{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T06:35:35Z","timestamp":1781850935350,"version":"3.54.5"},"reference-count":23,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T00:00:00Z","timestamp":1726704000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Idiopathic inflammatory myopathies (IIMs) are rare autoimmune disorders characterized by progressive proximal muscle weakness and varying extra-muscular manifestations. The latest 2017 EULAR\/ACR criteria classify them into subgroups. This study aims to evaluate the role of nailfold capillaroscopy (NFC) as a diagnostic and prognostic tool in IIMs by comparing capillaroscopic patterns across different IIM subtypes. Methods: We conducted an observational, cross-sectional study at the Institute of Rheumatology in Belgrade, analyzing 90 patients diagnosed with IIMs per the 2017 EULAR\/ACR criteria. Patients were categorized into dermatomyositis (DM) (n = 37), polymyositis (PM) (n = 35), amyopathic dermatomyositis (ADM) (n = 13), and juvenile dermatomyositis (JDM) (n = 5). A control group of 35 patients with primary Raynaud\u2019s phenomenon was also included. NFC findings, clinical manifestations, and laboratory data were compared across the groups. Results: In DM, 81.9% exhibited a scleroderma capillaroscopic pattern, which was also present in 76.9% of ADM patients. In PM, the most common pattern was nonspecific changes (48.6%). JDM patients showed a high prevalence of scleroderma changes (n = 4 (80%)). Scleroderma patterns correlated with Gottron\u2019s papules, heliotrope rash, periungual erythema, Raynaud\u2019s phenomenon, and interstitial lung disease (ILD). No significant differences were found in laboratory parameters across capillaroscopic groups, except for a higher prevalence of anti-Jo1 antibodies in patients with nonspecific capillaroscopic changes. Conclusions: NFC is a valuable tool for differentiating IIM subtypes and correlating clinical manifestations with specific capillaroscopic patterns. The high prevalence of scleroderma changes in DM and ADM suggests their potential as a diagnostic and prognostic marker in IIMs. Further research with larger cohorts is warranted to validate these findings.<\/jats:p>","DOI":"10.3390\/jcm13185550","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T08:12:27Z","timestamp":1726733547000},"page":"5550","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Nailfold Capillaroscopy Changes in Patients with Idiopathic Inflammatory Myopathies"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1037-1342","authenticated-orcid":false,"given":"Milan","family":"Bogojevic","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Clinical Centre of Montenegro, 81000 Podgorica, Montenegro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2488-4975","authenticated-orcid":false,"given":"Milica","family":"Markovic Vlaisavljevic","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Clinical Centre of Montenegro, 81000 Podgorica, Montenegro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6296-1218","authenticated-orcid":false,"given":"Rifat","family":"Medjedovic","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Clinical Centre of Montenegro, 81000 Podgorica, Montenegro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvira","family":"Strujic","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Clinical Centre of Montenegro, 81000 Podgorica, Montenegro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragana","family":"Pravilovic Lutovac","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Clinical Centre of Montenegro, 81000 Podgorica, Montenegro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Slavica","family":"Pavlov-Dolijanovic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Rheumatology, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1056\/NEJM197502132920706","article-title":"Polymyositis and dermatomyositis (first of two parts)","volume":"292","author":"Bohan","year":"1975","journal-title":"N. Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.autrev.2018.10.004","article-title":"Autoantibodies in idiopathic inflammatory myopathies: Clinical associations and laboratory evaluation by mono- and multispecific immunoassays","volume":"18","author":"Damoiseaux","year":"2019","journal-title":"Autoimmun. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1002\/art.40320","article-title":"2017 European league against rheumatism\/American College of Rheumatology Classification Criteria for Adult and Juvenile Idiopathic Inflammatory Myopathies and Their Major Subgroups","volume":"69","author":"Lundberg","year":"2017","journal-title":"Arthritis Rheumatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"102458","DOI":"10.1016\/j.autrev.2020.102458","article-title":"Standardisation of nailfold capillaroscopy for the assessment of patients with Raynaud\u2019s phenomenon and systemic sclerosis","volume":"19","author":"Smith","year":"2020","journal-title":"Autoimmun. Rev."},{"key":"ref_5","first-page":"155","article-title":"Nailfold videocapillaroscopy assessment of microvascular damage in systemic sclerosis","volume":"27","author":"Cutolo","year":"2000","journal-title":"J. Rheumatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"103087","DOI":"10.1016\/j.autrev.2022.103087","article-title":"Standardised interpretation of capillaroscopy in autoimmune idiopathic inflammatory myopathies: A structured review on behalf of the EULAR study group on microcirculation in Rheumatic Diseases","volume":"6","author":"Piette","year":"2022","journal-title":"Autoimmun. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/art.1780230208","article-title":"Diagnostic potential of in vivo capillary microscopy in scleroderma andrelated disorders","volume":"23","author":"Maricq","year":"1980","journal-title":"Arthritis Rheumatol."},{"key":"ref_8","unstructured":"Grassi, W., and Del Medico, P. (2004). Atlas of Capillaroscopy, EDRA. [1st ed.]."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1002\/acr.23338","article-title":"Assessment of Microvascular Abnormalities by Nailfold Capillaroscopy in Juvenile Dermatomyositis After Medium- to Long-Term Followup","volume":"70","author":"Barth","year":"2018","journal-title":"Arthritis Care Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1093\/rheumatology\/keq430","article-title":"Association between nail-fold capillary findings and disease activity in dermatomyositis","volume":"50","author":"Mugii","year":"2011","journal-title":"Rheumatology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1002\/art.23299","article-title":"Persistent association of nailfold capillaroscopy changes and skin involvement over thirty-six months with duration of untreated disease in patients with juvenile dermatomyositis","volume":"58","author":"Seshadri","year":"2008","journal-title":"Arthritis Rheumatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.berh.2007.10.001","article-title":"The contribution of capillaroscopy to the differential diagnosis of connective autoimmune diseases","volume":"21","author":"Cutolo","year":"2007","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"42","DOI":"10.5114\/reum.2022.114109","article-title":"Nailfold capillaroscopy changes with disease activity in patients with inflammatory myositis including overlap myositis, pure dermatomyositis, and pure polymyositis","volume":"60","author":"Shenavandeh","year":"2022","journal-title":"Reumatologia"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s10067-014-2795-8","article-title":"Nailfold capillaroscopic changes in dermatomyositis and polymyositis","volume":"34","author":"Manfredi","year":"2015","journal-title":"Clin. Rheumatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1093\/rheumatology\/key257","article-title":"Significance of nailfold videocapillaroscopy in patients with idiopathic inflammatory myopathies","volume":"58","author":"Kubo","year":"2019","journal-title":"Rheumatology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1546-0096-5-6","article-title":"Clinical characteristics of children with Juvenile Systemic Sclerosis: Follow-up of 23 patients in a single tertiary center","volume":"5","author":"Russo","year":"2007","journal-title":"Pediatr. Rheumatol. Online J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/art.1780310116","article-title":"Nailfold capillary microscopy in polymyositis and dermatomyositis","volume":"31","author":"Ganczarczyk","year":"1988","journal-title":"Arthritis Rheumatol."},{"key":"ref_18","first-page":"233","article-title":"Association of nailfold capillary changes with disease activity, clinical and laboratory findings in patients with dermatomyositis","volume":"29","author":"Shenavandeh","year":"2015","journal-title":"Med. J. Islam. Repub. Iran"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3899\/jrheum.180355","article-title":"Nailfold Capillaroscopy Characteristics of Antisynthetase Syndrome and Possible Clinical Associations: Results of a Multicenter International Study","volume":"46","author":"Sebastiani","year":"2019","journal-title":"J. Rheumatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1001\/archderm.139.8.1027","article-title":"The handheld dermatoscope as a nail-fold capillaroscopic instrument","volume":"139","author":"Bergman","year":"2003","journal-title":"Arch. Dermatol."},{"key":"ref_21","first-page":"905","article-title":"Capillaroscopic observations in childhood rheumatic diseases and healthy controls","volume":"23","author":"Ingegnoli","year":"2005","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"40","DOI":"10.2223\/JPED.1435","article-title":"Inflammatory myopathies in childhood: Correlation between nailfoldcapillaroscopy findings and clinical and laboratory data","volume":"82","author":"Nascif","year":"2006","journal-title":"J. Pediatr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1007\/s00296-011-2109-2","article-title":"Scleroderma pattern of nailfold capillary changes as predictive value for the development of a connective tissue disease: A follow-up study of 3029 patients with primary Raynaud\u2019s phenomenon","volume":"32","author":"Damjanov","year":"2012","journal-title":"Rheumatol. Int."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/18\/5550\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:59:27Z","timestamp":1760111967000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/18\/5550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,19]]},"references-count":23,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["jcm13185550"],"URL":"https:\/\/doi.org\/10.3390\/jcm13185550","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,19]]}}}