{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:31:27Z","timestamp":1787614287113,"version":"build-2736575974"},"reference-count":34,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T00:00:00Z","timestamp":1727481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Multi-organ failure (MOF) often complicates advanced heart failure (HF), contributing to a poor prognosis. The Model of End-Stage Liver Disease 3.0 (MELD-3.0) scale incorporates liver and kidney function parameters. This study aims to evaluate the prognostic significance of the MELD-3.0 score in patients with advanced HF who have undergone heart transplantation (HTx). Methods: The MELD-3.0 score was computed using the average values of the international normalized ratio and bilirubin, creatinine, sodium, and albumin levels during a hospital stay following HTx. The average MELD-3.0 scores from the period of 1 month preceding HTx and 1 week after HTx were analyzed. The primary endpoint of the study was the 6-month total mortality, and the secondary endpoint was ICU hospitalization time after HTx. Results: The analysis included 106 patients undergoing HTx, with a median age of 53 years (44\u201363), 81% of whom were male. Within 6 months post-HTx, 17 patients (16%) died; those patients had a higher 1-week post-HTx MELD-3.0 score of 18.3 (14.5\u201322.7) in comparison to survivors, whose average score was 13.9 (9.5\u201316.4), p &lt; 0.01. There was no difference in MELD 3.0 score in the pre-HTx period: 16.6 (11.4\u201317.8) vs. 12.3 (8.6\u201317.1), p = 0.36. The post-HTx MELD-3.0 score independently predicted death: RR 1.17 (95% CI 1.05\u20131.30), p &lt; 0.01. A Receiver Operating Characteristic (ROC) determined the cut-off value of the MELD-3.0 score as 17.3 (AUC = 0.83; sensitivity\u201467%; specificity\u201486%). Survivors with scores above this value had a longer ICU hospitalization time: 7 (5.0\u201311.0) vs. 12 (8\u201320) days (p = 0.01). Conclusions: The post-HTx MELD-3.0 score serves as an independent predictor of an unfavorable prognosis in patients with advanced HF undergoing HTx. The evaluation of MELD-3.0 scores provides additional prognostic information in this population.<\/jats:p>","DOI":"10.3390\/jcm13195816","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T06:39:35Z","timestamp":1727678375000},"page":"5816","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Postoperative, but Not Preoperative, MELD-3.0 Prognosticates 3-Month Procedural Success in Patients Undergoing Orthotopic Heart Transplantation"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3357-9253","authenticated-orcid":false,"given":"Jakub","family":"Ptak","sequence":"first","affiliation":[{"name":"Institute of Heart Diseases, Wroclaw Medical University, Poland Borowska 213, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9925-3566","authenticated-orcid":false,"given":"Mateusz","family":"Sokolski","sequence":"additional","affiliation":[{"name":"Institute of Heart Diseases, Wroclaw Medical University, Poland Borowska 213, 50-556 Wroclaw, Poland"},{"name":"Clinic of Cardiac Transplantation and Mechanical Circulatory Support, Institute of Heart Diseases, Wroclaw Medical University, 50-556 Wroclaw, Poland"},{"name":"Centre for Heart Diseases, University Hospital, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7512-8853","authenticated-orcid":false,"given":"Joanna","family":"Gontarczyk","sequence":"additional","affiliation":[{"name":"Student Scientific Club of Transplantology and Advanced Therapies of Heart Failure, Institute of Heart Diseases, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6981-0832","authenticated-orcid":false,"given":"Roksana","family":"Mania","sequence":"additional","affiliation":[{"name":"Student Scientific Club of Transplantology and Advanced Therapies of Heart Failure, Institute of Heart Diseases, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5543-9754","authenticated-orcid":false,"given":"Piotr","family":"Byszuk","sequence":"additional","affiliation":[{"name":"Student Scientific Club of Transplantology and Advanced Therapies of Heart Failure, Institute of Heart Diseases, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0944-4074","authenticated-orcid":false,"given":"Dominik","family":"Krupka","sequence":"additional","affiliation":[{"name":"Student Scientific Club of Transplantology and Advanced Therapies of Heart Failure, Institute of Heart Diseases, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Makowska","sequence":"additional","affiliation":[{"name":"Student Scientific Club of Transplantology and Advanced Therapies of Heart Failure, Institute of Heart Diseases, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Cielecka","sequence":"additional","affiliation":[{"name":"Clinic of Cardiac Transplantation and Mechanical Circulatory Support, Institute of Heart Diseases, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Boluk","sequence":"additional","affiliation":[{"name":"Centre for Heart Diseases, University Hospital, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateusz","family":"Rakowski","sequence":"additional","affiliation":[{"name":"Centre for Heart Diseases, University Hospital, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3159-5228","authenticated-orcid":false,"given":"Mateusz","family":"Wilk","sequence":"additional","affiliation":[{"name":"Student Scientific Club of Transplantology and Advanced Therapies of Heart Failure, Institute of Heart Diseases, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Bochenek","sequence":"additional","affiliation":[{"name":"Clinic of Cardiac Transplantation and Mechanical Circulatory Support, Institute of Heart Diseases, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Przybylski","sequence":"additional","affiliation":[{"name":"Clinic of Cardiac Transplantation and Mechanical Circulatory Support, Institute of Heart Diseases, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5730-019X","authenticated-orcid":false,"given":"Micha\u0142","family":"Zakliczy\u0144ski","sequence":"additional","affiliation":[{"name":"Clinic of Cardiac Transplantation and Mechanical Circulatory Support, Institute of Heart Diseases, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1177\/2048872612474906","article-title":"The predictive value of transaminases at admission in patients 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