{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:42:22Z","timestamp":1790397742431,"version":"4.1.0"},"reference-count":51,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T00:00:00Z","timestamp":1727308800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Orthodontic treatment involves moving teeth within the alveolar ridge. Bone remodeling is associated with the activity of osteoblasts and osteoclasts. Procedures such as corticotomy-assisted orthodontic therapy (CAOT) or periodontally accelerated osteogenic orthodontics (PAOO) are intended to reduce bone density and negative stress on the grip side and therefore limit bone resorption during orthodontic movement or add bone substitute material so that the tooth does not cross the vestibular plate. Methods: The study was conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The study design was defined in the PICO format\u2014Population (P): patients with full permanent dentition, both adolescents and adults; Intervention (I): orthodontic treatment with fixed appliances using additional supportive treatments such as CAOT or PAOO; Comparison (C): assessment of the impact of additional treatments during orthodontic treatment on the remodeling of the alveolar bone and the condition of the periodontium; Result (O): statistically significant\/non-significant differences in the condition of the alveolar bone before and after orthodontic treatment. Search filters include the time of publication of the article, systematic reviews from the last five years, and publications that appeared in English. The information provided in the abstracts of systematic reviews that describe the effects of additional procedures during orthodontic treatment such as CAOT or PAOO on the health of periodontium was analyzed. Articles unrelated to the subject of the planned study and those in which tooth movement acceleration was analyzed were excluded. Results: Eight articles were selected in which a total number of 835 subjects took part. The changes in bone density and effects on periodontium were different after CAOT and PAOO. Conclusions: The validity of CAOT and PAOO procedures remains controversial. Better results are obtained when combined with tissue augmentation or thickening of the gingival phenotype rather than as stand-alone procedures, as their uses to protect periodontal tissues are limited.<\/jats:p>","DOI":"10.3390\/jcm13195726","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T08:20:52Z","timestamp":1727338852000},"page":"5726","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The Effect of Corticotomy-Assisted Orthodontic Therapy (CAOT) or Periodontally Accelerated Osteogenic Orthodontics (PAOO) on Bone Remodeling and the Health of Periodontium: A Systematic Review of Systematic Reviews"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5281-0940","authenticated-orcid":false,"given":"Anna Ewa","family":"Kuc","sequence":"first","affiliation":[{"name":"Department of Dentofacial Orthopaedics and Orthodontics, Wroclaw Medical University, Krakowska 26, 50-425 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4973-0602","authenticated-orcid":false,"given":"Maria","family":"Kulgawczyk","sequence":"additional","affiliation":[{"name":"Dental Star Specialist Center for Aesthetic Dentistry, ul. Konopnicka 1c\/ U3, 15-215 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4326-8907","authenticated-orcid":false,"given":"Magdalena Ewa","family":"Sulewska","sequence":"additional","affiliation":[{"name":"Department of Periodontal and Oral Mucosa Diseases, ul. Waszyngtona 13, 15-269 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Kuc","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Medical University in Bialystok, ul. Kili\u0144skiego 1, 15-089 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3284-7893","authenticated-orcid":false,"given":"Beata","family":"Kawala","sequence":"additional","affiliation":[{"name":"Department of Dentofacial Orthopaedics and Orthodontics, Wroclaw Medical University, Krakowska 26, 50-425 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Lis","sequence":"additional","affiliation":[{"name":"Department of Dentofacial Orthopaedics and Orthodontics, Wroclaw Medical University, Krakowska 26, 50-425 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2518-0007","authenticated-orcid":false,"given":"Micha\u0142","family":"Sarul","sequence":"additional","affiliation":[{"name":"Department of Integrated Dentistry, Wroclaw Medical University, 50-425 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5781-6540","authenticated-orcid":false,"given":"Jacek","family":"Kotu\u0142a","sequence":"additional","affiliation":[{"name":"Department of Dentofacial Orthopaedics and Orthodontics, Wroclaw Medical University, Krakowska 26, 50-425 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00056-019-00196-4","article-title":"Dehiscence and fenestration in anterior teeth: Comparison before and after orthodontic treatment. Dehiszenz und Fenestration im Frontzahnbereich: Vergleich vor und nach kieferorthop\u00e4discher Behandlung","volume":"81","author":"Sheng","year":"2020","journal-title":"J. Orofac. Orthop."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Kuc, A.E., Kotu\u0142a, J., Nawrocki, J., Kulgawczyk, M., Kawala, B., Lis, J., and Sarul, M. (2024). Bone Remodeling of Maxilla after Retraction of Incisors during Orthodontic Treatment with Extraction of Premolars Based on CBCT Study: A Systematic Review. J. Clin. Med., 13.","DOI":"10.3390\/jcm13051503"},{"key":"ref_3","first-page":"156","article-title":"Mechanobiology of orthodontic tooth movement: An update","volume":"12","author":"Maltha","year":"2023","journal-title":"J. World Fed. Orthod."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Kuc, A.E., Sybilski, K., Kotu\u0142a, J., Pi\u0105tkowski, G., Kowala, B., Lis, J., Saternus, S., and Sarul, M. (2024). The Hydrostatic Pressure Distribution in the Periodontal Ligament and the Risk of Root Resorption-A Finite Element Method (FEM) Study on the Nonlinear Innovative Model. Materials, 17.","DOI":"10.3390\/ma17071661"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000351894","article-title":"Periodontal Ligament and Alveolar Bone in Health and Adaptation: Tooth Movement","volume":"18","author":"Jiang","year":"2016","journal-title":"Front. Oral Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1093\/ejo\/cjn020","article-title":"Mechanobiology of tooth movement","volume":"30","author":"Henneman","year":"2008","journal-title":"Eur. J. Orthod."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1093\/ejo\/cjl050","article-title":"Biomechanical behavior of the periodontal ligament of the beagle dog during the first 5 hours of orthodontic force application","volume":"28","author":"Giesen","year":"2006","journal-title":"Eur. J. Orthod."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.2319\/100508-519R.1","article-title":"Changes of caspase-1 after the application of orthodontic forces in the periodontal tissues of rats","volume":"79","author":"Yan","year":"2009","journal-title":"Angle Orthod."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1600-0722.2012.00980.x","article-title":"Initial responses of osteoblasts derived from human alveolar bone to various compressive forces","volume":"120","author":"Tripuwabhrut","year":"2012","journal-title":"Eur. J. Oral Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.ajodo.2014.07.007","article-title":"Accelerated orthodontic tooth movement: Molecular mechanisms","volume":"146","author":"Huang","year":"2014","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1177\/0022034510378521","article-title":"FAK pathway regulates PGE2 production in compressed periodontal ligament cells","volume":"89","author":"Kang","year":"2010","journal-title":"J. Dent. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1126\/science.289.5484.1501","article-title":"The osteoblast: A sophisticated fibroblast under central surveillance","volume":"289","author":"Ducy","year":"2000","journal-title":"Science"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1600-0722.2007.00469.x","article-title":"Cytokine expression pattern in compression and tension sides of the periodontal ligament during orthodontic tooth movement in humans","volume":"115","author":"Garlet","year":"2007","journal-title":"Eur. J. Oral Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0092-8674(01)00622-5","article-title":"The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation","volume":"108","author":"Nakashima","year":"2002","journal-title":"Cell"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.cyto.2008.03.003","article-title":"Differential expression of osteoblast and osteoclast chemoattractants in compression and tension sides during orthodontic movement","volume":"42","author":"Garlet","year":"2008","journal-title":"Cytokine"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/ejo\/cjx041","article-title":"Corticotomy affects both the mode and magnitude of orthodontic tooth movement","volume":"40","author":"Verna","year":"2018","journal-title":"Eur. J. Orthod."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1089\/ten.teb.2020.0212","article-title":"Bone Graft Materials for Alveolar Bone Defects in Orthodontic Tooth Movement","volume":"28","author":"Lu","year":"2022","journal-title":"Tissue Eng. Part B Rev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"l4898","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: A revised tool for assessing risk of bias in randomized trials","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"44","DOI":"10.23736\/S2724-6329.20.04355-1","article-title":"Is the corticotomy assisted orthodontic treatment efficient in the expansion of narrow arches in adult patients?","volume":"70","author":"Stefani","year":"2021","journal-title":"Minerva Dent. Oral Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/ocr.12272","article-title":"Short- and long-term potential effects of accelerated osteogenic orthodontic treatment: A systematic review and meta-analysis","volume":"22","author":"Dab","year":"2019","journal-title":"Orthod. Craniofac. Res."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Gao, J., Nguyen, T., Oberoi, S., Oh, H., Kapila, S., Kao, R.T., and Lin, G.H. (2021). The Significance of Utilizing A Corticotomy on Periodontal and Orthodontic Outcomes: A Systematic Review and Meta-Analysis. Biology, 10.","DOI":"10.3390\/biology10080803"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e04013","DOI":"10.1016\/j.heliyon.2020.e04013","article-title":"Corticotomy in orthodontic treatment: Systematic review","volume":"6","author":"Apalimova","year":"2020","journal-title":"Heliyon"},{"key":"ref_23","first-page":"e32879","article-title":"The Efficacy of Accelerating Orthodontic Tooth Movement by Combining Self-Ligating Brackets With One or More Acceleration Methods: A Systematic Review","volume":"14","author":"Hajeer","year":"2022","journal-title":"Cureus"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ortho.2019.03.006","article-title":"Does periodontally accelerated osteogenic orthodontics improve orthodontic treatment outcome? A systematic review and meta-analysis","volume":"17","author":"Kamal","year":"2019","journal-title":"Int. Orthod."},{"key":"ref_25","first-page":"e24985","article-title":"The Effectiveness of Periodontally Accelerated Osteogenic Orthodontics (PAOO) in Accelerating Tooth Movement and Supporting Alveolar Bone Thickness During Orthodontic Treatment: A Systematic Review","volume":"14","author":"Alsino","year":"2022","journal-title":"Cureus"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/JPER.19-0037","article-title":"Is periodontal phenotype modification therapy beneficial for patients receiving orthodontic treatment? An American Academy of Periodontology best evidence review","volume":"91","author":"Wang","year":"2020","journal-title":"J. Periodontol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1590\/2177-6709.24.4.034-045.oar","article-title":"Effect of orthodontic treatment on alveolar bone thickness in adults: A systematic review","volume":"24","author":"Sendyk","year":"2019","journal-title":"Dent. Press J. Orthod."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/ocr.12421","article-title":"Alveolar bone changes in maxillary and mandibular anterior teeth during orthodontic treatment: A systematic review and meta-analysis","volume":"24","author":"Guo","year":"2021","journal-title":"Orthod. Craniofac. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"S237","DOI":"10.1002\/JPER.17-0733","article-title":"Periodontal manifestations of systemic diseases and developmental and acquired conditions: Consensus report of workgroup 3 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions","volume":"89","author":"Jepsen","year":"2018","journal-title":"J. Periodontol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1902\/jop.2017.160781","article-title":"Cone-Beam Computed Tomography and Interdisciplinary Dentofacial Therapy: An American Academy of Periodontology Best Evidence Review Focusing on Risk Assessment of the Dentoalveolar Bone Changes Influenced by Tooth Movement","volume":"88","author":"Mandelaris","year":"2017","journal-title":"J. Periodontol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.ajodo.2007.02.054","article-title":"Gingival recession in young adults: Occurrence, severity, and relationship to past orthodontic treatment and oral piercing","volume":"134","author":"Slutzkey","year":"2008","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"794","DOI":"10.15537\/smj.2015.7.12437","article-title":"Corticotomy-assisted orthodontic treatment. A systematic review of the biological basis and clinical effectiveness","volume":"36","author":"Hassan","year":"2015","journal-title":"Saudi Med. J."},{"key":"ref_33","first-page":"e24888","article-title":"The Effectiveness of Conventional and Accelerated Methods of Orthodontic Traction and Alignment of Palatally Impacted Canines in Terms of Treatment Time, Velocity of Tooth Movement, Periodontal, and Patient-Reported Outcomes: A Systematic Review","volume":"14","author":"Mousa","year":"2022","journal-title":"Cureus"},{"key":"ref_34","first-page":"311","article-title":"Comparison of Corticotomy and Micro- osteoperforation during Canine Retraction: A Split-Mouth Design","volume":"42","author":"Polo","year":"2023","journal-title":"PR Health Sci. J."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2174\/1874210601004010159","article-title":"Corticotomy-assisted orthodontic treatment: Review","volume":"4","author":"Hassan","year":"2010","journal-title":"Open Dent. J."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jobcr.2017.11.001","article-title":"Can corticotomy (with or without bone grafting) expand the limits of safe orthodontic therapy?","volume":"8","author":"Brugnami","year":"2018","journal-title":"J. Oral Biol. Craniofac. Res."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Sulewska, M., Duraj, E., Buga\u0142a-Musiatowicz, B., Waszkiewicz-Sewastianik, E., Milewski, R., Pietruski, J.K., Sajewicz, E., and Pietruska, M. (2018). Assessment of the effect of the corticotomy-assisted orthodontic treatment on the maxillary periodontal tissue in patients with malocclusions with transverse maxillary deficiency: A case series. BMC Oral Health, 18.","DOI":"10.1186\/s12903-018-0625-0"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"225","DOI":"10.15171\/jlms.2019.36","article-title":"Maxillary Orthodontic Expansion Assisted by Unilateral Alveolar Corticotomy and Low-Level Laser Therapy: A Novel Approach for Correction of a Posterior Unilateral Cross-Bite in Adults","volume":"10","author":"Caccianiga","year":"2019","journal-title":"J. Lasers Med. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s40510-017-0159-z","article-title":"Influence of uncontrolled diabetes mellitus on periodontal tissues during orthodontic tooth movement: A systematic review of animal studies","volume":"18","author":"Najeeb","year":"2017","journal-title":"Prog. Orthod."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"26","DOI":"10.4041\/kjod23.064","article-title":"Role of vitamin D for orthodontic tooth movement, external apical root resorption, and bone biomarker expression and remodeling: A systematic review","volume":"54","author":"Ferrillo","year":"2024","journal-title":"Korean J. Orthod."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Omar, M., and Kaklamanos, E.G. (2020). Does the rate of orthodontic tooth movement change during pregnancy and lactation? A systematic review of the evidence from animal studies. BMC Oral Health, 20.","DOI":"10.1186\/s12903-020-01223-2"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Almidfa, N.S.S., Athanasiou, A.E., Makrygiannakis, M.A., and Kaklamanos, E.G. (2021). Does the rate of orthodontic tooth movement change during the estrus cycle? A systematic review based on animal studies. BMC Oral Health, 21.","DOI":"10.1186\/s12903-021-01875-8"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e12388","DOI":"10.1111\/jicd.12388","article-title":"Influence of psychological stress exposure on orthodontic therapy: A comprehensive review","volume":"10","author":"Michelogiannakis","year":"2019","journal-title":"J. Investig. Clin. Dent."},{"key":"ref_44","first-page":"e23105","article-title":"The Effectiveness of Repetition or Multiplicity of Different Surgical and Non-Surgical Procedures Compared to a Single Procedure Application in Accelerating Orthodontic Tooth Movement: A Systematic Review and Meta-Analysis","volume":"14","author":"Alfailany","year":"2022","journal-title":"Cureus"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/jcpe.13049","article-title":"Cell therapy for orofacial bone regeneration: A systematic review and meta-analysis","volume":"46","author":"Shanbhag","year":"2019","journal-title":"J. Clin. Periodontol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13005-024-00409-1","article-title":"The efficacy and safety of corticotomy and periodontally accelerated osteogenic orthodontic interventions in tooth movement: An updated meta-analysis","volume":"20","author":"Zhou","year":"2024","journal-title":"Head Face Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"427","DOI":"10.17219\/dmp\/161553","article-title":"Pain and root resorption due to surgical interventions to accelerate tooth movement in orthodontics: A systematic review and meta-analysis","volume":"61","author":"Castillo","year":"2024","journal-title":"Dent. Med. Probl."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/JPER.19-0577","article-title":"American Academy of Periodontology best evidence consensus statement on modifying periodontal phenotype in preparation for orthodontic and restorative treatment","volume":"91","author":"Kao","year":"2020","journal-title":"J. Periodontol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s13005-022-00344-z","article-title":"The clinical efficacy of periodontally accelerated osteogenic orthodontics in patients with bone fenestration and dehiscence: A retrospective study","volume":"18","author":"Chen","year":"2022","journal-title":"Head Face Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"e169","DOI":"10.11607\/prd.4545","article-title":"Periodontal effect of periodontally accelerated osteogenic orthodontics in skeletal angle class III: A Nonrandomized, Controlled Trial","volume":"40","author":"Xu","year":"2020","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.2147\/PPA.S89095","article-title":"Patients\u2019 acceptance of corticotomy-assisted orthodontics","volume":"9","author":"Zawawi","year":"2015","journal-title":"Patient Prefer. Adherence"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/19\/5726\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:03:26Z","timestamp":1760112206000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/19\/5726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,26]]},"references-count":51,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["jcm13195726"],"URL":"https:\/\/doi.org\/10.3390\/jcm13195726","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,26]]}}}