{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:45:25Z","timestamp":1792226725688,"version":"4.4.0"},"reference-count":44,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T00:00:00Z","timestamp":1726185600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Cardiovascular involvement in severe cirrhosis presents diagnostic challenges and carries significant prognostic implications. This study aims to evaluate the relationship between liver disease severity and portal hypertension with the burden of diastolic dysfunction. Methods: We prospectively enrolled patients with hepatic cirrhosis, classified according to the Child\u2013Pugh criteria. Of the 102 patients included, 65 were classified as Group A (non-severe cirrhosis: Child\u2013Pugh Classes A and B) and 37 as Group B (severe cirrhosis: Child\u2013Pugh Class C). Portal vein and spleen diameters were assessed using abdominal ultrasound. All patients underwent echocardiographic evaluation. LV systolic function was assessed by measuring ejection fraction, while diastolic function was evaluated using three parameters: E\/Em ratio, E\/Vp ratio, and indexed left atrial volume. Results: We observed a significantly greater burden of diastolic dysfunction in Group B compared to Group A. Specifically, the E\/Vp ratio was 2.2 \u00b1 0.4 in Group B versus 1.9 \u00b1 0.3 in Group A (p &lt; 0.001); the indexed LA volume was 34.5 \u00b1 3.2 mL\/m2 in Group B versus 30.1 \u00b1 2.9 mL\/m2 in Group A (p &lt; 0.001); and the E\/Em ratio was 17.0 \u00b1 3.0 in Group B versus 11.5 \u00b1 2.8 in Group A (p &lt; 0.001). Additionally, the mean diameters of the portal vein and spleen were larger in Group B, with measurements of 14.3 \u00b1 2.1 mm versus 11.5 \u00b1 1.6 mm for the portal vein and 15.0 \u00b1 1.2 mm versus 11.7 \u00b1 1.5 mm for the spleen (p &lt; 0.001), which correlated with the extent of diastolic dysfunction. Conclusions: Diastolic dysfunction was prevalent in 55% of patients with liver cirrhosis. The burden of diastolic dysfunction was higher in patients with severe hepatic cirrhosis compared to those with milder forms, and it correlated with the severity of portal hypertension, as assessed by measuring portal vein diameter and spleen diameter.<\/jats:p>","DOI":"10.3390\/jcm13185442","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T06:39:16Z","timestamp":1726209556000},"page":"5442","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Interplay between Severe Cirrhosis and Heart: A Focus on Diastolic Dysfunction"],"prefix":"10.3390","volume":"13","author":[{"given":"Drago\u0219","family":"Lupu","sequence":"first","affiliation":[{"name":"Department of Fundamental, Prophylactic, and Clinical Disciplines, Transilvania University of Brasov, 500036 Bra\u0219ov, Romania"},{"name":"ICCO Clinics Brasov, Transilvania University of Brasov, 500059 Bra\u0219ov, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren\u021biu","family":"Nedelcu","sequence":"additional","affiliation":[{"name":"Department of Fundamental, Prophylactic, and Clinical Disciplines, Transilvania University of Brasov, 500036 Bra\u0219ov, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6204-1364","authenticated-orcid":false,"given":"Diana","family":"\u021a\u00een\u021b","sequence":"additional","affiliation":[{"name":"ICCO Clinics Brasov, Transilvania University of Brasov, 500059 Bra\u0219ov, Romania"},{"name":"Department of Medical and Surgical Specialties, Transilvania University of Brasov, 500036 Bra\u0219ov, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1172\/JCI102813","article-title":"The cardiac output at rest in Laennec\u2019s cirrhosis","volume":"32","author":"Kowalski","year":"1953","journal-title":"J. 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