{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:25:39Z","timestamp":1760145939785,"version":"build-2065373602"},"reference-count":57,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T00:00:00Z","timestamp":1726099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Open Access Publishing Fund of the University of Regensburg"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: This study aimed to evaluate the diagnostic value of pre-existing computed tomography (CT) examinations for the detection of dental pathologies compared with clinical dental examination in patients with end-stage heart failure. Methods: For this purpose, 59 patients with end-stage heart failure and pre-existing non-dental CT images of the craniofacial region were included. Virtual orthopantomograms (vOPG) were reconstructed. Dental pathologies were analyzed in vOPG and source-CT images. Imaging and clinical findings less than 6 months apart were compared (n = 24). Results: The subjective image quality of vOPG was more often rated as insufficient than CT (66%; 20%; p &lt; 0.01). Depending on examination (CT, vOPG or clinic), between 33% and 92% of the patients could require dental intervention such as treatment of caries and periodontitis or tooth extraction. vOPG led to a higher (80%) prevalence of teeth requiring treatment than CT (39%; p &lt; 0.01). The prevalence of teeth requiring treatment was similar in CT (29%) and clinic (29%; p = 1.00) but higher in vOPG (63%; p &lt; 0.01). CT (stage 3 or 4: 42%) and vOPG (38%) underestimated the stage of periodontitis (clinic: 75%; p &lt; 0.01). Conclusions: In conclusion, available CT images including the craniofacial region from patients with end-stage heart failure may contain valuable information regarding oral health status. The assessability of vOPGs might be insufficient and must be interpreted with caution.<\/jats:p>","DOI":"10.3390\/jcm13185406","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T06:31:40Z","timestamp":1726122700000},"page":"5406","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of Dental Findings with Computed Tomographic and Clinical Examination in Patients with End-Stage Heart Failure"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0112-7631","authenticated-orcid":false,"given":"Cordula Leonie","family":"Merle","sequence":"first","affiliation":[{"name":"Department of Prosthetic Dentistry, UKR University Hospital Regensburg, 93042 Regensburg, Germany"},{"name":"Department of Cariology, Endodontology and Periodontology, University of Leipzig, 04103 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Gocke","sequence":"additional","affiliation":[{"name":"Department of Cariology, Endodontology and Periodontology, University of Leipzig, 04103 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Seitz","sequence":"additional","affiliation":[{"name":"Heart Center Leipzig, University Department for Cardiac Surgery, 04289 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4879-0438","authenticated-orcid":false,"given":"Matthias","family":"Gutberlet","sequence":"additional","affiliation":[{"name":"Heart Center Leipzig, University Department for Cardiac Surgery, 04289 Leipzig, Germany"},{"name":"Department of Diagnostic and Interventional Radiology, Heart Center Leipzig, 04289 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diyar","family":"Saeed","sequence":"additional","affiliation":[{"name":"Medical Faculty, University of Leipzig, 04103 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3716-4231","authenticated-orcid":false,"given":"Rainer","family":"Haak","sequence":"additional","affiliation":[{"name":"Department of Cariology, Endodontology and Periodontology, University of Leipzig, 04103 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9810-2368","authenticated-orcid":false,"given":"Dirk","family":"Ziebolz","sequence":"additional","affiliation":[{"name":"Department of Cariology, Endodontology and Periodontology, University of Leipzig, 04103 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8629-8490","authenticated-orcid":false,"given":"Robin Fabian","family":"Gohmann","sequence":"additional","affiliation":[{"name":"Heart Center Leipzig, University Department for Cardiac Surgery, 04289 Leipzig, Germany"},{"name":"Department of Diagnostic and Interventional Radiology, Heart Center Leipzig, 04289 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6602-377X","authenticated-orcid":false,"given":"Gerhard","family":"Schmalz","sequence":"additional","affiliation":[{"name":"Department of Cariology, Endodontology and Periodontology, University of Leipzig, 04103 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1002\/ehf2.12555","article-title":"Highlights in heart failure","volume":"6","author":"Tomasoni","year":"2019","journal-title":"ESC Heart Fail"},{"key":"ref_2","unstructured":"Bundes\u00e4rztekammer (B\u00c4K), and Kassen\u00e4rztliche Bundesvereinigung (KBV) (2022, May 29). National Disease Management Guideline: Chronic Heart Failure (in German). Available online: https:\/\/www.leitlinien.de\/themen\/herzinsuffizienz\/3-auflage\/kapitel-2."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1002\/ejhf.2143","article-title":"The Heart Failure Association Atlas: Heart Failure Epidemiology and Management Statistics 2019","volume":"23","author":"Vardas","year":"2021","journal-title":"Eur. J. Heart Fail"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1002\/ejhf.1236","article-title":"Advanced heart failure: A position statement of the Heart Failure Association of the European Society of Cardiology","volume":"20","author":"Metra","year":"2018","journal-title":"Eur. J. Heart Fail"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1586\/erd.11.36","article-title":"Left ventricular assist device-related infections: Past, present and future","volume":"8","author":"Maniar","year":"2011","journal-title":"Expert. Rev. Med. Devices"},{"key":"ref_6","first-page":"2151","article-title":"Left ventricular assist device driveline infections: Recent advances and future goals","volume":"7","author":"Leuck","year":"2015","journal-title":"J. Thorac. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1016\/j.athoracsur.2019.09.021","article-title":"Diabetes Mellitus Is Not a Risk Factor for Patients Supported with Left Ventricular Assist Device","volume":"109","author":"Zhou","year":"2020","journal-title":"Ann. Thorac. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00784-007-0101-8","article-title":"Necessity of surgical dental foci treatment prior to organ transplantation and heart valve replacement","volume":"11","author":"Rustemeyer","year":"2007","journal-title":"Clin. Oral. Investig."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e012386","DOI":"10.1136\/bmjopen-2016-012386","article-title":"Is poor oral health a risk marker for incident cardiovascular disease hospitalisation and all-cause mortality? Findings from 172 630 participants from the prospective 45 and Up Study","volume":"6","author":"Joshy","year":"2016","journal-title":"BMJ Open"},{"key":"ref_10","unstructured":"National Institute of Dental and Craniofacial Research (2022, May 29). Dental Management of the Organ or Stem Cell Transplant Patient, Available online: https:\/\/nidcr.nih.gov\/sites\/default\/files\/2017-09\/dental-management-organ-stem-cell-transplant.pdf."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"151","DOI":"10.21470\/1678-9741-2017-0137","article-title":"Oral Health Status, Health Behaviour and Treatment Needs of Patients Undergoing Cardiovascular Surgery","volume":"33","author":"Kumar","year":"2018","journal-title":"Braz. J. Cardiovasc. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Binner, C., Wagner, J., Schmalz, G., Eisner, M., Rast, J., Kottmann, T., Haak, R., Oberbach, A., Borger, M.A., and Garbade, J. (2019). Insufficient Oral Behaviour and the High Need for Periodontal Treatment in Patients with Heart Insufficiency and after Heart Transplantation: A Need for Special Care Programs?. J. Clin. Med., 8.","DOI":"10.3390\/jcm8101668"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Ziebolz, D., Friedrich, S., Binner, C., Rast, J., Eisner, M., Wagner, J., Schmickler, J., Kottmann, T., Haak, R., and Borger, M.A. (2020). Lack in Periodontal Care of Patients Suffering from Severe Heart Diseases-Results after 12 Months Follow-Up. J. Clin. Med., 9.","DOI":"10.3390\/jcm9020352"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1002\/ehf2.12636","article-title":"Oral health and dental behaviour of patients with left ventricular assist device: A cross-sectional study","volume":"7","author":"Garbade","year":"2020","journal-title":"ESC Heart Fail"},{"key":"ref_15","first-page":"3","article-title":"Development and evaluation of the Oral Health Impact Profile","volume":"11","author":"Slade","year":"1994","journal-title":"Community Dent. Health"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1002\/ehf2.12479","article-title":"Emerging role of cardiac computed tomography in heart failure","volume":"6","author":"Aziz","year":"2019","journal-title":"ESC Heart Fail"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1148\/rg.2019190012","article-title":"CT of the Neck: Image Analysis and Reporting in the Emergency Setting","volume":"39","author":"Cunqueiro","year":"2019","journal-title":"Radiographics"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1086\/344777","article-title":"Recipient screening prior to solid-organ transplantation","volume":"35","author":"Avery","year":"2002","journal-title":"Clin. Infect. Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1007\/s10278-021-00481-y","article-title":"Panoramic Dental Reconstruction for Faster Detection of Dental Pathology on Medical Non-dental CT Scans: A Proof of Concept from CT Neck Soft Tissue","volume":"34","author":"Stember","year":"2021","journal-title":"J. Digit. Imaging"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1002\/alr.21212","article-title":"Clinical and radiologic findings in a case series of maxillary sinusitis of dental origin","volume":"12","author":"Pokorny","year":"2013","journal-title":"Int. Forum Allergy Rhinol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"S162","DOI":"10.1111\/jcpe.12946","article-title":"Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions","volume":"45","author":"Papapanou","year":"2018","journal-title":"J. Clin. Periodontol."},{"key":"ref_22","unstructured":"World Health Organization (1997). Oral Health Surveys: Basic Methods, World Health Organization. [4th ed.]."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1111\/j.1600-051X.2008.01249.x","article-title":"Periodontal inflamed surface area: Quantifying inflammatory burden","volume":"35","author":"Nesse","year":"2008","journal-title":"J. Clin. Periodontol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1111\/jcpe.12935","article-title":"A new classification scheme for periodontal and peri-implant diseases and conditions-Introduction and key changes from the 1999 classification","volume":"45","author":"Caton","year":"2018","journal-title":"J. Clin. Periodontol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.anaerobe.2013.09.010","article-title":"Oral microbiota and systemic disease","volume":"24","author":"Kumar","year":"2013","journal-title":"Anaerobe"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/jcpe.12029","article-title":"Incidence and magnitude of bacteraemia caused by flossing and by scaling and root planing","volume":"40","author":"Zhang","year":"2013","journal-title":"J. Clin. Periodontol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1600-051X.2011.01784.x","article-title":"Periodontal health status and bacteraemia from daily oral activities: Systematic review\/meta-analysis","volume":"39","author":"Diz","year":"2012","journal-title":"J. Clin. Periodontol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ijcard.2017.09.001","article-title":"Periodontal bacteria DNA findings in human cardiac tissue-Is there a link of periodontitis to heart valve disease?","volume":"251","author":"Ziebolz","year":"2018","journal-title":"Int. J. Cardiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1111\/ajt.14208","article-title":"Infection in Organ Transplantation","volume":"17","author":"Fishman","year":"2017","journal-title":"Am. J. Transplant."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.bjoms.2015.08.262","article-title":"Haemostatic management for oral surgery in patients supported with left ventricular assist device\u2014A preliminary retrospective study","volume":"53","author":"Morimoto","year":"2015","journal-title":"Br. J. Oral. Maxillofac. Surg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.ijcard.2010.11.014","article-title":"A systematic review of the effectiveness of oral health promotion activities among patients with cardiovascular disease","volume":"151","author":"Lam","year":"2011","journal-title":"Int. J. Cardiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"845","DOI":"10.14219\/jada.archive.2010.0282","article-title":"Dental care for patients with heart failure: An update","volume":"141","author":"Herman","year":"2010","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_33","first-page":"136","article-title":"Medical emergencies in the oral health care setting","volume":"74","author":"Nunn","year":"2000","journal-title":"J. Dent. Hyg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e12832","DOI":"10.1111\/tid.12832","article-title":"Association between the time after transplantation and different immunosuppressive medications with dental and periodontal treatment need in patients after solid organ transplantation","volume":"20","author":"Schmalz","year":"2018","journal-title":"Transpl. Infect. Dis."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"317","DOI":"10.5051\/jpis.2018.48.5.317","article-title":"Panoramic radiography can be an effective diagnostic tool adjunctive to oral examinations in the national health checkup program","volume":"48","author":"Kweon","year":"2018","journal-title":"J. Periodontal Implant. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1111\/j.1834-7819.2009.01141.x","article-title":"Radiographs in periodontal disease diagnosis and management","volume":"54","author":"Corbet","year":"2009","journal-title":"Aust. Dent. J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1902\/jop.2016.150636","article-title":"Cone-Beam Computed Tomography for Detection of Intrabony and Furcation Defects: A Systematic Review Based on a Hierarchical Model for Diagnostic Efficacy","volume":"87","author":"Wenzel","year":"2016","journal-title":"J. Periodontol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"552","DOI":"10.12998\/wjcc.v2.i10.552","article-title":"Reporting of dental status from full-arch radiographs: Descriptive analysis and methodological aspects","volume":"2","author":"Huettig","year":"2014","journal-title":"World J. Clin. Cases"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s00117-017-0242-y","article-title":"H\u00e4ufigkeit und Dosis diagnostischer und interventioneller R\u00f6ntgenanwendungen: Trends zwischen 2007 und 2014. [Frequency and doses of diagnostic and interventional X-ray applications: Trends between 2007 and 2014]","volume":"57","author":"Nekolla","year":"2017","journal-title":"Radiologe"},{"key":"ref_40","unstructured":"Bushberg, J. (2014, January 10\u201311). National Council on Radiation Protection and Measurements. Alada (as low as diagnostically acceptable): 2014. Proceedings of the NCRP Annual Meeting, Bethesda, MD, USA."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"E15","DOI":"10.1148\/rg.331125172","article-title":"Periapical lucency around the tooth: Radiologic evaluation and differential diagnosis","volume":"33","author":"Chapman","year":"2013","journal-title":"Radiographics"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"104115","DOI":"10.1016\/j.jdent.2022.104115","article-title":"Deep learning for caries detection: A systematic review","volume":"122","author":"Motamedian","year":"2022","journal-title":"J. Dent."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1007\/s10278-024-01054-5","article-title":"A Systematic Review on Caries Detection, Classification, and Segmentation from X-Ray Images: Methods, Datasets, Evaluation, and Open Opportunities","volume":"37","author":"Zanini","year":"2024","journal-title":"J. Imaging Inf. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1259\/dmfr\/30642039","article-title":"Artefacts in CBCT: A review","volume":"40","author":"Schulze","year":"2011","journal-title":"Dentomaxillofac Radiol."},{"key":"ref_45","first-page":"566","article-title":"E.A.O. guidelines fo the use of diagnostic imaging in implant dentistry","volume":"13","author":"Harris","year":"2002","journal-title":"A consensus workshop organized by the European Association for Osseointegration in Trinity College Dublin. Clin. Oral. Implant. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1259\/dmfr\/14340323","article-title":"Dosimetry of 3 CBCT devices for oral and maxillofacial radiology: CB Mercuray, NewTom 3G and i-CAT","volume":"35","author":"Ludlow","year":"2006","journal-title":"Dentomaxillofac Radiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1902\/jop.2017.170234","article-title":"American Academy of Periodontology Best Evidence Consensus Statement on Selected Oral Applications for Cone-Beam Computed Tomography","volume":"88","author":"Mandelaris","year":"2017","journal-title":"J. Periodontol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1902\/jop.2017.160505","article-title":"When Is Cone-Beam Computed Tomography Imaging Appropriate for Diagnostic Inquiry in the Management of Inflammatory Periodontitis? An American Academy of Periodontology Best Evidence Review","volume":"88","author":"Kim","year":"2017","journal-title":"J. Periodontol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1111\/j.1365-2591.2006.01157.x","article-title":"Diagnostic value of computed tomography in re-treatment of root fillings in maxillary molars","volume":"39","author":"Huumonen","year":"2006","journal-title":"Int. Endod. J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.oooo.2018.10.005","article-title":"Panoramic radiography is of limited value in the evaluation of maxillary sinus disease","volume":"127","author":"Constantine","year":"2019","journal-title":"Oral. Surg. Oral. Med. Oral. Pathol. Oral. Radiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"S74","DOI":"10.1002\/JPER.17-0719","article-title":"Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions","volume":"89","author":"Chapple","year":"2018","journal-title":"J. Periodontol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00520-017-3829-y","article-title":"A systematic review of dental disease management in cancer patients","volume":"26","author":"Hong","year":"2018","journal-title":"Support. Care Cancer"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Miki, K., Kitamura, M., Hatta, K., Kamide, K., Gondo, Y., Yamashita, M., Takedachi, M., Nozaki, T., Fujihara, C., and Kashiwagi, Y. (2021). Periodontal inflamed surface area is associated with hs-CRP in septuagenarian Japanese adults in cross-sectional findings from the SONIC study. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-93872-8"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"11300","DOI":"10.12998\/wjcc.v9.i36.11300","article-title":"Correlation of periodontal inflamed surface area with glycemic status in controlled and uncontrolled type 2 diabetes mellitus","volume":"9","author":"Anil","year":"2021","journal-title":"World J. Clin. Cases"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.1088\/0031-9155\/59\/12\/3201","article-title":"Dose measurements for dental cone-beam CT: A comparison with MSCT and panoramic imaging","volume":"59","author":"Deman","year":"2014","journal-title":"Phys. Med. Biol."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Schmalz, G., Hennecke, A., Haak, R., Kottmann, T., Garbade, J., Binner, C., and Ziebolz, D. (2023). Secondary analysis of potential associations between oral health and infection-related parameters in patients with severe heart failure-results of a German cohort. BMC Cardiovasc. Disord., 21.","DOI":"10.1186\/s12872-023-03612-1"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Schmalz, G., Reuschel, F., Bartl, M., Schmidt, L., Runge, J., Haak, R., Goralski, S., Roth, A., and Ziebolz, D. (2022). One Third of Patients before Endoprosthesis Implantation Show an Oral Focus as Potential Source of Infectious Complication-The Value of Pre-Operative Dental Risk Stratification in a German Cohort. J. Clin. Med., 11.","DOI":"10.3390\/jcm11133686"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/18\/5406\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:54:43Z","timestamp":1760111683000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/18\/5406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,12]]},"references-count":57,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["jcm13185406"],"URL":"https:\/\/doi.org\/10.3390\/jcm13185406","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2024,9,12]]}}}