{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T03:34:06Z","timestamp":1778556846701,"version":"3.51.4"},"reference-count":32,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:00Z","timestamp":1727136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Purpose: Glaucoma medication may accelerate the progression of presbyopia. The aim of this study was to compare presbyopia between controls and patients with glaucoma in their 40s. Methods: This was a cross-sectional study of bilateral phakic participants aged between 40 and 49, which included controls (n = 114, mean age 46.1 \u00b1 2.7 y) and patients with primary open-angle glaucoma (n = 105, 46.4 \u00b1 2.7 y) who had been using FP receptor agonists, beta blockers, and carbonic anhydrase inhibitors for at least six months. We compared the near add power between the two groups. Results: The mean near add power and the prevalence of symptomatic presbyopia (near add power \u2265 1.50 D) were 1.16 \u00b1 0.74 D and 42.1% for controls and 1.77 \u00b1 0.71 D (p &lt; 0.01) and 79.0% (p &lt; 0.01) for glaucoma patients, respectively. The odds ratio (OR) and confidence interval for symptomatic presbyopia were associated with age (1.36, 1.21\u20131.52), ganglion cell complex thickness (0.96, 0.94\u20130.99), presence of glaucoma (6.19, 3.13\u201312.23), and number of glaucoma medications (4.26, 2.42\u20137.43). Among medications, only FP receptor agonists (5.79, 2.68\u201312.32) produced significant results. Survival analysis showed that glaucoma patients reached the threshold of a near add power of +1.50 D significantly sooner than controls (p &lt; 0.05; log-rank test). Conclusions: Glaucoma patients, especially those using FP receptor agonists, had higher near add power than controls.<\/jats:p>","DOI":"10.3390\/jcm13195675","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T08:56:06Z","timestamp":1727168166000},"page":"5675","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Near Add Power of Glaucoma Patients with Early Presbyopia"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9481-0164","authenticated-orcid":false,"given":"Masahiko","family":"Ayaki","sequence":"first","affiliation":[{"name":"Chukyo Eye Clinic, Nagoya 456-0032, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Ichikawa","sequence":"additional","affiliation":[{"name":"Chukyo Eye Clinic, Nagoya 456-0032, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e001122","DOI":"10.1136\/bmjophth-2022-001122","article-title":"New insights in presbyopia: Impact of correction strategies","volume":"8","author":"Wolffsohn","year":"2023","journal-title":"BMJ Open Ophthalmol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1001\/archopht.126.12.1731","article-title":"Global vision impairment due to uncorrected presbyopia","volume":"126","author":"Holden","year":"2008","journal-title":"Arch. Ophthalmol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"102185","DOI":"10.1016\/j.clae.2024.102185","article-title":"BCLA CLEAR presbyopia: Mechanism and optics","volume":"24","author":"Davies","year":"2024","journal-title":"Cont. Lens. Anterior Eye"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1046\/j.1475-1313.1995.9500059m.x","article-title":"Broken Down by Age and Sex. The Optical Correction of Presbyopia Revisited","volume":"15","author":"Pointer","year":"1995","journal-title":"Ophthalmic Physiol. Opt."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1046\/j.1475-1313.2002.00012.x","article-title":"Gender-Related Optical Aspects of the Onset of Presbyopia","volume":"22","author":"Pointer","year":"2002","journal-title":"Ophthalmic Physiol. Opt."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.exer.2007.10.007","article-title":"Enhancing trabecular outflow by disrupting the actin cytoskeleton, increasing uveoscleral outflow with prostaglandins, and understanding the pathophysiology of presbyopia interrogating Mother Nature: Asking why, asking how, recognizing the signs, following the trail","volume":"86","author":"Kaufman","year":"2008","journal-title":"Exp. Eye Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/S0140-6736(10)61423-7","article-title":"Glaucoma","volume":"377","author":"Quigley","year":"2011","journal-title":"Lancet"},{"key":"ref_8","first-page":"1641","article-title":"The prevalence of primary open-angle glaucoma in Japanese: The Tajimi Study","volume":"111","author":"Iwase","year":"2004","journal-title":"Ophthalmology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.ajo.2023.04.017","article-title":"Progressive Visual Field Loss and Subsequent Quality of Life Outcomes in Glaucoma","volume":"252","author":"Moghimi","year":"2023","journal-title":"Am. J. Ophthalmol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1136\/bjophthalmol-2016-308754","article-title":"The role of specific visual subfields in collisions with oncoming cars during simulated driving in patients with advanced glaucoma","volume":"101","author":"Iwase","year":"2017","journal-title":"Br. J. Ophthalmol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ophtha.2015.09.005","article-title":"Comparative Effectiveness of First-Line Medications for Primary Open-Angle Glaucoma: A Systematic Review and Network Meta-analysis","volume":"123","author":"Li","year":"2016","journal-title":"Ophthalmology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jtos.2022.07.007","article-title":"Topical glaucoma medications\u2014Clinical implications for the ocular surface","volume":"26","author":"Fineide","year":"2022","journal-title":"Ocul. Surf."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ajo.2021.12.011","article-title":"Periocular Adverse Reactions to Omidenepag Isopropyl","volume":"237","author":"Inoue","year":"2022","journal-title":"Am. J. Ophthalmol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.ophtha.2022.10.024","article-title":"Surgical Results of Trabeculectomy among Groups Stratified by Prostaglandin-Associated Periorbitopathy Severity","volume":"130","author":"Ishida","year":"2023","journal-title":"Ophthalmology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/BF00153502","article-title":"Effect of timolol on the amplitude and dynamics of accommodation","volume":"72","author":"Weber","year":"1989","journal-title":"Doc. Ophthalmol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1600-0420.2000.tb01104.x","article-title":"Latanoprost 0.005%: Evaluation of its effect on accommodative capacity","volume":"232","author":"Troiano","year":"2000","journal-title":"Acta Ophthalmol. Scand. Suppl."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Ayaki, M., Tsuneyoshi, Y., Yuki, K., Tsubota, K., and Negishi, K. (2019). Latanoprost could exacerbate the progression of presbyopia. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0211631"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1167\/tvst.13.4.21","article-title":"Symptomatic presbyopia may develop earlier in patients with glaucoma\u2014A cross-sectional retrospective cohort study","volume":"13","author":"Ayaki","year":"2024","journal-title":"Transl. Vis. Sci. Technol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1167\/iovs.19-26899","article-title":"Presbyopia and glaucoma: Two diseases, one pathophysiology? The 2017 Friedenwald lecture","volume":"60","author":"Kaufman","year":"2019","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3677","DOI":"10.1167\/iovs.06-0896","article-title":"Evidence for the involvement of cannabinoid CB1 receptors in the bimatoprost-induced contractions on the human isolated ciliary muscle","volume":"48","author":"Romano","year":"2007","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"100897","DOI":"10.1016\/j.preteyeres.2020.100897","article-title":"Normal and glaucomatous outflow regulation","volume":"82","author":"Acott","year":"2021","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.exer.2008.11.033","article-title":"The changing paradigm of outflow resistance generation: Towards synergistic models of the JCT and inner wall endothelium","volume":"88","author":"Overby","year":"2009","journal-title":"Exp. Eye Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1001\/archopht.1992.01080180143043","article-title":"Age-related loss of ciliary muscle mobility in the rhesus monkey: Role of the choroid","volume":"110","author":"Tamm","year":"1992","journal-title":"Arch. Ophthalmol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1001\/jamaophthalmol.2013.4503","article-title":"Development and validation of the Dry Eye-Related Quality-of-Life Score questionnaire","volume":"131","author":"Sakane","year":"2013","journal-title":"JAMA Ophthalmol."},{"key":"ref_25","unstructured":"Anderson, D.R., and Patella, V.M. (1990). Automated Static Perimetry, Mosby. [2nd ed.]."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"271","DOI":"10.7326\/0003-4819-158-4-201302190-00008","article-title":"Comparative effectiveness of treatments for open-angle glaucoma: A systematic review for the US Preventive Services Task Force","volume":"158","author":"Boland","year":"2013","journal-title":"Ann. Intern. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"6138132","DOI":"10.1155\/2020\/6138132","article-title":"Current medical therapy and future trends in the management of glaucoma treatment","volume":"2020","author":"Cvenkel","year":"2020","journal-title":"J. Ophthalmol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ajo.2017.05.022","article-title":"Classification of fluorescein breakup patterns: A novel method of differential diagnosis for dry eye","volume":"180","author":"Yokoi","year":"2017","journal-title":"Am. J. Ophthalmol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"109029","DOI":"10.1016\/j.exer.2022.109029","article-title":"Intraocular accommodative movements in monkeys; relationship to presbyopia","volume":"222","author":"Croft","year":"2022","journal-title":"Exp. Eye Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.exer.2016.07.007","article-title":"Age-related posterior ciliary muscle restriction\u2014A link between trabecular meshwork and optic nerve head pathophysiology","volume":"158","author":"Croft","year":"2017","journal-title":"Exp. Eye Res."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Ra, S., Ayaki, M., Yuki, K., Tsubota, K., and Negishi, K. (2017). Dry eye, sleep quality, and mood status in glaucoma patients receiving prostaglandin monotherapy were comparable with those in non-glaucoma subjects. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0188534"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/s41433-021-01668-x","article-title":"Ocular benzalkonium chloride exposure: Problems and solutions","volume":"36","author":"Goldstein","year":"2022","journal-title":"Eye"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/19\/5675\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:01:37Z","timestamp":1760112097000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/19\/5675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,24]]},"references-count":32,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["jcm13195675"],"URL":"https:\/\/doi.org\/10.3390\/jcm13195675","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,24]]}}}