{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:45:14Z","timestamp":1791614714476,"version":"4.3.4"},"reference-count":59,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Colexio Oficial de Fisioterapeutas de Galicia (Official Physical Therapy Council of Galician, Spain)","award":["2023"],"award-info":[{"award-number":["2023"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Multiple sclerosis is a chronic, inflammatory, neurodegenerative autoimmune disease caused by myelin loss in the central nervous system, which leads to motor and non-motor problems. The main objective of this study was to explore whether an immersive virtual reality (IVR) exercise programme would be feasible as a form of physical therapy for people with MS (pwMS). Methods: 18 participants (13 women; 45.06 years) were assigned to an experimental group (EG, n = 8) and a control group (CG, n = 10). The EG took part in a twice-weekly IVR exergame physical therapy programme\u2014ExeRVIEM programme. A randomised, single-blind clinical trial was conducted and was registered in clinicaltrials (NCT05870254). Results: The intervention was feasible and safe. The participants completed the programme with no adverse effects (no symptoms on the Simulator Sickness Questionnaire), high usability (System Usability Scale 90.31%), and outstandingly positive post-game experiences (Game Experience Questionnaire 3.10\/4). In addition, the GE significantly improved several of their functional capacities: increased lower limb strength (Five Times Sit-to-Stand Test p = 0.042), improved functional mobility, and reduced fall risk (Timed Up and Go Test-simple p = 0.009; Timed Up and Go Test-cognitive p = 0.003). There were no statistically significant differences between the groups. Conclusions: The findings support that the use of exergames and IVR as physical therapy in pwMS is feasible and safe. Furthermore, there is the suggestion of possible benefits to participants\u2019 functional abilities, all of which position IVR as a promising tool for the rehabilitation of this neurodegenerative pathology affecting young adults.<\/jats:p>","DOI":"10.3390\/jcm13195845","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T07:19:37Z","timestamp":1727680777000},"page":"5845","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Exergames and Immersive Virtual Reality as a Novel Therapy Approach in Multiple Sclerosis: Randomised Feasibility Study"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2720-1497","authenticated-orcid":false,"given":"Gustavo","family":"Rodr\u00edguez-Fuentes","sequence":"first","affiliation":[{"name":"Departamento de Biolox\u00eda Funcional e Ciencias da Sa\u00fade, Facultade de Fisioterapia, Universidade de Vigo, E-36005 Pontevedra, Spain"},{"name":"HealthyFit Research Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, E-36312 Pontevedra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Ferreiro-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Fisionova, Physiotherapy Center, E-36002 Pontevedra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1706-5639","authenticated-orcid":false,"given":"Pablo","family":"Campo-Prieto","sequence":"additional","affiliation":[{"name":"Departamento de Biolox\u00eda Funcional e Ciencias da Sa\u00fade, Facultade de Fisioterapia, Universidade de Vigo, E-36005 Pontevedra, Spain"},{"name":"HealthyFit Research Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, E-36312 Pontevedra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2903-3829","authenticated-orcid":false,"given":"Jos\u00e9 M\u00aa","family":"Cancela-Carral","sequence":"additional","affiliation":[{"name":"HealthyFit Research Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, E-36312 Pontevedra, Spain"},{"name":"Departamento de Did\u00e1cticas Especiais, Facultade de Ciencias da Educaci\u00f3n e do Deporte, Universidade de Vigo, E-36005 Pontevedra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1177\/1352458520970841","article-title":"Rising prevalence of multiple sclerosis worldwide: Insights from the Atlas of MS, third edition","volume":"26","author":"Walton","year":"2020","journal-title":"Mult. Scler."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/ene.13819","article-title":"Multiple sclerosis\u2014A review","volume":"26","author":"Dobson","year":"2019","journal-title":"Eur. J. Neurol."},{"key":"ref_3","first-page":"1","article-title":"Multiple Sclerosis: Pathogenesis, Symptoms, Diagnoses and Cell-Based Therapy","volume":"19","author":"Ghasemi","year":"2017","journal-title":"Cell J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1056\/NEJMra1401483","article-title":"Multiple Sclerosis","volume":"378","author":"Reich","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Global 2016 Multiple Sclerosis Collaborators (2019). Global, regional, and national burden of multiple sclerosis 1990\u20132016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol., 18, 269\u2013285.","DOI":"10.1016\/S1474-4422(18)30443-5"},{"key":"ref_6","first-page":"CD012732","article-title":"Rehabilitation for people with multiple sclerosis: An overview of Cochrane Reviews","volume":"1","author":"Amatya","year":"2019","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Learmonth, Y.C., and Motl, R.W. (2021). Exercise Training for Multiple Sclerosis: A Narrative Review of History, Benefits, Safety, Guidelines, and Promotion. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph182413245"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Hao, Z., Zhang, X., and Chen, P. (2022). Effects of Different Exercise Therapies on Balance Function and Functional Walking Ability in Multiple Sclerosis Disease Patients\u2014A Network Meta-Analysis of Randomized Controlled Trials. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19127175"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"104424","DOI":"10.1016\/j.msard.2022.104424","article-title":"Mobility and balance rehabilitation in multiple sclerosis: A systematic review and dose-response meta-analysis","volume":"69","author":"Corrini","year":"2023","journal-title":"Mult. Scler. Relat. Disord."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1089\/g4h.2021.0096","article-title":"Active Videogaming Interventions in Adults with Neuromuscular Conditions: A Scoping Review","volume":"11","author":"Malone","year":"2022","journal-title":"Games Health J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.apmr.2021.08.008","article-title":"Effect of Exercise on Fatigue in Multiple Sclerosis: A Network Meta-analysis Comparing Different Types of Exercise","volume":"103","year":"2022","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Shobeiri, P., Karimi, A., Momtazmanesh, S., Teixeira, A.L., Teunissen, C.E., van Wegen, E.E.H., Hirsch, M.A., Yekaninejad, M.S., and Rezaei, N. (2022). Exercise-induced increase in blood-based brain-derived neurotrophic factor (BDNF) in people with multiple sclerosis: A systematic review and meta-analysis of exercise intervention trials. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0264557"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1007\/s00415-023-11649-7","article-title":"The effect of exercise on cognitive function in people with multiple sclerosis: A systematic review and meta-analysis of randomized controlled trials","volume":"270","author":"Li","year":"2023","journal-title":"J. Neurol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"103559","DOI":"10.1016\/j.msard.2022.103559","article-title":"Pelvic floor muscle training in multiple sclerosis patients with lower urinary tract dysfunction: A systematic review and meta-analysis","volume":"59","author":"Kajbafvala","year":"2022","journal-title":"Mult. Scler. Relat. Disord."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"104407","DOI":"10.1016\/j.msard.2022.104407","article-title":"The effect of therapeutic exercise on depressive symptoms in people with multiple sclerosis\u2014A systematic review","volume":"68","author":"Kyriakatis","year":"2022","journal-title":"Mult. Scler. Relat. Disord."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1016\/j.apmr.2013.04.020","article-title":"Effects of exercise training on fitness, mobility, fatigue, and health-related quality of life among adults with multiple sclerosis: A systematic review to inform guideline development","volume":"94","author":"Pilutti","year":"2013","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"104412","DOI":"10.1016\/j.msard.2022.104412","article-title":"Unwrapping the \u201cblack box\u201d of balance training in people with multiple sclerosis\u2014A descriptive systematic review of intervention components, progression, and intensity","volume":"69","author":"Brincks","year":"2022","journal-title":"Mult. Scler. Relat. Disord."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1177\/1352458506072188","article-title":"Enhancing physical activity adherence and well-being in multiple sclerosis: A randomised controlled trial","volume":"13","author":"McAuley","year":"2007","journal-title":"Mult. Scler. J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1177\/1352458520910360","article-title":"Moving exercise research in multiple sclerosis forward (the MoXFo initiative): Developing consensus statements for research","volume":"26","author":"Dalgas","year":"2020","journal-title":"Mult. Scler. J."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Campo-Prieto, P., Cancela-Carral, J.M., and Rodr\u00edguez-Fuentes, G. (2022). Wearable Immersive Virtual Reality Device for Promoting Physical Activity in Parkinson\u2019s Disease Patients. Sensors, 22.","DOI":"10.3390\/s22093302"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Demeco, A., Zola, L., Frizziero, A., Martini, C., Palumbo, A., Foresti, R., Buccino, G., and Costantino, C. (2023). Immersive Virtual Reality in Post-Stroke Rehabilitation: A Systematic Review. Sensors, 23.","DOI":"10.3390\/s23031712"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Castellano-Aguilera, A., Bivi\u00e1-Roig, G., Cuenca-Mart\u00ednez, F., Suso-Mart\u00ed, L., Calatayud, J., Blanco-D\u00edaz, M., and Casa\u00f1a, J. (2022). Effectiveness of Virtual Reality on Balance and Risk of Falls in People with Multiple Sclerosis: A Systematic Review and Meta-Analysis. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph192114192"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"101092","DOI":"10.1016\/j.eujim.2020.101092","article-title":"Effect of immersive virtual reality on balance, mobility, and fatigue in patients with multiple sclerosis: A single-blinded randomized controlled trial","volume":"35","author":"Ozkul","year":"2020","journal-title":"Eur. J. Integr. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1177\/1539449218817291","article-title":"Immersive Virtual Reality for the Management of Pain in Community-Dwelling Older Adults","volume":"39","author":"Benham","year":"2019","journal-title":"OTJR Occup. Particip. Health"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3390\/sclerosis1020009","article-title":"Immersive Virtual Reality to Improve Functional Capacities in People with Multiple Sclerosis: Study Protocol","volume":"1","year":"2023","journal-title":"Sclerosis"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"c869","DOI":"10.1136\/bmj.c869","article-title":"CONSORT 2010 explanation and elaboration: Updated guidelines for reporting parallel group randomised trials","volume":"340","author":"Moher","year":"2010","journal-title":"BMJ"},{"key":"ref_27","unstructured":"(2023, September 27). World Medical Association, \u2018Declaration of Helsinki\u2019. Available online: https:\/\/www.wma.net\/es\/policies-post\/declaracion-de-helsinki-de-la-amm-principios-eticos-para-las-investigaciones-medicas-en-seres-humanos\/."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/0002-9343(86)90717-5","article-title":"Fall risk index for elderly patients based on number of chronic disabilities","volume":"80","author":"Tinetti","year":"1986","journal-title":"Am. J. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/BF03325265","article-title":"The five-times-sit-to-stand test: Validity, reliability and detectable change in older females","volume":"24","author":"Goldberg","year":"2012","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1532-5415.1991.tb01616.x","article-title":"The Timed \u201cUp & Go\u201d: A Test of Basic Functional Mobility for Frail Elderly Persons","volume":"39","author":"Podsiadlo","year":"1991","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"450","DOI":"10.23736\/S1973-9087.18.05366-2","article-title":"Timed Up-and-Go and 2-Minute Walk Test in patients with multiple sclerosis with mild disability: Reliability, responsiveness and link with perceived fatigue","volume":"55","author":"Valet","year":"2019","journal-title":"Eur. J. Phys. Rehabil. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1001\/archneur.1989.00520460115022","article-title":"The Fatigue Severity Scale: Application to Patients With Multiple Sclerosis and Systemic Lupus Erythematosus","volume":"46","author":"Krupp","year":"1989","journal-title":"Arch. Neurol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1016\/j.apmr.2010.07.225","article-title":"Grip Strength in Older Adults: Test-Retest Reliability and Cutoff for Subjective Weakness of Using the Hands in Heavy Tasks","volume":"91","author":"Wang","year":"2010","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"103817","DOI":"10.1016\/j.msard.2022.103817","article-title":"Isometric tests to evaluate upper and lower extremity functioning in people with multiple sclerosis: Reliability and validity","volume":"63","author":"Uygur","year":"2022","journal-title":"Mult. Scler. Relat. Disord."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Campo-Prieto, P., Cancela-Carral, J.M., and Rodr\u00edguez-Fuentes, G. (2023). Immersive Virtual Reality Reaction Time Test and Relationship with the Risk of Falling in Parkinson\u2019s Disease. Sensors, 23.","DOI":"10.3390\/s23094529"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1207\/s15327108ijap0303_3","article-title":"Simulator Sickness Questionnaire: An Enhanced Method for Quantify- ing Simulator Sickness","volume":"3","author":"Kennedy","year":"1993","journal-title":"Int. J. Aviat. Psychol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.apergo.2009.11.006","article-title":"Research in visually induced motion sickness","volume":"41","author":"Kennedy","year":"2010","journal-title":"Appl. Ergon."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"503","DOI":"10.47197\/retos.v43i0.87605","article-title":"Traducci\u00f3n y adaptaci\u00f3n transcultural al espa\u00f1ol del Simulator Sickness Questionnaire (Translation and cross-cultural adaptation to Spanish of the Simulator Sickness Questionnaire)","volume":"43","year":"2021","journal-title":"Retos"},{"key":"ref_39","first-page":"4","article-title":"SUS-A quick and dirty usability scale","volume":"189","author":"Brooke","year":"1996","journal-title":"Usability Eval. Ind."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"44","DOI":"10.23913\/reci.v5i10.48","article-title":"An\u00e1lisis comparativo de la Escala de Usabilidad del Sistema (EUS) en dos versiones","volume":"5","year":"2016","journal-title":"RECI"},{"key":"ref_41","unstructured":"IJsselsteijn, W.A., and de Kort, Y.A.W. (2013). The Game Experience Questionnaire, Technische Universiteit Eindhoven."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Campo-Prieto, P., Cancela-Carral, J.M., and Rodr\u00edguez-Fuentes, G. (2022). Feasibility and Effects of an Immersive Virtual Reality Exergame Program on Physical Functions in Institutionalized Older Adults: A Randomized Clinical Trial. Sensors, 22.","DOI":"10.3390\/s22186742"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Campo-Prieto, P., Rodr\u00edguez-Fuentes, G., and Cancela-Carral, J.M. (2021). Immersive Virtual Reality Exergame Promotes the Practice of Physical Activity in Older People: An Opportunity during COVID-19. Multimodal Technol. Interact., 5.","DOI":"10.3390\/mti5090052"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1249\/00005768-198205000-00012","article-title":"Psychophysical bases of perceived exertion","volume":"14","author":"Borg","year":"1982","journal-title":"Med. Sci. Sport. Exerc."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12984-021-00848-w","article-title":"Immersive virtual reality during gait rehabilitation increases walking speed and motivation: A usability evaluation with healthy participants and patients with multiple sclerosis and stroke","volume":"18","author":"Winter","year":"2021","journal-title":"J. Neuroeng. Rehabil."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Pau, M., Arippa, F., Leban, B., Porta, M., Casu, G., Frau, J., Lorefice, L., Coghe, G., and Cocco, E. (2024). Cybersickness in People with Multiple Sclerosis Exposed to Immersive Virtual Reality. Bioengineering, 11.","DOI":"10.3390\/bioengineering11020115"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Campo-Prieto, P., Cancela-Carral, J.M., Alsina-Rey, B., and Rodr\u00edguez-Fuentes, G. (2022). Immersive Virtual Reality as a Novel Physical Therapy Approach for Nonagenarians: Usability and Effects on Balance Outcomes of a Game-Based Exercise Program. J. Clin. Med., 11.","DOI":"10.3390\/jcm11133911"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.33546\/bnj.3006","article-title":"Exercise-based gaming in patients with multiple sclerosis: A systematic review and meta-analysis","volume":"10","author":"Elhusein","year":"2024","journal-title":"Belitung Nurs. J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1682\/JRRD.2009.07.0096","article-title":"Multiple sclerosis and mobility-related assistive technology: Systematic review of literature","volume":"47","author":"Souza","year":"2010","journal-title":"J. Rehabil. Res. Dev."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"104525","DOI":"10.1016\/j.msard.2023.104525","article-title":"Feasibility and usability of a new home-based immersive virtual reality headset-based dexterity training in multiple sclerosis","volume":"71","author":"Kamm","year":"2023","journal-title":"Mult. Scler. Relat. Disord."},{"key":"ref_51","first-page":"65","article-title":"Realidad virtual: Impacto en el aprendizaje percibido de estudiantes de Ciencias de la Salud","volume":"16","author":"Tumino","year":"2020","journal-title":"TCE"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez-Hern\u00e1ndez, M., Polonio-L\u00f3pez, B., Corregidor-S\u00e1nchez, A.I., Mart\u00edn-Conty, J.L., Mohedano-Moriano, A., and Criado-\u00c1lvarez, J.J. (2021). Effects of Specific Virtual Reality-Based Therapy for the Rehabilitation of the Upper Limb Motor Function Post-Ictus: Randomized Controlled Trial. Brain Sci., 11.","DOI":"10.3390\/brainsci11050555"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s00421-010-1519-2","article-title":"Enhanced neural drive after maximal strength training in multiple sclerosis patients","volume":"110","author":"Fimland","year":"2010","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1177\/1352458515579442","article-title":"Effects of a home-based step training programme on balance, stepping, cognition and functional performance in people with multiple sclerosis\u2014A randomized controlled trial","volume":"22","author":"Hoang","year":"2016","journal-title":"Mult. Scler."},{"key":"ref_55","first-page":"496325","article-title":"Predicting Falls in People with Multiple Sclerosis: Fall History Is as Accurate as More Complex Measures","volume":"2013","author":"Cameron","year":"2013","journal-title":"Mult. Scler. Int."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.gaitpost.2010.06.002","article-title":"Walking while talking\u2014Difficulties incurred during the initial stages of multiple sclerosis disease process","volume":"32","author":"Kalron","year":"2010","journal-title":"Gait Posture"},{"key":"ref_57","first-page":"169","article-title":"Validez y confiabilidad de la escala de esfuerzo percibido de Borg","volume":"14","year":"2009","journal-title":"Ense\u00f1. Investig. Psicol."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Stewart, T.H., Villaneuva, K., Hahn, A., Ortiz-Delatorre, J., Wolf, C., Nguyen, R., Bolter, N.D., Kern, M., and Bagley, J.R. (2022). Actual vs. perceived exertion during active virtual reality game exercise. Front. Rehabil. Sci., 3.","DOI":"10.3389\/fresc.2022.887740"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Runswick, O.R., Siegel, L., Rafferty, G.F., Knudsen, H.S., Sefton, L., Taylor, S., Reilly, C.C., Finnegan, S., Sargeant, M., and Pattinson, K. (2023). The Effects of Congruent and Incongruent Immersive Virtual Reality Modulated Exercise Environments in Healthy Individuals: A Pilot Study. Int. J. Hum. Comput. Interact., 1\u201311.","DOI":"10.1080\/10447318.2023.2276524"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/19\/5845\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:07:30Z","timestamp":1760112450000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/19\/5845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,30]]},"references-count":59,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["jcm13195845"],"URL":"https:\/\/doi.org\/10.3390\/jcm13195845","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,30]]}}}