{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:42:52Z","timestamp":1791337372792,"version":"4.3.1"},"reference-count":30,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T00:00:00Z","timestamp":1728777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Purpose: To compare the postoperative complications and clinical outcomes of Descemet membrane endothelial keratoplasty (DMEK) and Descemet stripping automated endothelial keratoplasty (DSAEK) in eyes with previous glaucoma filtering surgery. Methods: In this retrospective comparative case series, we analysed postoperative visual acuity and intraocular pressure, graft survival, rate of graft detachment and\/or dislocation, number of rebubbling and\/or graft repositioning procedures, and graft rejection or failure (primary and secondary). Results: Sixteen eyes with DMEK and 80 eyes with DSAEK with previous glaucoma surgery were studied. The results were recorded at 3 and 12 months postoperatively. No statistically significant differences in postoperative visual acuity were found between the two groups at any stage of the follow-up. Intraocular pressure was lower in the DMEK group at the follow-up stage of 3 (p = 0.0022) and 12 months (p = 0.0480). Visually significant graft detachment was recorded in 31.3% and 22.5% of DMEK and DSAEK cases, respectively (p = 0.4541). All DMEK detachments (n = 5) were managed with slit-lamp rebubbling. Out of 18 graft detachments in the DSAEK group, 2 grafts were observed due to small graft detachment, 6 large graft detachments underwent rebubbling performed in the operating theatre, and 10 eyes needed primary graft repositioning for graft dislocation. Conclusions: DMEK is a feasible option to treat endothelial failure in complex eyes with previous glaucoma surgery. In the DMEK group, visual acuity outcomes and possibly postoperative intraocular pressure control were better compared with the DSAEK group.<\/jats:p>","DOI":"10.3390\/jcm13206097","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T12:44:31Z","timestamp":1728909871000},"page":"6097","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Endothelial Keratoplasty Following Glaucoma Filtration Surgery: A UK Tertiary Eye Care Referral Centre Experience"],"prefix":"10.3390","volume":"13","author":[{"given":"Francesco","family":"Aiello","sequence":"first","affiliation":[{"name":"Ophthalmology Unit, Department of Experimental Medicine, University of Rome \u201cTor Vergata\u201d, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2614-0234","authenticated-orcid":false,"given":"Francesco","family":"Matarazzo","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Reproductive Sciences and Dentistry, University of Naples \u201cFederico II\u201d, 80131 Naples, Italy"},{"name":"Department of Physics \u201cEttore Pancini\u201d, University of Naples \u201cFederico II\u201d, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3471-8913","authenticated-orcid":false,"given":"Maria","family":"Phylactou","sequence":"additional","affiliation":[{"name":"Cornea Service, Moorfields Eye Hospital, NHS Foundation Trust, London EC1V2PD, UK"},{"name":"Nicosia Vision Clinic, Private Clinic, Ilia Venezi 2A, Strovolos, Nicosia 2042, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirithika","family":"Muthusamy","sequence":"additional","affiliation":[{"name":"Cornea Service, Moorfields Eye Hospital, NHS Foundation Trust, London EC1V2PD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Maurino","sequence":"additional","affiliation":[{"name":"Cornea Service, Moorfields Eye Hospital, NHS Foundation Trust, London EC1V2PD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3091695","DOI":"10.1155\/2022\/3091695","article-title":"Global Prevalence of Fuchs Endothelial Corneal Dystrophy (FECD) in Adult Population: A Systematic Review and Meta-Analysis","volume":"2022","author":"Aiello","year":"2022","journal-title":"J. Ophthalmol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/bs.pbr.2015.06.009","article-title":"Glaucoma risks in advanced corneal surgery","volume":"221","author":"Maurino","year":"2015","journal-title":"Prog. Brain Res."},{"key":"ref_3","first-page":"CD008420","article-title":"Endothelial keratoplasty versus penetrating keratoplasty for Fuchs endothelial dystrophy","volume":"2","author":"Nanavaty","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1097\/ICO.0000000000001320","article-title":"Systematic Review and Meta-Analysis of Clinical Outcomes of Descemet Membrane Endothelial Keratoplasty Versus Descemet Stripping Endothelial Keratoplasty\/Descemet Stripping Automated Endothelial Keratoplasty","volume":"36","author":"Singh","year":"2017","journal-title":"Cornea"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1097\/ICO.0000000000001384","article-title":"Meta-Analysis of Postoperative Outcome Parameters Comparing Descemet Membrane Endothelial Keratoplasty Versus Descemet Stripping Automated Endothelial Keratoplasty","volume":"36","author":"Pavlovic","year":"2017","journal-title":"Cornea"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1016\/j.ophtha.2011.03.037","article-title":"Learning Curve in Descemet\u2019s Membrane Endothelial Keratoplasty: First Series of 135 Consecutive Cases","volume":"118","author":"Dapena","year":"2011","journal-title":"Ophthalmology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1007\/s00417-023-06073-6","article-title":"Incidence and management of early postoperative complications in lamellar corneal transplantation","volume":"261","author":"Romano","year":"2023","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"4345","DOI":"10.2147\/OPTH.S379849","article-title":"Effect of COVID-19 on Eye Banks and Corneal Transplantations: Current Perspectives","volume":"16","author":"Aiello","year":"2022","journal-title":"Clin. Ophthalmol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1097\/j.jcrs.0000000000000585","article-title":"Incidence and complications of retained lens fragment in the anterior chamber after uneventful cataract surgery in a United Kingdom tertiary center","volume":"47","author":"Matarazzo","year":"2021","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1097\/IJG.0000000000002083","article-title":"Primary Open Angle Glaucoma Prevalence in Europe: A Systematic Review and Meta-Analysis","volume":"31","author":"Aiello","year":"2022","journal-title":"J. Glaucoma"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1007\/s10792-020-01295-7","article-title":"Paracentesis as valve re-bubbling technique for Descemet\u2019s membrane endothelial keratoplasty (DMEK) graft detachment","volume":"40","author":"Allan","year":"2020","journal-title":"Int. Ophthalmol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.ophtha.2012.08.011","article-title":"Predictive value of optical coherence tomography in graft attachment after Descemet\u2019s membrane endothelial keratoplasty","volume":"120","author":"Yeh","year":"2013","journal-title":"Ophthalmology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1097\/ICO.0000000000000417","article-title":"Cornea preservation time study: Methods and potential impact on the cornea donor pool in the United States","volume":"34","author":"Lass","year":"2015","journal-title":"Cornea"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.ophtha.2013.12.017","article-title":"A comparison of lamellar and penetrating keratoplasty outcomes: A registry study","volume":"121","author":"Coster","year":"2014","journal-title":"Ophthalmology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.ajo.2011.10.004","article-title":"Graft rejection following descemet stripping automated endothelial keratoplasty: Features, risk factors, and outcomes","volume":"153","author":"Wu","year":"2012","journal-title":"Am. J. Ophthalmol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1097\/ICO.0000000000002585","article-title":"Four-Year Survival Comparison of Endothelial Keratoplasty Techniques in Patients With Previous Glaucoma Surgery","volume":"40","author":"Alshaker","year":"2021","journal-title":"Cornea"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1007\/s00417-021-05506-4","article-title":"Graft survival of Descemet membrane endothelial keratoplasty (DMEK) in corneal endothelial decompensation after glaucoma surgery","volume":"260","author":"Schrittenlocher","year":"2022","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ajo.2020.05.020","article-title":"Four-Year Survival of Descemet Membrane Endothelial Keratoplasty in Patients With Previous Glaucoma Surgery","volume":"218","author":"Sorkin","year":"2020","journal-title":"Am. J. Ophthalmol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.ajo.2018.11.014","article-title":"Clinical Outcomes of Descemet Membrane Endothelial Keratoplasty in Eyes with a Glaucoma Drainage Device","volume":"199","author":"Birbal","year":"2019","journal-title":"Am. J. Ophthalmol."},{"key":"ref_20","first-page":"CD012097","article-title":"Descemet\u2019s membrane endothelial keratoplasty (DMEK) versus Descemet\u2019s stripping automated endothelial keratoplasty (DSAEK) for corneal endothelial failure","volume":"6","author":"Stuart","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.survophthal.2019.02.011","article-title":"Intraocular pressure measurement after corneal transplantation","volume":"64","author":"Chan","year":"2019","journal-title":"Surv. Ophthalmol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ajo.2011.01.030","article-title":"Corneal graft survival and intraocular pressure control after descemet stripping automated endothelial keratoplasty in eyes with pre-existing glaucoma","volume":"152","author":"Quek","year":"2011","journal-title":"Am. J. Ophthalmol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1097\/ICO.0b013e3181c11bf3","article-title":"Descemet stripping automated endothelial keratoplasty in eyes with previous trabeculectomy and tube shunt procedures: Intraoperative and early postoperative complications","volume":"29","author":"Phillips","year":"2010","journal-title":"Cornea"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Luo, L.J., Nguyen, D.D., and Lai, J.Y. (2020). Dually functional hollow ceria nanoparticle platform for intraocular drug delivery: A push beyond the limits of static and dynamic ocular barriers toward glaucoma therapy. Biomaterials, 243.","DOI":"10.1016\/j.biomaterials.2020.119961"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.ajo.2011.12.012","article-title":"Descemet membrane endothelial keratoplasty versus descemet stripping automated endothelial keratoplasty","volume":"153","author":"Tourtas","year":"2012","journal-title":"Am. J. Ophthalmol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ajo.2019.03.020","article-title":"Comparison of endothelial keratoplasty techniques in patients with prior glaucoma surgery\u2014A case-matched study","volume":"206","author":"Lin","year":"2019","journal-title":"Am. J. Ophthalmol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ajo.2016.08.023","article-title":"Descemet Membrane Endothelial Keratoplasty: Preliminary Results of a Donor Insertion Pull-through Technique Using a Donor Mat Device","volume":"171","author":"Ang","year":"2016","journal-title":"Am. J. Ophthalmol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ajo.2018.06.013","article-title":"Clinical Outcomes of Preloaded Descemet Membrane Endothelial Keratoplasty Grafts with Endothelium Tri-Folded Inwards","volume":"193","author":"Busin","year":"2018","journal-title":"Am. J. Ophthalmol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1097\/ICO.0000000000001650","article-title":"Endothelium-in Versus Endothelium-out Insertion With Descemet Membrane Endothelial Keratoplasty","volume":"37","author":"Price","year":"2018","journal-title":"Cornea"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1007\/s10792-021-01797-y","article-title":"Descemet membrane endothelial keratoplasty in vitrectomized eyes: A case series of outcomes and complications","volume":"41","author":"Phylactou","year":"2021","journal-title":"Int. Ophthalmol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/20\/6097\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:12:26Z","timestamp":1760112746000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/20\/6097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,13]]},"references-count":30,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["jcm13206097"],"URL":"https:\/\/doi.org\/10.3390\/jcm13206097","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,13]]}}}