{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:27:45Z","timestamp":1760146065532,"version":"build-2065373602"},"reference-count":19,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:00:00Z","timestamp":1727395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>This study reports two cases of Global Rostral Midbrain Syndrome (GRMS) and corpus callosum infarction in the context of shunt overdrainage caused by obstructive hydrocephalus due to aqueductal stenosis. We detail how thorough clinical evaluation and appropriate investigation helped avoid a coma misdiagnosis and describe the excellent response to pharmacological treatment and successful neurorehabilitation in both cases. We analyze the cognitive profile of patients with GRMS, a rare condition that mimics disorders such as coma and progressive supranuclear palsy at various stages. In conscious cases, GRMS typically presents with parkinsonian syndrome, Parinaud syndrome, and cognitive issues. The awareness of this rare complication of shunt overdrainage facilitates more accurate diagnosis and better management.<\/jats:p>","DOI":"10.3390\/jcm13195752","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T03:44:13Z","timestamp":1727408653000},"page":"5752","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Avoiding Misdiagnosis in Global Rostral Midbrain Syndrome (GRMS): Clinical Insights and Neurorehabilitation Approaches"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4280-9310","authenticated-orcid":false,"given":"Jane","family":"J\u00f6hr","sequence":"first","affiliation":[{"name":"Service of Neurology, Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), 1011 Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurea","family":"Alioth","sequence":"additional","affiliation":[{"name":"Service of Neurology, Department of Clinical Neurosciences, Geneva University Hospital, 1211 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabina","family":"Catalano Chiuv\u00e9","sequence":"additional","affiliation":[{"name":"Service of Neurology, Department of Clinical Neurosciences, Geneva University Hospital, 1211 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameer","family":"Nazeeruddin","sequence":"additional","affiliation":[{"name":"Service of Neurosurgery, Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), 1011 Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amani","family":"Belouaer","sequence":"additional","affiliation":[{"name":"Service of Neurosurgery, Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), 1011 Lausanne, Switzerland"},{"name":"Service of Neurosurgery, Department of Clinical Neurosciences, Geneva University Hospitals (HUG) and University of Geneva, 1205 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roy Thomas","family":"Daniel","sequence":"additional","affiliation":[{"name":"Service of Neurosurgery, Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), 1011 Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahan","family":"Momjian","sequence":"additional","affiliation":[{"name":"Service of Neurosurgery, Department of Clinical Neurosciences, Geneva University Hospitals (HUG) and University of Geneva, 1205 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Diserens","sequence":"additional","affiliation":[{"name":"Service of Neurology, Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), 1011 Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0970-8844","authenticated-orcid":false,"given":"Julien F.","family":"Bally","sequence":"additional","affiliation":[{"name":"Service of Neurology, Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), 1011 Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1227\/00006123-198010000-00003","article-title":"Global Rostral Midbrain Dysfunction Secondary to Shunt Malfunction in Hydrocephalus","volume":"7","author":"Barrer","year":"1980","journal-title":"Neurosurgery"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3171\/jns.1999.90.2.0227","article-title":"Sylvian Aqueduct Syndrome and Global Rostral Midbrain Dysfunction Associated with Shunt Malfunction","volume":"90","author":"Cinalli","year":"1999","journal-title":"J. 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