{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T19:19:42Z","timestamp":1784229582068,"version":"3.55.0"},"reference-count":17,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T00:00:00Z","timestamp":1727827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Endovascular embolization is an effective treatment option for cerebral arteriovenous malformation (AVM) and dural arteriovenous fistulas (DAVFs). The objective of this study was to assess the safety and efficacy of MenoxTM in patients with cranial dural arteriovenous fistulas. Methods: From January 2021 to January 2023, 19 patients with intracranial DAVFs underwent embolization procedures. All patients were treated by embolization with MenoxTM or\/and in combination with other embolization products such as Onyx (Covidien, Irvine, California), PHIL (MicroVention, Tustin, California), and Squid (Balt Extrusion, Montmorency, France). Treatment approaches were selected depending on the anatomical location of the fistula. Patients were monitored and followed-up for 12 months. Results: The patients\u2019 mean age was 56.26 \u00b1 16.49 years. Of these 19 patients, 58% (n = 11) were treated with the MenoxTM liquid embolizing agent (LEA) alone or in combination with different LEAs, while n = 7 were treated with other LEAs and 1 patient was treated solely with coils. Complete occlusion of DAVFs with MenoxTM and other agents was evident in 68.4% (n = 13\/19) of patients. Complete occlusion (100%) was observed in the sinus rectus, transverse sinus, and diploic veins of the orbital roof, while complete occlusion was observed in 50% of falcotentorial patients and 60% of superior sagittal sinus patients. The lowest rate of complete fistula obliteration was observed in the dural carotid cavernous fistula (CCF) group (25%). An intra-procedural adverse event occurred in one patient. No other post-procedural adverse events were noted. Furthermore, in patients treated with MenoxTM, total occlusion was achieved in 72.7% (n = 8) of patients, whereas the non-MenoxTM group had 62.5% (n = 5) of patients with 100% occlusion and 37.5% (n = 3) of patients with subtotal occlusion. Conclusions: Outcomes using MenoxTM alone and in combination with other agents were effective, and it is safe for the treatment of dural arteriovenous fistulas.<\/jats:p>","DOI":"10.3390\/jcm13195899","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T03:36:03Z","timestamp":1727926563000},"page":"5899","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of a Novel Liquid Embolic System with Commonly Used Embolic Agents in the Endovascular Treatment of Intracranial Dural Arteriovenous Fistulas: A Single-Center Experience"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7937-3752","authenticated-orcid":false,"given":"Zarko","family":"Nedeljkovic","sequence":"first","affiliation":[{"name":"Clinic for Neurosurgery, University Clinical Center of Serbia, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9396-5319","authenticated-orcid":false,"given":"Ivan","family":"Vukasinovic","sequence":"additional","affiliation":[{"name":"Clinic for Neurosurgery, University Clinical Center of Serbia, 11000 Belgrade, Serbia"},{"name":"Center for Radiology, University Clinical Center of Serbia, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1709-8449","authenticated-orcid":false,"given":"Masa","family":"Petrovic","sequence":"additional","affiliation":[{"name":"Institute for Cardiovascular Diseases \u201dDedinje\u201d, Heroja Milana Tepica 1, 11000 Belgrade, Serbia"},{"name":"Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0980-0840","authenticated-orcid":false,"given":"Aleksandra","family":"Nedeljkovic","sequence":"additional","affiliation":[{"name":"Clinic for Neurosurgery, University Clinical Center of Serbia, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6147-7070","authenticated-orcid":false,"given":"Tijana","family":"Nastasovic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"},{"name":"Department of Anesthesiology and Resuscitation on Neurosurgery Clinic, University Clinical Center of Serbia, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Bascarevic","sequence":"additional","affiliation":[{"name":"Clinic for Neurosurgery, University Clinical Center of Serbia, 11000 Belgrade, Serbia"},{"name":"Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9670-2184","authenticated-orcid":false,"given":"Mirko","family":"Micovic","sequence":"additional","affiliation":[{"name":"Clinic for Neurosurgery, University Clinical Center of Serbia, 11000 Belgrade, Serbia"},{"name":"Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9793-0471","authenticated-orcid":false,"given":"Mihailo","family":"Milicevic","sequence":"additional","affiliation":[{"name":"Clinic for Neurosurgery, University Clinical Center of Serbia, 11000 Belgrade, Serbia"},{"name":"Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4027-448X","authenticated-orcid":false,"given":"Marina","family":"Milic","sequence":"additional","affiliation":[{"name":"Clinic for Neurosurgery, University Clinical Center of Serbia, 11000 Belgrade, Serbia"},{"name":"Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2704-7653","authenticated-orcid":false,"given":"Nemanja","family":"Jovanovic","sequence":"additional","affiliation":[{"name":"Clinic for Neurosurgery, University Clinical Center of Serbia, 11000 Belgrade, Serbia"},{"name":"Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandar","family":"Stanimirovic","sequence":"additional","affiliation":[{"name":"Clinic for Neurosurgery, University Clinical Center of Serbia, 11000 Belgrade, Serbia"},{"name":"Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vuk","family":"Scepanovic","sequence":"additional","affiliation":[{"name":"Clinic for Neurosurgery, University Clinical Center of Serbia, 11000 Belgrade, Serbia"},{"name":"Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danica","family":"Grujicic","sequence":"additional","affiliation":[{"name":"Clinic for Neurosurgery, University Clinical Center of Serbia, 11000 Belgrade, Serbia"},{"name":"Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/978-3-030-87649-4_14","article-title":"Management of Dural Arteriovenous Fistulas","volume":"44","author":"Kuwayama","year":"2022","journal-title":"Adv. Tech. Stand Neurosurg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.nic.2015.12.003","article-title":"Dural Arteriovenous Fistulae: Imaging and Management","volume":"26","author":"Serulle","year":"2016","journal-title":"Neuroimaging Clin. N. Am."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1177\/159101999700300404","article-title":"The natural history and management of intracranial dural arteri-ovenous fistulae: Part 1: Benign lesions","volume":"3","author":"Davies","year":"1997","journal-title":"Interv. Neuroradiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.nec.2009.07.014","article-title":"Neuroendovascular management of dural arteriovenous malformations","volume":"20","author":"McConnell","year":"2009","journal-title":"Neurosurg. Clin. N. Am."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1136\/svn-2019-000269","article-title":"Updates in the management of cranial dural arteriovenous fistula","volume":"5","author":"Baharvahdat","year":"2019","journal-title":"Stroke Vasc. Neurol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3174\/ajnr.A0817","article-title":"Endovascular treatment of intracranial dural arteriovenous fistulas with cortical venous drainage: New management using onyx","volume":"29","author":"Cognard","year":"2008","journal-title":"Am. J. Neuroradiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"733","DOI":"10.3171\/2010.3.JNS09370","article-title":"A prospective, multicenter, randomized trial of the Onyx liquid embolic system and N-butyl cyanoacrylate embolization of cerebral arteriovenous malformations","volume":"113","author":"Loh","year":"2010","journal-title":"J. Neurosurg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1080\/02688697.2019.1639619","article-title":"Dural arteriovenous fistulas as a relative contraindication for lumbar puncture: Brief report and literature review","volume":"36","author":"Ghorbani","year":"2022","journal-title":"Br. J. Neurosurg."},{"key":"ref_9","first-page":"49","article-title":"Evolution apr\u00e8s traitement endovas-culaire des signes angiographiques d\u2019hypertension veineuse et des signes cliniques d\u2019hypertension intracr\u00e2nienne dans les fis-tules art\u00e9rioveineuses durales intracr\u00e2niennes [Evolution of angiographic signs of venous hypertension and clinical signs of intracranial hypertension in intracranial dural arteriovenous fistulas]","volume":"26","author":"Biondi","year":"1999","journal-title":"J. Neuroradiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1136\/jnnp.65.3.308","article-title":"Dural arteriovenous fistulas as a cause of intracranial hypertension due to impairment of cranial venous outflow","volume":"65","author":"Cognard","year":"1998","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1148\/radiology.194.3.7862961","article-title":"Cerebral dural arteriovenous fistulas: Clinical and angiographic correlation with a revised classification of venous drainage","volume":"194","author":"Cognard","year":"1995","journal-title":"Radiology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1093\/neuros\/nyx309","article-title":"Transarterial Onyx Embolization of Intracranial Dural Fistulas: A Prospective Cohort, Systematic Review, and Meta-Analysis","volume":"82","author":"Magand","year":"2018","journal-title":"Neurosurgery"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3174\/ajnr.A5037","article-title":"Embolization of Intracranial Dural Arteriovenous Fistulas Using PHIL Liquid Embolic Agent in 26 Patients: A Multicenter Study","volume":"38","author":"Lamin","year":"2017","journal-title":"Am. J. Neuroradiol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Pal, A., Blanzy, J., G\u00f3mez, K.J.R., Preul, M.C., and Vernon, B.L. (2023). Liquid Embolic Agents for Endovascular Embolization: A Review. Gels, 9.","DOI":"10.3390\/gels9050378"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1136\/jnis.2010.003707","article-title":"Cranial dural arteriovenous fistula: Transarterial Onyx embolization experience and technical nuances","volume":"3","author":"Hu","year":"2011","journal-title":"J. NeuroInterventional Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3174\/ajnr.A0768","article-title":"Preliminary experience with onyx embolization for the treatment of intracranial dural arteriovenous fistulas","volume":"29","author":"Nogueira","year":"2007","journal-title":"Am. J. Neuroradiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.3171\/2020.10.JNS203604","article-title":"Results of transvenous embolization of intracranial dural arteriovenous fistula: A consecutive series of 136 patients with 142 fistulas","volume":"135","author":"Labeyrie","year":"2021","journal-title":"J. Neurosurg."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/19\/5899\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:09:36Z","timestamp":1760112576000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/19\/5899"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,2]]},"references-count":17,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["jcm13195899"],"URL":"https:\/\/doi.org\/10.3390\/jcm13195899","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,2]]}}}