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Mohseni Charitable Foundation","award":["708165"],"award-info":[{"award-number":["708165"]}]},{"name":"Mohammad H. Mohseni Charitable Foundation","award":["R01 HD107494"],"award-info":[{"award-number":["R01 HD107494"]}]},{"name":"Mohammad H. Mohseni Charitable Foundation","award":["R21 EY035816"],"award-info":[{"award-number":["R21 EY035816"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Optical coherence tomography (OCT) is a leading ocular imaging modality, known for delivering high-resolution volumetric morphological images. However, conventional OCT systems are limited by their narrow field-of-view (FOV) and their reliance on scattering contrast, lacking molecular specificity. Methods: To address these limitations, we developed a custom-built 105\u2218 ultra-widefield polarization-diversity OCT (UWF PD-OCT) system for assessing various retinal and choroidal conditions, which is particularly advantageous for visualizing peripheral retinal abnormalities. Patients with peripheral lesions or pigmentary changes were imaged using the UWF PD-OCT to evaluate the system\u2019s diagnostic capabilities. Comparisons were made with conventional swept-source OCT and other standard clinical imaging modalities to highlight the benefits of depolarization contrast for identifying pathological changes. Results: The molecular-specific contrast offered by UWF PD-OCT enhanced the detection of disease-specific features, particularly in the peripheral retina, by capturing melanin distribution and pigmentary changes in a single shot. This detailed visualization allows clinicians to monitor disease progression with greater precision, offering more accurate insights into retinal and choroidal pathologies. Conclusions: Integrating UWF PD-OCT into clinical practice represents a major advancement in ocular imaging, enabling comprehensive views of retinal pathologies that are difficult to capture with current modalities. This technology holds great potential to transform the diagnosis and management of retinal and choroidal diseases by providing unique insights into peripheral retinal abnormalities and melanin-specific changes, critical for early detection and timely intervention.<\/jats:p>","DOI":"10.3390\/jcm13185415","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T10:15:27Z","timestamp":1726136127000},"page":"5415","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Single-Shot Ultra-Widefield Polarization-Diversity Optical Coherence Tomography for Assessing Retinal and Choroidal Pathologies"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9895-8165","authenticated-orcid":false,"given":"Tiffany","family":"Tse","sequence":"first","affiliation":[{"name":"School of Biomedical Engineering, Faculty of Medicine and Applied Science, University of British Columbia, Vancouver, BC V6T 1Z3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoyoung","family":"Jung","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Shahidul Islam","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Faculty of Medicine and Applied Science, University of British Columbia, Vancouver, BC V6T 1Z3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Song","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Faculty of Medicine and Applied Science, University of British Columbia, Vancouver, BC V6T 1Z3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5626-4306","authenticated-orcid":false,"given":"Grace","family":"Soo","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Faculty of Medicine and Applied Science, University of British Columbia, Vancouver, BC V6T 1Z3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaldon","family":"Abbas","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3146-5006","authenticated-orcid":false,"given":"Shuibin","family":"Ni","sequence":"additional","affiliation":[{"name":"Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5346-2167","authenticated-orcid":false,"given":"Fernando","family":"Sumita","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC V6T 1Z3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Paton","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC V6T 1Z3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusi","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC V6T 1Z3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7988-7385","authenticated-orcid":false,"given":"Yifan","family":"Jian","sequence":"additional","affiliation":[{"name":"Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaid","family":"Mammo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC V6T 1Z3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo V.","family":"Navajas","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC V6T 1Z3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4907-3732","authenticated-orcid":false,"given":"Myeong Jin","family":"Ju","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Faculty of Medicine and Applied Science, University of British Columbia, Vancouver, BC V6T 1Z3, Canada"},{"name":"Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC V6T 1Z3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1126\/science.1957169","article-title":"Optical Coherence Tomography","volume":"254","author":"Huang","year":"1991","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Drexler, W., Liu, M., Kumar, A., Kamali, T., Unterhuber, A., and Leitgeb, R.A. (2014). Optical coherence tomography today: Speed, contrast, and multimodality. J. Biomed. Opt., 19.","DOI":"10.1117\/1.JBO.19.7.071412"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4734","DOI":"10.1364\/BOE.7.004734","article-title":"Long-range and wide field of view optical coherence tomography for in vivo 3D imaging of large volume object based on akinetic programmable swept source","volume":"7","author":"Song","year":"2016","journal-title":"Biomed. Opt. Express"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"5878","DOI":"10.1364\/OL.443672","article-title":"105\u2218 field of view non-contact handheld swept-source optical coherence tomography","volume":"46","author":"Ni","year":"2021","journal-title":"Opt. Lett."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1136\/bjophthalmol-2015-307480","article-title":"Wide field of view swept-source optical coherence tomography for peripheral retinal disease","volume":"100","author":"McNabb","year":"2016","journal-title":"Br. J. Ophthalmol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3412","DOI":"10.1364\/BOE.520739","article-title":"Panretinal handheld OCT angiography for pediatric retinal imaging","volume":"15","author":"Ni","year":"2024","journal-title":"Biomed. Opt. Express"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1364\/BOE.8.001838","article-title":"Polarization sensitive optical coherence tomography\u2014A review [Invited]","volume":"8","author":"Hitzenberger","year":"2017","journal-title":"Biomed. Opt. Express"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Yamanari, M., Mase, M., Obata, R., Matsuzaki, M., Minami, T., Takagi, S., Yamamoto, M., Miyamoto, N., Ueda, K., and Koide, N. (2020). Melanin concentration and depolarization metrics measurement by polarization-sensitive optical coherence tomography. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-76397-4"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Miura, M., Makita, S., Yasuno, Y., Iwasaki, T., Azuma, S., Mino, T., and Yamaguchi, T. (2022). Evaluation of choroidal melanin-containing tissue in healthy Japanese subjects by polarization-sensitive optical coherence tomography. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-07818-9"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/j.1751-1097.2008.00316.x","article-title":"Role of Ocular Melanin in Ophthalmic Physiology and Pathology\u2020","volume":"84","author":"Hu","year":"2008","journal-title":"Photochem. Photobiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1364\/BOE.3.001670","article-title":"Polarization sensitive optical coherence tomography of melanin provides intrinsic contrast based on depolarization","volume":"3","author":"Baumann","year":"2012","journal-title":"Biomed. Opt. Express"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Sakai, D., Takagi, S., Totani, K., Yamamoto, M., Matsuzaki, M., Yamanari, M., Sugiyama, S., Yokota, S., Maeda, A., and Hirami, Y. (2022). Retinal pigment epithelium melanin imaging using polarization-sensitive optical coherence tomography for patients with retinitis pigmentosa. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-11192-x"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"6945","DOI":"10.1364\/BOE.403209","article-title":"Quantitative multi-contrast in vivo mouse imaging with polarization diversity optical coherence tomography and angiography","volume":"11","author":"Hsu","year":"2020","journal-title":"Biomed. Opt. Express"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1167\/iovs.64.14.6","article-title":"Polarization-Diversity Optical Coherence Tomography Assessment of Choroidal Nevi","volume":"64","author":"Miao","year":"2023","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.oret.2019.05.007","article-title":"Classification and Guidelines for Widefield Imaging: Recommendations from the International Widefield Imaging Study Group","volume":"3","author":"Choudhry","year":"2019","journal-title":"Ophthalmol. Retin."},{"key":"ref_16","unstructured":"(2024, September 05). DRCR Retina Network\u2014Public Site. Available online: https:\/\/public.jaeb.org\/drcrnet."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1007\/s40123-024-00905-2","article-title":"Clinical Utilisation of Wide-Field Optical Coherence Tomography and Angiography: A Narrative Review","volume":"13","author":"Nissen","year":"2024","journal-title":"Ophthalmol. Ther."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1097\/IAE.0000000000000703","article-title":"Retinochoroidal morphology described By wide-field montage imaging of spectral domain optical coherence tomography","volume":"36","author":"Mori","year":"2016","journal-title":"Retina"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Ripa, M., Motta, L., Florit, T., Sahyoun, J.Y., Matello, V., and Parolini, B. (2022). The Role of Widefield and Ultra Widefield Optical Coherence Tomography in the Diagnosis and Management of Vitreoretinal Diseases. Diagnostics, 12.","DOI":"10.3390\/diagnostics12092247"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2515841419899495","DOI":"10.1177\/2515841419899495","article-title":"Ultra-widefield retinal imaging: An update on recent advances","volume":"12","author":"Patel","year":"2020","journal-title":"Ther. Adv. Ophthalmol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.ophtha.2016.12.004","article-title":"Peripheral Retinal Changes Associated with Age-Related Macular Degeneration in the Age-Related Eye Disease Study 2: Age-Related Eye Disease Study 2 Report Number 12 by the Age-Related Eye Disease Study 2 Optos PEripheral RetinA (OPERA) Study Research Group","volume":"124","author":"Domalpally","year":"2017","journal-title":"Ophthalmology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ophtha.2023.04.016","article-title":"Ultrawide-field En face OCT of Multiple Evanescent White Dot Syndrome","volume":"131","author":"Duan","year":"2024","journal-title":"Ophthalmology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ophtha.2022.05.001","article-title":"Ultrawide-field Swept Source-OCT Angiography of Retinitis Pigmentosa","volume":"130","author":"Zheng","year":"2023","journal-title":"Ophthalmology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.ophtha.2021.11.012","article-title":"Ultrawide-field OCT for Retinoblastoma","volume":"129","author":"Skalet","year":"2022","journal-title":"Ophthalmology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1364\/BOE.425411","article-title":"High-speed and widefield handheld swept-source OCT angiography with a VCSEL light source","volume":"12","author":"Ni","year":"2021","journal-title":"Biomed. Opt. Express"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"10652","DOI":"10.1364\/OPEX.13.010652","article-title":"Three-dimensional and high-speed swept-source optical coherence tomography for in vivo investigation of human anterior eye segments","volume":"13","author":"Yasuno","year":"2005","journal-title":"Opt. Express"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"6783","DOI":"10.1364\/OL.39.006783","article-title":"Degree of polarization uniformity with high noise immunity using polarization-sensitive optical coherence tomography","volume":"39","author":"Makita","year":"2014","journal-title":"Opt. Lett."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"6121","DOI":"10.1364\/OE.15.006121","article-title":"In vivo high-contrast imaging of deep posterior eye by 1-\u03bcm swept source optical coherence tomography and scattering optical coherence angiography","volume":"15","author":"Yasuno","year":"2007","journal-title":"Opt. Express"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"19412","DOI":"10.1364\/OE.21.019412","article-title":"Advanced multi-contrast Jones matrix optical coherence tomography for Doppler and polarization sensitive imaging","volume":"21","author":"Ju","year":"2013","journal-title":"Opt. Express"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.neuroimage.2006.01.015","article-title":"User-guided 3D active contour segmentation of anatomical structures: Significantly improved efficiency and reliability","volume":"31","author":"Yushkevich","year":"2006","journal-title":"NeuroImage"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1016\/S0140-6736(06)69740-7","article-title":"Retinitis pigmentosa","volume":"368","author":"Hartong","year":"2006","journal-title":"Lancet"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1080\/21678707.2020.1735352","article-title":"Monitoring progression of retinitis pigmentosa: Current recommendations and recent advances","volume":"8","author":"Menghini","year":"2020","journal-title":"Expert Opin. Orphan Drugs"},{"key":"ref_33","first-page":"175","article-title":"Histopathology of the human retina in retinitis pigmentosa","volume":"17","author":"Milam","year":"1998","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.ajo.2015.06.032","article-title":"Multimodal Imaging of Central Retinal Disease Progression in a 2-Year Mean Follow-up of Retinitis Pigmentosa","volume":"160","author":"Sujirakul","year":"2015","journal-title":"Am. J. Ophthalmol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Jauregui, R., Takahashi, V.K.L., Park, K.S., Cui, X., Takiuti, J.T., Lima de Carvalho, J.R., and Tsang, S.H. (2019). Multimodal structural disease progression of retinitis pigmentosa according to mode of inheritance. Sci. Rep., 9.","DOI":"10.1038\/s41598-019-47251-z"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"6416","DOI":"10.1167\/iovs.12-11550","article-title":"Characterization of Stargardt Disease Using Polarization-Sensitive Optical Coherence Tomography and Fundus Autofluorescence Imaging","volume":"54","author":"Ritter","year":"2013","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1038\/eye.2008.280","article-title":"Lipofuscin- and melanin-related fundus autofluorescence visualize different retinal pigment epithelial alterations in patients with retinitis pigmentosa","volume":"23","author":"Kellner","year":"2009","journal-title":"Eye"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1097\/ICU.0000000000000361","article-title":"Choroidal nevus: A review of prevalence, features, genetics, risks, and outcomes","volume":"28","author":"Chien","year":"2017","journal-title":"Curr. Opin. Ophthalmol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1016\/j.ophtha.2011.05.007","article-title":"Prevalence and Characteristics of Choroidal Nevi: The Multi-Ethnic Study of Atherosclerosis","volume":"118","author":"Greenstein","year":"2011","journal-title":"Ophthalmology"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1016\/j.ophtha.2005.06.011","article-title":"Estimating the risk of malignant transformation of a choroidal nevus","volume":"112","author":"Singh","year":"2005","journal-title":"Ophthalmology"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1097\/IAE.0000000000000288","article-title":"Enhanced depth imaging optical coherence tomography of intraocular tumors: From placid to seasick to rock and rolling topography\u2013the 2013 Francesco Orzalesi Lecture","volume":"34","author":"Shields","year":"2014","journal-title":"Retina"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1001\/archopht.1984.01040031440019","article-title":"Multifocal Choroiditis and Panuveitis: A Syndrome That Mimics Ocular Histoplasmosis","volume":"102","author":"Dreyer","year":"1984","journal-title":"Arch. Ophthalmol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"426","DOI":"10.3109\/09273948.2011.624287","article-title":"White Dot Syndromes: A 20-year Study of Incidence, Clinical Features, and Outcomes","volume":"19","author":"Hartono","year":"2011","journal-title":"Ocul. Immunol. Inflamm."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"429","DOI":"10.4103\/2008-322X.194141","article-title":"Idiopathic Multifocal Choroiditis","volume":"11","author":"Tavallali","year":"2016","journal-title":"J. Ophthalmic Vis. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ajo.2023.03.022","article-title":"Exploring Imaging Characteristics Associated with Disease Activity in Idiopathic Multifocal Choroiditis: A Multimodal Imaging Approach","volume":"252","author":"Kouwenberg","year":"2023","journal-title":"Am. J. Ophthalmol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1177\/112067210701700332","article-title":"Curvilinear Streaks in Multifocal Choroiditis","volume":"17","author":"Matsumoto","year":"2007","journal-title":"Eur. J. Ophthalmol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1097\/ICU.0000000000000392","article-title":"Choroideremia","volume":"28","author":"Dimopoulos","year":"2017","journal-title":"Curr. Opin. Ophthalmol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.ophtha.2009.01.016","article-title":"Fundus Autofluorescence in Carriers of Choroideremia and Correlation with Electrophysiologic and Psychophysical Data","volume":"116","author":"Preising","year":"2009","journal-title":"Ophthalmology"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ajoc.2016.04.003","article-title":"A case study of choroideremia carrier\u2014Use of multi-spectral imaging in highlighting clinical features","volume":"2","author":"Dugel","year":"2016","journal-title":"Am. J. Ophthalmol. Case Rep."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s42003-022-03842-7","article-title":"Widespread subclinical cellular changes revealed across a neural-epithelial-vascular complex in choroideremia using adaptive optics","volume":"5","author":"Aguilera","year":"2022","journal-title":"Commun. Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"3954","DOI":"10.1364\/OL.40.003954","article-title":"Degree of polarization (uniformity) and depolarization index: Unambiguous depolarization contrast for optical coherence tomography","volume":"40","author":"Lippok","year":"2015","journal-title":"Opt. Lett."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Lippok, N., Braaf, B., Villiger, M., Oh, W.Y., Vakoc, B.J., and Bouma, B.E. (2019). Quantitative depolarization measurements for fiber-based polarization-sensitive optical frequency domain imaging of the retinal pigment epithelium. J. 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