{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:25:46Z","timestamp":1760145946098,"version":"build-2065373602"},"reference-count":19,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T00:00:00Z","timestamp":1726099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: 18F-fluorodeoxyglucose positron emission tomography\u2013CT (FDG-PET\/CT) is useful for identifying infective endocarditis (IE) but also the detection of other concomitant septic foci. Previously, we found that FDG-PET\/CT identified an osteoarthritic septic graft (OASG) in 19.1% of IE patients, frequently asymptomatic. These preliminary results encouraged us to extend our analyses to a larger population, including all patients initially explored for suspected IE, to assess the prevalence, characteristics, and OASG locations brought out by FDG-PET\/CT and to identify predictive factors. Methods: From a single-center cohort of patients referred for a clinical and\/or biological suspicion of IE, we included all patients who underwent FDG-PET\/CT, mainly performed to confirm a prosthesis heart valve or a foreign cardiac device infection. We excluded those who did not meet the 2015 modified Duke Criteria and those for whom another infectious diagnosis was finally retained or for whom all bacterial samples were negative. Demographic, clinical, bacteriological, imaging, and therapeutic data were collected. FDG-PET\/CT images were retrospectively analyzed by three blinded nuclear medicine specialists to identify OASGs. Results: We identified 72 distinct OASG locations by FDG-PET\/CT in 48 of 174 patients (27.6%), mainly located in the spine (21 OASGs in 20 patients); 14 patients (8.0%) had several OASG locations. In total, 43.8% of OASG locations were asymptomatic. In multivariate analysis, the presence of OASGs was associated with musculoskeletal pain (p &lt; 0.001) and tricuspid valve involvement (p = 0.002). Conclusions: FDG-PET\/CT is useful for identifying OASGs in patients with suspected IE, especially those with tricuspid IE or musculoskeletal pain. The identification of OASGs could impact antibiotic therapy and would allow adapted orthopedic management to be proposed.<\/jats:p>","DOI":"10.3390\/jcm13185419","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T11:04:33Z","timestamp":1726139073000},"page":"5419","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Value of Fluorodeoxyglucose Positron Emission Tomography\/Computed Tomography in Identifying Osteoarticular Septic Grafts in Suspected Infective Endocarditis: Results from a Large Monocentric Cohort"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7583-1632","authenticated-orcid":false,"given":"C\u00e9dric","family":"Luczak","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Assistance Publique\u2014H\u00f4pitaux de Paris, Henri Mondor Hospital, 94000 Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lionel","family":"Lerman","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Assistance Publique\u2014H\u00f4pitaux de Paris, Henri Mondor Hospital, 94000 Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2735-1148","authenticated-orcid":false,"given":"Laura","family":"Pina Vegas","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Assistance Publique\u2014H\u00f4pitaux de Paris, Henri Mondor Hospital, 94000 Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berivan","family":"Emsen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Assistance Publique\u2014H\u00f4pitaux de Paris, Henri Mondor Hospital, 94000 Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Hugues","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Assistance Publique\u2014H\u00f4pitaux de Paris, Henri Mondor Hospital, 94000 Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rapha\u00ebl","family":"Lepeule","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Assistance Publique\u2014H\u00f4pitaux de Paris, Henri Mondor Hospital, 94000 Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9629-5864","authenticated-orcid":false,"given":"Julien","family":"Ternacle","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Haut Leveque Hospital, 33600 Pessac, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rapha\u00eblle","family":"Huguet","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Assistance Publique\u2014H\u00f4pitaux de Paris, Henri Mondor Hospital, 94000 Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Assistance Publique\u2014H\u00f4pitaux de Paris, Henri Mondor Hospital, 94000 Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Winoc","family":"Decousser","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Assistance Publique\u2014H\u00f4pitaux de Paris, Henri Mondor Hospital, 94000 Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7962-7276","authenticated-orcid":false,"given":"Antonio","family":"Fiore","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Assistance Publique\u2014H\u00f4pitaux de Paris, Henri Mondor Hospital, 94000 Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Itti","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Assistance Publique\u2014H\u00f4pitaux de Paris, Henri Mondor Hospital, 94000 Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Chevalier","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Assistance Publique\u2014H\u00f4pitaux de Paris, Henri Mondor Hospital, 94000 Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mukedaisi","family":"Abilizi","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Assistance Publique\u2014H\u00f4pitaux de Paris, Henri Mondor Hospital, 94000 Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2758-5216","authenticated-orcid":false,"given":"Florent","family":"Eymard","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Assistance Publique\u2014H\u00f4pitaux de Paris, Henri Mondor Hospital, 94000 Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1093\/cid\/cis199","article-title":"Preeminence of Staphylococcus aureus in infective endocarditis: A 1-year population-based survey","volume":"54","author":"Chirouze","year":"2012","journal-title":"Clin. Infect. Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1093\/cid\/ciad271","article-title":"The 2023 Duke-International Society for Cardiovascular Infectious Diseases Criteria for Infective Endocarditis: Updating the Modified Duke Criteria","volume":"77","author":"Fowler","year":"2023","journal-title":"Clin. Infect. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3948","DOI":"10.1093\/eurheartj\/ehad193","article-title":"2023 ESC Guidelines for the management of endocarditis","volume":"44","author":"Delgado","year":"2023","journal-title":"Eur. Heart J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/S0140-6736(11)60755-1","article-title":"Management of infective endocarditis: Challenges and perspectives","volume":"379","author":"Thuny","year":"2012","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"bcr2014204260","DOI":"10.1136\/bcr-2014-204260","article-title":"Septic sacroiliitis revealing an infectious endocarditis","volume":"2014","author":"Mahfoudhi","year":"2014","journal-title":"BMJ Case Rep."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s15010-018-1121-9","article-title":"Endocarditis associated with vertebral osteomyelitis and septic arthritis of the axial skeleton","volume":"46","author":"Murillo","year":"2018","journal-title":"Infection"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.jbspin.2020.07.012","article-title":"2020 French recommendations on the management of septic arthritis in an adult native joint","volume":"87","author":"Couderc","year":"2020","journal-title":"Jt. Bone Spine"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e26","DOI":"10.1093\/cid\/civ482","article-title":"2015 Infectious Diseases Society of America (IDSA) Clinical Practice Guidelines for the Diagnosis and Treatment of Native Vertebral Osteomyelitis in Adults","volume":"61","author":"Berbari","year":"2015","journal-title":"Clin. Infect. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1093\/eurheartj\/ehv319","article-title":"2015 ESC Guidelines for the management of infective endocarditis: The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC)","volume":"36","author":"Habib","year":"2015","journal-title":"Eur. Heart J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.jcmg.2015.09.014","article-title":"Contribution of PET Imaging to the Diagnosis of Septic Embolism in Patients with Pacing Lead Endocarditis","volume":"9","author":"Amraoui","year":"2016","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s10554-016-1047-1","article-title":"Clinical utility of 18F-FDG positron emission tomography\/computed tomography scan vs. 99mTc-HMPAO white blood cell single-photon emission computed tomography in extra-cardiac work-up of infective endocarditis","volume":"33","author":"Lauridsen","year":"2017","journal-title":"Int. J. Cardiovasc. Imaging"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"105577","DOI":"10.1016\/j.jbspin.2023.105577","article-title":"PET\/CT for osteoarticular septic grafts in endocarditis: A large monocentric cohort","volume":"90","author":"Hugues","year":"2023","journal-title":"Jt. Bone Spine"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1093\/eurheartj\/ehl427","article-title":"Infective endocarditis: Changing epidemiology and predictors of 6-month mortality: A prospective cohort study","volume":"28","author":"Hill","year":"2007","journal-title":"Eur. Heart J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1093\/qjmed\/hcz134","article-title":"Infective endocarditis: A retrospective cohort study","volume":"112","author":"Buckley","year":"2019","journal-title":"QJM"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jacc.2015.10.065","article-title":"Systematic Search for Present and Potential Portals of Entry for Infective Endocarditis","volume":"67","author":"Delahaye","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/00005792-200101000-00002","article-title":"Rheumatic Manifestations of Infective Endocarditis in Non-Addicts: A 12-Year Study","volume":"80","author":"Llorca","year":"2001","journal-title":"Medicine"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.2967\/jnumed.113.134981","article-title":"Role of (18)F-FDG PET in Patients with Infectious Endocarditis","volume":"55","author":"Kestler","year":"2014","journal-title":"J. Nucl. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1093\/cid\/ciaa666","article-title":"Impact of Systematic Whole-body 18F-Fluorodeoxyglucose PET\/CT on the Management of Patients Suspected of Infective Endocarditis: The Prospective Multicenter TEPvENDO Study","volume":"73","author":"Duval","year":"2021","journal-title":"Clin. Infect. Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S0140-6736(14)61233-2","article-title":"Antibiotic treatment for 6 weeks versus 12 weeks in patients with pyogenic vertebral osteomyelitis: An open-label, non-inferiority, randomised, controlled trial","volume":"385","author":"Bernard","year":"2015","journal-title":"Lancet"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/18\/5419\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:55:06Z","timestamp":1760111706000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/18\/5419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,12]]},"references-count":19,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["jcm13185419"],"URL":"https:\/\/doi.org\/10.3390\/jcm13185419","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2024,9,12]]}}}