{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T23:47:21Z","timestamp":1771631241293,"version":"3.50.1"},"reference-count":41,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T00:00:00Z","timestamp":1726617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Various bone substitutes have been recommended to augment the horizontal gap following immediate implantation. The purpose of this study was to compare the effectiveness of an autogenous mineralized dentin graft or a deproteinized bovine bone in horizontal gap augmentation following immediate implant placement in the maxillary anterior region. Methods: A total of 110 patients underwent tooth extraction followed by immediate implant placement. The patients were divided into two groups. The first group received an autogenous mineralized dentin graft (the test group) while the second group received a deproteinized bovine bone (the control group) to augment the horizontal gap. Preoperative (T0), immediate postoperative (T1), and 1-year postoperative (T2) cone beam computed tomography scans were taken from all the patients. Linear measurements were recorded 1 mm (R1) and 5 mm (R2) points apical to the implant platform at both T1 and T2 time intervals. Pink Esthetic Scores and prosthetic complications were evaluated as well. Results: There were 57 patients with a mean age of 45.42 \u00b1 9.86 (range 24\u201363 years) selected as the test group and 53 patients with a mean age of 40.28 \u00b1 11.69 (range 20\u201363 years) as the control group. The mean reduction in the buccal bone plate at R1 was 6.39 \u00b1 3.78% in the test group and 6.99 \u00b1 5.01% in the control group (p &gt; 0.05). The mean reduction in the buccal bone plate at R2 was 5.46 \u00b1 4.98% in the test group and 6.77 \u00b1 7.60% in the control group (p &lt; 0.05). The PES and prosthetic-related complications were shown to be negligible between the groups (p &gt; 0.05). Conclusions: The efficiency of using an autogenous mineralized dentin graft for horizontal gap augmentation showed similar results in comparison to using a deproteinized bovine bone in relation to buccolingual socket reduction following immediate implantation.<\/jats:p>","DOI":"10.3390\/jcm13185521","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T09:49:19Z","timestamp":1726652959000},"page":"5521","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Immediate Implantation with Autologous Mineralized Dentin Graft versus Deproteinized Bovine Bone as Space-Filling Substitute in Maxillary Anterior Zone: Retrospective Radiological and Clinical Study"],"prefix":"10.3390","volume":"13","author":[{"given":"Ihsan Caglar","family":"Cinar","sequence":"first","affiliation":[{"name":"Department of Oral Implantology, Faculty of Dentistry, Istanbul University, Fatih, Istanbul 34093, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7575-3515","authenticated-orcid":false,"given":"Mohammed","family":"Zboun","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial Surgery and Periodontology, Faculty of Dentistry, Arab American University, 13 Zababdeh, Jenin 240, Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7121-0257","authenticated-orcid":false,"given":"Alper","family":"Saglanmak","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology, Faculty of Dentistry, Istanbul University, Fatih, Istanbul 34093, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1661-7529","authenticated-orcid":false,"given":"Eitan","family":"Mijiritsky","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery and Maxillofacial Surgery, Tel-Aviv Sourasky Medical Center, School of Medicine, Tel Aviv University, Tel Aviv 64239, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Hattingh, A., De Bruyn, H., Van Weehaeghe, M., Hommez, G., and Vandeweghe, S. (2020). Contour changes following immediate placement of ultra-wide implants in molar extraction sockets without bone grafting. J. Clin. Med., 9.","DOI":"10.3390\/jcm9082504"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1067\/moe.2000.110035","article-title":"Influence of bioactive glass on changes in alveolar process dimensions after exodontia","volume":"90","author":"Camargo","year":"2000","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endodontol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1834-7819.2007.00008.x","article-title":"Ridge preservation: What is it and when should it be considered","volume":"53","author":"Darby","year":"2008","journal-title":"Aust. Dent. J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/prd.12209","article-title":"Alveolar ridge preservation in the esthetic zone","volume":"77","author":"Jung","year":"2018","journal-title":"Periodontology 2000"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/ID.0b013e3181d47eaf","article-title":"Immediate implant placement: Positives and negatives","volume":"19","author":"Koh","year":"2010","journal-title":"Implant. Dent."},{"key":"ref_6","first-page":"205","article-title":"Immediate placement of implants into extraction sockets: Implant survival","volume":"11","author":"Rosenquist","year":"1996","journal-title":"Int. J. Oral Maxillofac. Implants"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1902\/jop.1997.68.10.915","article-title":"The ways and wherefores of immediate placement of implants into fresh extraction sites: A literature review","volume":"68","author":"Chaushu","year":"1997","journal-title":"J. Periodontol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"165","DOI":"10.11607\/prd.3558","article-title":"Clinical and Histologic Evaluations of Immediately Placed SLA Dental Implants","volume":"38","author":"Nevins","year":"2018","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"7442","DOI":"10.1166\/jnn.2011.4857","article-title":"Analysis of the inorganic component of autogenous tooth bone graft material","volume":"11","author":"Kim","year":"2011","journal-title":"J. Nanosci. Nanotechnol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1111\/clr.12694","article-title":"A histomorphometric assessment of collagen-stabilized anorganic bovine bone mineral in maxillary sinus augmentation\u2014A prospective clinical trial","volume":"27","author":"Alayan","year":"2016","journal-title":"Clin. Oral. Implants Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1177\/00220345910700030301","article-title":"Human dentin-matrix-derived bone morphogenetic protein","volume":"70","author":"Bessho","year":"1991","journal-title":"J. Dent. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.tripleo.2007.05.004","article-title":"Comparative localized linear accuracy of small-field cone-beam CT and multislice CT for alveolar bone measurements","volume":"105","author":"Loubele","year":"2008","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endodontol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/j.1600-0501.2005.01193.x","article-title":"Evaluation of soft tissue around single-tooth implant crowns: The pink esthetic score","volume":"16","author":"Florescu","year":"2005","journal-title":"Clin. Oral Implants Res."},{"key":"ref_14","first-page":"210","article-title":"A 3-year prospective multicenter follow-up report on the immediate and delayed-immediate placement of implants","volume":"14","author":"Grunder","year":"1999","journal-title":"Int. J. Oral Maxillofac. Implants"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1902\/jop.1998.69.8.920","article-title":"A prospective clinical trial of endosseous screw-shaped implants placed at the time of tooth extraction without augmentation","volume":"69","author":"Becker","year":"1998","journal-title":"J. Periodontol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.ijom.2012.11.009","article-title":"Buccal plate preservation with immediate post-extraction implant placement and provisionalization: Preliminary results of a new technique","volume":"42","author":"Caiazzo","year":"2013","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/cid.12701","article-title":"Buccal bone thickness at dental implants in the maxillary anterior region with large bony defects at time of immediate implant placement: A 1-year cohort study","volume":"21","author":"Meijer","year":"2019","journal-title":"Clin. Implant Dent. Relat. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1034\/j.1600-0501.2003.140105.x","article-title":"The jumping distance revisited: An experimental study in the dog","volume":"14","author":"Botticelli","year":"2003","journal-title":"Clin. Oral Implants Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1111\/clr.12896","article-title":"The effect of placing a bone replacement graft in the gap at immediately placed implants: A randomized clinical trial","volume":"28","author":"Sanz","year":"2017","journal-title":"Clin. Oral Implants Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"186","DOI":"10.11607\/jomi.2014suppl.g3.3","article-title":"Esthetic outcomes following immediate and early implant placement in the anterior maxilla\u2014A systematic review","volume":"29","author":"Chen","year":"2014","journal-title":"Int. J. Oral Maxillofac. Implants"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1006\/bbrc.1998.8213","article-title":"Gene expression of growth and differentiation factors-5, -6, and -7 in developing bovine tooth at the root forming stage","volume":"244","author":"Morotome","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_22","first-page":"e112","article-title":"Autogenous teeth used for bone grafting: A systematic review","volume":"23","year":"2018","journal-title":"Med. Oral Patol. Oral Cirug\u00eda Buccal"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"21","DOI":"10.5856\/JKDS.2012.5.1.21","article-title":"Bone healing capacity of demineralized dentin matrix materials in a mini-pig cranium defect","volume":"5","author":"Kim","year":"2012","journal-title":"J. Korean Dent. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Koga, T., Minamizato, T., Kawai, Y., Miura, K., Nakatani, Y., Sumita, Y., and Asahina, I. (2016). Bone regeneration using dentin matrix depends on the degree of demineralization and particle size. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0147235"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.tripleo.2009.10.017","article-title":"Development of a novel bone grafting material using autogenous teeth","volume":"109","author":"Kim","year":"2010","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endodontol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Ozkahraman, N., Balc\u0131oglu, N.B., Soluk Tekkesin, M., Altundag, Y., and Yal\u00e7\u0131n, S. (2022). Evaluation of the Efficacy of Mineralized Dentin Graft in the Treatment of Intraosseous Defects: An Experimental In Vivo Study. Medicina, 58.","DOI":"10.3390\/medicina58010103"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40729-017-0071-9","article-title":"Alveolar ridge preservation with autologous particulated dentin\u2014A case series","volume":"3","author":"Valdec","year":"2017","journal-title":"Int. J. Implant Dent."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"157","DOI":"10.11607\/prd.4045","article-title":"New Bone Formation Using an Extracted Tooth as a Biomaterial: A Case Report with Histologic Evidence","volume":"39","author":"Cardaropoli","year":"2019","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/clr.13722","article-title":"Alveolar ridge preservation using autogenous whole-tooth versus demineralized dentin grafts: A randomized controlled clinical trial","volume":"32","author":"Elfana","year":"2021","journal-title":"Clin. Oral Implants Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1111\/clr.12885","article-title":"Autogenous demineralized dentin matrix from extracted tooth for the augmentation of alveolar bone defect: A prospective randomized clinical trial in comparison with anorganic bovine bone","volume":"28","author":"Pang","year":"2017","journal-title":"Clin. Oral Implants Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"622","DOI":"10.11607\/jomi.4172","article-title":"A new method using autogenous impacted third molars for sinus augmentation to enhance implant treatment: Case series with preliminary results of an open, prospective longitudinal study","volume":"31","author":"Pohl","year":"2016","journal-title":"Int. J. Oral Maxillofac. Implants"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1600-0501.2009.01825.x","article-title":"Factors influencing ridge alterations following immediate implant placement into extraction sockets","volume":"21","author":"Ferrus","year":"2010","journal-title":"Clin. Oral Implants Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/j.1600-0501.2007.01428.x","article-title":"Bone healing dynamics at buccal peri-implant sites","volume":"19","author":"Qahash","year":"2008","journal-title":"Clin. Oral Implants Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1111\/clr.12447","article-title":"Fresh extraction socket: Spontaneous healing vs. immediate implant placement","volume":"26","author":"Discepoli","year":"2015","journal-title":"Clin. Oral Implants Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1600-0501.2009.01842.x","article-title":"Influence of implant positioning in extraction sockets on osseointegration: Histomorphometric analyses in dogs","volume":"21","author":"Caneva","year":"2010","journal-title":"Clin. Oral Implants Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1600-0501.2007.01413.x","article-title":"Esthetic outcomes of immediate implant placements","volume":"19","author":"Evans","year":"2008","journal-title":"Clin. Oral Implants Res."},{"key":"ref_37","first-page":"499","article-title":"Multichannel computed tomography versus cone-beam computed tomography: Linear accuracy of in vitro measurements of the maxilla for implant placement","volume":"25","author":"Fatemitabar","year":"2010","journal-title":"Int. J. Oral Maxillofac. Implants"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"308","DOI":"10.11607\/jomi.2014suppl.g5.2","article-title":"Improvements in implant dentistry over the last decade: Comparison of survival and complication rates in older and newer publications","volume":"29","author":"Pjetursson","year":"2014","journal-title":"Int. J. Oral Maxillofac. Implants"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1111\/jcpe.12423","article-title":"Dimensional changes after immediate implant placement with or without simultaneous regenerative procedures: A systematic review and meta-analysis","volume":"42","author":"Clementini","year":"2015","journal-title":"J. Clin. Periodontol."},{"key":"ref_40","first-page":"1107","article-title":"Single-tooth replacement in the aesthetic zone with immediate provisionalization: Fourteen consecutive case reports","volume":"10","author":"Wohrle","year":"1998","journal-title":"Pract. Periodontics Aesthetic Dent."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"47","DOI":"10.11607\/prd.1945","article-title":"Provisional restorations used in immediate implant placement provide a platform to promote peri-implant soft tissue healing: A pilot study","volume":"36","author":"Saito","year":"2016","journal-title":"Int. J. Periodontics Restor. Dent."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/18\/5521\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:58:44Z","timestamp":1760111924000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/18\/5521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,18]]},"references-count":41,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["jcm13185521"],"URL":"https:\/\/doi.org\/10.3390\/jcm13185521","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,18]]}}}