{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:41:32Z","timestamp":1760114492390,"version":"build-2065373602"},"reference-count":48,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T00:00:00Z","timestamp":1726704000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objective: This study aimed to assess changes in the morphology of the retina and cornea in patients treated and hospitalized during the acute active phase of SARS-CoV-2 infection. Methods: A total of 24 patients with symptomatic early COVID-19 disease and 38 healthy participants from a control group were enrolled in our study. Among them, 20 received oxygen therapy at flow rates ranging from 1\u201310 L, while four received high-flow intranasal oxygen therapy (HFNOT). Some patients were treated with other types of therapy, such as Remdesivir, COVID-19 convalescent plasma therapy, or Tocilizumab. In the study, we focused on the analysis of optical coherence tomography (OCT) images of the cornea and retina including corneal thickness, central retinal thickness, retinal nerve fiber layer (RNFL), and optic disc parameters. The measurements were acquired using Spectral-domain OCT REVO FC 130. Results: The analysis did not show significant changes between the examined ophthalmological parameters before and after therapy. Furthermore, there were no detected significant differences between the tested parameters of the retina and cornea in COVID-19-positive patients compared to the control group. Conclusions: No ophthalmological manifestations of COVID-19 disease were observed during the study. Taking into account the results of other publications, the lack of an unambiguous position on this topic requires further research.<\/jats:p>","DOI":"10.3390\/jcm13185564","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T09:23:04Z","timestamp":1726737784000},"page":"5564","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Retinal and Corneal OCT Results of Patients Hospitalized and Treated in the Acute Phase of COVID-19"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6707-5790","authenticated-orcid":false,"given":"Edward","family":"Wyl\u0119ga\u0142a","sequence":"first","affiliation":[{"name":"Chair and Clinical Department of Ophthalmology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-760 Katowice, Poland"},{"name":"Department of Ophthalmology, Railway Hospital, 40-760 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Prus-Ludwig","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Railway Hospital, 40-760 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrycja","family":"Mocek","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, I School of Medicine, Katowice, Medical University of Silesia, 40-514 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Tomczyk","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, I School of Medicine, Katowice, Medical University of Silesia, 40-514 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogdan","family":"Dugie\u0142\u0142o","sequence":"additional","affiliation":[{"name":"Chair and Clinical Department of Ophthalmology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-760 Katowice, Poland"},{"name":"Department of Ophthalmology, Railway Hospital, 40-760 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Madej","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, WSB University, 41-300 D\u0105browa G\u00f3rnicza, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5950-2425","authenticated-orcid":false,"given":"Bogus\u0142awa","family":"Orzechowska-Wyl\u0119ga\u0142a","sequence":"additional","affiliation":[{"name":"Department of Pediatric Otolaryngology, Head and Neck Surgery, Department of Pediatric Surgery, Medical University of Silesia, 40-760 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7295-4936","authenticated-orcid":false,"given":"Adam","family":"Wyl\u0119ga\u0142a","sequence":"additional","affiliation":[{"name":"Health Promotion and Obesity Management Unit, Department of Pathophysiology, Faculty of Medical Sciences, Medical University of Silesia, 40-752 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,19]]},"reference":[{"key":"ref_1","unstructured":"World Health Organisation (2024, April 15). COVID-19 Epidemiological Update Edition 165, 15 March 2024. Available online: https:\/\/iris.who.int\/handle\/10665\/376322."},{"key":"ref_2","first-page":"243","article-title":"Prevalence of Cardiovascular Complications in Coronavirus Disease 2019 adult Patients: A Systematic Review and Meta-Analysis","volume":"48","author":"Torabizadeh","year":"2023","journal-title":"Iran. J. Med. Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/s41591-020-0968-3","article-title":"Extrapulmonary manifestations of COVID-19","volume":"26","author":"Gupta","year":"2020","journal-title":"Nat. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2147\/OPTH.S336963","article-title":"Ocular and Systemic Complications of COVID-19: Impact on Patients and Healthcare","volume":"16","author":"Leung","year":"2022","journal-title":"Clin. Ophthalmol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Akbari, M., and Dourandeesh, M. (2022). Update on overview of ocular manifestations of COVID-19. Front. Med., 9.","DOI":"10.3389\/fmed.2022.877023"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.aopr.2022.11.001","article-title":"COVID-19 and ocular complications: A review of ocular manifestations, diagnostic tools, and prevention strategies","volume":"3","author":"Dong","year":"2023","journal-title":"Adv. Ophthalmol. Pract. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"100550","DOI":"10.1016\/j.eclinm.2020.100550","article-title":"Retinal findings in patients with COVID-19: Results from the SERPICO-19 study","volume":"27","author":"Invernizzi","year":"2020","journal-title":"EClinicalMedicine"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1136\/archdischild-2021-321803","article-title":"Retinal nerve fibre layer and ganglion cell layer changes in children who recovered from COVID-19: A cohort study","volume":"107","year":"2022","journal-title":"Arch. Dis. Child."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1109\/JSTQE.2016.2556226","article-title":"Swept source OCT beyond the coherence length limit","volume":"22","author":"Kolokoltsev","year":"2016","journal-title":"IEEE J. Sel. Top. Quantum Electron."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.omtn.2022.04.015","article-title":"CRISPR-based VEGF suppression using paired guide RNAs for treatment of choroidal neovascularization","volume":"28","author":"Chung","year":"2022","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Daher, N.D., and Syed, Z.A. (2023). Bilateral interstitial keratitis following COVID-19: A case report. BMC Ophthalmol., 23.","DOI":"10.1186\/s12886-023-03160-4"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1097\/ICO.0000000000002757","article-title":"Late corneal stromal deposits after covid-19","volume":"40","year":"2021","journal-title":"Cornea"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e125","DOI":"10.1016\/j.jcjo.2020.03.003","article-title":"Keratoconjunctivitis as the initial medical presentation of the novel coronavirus disease 2019 (COVID-19)","volume":"55","author":"Cheema","year":"2020","journal-title":"Can. J. Ophthalmol."},{"key":"ref_14","first-page":"e1056","article-title":"Episcleritis as an ocular manifestation in a patient with COVID-19","volume":"98","author":"Barraquer","year":"2020","journal-title":"Acta Ophthalmol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"25158414221096057","DOI":"10.1177\/25158414221096057","article-title":"Assessment of corneal endothelial cell morphology and anterior segment parameters in COVID-19","volume":"14","author":"Oren","year":"2022","journal-title":"Ther. Adv. Ophthalmol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.brainresbull.2009.05.019","article-title":"Corneal transparency: Genesis, maintenance and dysfunction","volume":"81","author":"Qazi","year":"2010","journal-title":"Brain Res. Bull."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1007\/s00417-021-05259-0","article-title":"Examination of the effects of COVID 19 on corneal endothelium","volume":"259","author":"Erdem","year":"2021","journal-title":"Graefe\u2019s Arch. Clin. Exp. Ophthalmol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"234","DOI":"10.4103\/ejos.ejos_48_23","article-title":"Evaluation of corneal structural changes in post-COVID-19 patients using anterior segment optical coherence tomography and specular microscopy","volume":"116","author":"Ismail","year":"2023","journal-title":"J. Egypt. Ophthalmol. Soc."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Szkodny, D., Wyl\u0119ga\u0142a, A., Chlasta-Twardzik, E., and Wyl\u0119ga\u0142a, E. (2022). The Ocular Surface Symptoms and Tear Film Parameters during and after COVID-19 Infection. J. Clin. Med., 11.","DOI":"10.3390\/jcm11226697"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.2147\/CIA.S378050","article-title":"Age-Related Changes in Corneal Epithelial Thickness Measured with an Ultrasound Pachymeter","volume":"17","author":"Colakoglu","year":"2022","journal-title":"Clin. Interv. Aging"},{"key":"ref_21","first-page":"301","article-title":"Anterior segment parameters in patients with coronavirus disease","volume":"84","author":"Temel","year":"2021","journal-title":"Arq. Bras. Oftalmol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1016\/S0140-6736(20)31014-X","article-title":"Retinal findings in patients with COVID-19","volume":"395","author":"Marinho","year":"2020","journal-title":"Lancet"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1136\/bjophthalmol-2020-317576","article-title":"Retinal findings in hospitalised patients with severe COVID-19","volume":"106","author":"Pereira","year":"2022","journal-title":"Br. J. Ophthalmol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Bansal, R., Markan, A., Gautam, N., Guru, R.R., Lakshmi, P.V.M., Katoch, D., Agarwal, A., Singh, M.P., Suri, V., and Mohindra, R. (2021). Retinal Involvement in COVID-19: Results From a Prospective Retina Screening Program in the Acute and Convalescent Phase. Front. Med., 8.","DOI":"10.3389\/fmed.2021.681942"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Lani-Louzada, R., do Val Ferreira Ramos, C., Cordeiro, R.M., and Sadun, A.A. (2020). Retinal changes in COVID-19 hospitalized cases. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0243346"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1038\/s41433-020-1084-9","article-title":"Concerns about the interpretation of OCT and fundus findings in COVID-19 patients in recent Lancet publication","volume":"34","author":"Vavvas","year":"2020","journal-title":"Eye"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Szkodny, D., Wyl\u0119ga\u0142a, E., Sujka-Franczak, P., Chlasta-Twardzik, E., Fiolka, R., Tomczyk, T., and Wyl\u0119ga\u0142a, A. (2021). Retinal oct findings in patients after covid infection. J. Clin. Med., 10.","DOI":"10.3390\/jcm10153233"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Kal, M., Brzd\u0119k, M., Zar\u0119bska-Michaluk, D., Pinna, A., Mackiewicz, J., Odrobina, D., Winiarczyk, M., and Karska-Basta, I. (2024). Optical Coherence Tomography Angiography Assessment of the Optic Nerve Head in Patients Hospitalized Due to COVID-19 Bilateral Pneumonia. Medicina, 60.","DOI":"10.3390\/medicina60030502"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1007\/s00405-020-05965-1","article-title":"Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): A multicenter European study","volume":"277","author":"Lechien","year":"2020","journal-title":"Eur. Arch. Oto-Rhino-Laryngol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1177\/11206721211001019","article-title":"Optic nerve and macular optical coherence tomography in recovered COVID-19 patients","volume":"32","author":"Martin","year":"2022","journal-title":"Eur. J. Ophthalmol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Savastano, A., Crincoli, E., Savastano, M.C., Younis, S., Gambini, G., De Vico, U., Cozzupoli, G.M., Culiersi, C., Rizzo, S., and Gemelli Against COVID-19 Post-Acute Care Study Group (2020). Peripapillary retinal vascular involvement in early post-COVID-19 patients. J. Clin. Med., 9.","DOI":"10.3390\/jcm9092895"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"102898","DOI":"10.1016\/j.amsu.2021.102898","article-title":"Central Retinal Vein Occlusion in patients with COVID-19 infection: A systematic review","volume":"71","author":"Ullah","year":"2021","journal-title":"Ann. Med. Surg."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1080\/09273948.2021.1891262","article-title":"Simultaneous Bilateral Central Retinal Artery Occlusion following COVID-19 Infection","volume":"29","author":"Bapaye","year":"2021","journal-title":"Ocul. Immunol. Inflamm."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1007\/s00417-021-05420-9","article-title":"Posterior ocular structural and vascular alterations in severe COVID-19 patients","volume":"260","author":"Bayram","year":"2022","journal-title":"Graefe\u2019s Arch. Clin. Exp. Ophthalmol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1080\/09273948.2020.1850800","article-title":"Optic Nerve Head Parameters and Peripapillary Retinal Nerve Fiber Layer Thickness in Patients with Coronavirus Disease 2019","volume":"30","author":"Abrishami","year":"2022","journal-title":"Ocul. Immunol. Inflamm."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"4643973","DOI":"10.1155\/2022\/4643973","article-title":"Peripapillary Nerve Fiber Layer Thickness and Optic Nerve Head Parameters in Patients Recovered from COVID-19: A Longitudinal Study","volume":"2022","author":"Abrishami","year":"2022","journal-title":"J. Ophthalmol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"401","DOI":"10.2147\/OPTH.S157429","article-title":"Age-related changes in the peripheral retinal nerve fiber layer thickness","volume":"12","author":"Hondur","year":"2018","journal-title":"Clin. Ophthalmol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1007\/s00417-022-05887-0","article-title":"The impact of acute COVID-19 on the retinal microvasculature assessed with multimodal imaging","volume":"261","author":"Jevnikar","year":"2023","journal-title":"Graefe\u2019s Arch. Clin. Exp. Ophthalmol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Kal, M., Winiarczyk, M., Cie\u015bla, E., P\u0142atkowska-Adamska, B., Walczyk, A., Biskup, M., Pabjan, P., G\u0142uszek, S., Odrobina, D., and Mackiewicz, J. (2022). Retinal Microvascular Changes in COVID-19 Bilateral Pneumonia Based on Optical Coherence Tomography Angiography. J. Clin. Med., 11.","DOI":"10.3390\/jcm11133621"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.1007\/s10792-021-01952-5","article-title":"COVID-19: More than a respiratory virus, an optical coherence tomography study","volume":"41","year":"2021","journal-title":"Int. Ophthalmol."},{"key":"ref_41","unstructured":"WHO Team (2020). Oxygen Sources and Distribution for COVID-19 Treatment Centres Interim Guidance 4 April 2020 Background, World Health Organization."},{"key":"ref_42","first-page":"2165","article-title":"Eye care in intensive care in COVID-19 era: A prospective observational study from Turkey","volume":"26","author":"Ceylan","year":"2022","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1097\/APO.0000000000000453","article-title":"COVID-19: Update on Its Ocular Involvements, and Complications from Its Treatments and Vaccinations","volume":"10","author":"Lin","year":"2021","journal-title":"Asia-Pac. J. Ophthalmol."},{"key":"ref_44","unstructured":"The WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group, Shankar-Hari, M., Vale, C.L., Godolphin, P.J., Fisher, D., Higgins, J.P.T., Spiga, F., Savovi\u0107, J., Tierney, J., and Baron, G. (2021). Association between Administration of IL-6 Antagonists and Mortality among Patients Hospitalized for COVID-19: A Meta-analysis. JAMA\u2014J. Am. Med. Assoc., 326, 499\u2013518."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Abidi, E., El Nekidy, W.S., Alefishat, E., Rahman, N., Petroianu, G.A., El-Lababidi, R., and Mallat, J. (2022). Tocilizumab and COVID-19: Timing of Administration and Efficacy. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.825749"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s40249-021-00857-w","article-title":"Tocilizumab treatment for COVID-19 patients: A systematic review and meta-analysis","volume":"10","author":"Wei","year":"2021","journal-title":"Infect. Dis. Poverty"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Jorda, A., Kussmann, M., Kolenchery, N., Siller-Matula, J.M., Zeitlinger, M., Jilma, B., and Gelbenegger, G. (2022). Convalescent Plasma Treatment in Patients with COVID-19: A Systematic Review and Meta-Analysis. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.817829"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1097\/j.jcrs.0000000000001090","article-title":"Corneal topography and tomography readings with mask wear during the COVID-19 pandemic","volume":"49","author":"Zein","year":"2023","journal-title":"J. Cataract Refract. Surg."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/18\/5564\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:59:45Z","timestamp":1760111985000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/18\/5564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,19]]},"references-count":48,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["jcm13185564"],"URL":"https:\/\/doi.org\/10.3390\/jcm13185564","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2024,9,19]]}}}