003-4975(95)00207-2","article-title":"Colobronchial fistula due to Crohn\u2019s disease","volume":"60","author":"Chagpar","year":"1995","journal-title":"Ann. Thorac. Surg."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/00004836-200104000-00021","article-title":"Rice, and Steven Mawhorter. Recurrent pneumonia from an ileobronchial fistula complicating Crohn\u2019s disease","volume":"32","author":"Gumbo","year":"2001","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1097\/00004836-200204000-00025","article-title":"Infliximab treatment of an esophagobronchial fistula in a patient with extensive Crohn\u2019s disease of the esophagus","volume":"34","author":"Ho","year":"2002","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"66","DOI":"10.4103\/jms.jms_92_16","article-title":"Iatrogenic fecopneumothorax: A rare cause of hydropneumothorax","volume":"32","author":"Kumar","year":"2018","journal-title":"J. Med. Soc."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.athoracsur.2007.03.020","article-title":"Fecopneumothorax: A rare complication of esophagectomy","volume":"84","author":"Markogiannakis","year":"2007","journal-title":"Ann. Thorac. Surg."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1378\/chest.115.1.288","article-title":"Tension fecopneumothorax due to colonic perforation in a diaphragmatic hernia","volume":"115","author":"Seelig","year":"1999","journal-title":"Chest"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"187","DOI":"10.21037\/jtd.2017.01.11","article-title":"Colobronchial fistula: The pathogenesis, clinical presentations, diagnosis and treatment","volume":"9","author":"Zhao","year":"2017","journal-title":"J. Thorac. Dis."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0889-8553(01)00019-X","article-title":"Extraintestinal manifestations of inflammatory bowel disease","volume":"31","author":"Su","year":"2002","journal-title":"Gastroenterol. Clin."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Perluk, T.M., Friedman Regev, I., Freund, O., Kleinhendler, E., Hershko, T., Ben-Ami, S., Bar-Shai, A., and Unterman, A. (2022). Importance of physician history taking in complementing patient-reported interstitial lung disease questionnaire. BMC Pulm. Med., 22.","DOI":"10.1186\/s12890-022-02294-3"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1093\/ecco-jcc\/jjab024","article-title":"Subclinical Pulmonary Involvement in Active IBD Responds to Biologic Therapy","volume":"15","author":"Ellrichmann","year":"2021","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1097\/00004836-200310000-00006","article-title":"Pulmonary function tests and high-resolution CT in the detection of pulmonary involvement in inflammatory bowel disease","volume":"37","author":"Ensari","year":"2003","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1183\/09031936.00.15104100","article-title":"Clinical and radiological characteristics of lung disease in inflammatory bowel disease","volume":"15","author":"Mahadeva","year":"2000","journal-title":"Eur. Respir. J."},{"key":"ref_73","first-page":"235","article-title":"Extraintestinal manifestations of inflammatory bowel disease","volume":"7","author":"Levine","year":"2011","journal-title":"Gastroenterol. Hepatol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/5697846","article-title":"Radiological patterns of lung involvement in inflammatory bowel disease","volume":"2018","author":"Cozzi","year":"2018","journal-title":"Gastroenterol. Res. Pract."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1111\/resp.13615","article-title":"Paediatric and adult bronchiectasis: Specific management with coexisting asthma, COPD, rheumatological disease and inflammatory bowel disease","volume":"24","author":"Maglione","year":"2019","journal-title":"Respirology"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"e226934","DOI":"10.1136\/bcr-2018-226934","article-title":"Case of steroid-resistant Crohn\u2019s-associated bronchiolitis in the setting of quiescent gastrointestinal disease treated with infliximab","volume":"11","author":"Chuah","year":"2018","journal-title":"BMJ Case Rep."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"100018","DOI":"10.1016\/j.chpulm.2023.100018","article-title":"Pulmonary Manifestations of Inflammatory Bowel Disease and Treatment Strategies","volume":"1","author":"Ghosh","year":"2023","journal-title":"CHEST Pulm."},{"key":"ref_78","first-page":"85","article-title":"Inflammatory bowel disease of the lung: The role of infliximab?","volume":"15","author":"Hayek","year":"2015","journal-title":"Respir. Med. Case Rep."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.crohns.2009.03.007","article-title":"Pulmonary Crohn\u2019s disease: A rare extra-intestinal manifestation treated with infliximab","volume":"3","author":"Pedersen","year":"2009","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1183\/09031936.00.15100500","article-title":"The lung in inflammatory bowel disease","volume":"15","author":"Camus","year":"2000","journal-title":"Eur. Respir. J."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.crohns.2007.08.009","article-title":"Pulmonary abnormalities in inflammatory bowel disease","volume":"1","author":"Schleiermacher","year":"2007","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1097\/MIB.0000000000001109","article-title":"Anti-TNF treatment for extraintestinal manifestations of inflammatory bowel disease in the Swiss IBD Cohort Study","volume":"23","author":"Vavricka","year":"2017","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1080\/14740338.2016.1186640","article-title":"Pulmonary implications in inflammatory bowel disease: Not a rare event","volume":"15","author":"Romano","year":"2016","journal-title":"Expert Opin. Drug Saf."},{"key":"ref_84","first-page":"e14216","article-title":"Pulmonary manifestations of inflammatory bowel disease","volume":"13","author":"Taveras","year":"2021","journal-title":"Cureus"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/S0140-6736(12)60953-2","article-title":"Azithromycin for prevention of exacerbations in non-cystic fibrosis bronchiectasis (EMBRACE): A randomised, double-blind, placebo-controlled trial","volume":"380","author":"Wong","year":"2012","journal-title":"Lancet"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1164\/rccm.202306-1113ST","article-title":"Treatment of Systemic Sclerosis-associated Interstitial Lung Disease: Evidence-based Recommendations. An Official American Thoracic Society Clinical Practice Guideline","volume":"209","author":"Raghu","year":"2024","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_87","first-page":"1064","article-title":"Therapeutic strategy combining intravenous cyclophosphamide followed by oral azathioprine to treat worsening interstitial lung disease associated with systemic sclerosis: A retrospective multicenter open-label study","volume":"35","author":"Berezne","year":"2008","journal-title":"J. Rheumatol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.semarthrit.2014.09.003","article-title":"Low-dose pulse cyclophosphamide in interstitial lung disease associated with systemic sclerosis (SSc-ILD): Efficacy of maintenance immunosuppression in responders and non-responders","volume":"44","author":"Iudici","year":"2015","journal-title":"Semin. Arthritis Rheum."},{"key":"ref_89","first-page":"708","article-title":"Mycophenolate Mofetil versus Oral Cyclophosphamide in Scleroderma-related Interstitial Lung Disease: Scleroderma Lung Study II (SLS-II), a double-blind, parallel group, randomised controlled trial. The Lancet","volume":"4","author":"Tashkin","year":"2016","journal-title":"Respir. Med."},{"key":"ref_90","first-page":"e18414","article-title":"Pulmonary Rehabilitation in Management of Chronic Obstructive Pulmonary Disease","volume":"13","author":"Alharbi","year":"2021","journal-title":"Cureus"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.3748\/wjg.v19.i9.1349","article-title":"Efficacy of the vaccination in inflammatory bowel disease","volume":"19","author":"Carrera","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1038\/ajg.2009.733","article-title":"A Practical Guide to Vaccinating the Inflammatory Bowel Disease Patient","volume":"105","author":"Wasan","year":"2010","journal-title":"Am. J. Gastroenterol."},{"key":"ref_93","first-page":"540","article-title":"Vaccinating Patients with Inflammatory Bowel Disease","volume":"12","author":"Reich","year":"2016","journal-title":"Gastroenterol. Hepatol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1159\/000503253","article-title":"Vaccination in Patients with Inflammatory Bowel Diseases","volume":"101","author":"Manser","year":"2020","journal-title":"Digestion"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2147\/CEG.S42514","article-title":"Hospitalizations for vaccine preventable pneumonias in patients with inflammatory bowel disease: A 6-year analysis of the Nationwide Inpatient Sample","volume":"6","author":"Stobaugh","year":"2013","journal-title":"Clin. Exp. Gastroenterol."},{"key":"ref_96","first-page":"101914","article-title":"Pulmonary manifestation of inflammatory bowel disease: Two case reports","volume":"45","author":"Suzuki","year":"2023","journal-title":"Respir. Med. Case Rep."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s00408-024-00683-5","article-title":"Asymptomatic Dysphagia and Aspiration in Patients with Idiopathic Bronchiectasis","volume":"202","author":"Perluk","year":"2024","journal-title":"Lung"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1136\/gut.2005.079350","article-title":"Survival and cause specific mortality in patients with inflammatory bowel disease: A long term outcome study in Olmsted County 2022, Minnesota, 1940\u20132004","volume":"55","author":"Jess","year":"2006","journal-title":"Gut"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1093\/ibd\/izac064","article-title":"Severe Activity of Inflammatory Bowel Disease is a Risk Factor for Severe COVID-19","volume":"29","author":"Macaluso","year":"2023","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S0025-6196(12)65200-8","article-title":"Vascular complications of inflammatory bowel disease","volume":"61","author":"Talbot","year":"1986","journal-title":"Mayo Clin. Proc."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/18\/5401\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:54:36Z","timestamp":1760111676000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/18\/5401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,12]]},"references-count":100,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["jcm13185401"],"URL":"https:\/\/doi.org\/10.3390\/jcm13185401","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,12]]}}}