{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:31Z","timestamp":1783468831374,"version":"3.55.0"},"reference-count":23,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T00:00:00Z","timestamp":1728691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Cardiac calcified amorphous tumors (CATs) are rare non-neoplastic formations containing amorphous fibrinous material and calcifications. In our research, we present the case of a 42-year-old male patient who developed, during his 6-months monitoring for coronary artery disease, a left ventricular (LV) CAT raising diagnostic challenges. Methods: To gather additional information on CATs, we researched the international medical literature for scientific articles published with the full text in English, on PubMed, ResearchGate, Clarivate, and Google Scholar between 2020 and 2024. Results: Compared to most described cases, our patient was a young male, without mitral annular calcification or chronic renal disease, but he was suffering from chronic peripheral and coronary artery disease, and genetic testing revealed a higher risk for thromboembolic events. During 6 months, he developed a LV CAT of 4.5\/3.5\/3 cm. Although we found in the medical literature 16 case reports of patients with CAT, only six authors could specify a precise postoperative evolution of the CAT, most of them sustaining that if completely removed, it would not relapse, an aspect observed also in our patient during 3 years of follow-up. Conclusions: CATs are rare heart tumors with slow growth, but with a high embolization risk that raises diagnostic and therapeutic challenges.<\/jats:p>","DOI":"10.3390\/jcm13206092","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T12:44:31Z","timestamp":1728909871000},"page":"6092","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Particularities of a Cardiac Amorphous Left Ventricular Tumor in a Patient with Coronary Artery Disease\u2014Diagnostic and Therapeutic Challenges: A Case Report and Literature Review"],"prefix":"10.3390","volume":"13","author":[{"given":"Caius Glad","family":"Streian","sequence":"first","affiliation":[{"name":"Department VI Cardiology-Cardiovascular Surgery, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timi\u0219oara, Eftimie Murgu Square No. 2, 300041 Timi\u0219oara, Romania"},{"name":"Institute for Cardiovascular Diseases of Timisoara, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timi\u0219oara, G. Adam Str. No. 13A, 300310 Timisoara, Romania"},{"name":"Advanced Research Center of the Institute for Cardiovascular Diseases, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timi\u0219oara, Eftimie Murgu Square No. 2, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7351-741X","authenticated-orcid":false,"given":"Cristina","family":"Tudoran","sequence":"additional","affiliation":[{"name":"Department VII, Discipline of Cardiology, Internal Medicine II, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timi\u0219oara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"},{"name":"Center of Molecular Research in Nephrology and Vascular Disease, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timi\u0219oara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"},{"name":"Cardiology Clinic, County Emergency Hospital \u201cPius Brinzeu\u201d, L. Rebreanu, No. 156, 300723 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0173-3617","authenticated-orcid":false,"given":"Raluca Elisabeta","family":"Staicu","sequence":"additional","affiliation":[{"name":"Institute for Cardiovascular Diseases of Timisoara, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timi\u0219oara, G. Adam Str. No. 13A, 300310 Timisoara, Romania"},{"name":"Doctoral School Medicine-Pharmacy, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timi\u0219oara, Eftimie Murgu Square No. 2, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9838-744X","authenticated-orcid":false,"given":"Alina Gabriela","family":"Negru","sequence":"additional","affiliation":[{"name":"Department VI Cardiology-Cardiovascular Surgery, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timi\u0219oara, Eftimie Murgu Square No. 2, 300041 Timi\u0219oara, Romania"},{"name":"Institute for Cardiovascular Diseases of Timisoara, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timi\u0219oara, G. Adam Str. No. 13A, 300310 Timisoara, Romania"},{"name":"Advanced Research Center of the Institute for Cardiovascular Diseases, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timi\u0219oara, Eftimie Murgu Square No. 2, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra Laura","family":"Mederle","sequence":"additional","affiliation":[{"name":"Surgery Clinic, County Emergency Hospital \u201cPius Brinzeu\u201d, L. Rebreanu, No. 156, 300723 Timisoara, Romania"},{"name":"Faculty of Medicine, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timi\u0219oara, Eftimie Murgu Square No. 2, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Borza","sequence":"additional","affiliation":[{"name":"Centre of Cognitive Research in Pathological Neuro-Psychiatry NEUROPSY-COG, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timi\u0219oara, Eftimie Murgu Square No. 2, 300041 Timi\u0219oara, Romania"},{"name":"Department III Functional Sciences\u2014Pathophysiology, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timi\u0219oara, Eftimie Murgu Square No. 2, 300041 Timi\u0219oara, Romania"},{"name":"Centre for Translational Research and Systems Medicine, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timi\u0219oara, Eftimie Murgu Square No. 2, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0600-1103","authenticated-orcid":false,"given":"Ana","family":"Lascu","sequence":"additional","affiliation":[{"name":"Institute for Cardiovascular Diseases of Timisoara, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timi\u0219oara, G. Adam Str. No. 13A, 300310 Timisoara, Romania"},{"name":"Department III Functional Sciences\u2014Pathophysiology, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timi\u0219oara, Eftimie Murgu Square No. 2, 300041 Timi\u0219oara, Romania"},{"name":"Centre for Translational Research and Systems Medicine, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timi\u0219oara, Eftimie Murgu Square No. 2, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0046-8177(97)90083-6","article-title":"Calcified Amorphous Tumor of the Heart (Cardiac CAT)","volume":"28","author":"Reynolds","year":"1997","journal-title":"Hum. 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