{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T05:50:57Z","timestamp":1769838657376,"version":"3.49.0"},"reference-count":68,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T00:00:00Z","timestamp":1727049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deputyship for Research and Innovation, Ministry of Education in Saudi Arabia","award":["IFKSURC-1-4422"],"award-info":[{"award-number":["IFKSURC-1-4422"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Obesity is a pathological condition and a major risk factor for dyslipidemia, type 2 diabetes, and non-alcoholic fatty liver disease. Recent research highlighted the association of non-invasive serum markers with these conditions but the clinical utility of ALT APRI in obesity and its relationship with dyslipidemia remain unexplored. Methods: We examined the association of ALT APRI in 165 non-diabetic adults stratified by BMI and serum lipid parameters. Results: Obese subjects had significantly higher APRI than lean subjects, with an area under the curve (AUC) of 0.65 (p = 0.019). Medians of APRI were significantly increased in subjects with high TG, TG\/HDL, TC\/HDL, and LDL\/HDL and low HDL. Notably, all lipid parameters and ratios were significantly elevated in the highest APRI tertile, compared with patients in the lowest tertile. APRI was weakly yet significantly correlated with BMI (R2 = 0.032, p = 0.022), HDL (R2 = 0.071), TG\/HDL (R2 = 0.031), TC\/HDL (R2 = 0.063), LDL\/HDL (R2 = 0.072), and TyG index (R2 = 0.081). While APRI only showed a discriminating capacity for HDL (AUC: 0.69, p = 0.003), TG\/HDL (AUC: 0.63, p = 0.020), LDL\/HDL (AUC: 0.68, p &lt; 0.001), and TyG index (AUC: 0.65, p = 0.037), the highest diagnostic performance of APRI was observed with TC\/HDL (AUC: 0.74, p &lt; 0.001). Additionally, APRI was a risk factor for high TG (OR: 1.6, p = 0.028), low HDL (OR: 2.7, p = 0.0002), high TG\/HDL (OR: 1.94, p = 0.0011), high TC\/HDL (OR: 2.3, p &lt; 0.0001), high LDL\/HDL (OR: 2.2, p = 0.0001), and high TyG index (OR: 2.1, p = 0.008). Conclusions: Our findings argue for the role of APRI as a potential marker for obesity and dyslipidemia, which requires further confirmation in longitudinal studies.<\/jats:p>","DOI":"10.3390\/jcm13185650","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T08:56:06Z","timestamp":1727168166000},"page":"5650","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Elevated Alanine Transaminase-to-Platelet Index (APRI) Is Associated with Obesity and Distinct Forms of Dyslipidemia: A Retrospective Cross-Sectional Study"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9476-8197","authenticated-orcid":false,"given":"Yazeed","family":"Alshuweishi","sequence":"first","affiliation":[{"name":"Chair of Medical and Molecular Genetics Research, Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 12372, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalal","family":"Alfayez","sequence":"additional","affiliation":[{"name":"Department of Family and Community Medicine, Prince Sultan Military Medical City, Riyadh 11159, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulmalik A.","family":"Almufarrih","sequence":"additional","affiliation":[{"name":"Department of Family and Community Medicine, Prince Sultan Military Medical City, Riyadh 11159, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arwa","family":"Abudawood","sequence":"additional","affiliation":[{"name":"Department of Family and Community Medicine, Prince Sultan Military Medical City, Riyadh 11159, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3176-2756","authenticated-orcid":false,"given":"Hanan","family":"Alyami","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Nursing, College of Nursing, Princess Norah bint Abdurrahman University, Riyadh 11564, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faisal A.","family":"Alshuweishi","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, King Khalid University Hospital, King Saud University Medical City, Riyadh 12372, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yazeed A.","family":"Al-Sheikh","sequence":"additional","affiliation":[{"name":"Chair of Medical and Molecular Genetics Research, Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 12372, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3095-9154","authenticated-orcid":false,"given":"Mohammad A.","family":"Alfhili","sequence":"additional","affiliation":[{"name":"Chair of Medical and Molecular Genetics Research, Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 12372, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,23]]},"reference":[{"key":"ref_1","unstructured":"(2024, July 01). 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