{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:59:36Z","timestamp":1790906376723,"version":"4.1.0"},"reference-count":236,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T00:00:00Z","timestamp":1729036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>This article provides an updated review of hypopituitarism (HP), an endocrine disorder characterized by a deficiency of one or more pituitary hormones. The various etiologies are reviewed, including pituitary neuroendocrine tumors (PitNETs), hypothalamic lesions, genetic mutations, and acquired factors such as head trauma, medications, neoplasms, and infiltrative diseases. It is noted that PitNETs are responsible for approximately half of the cases in adults, whereas in children the causes are predominantly congenital. Diagnosis is based on clinical evaluation and hormonal testing, with identification of the specific hormonal deficiencies essential for effective treatment. Laboratory tests present challenges and limitations that must be understood and addressed. Hormone replacement therapy is the mainstay of treatment, significantly improving patients\u2019 quality of life. It is important to know the possible interactions between hormone replacement therapies in HP. Recent advances in understanding the pathophysiology of HP and the importance of a multidisciplinary approach to the management of associated complications are discussed. This article emphasizes the need for comprehensive evaluation and continuous follow-up to optimize outcomes in patients with HP and highlights the importance of ongoing research to improve diagnostic and treatment strategies.<\/jats:p>","DOI":"10.3390\/jcm13206161","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T07:58:32Z","timestamp":1729065512000},"page":"6161","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["An Update on Advances in Hypopituitarism: Etiology, Diagnosis, and Current Management"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0126-1985","authenticated-orcid":false,"given":"Pedro","family":"Iglesias","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Nutrition, Hospital Universitario Puerta de Hierro Majadahonda, Calle Joaqu\u00edn Rodrigo, 1, 28222 Majadahonda, Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro Segovia de Arana, 28222 Majadahonda, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1046\/j.1365-2265.2001.01406.x","article-title":"Prevalence and Incidence of Hypopituitarism in an Adult Caucasian Population in Northwestern Spain","volume":"55","author":"Regal","year":"2001","journal-title":"Clin. Endocrinol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/j.1365-2265.2012.04516.x","article-title":"Epidemiology, Mortality Rate and Survival in a Homogeneous Population of Hypopituitary Patients","volume":"78","author":"Andujar","year":"2013","journal-title":"Clin. Endocrinol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.arcped.2024.01.003","article-title":"Diagnosis and Management of Congenital Hypopituitarism in Children","volume":"31","author":"Castets","year":"2024","journal-title":"Arch. Pediatr."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/s12020-013-0127-4","article-title":"Etiology of Hypopituitarism in Tertiary Care Institutions in Turkish Population: Analysis of 773 Patients from Pituitary Study Group Database","volume":"47","author":"Tanriverdi","year":"2014","journal-title":"Endocrine"},{"key":"ref_5","first-page":"6969286","article-title":"Etiology of Hypopituitarism in Adult Patients: The Experience of a Single Center Database in the Serbian Population","volume":"2017","author":"Petakov","year":"2017","journal-title":"Int. J. Endocrinol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"dgaa517","DOI":"10.1210\/clinem\/dgaa517","article-title":"Excess Mortality Among Hospitalized Patients with Hypopituitarism-A Population-Based, Matched-Cohort Study","volume":"105","author":"Ebrahimi","year":"2020","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s12020-016-1159-3","article-title":"Mortality in Adults with Hypopituitarism: A Systematic Review and Meta-Analysis","volume":"56","author":"Jasim","year":"2017","journal-title":"Endocrine"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s11154-024-09881-1","article-title":"Pitfalls in the Lab Assessment of Hypopituitarism","volume":"25","author":"Schilbach","year":"2024","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s11154-024-09889-7","article-title":"Progress, Challenges and Perspectives in the Management of Hypopituitarism","volume":"25","author":"Boguszewski","year":"2024","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Bosch I Ara, L., Katugampola, H., and Dattani, M.T. (2020). Congenital Hypopituitarism During the Neonatal Period: Epidemiology, Pathogenesis, Therapeutic Options, and Outcome. Front. Pediatr., 8.","DOI":"10.3389\/fped.2020.600962"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Stagi, S., Tufano, M., Chiti, N., Cerutti, M., Li Pomi, A., Aversa, T., and Wasniewska, M. (2023). Management of Neonatal Isolated and Combined Growth Hormone Deficiency: Current Status. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241210114"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"57","DOI":"10.14341\/probl12761","article-title":"Congenital hypopituitarism with monosomy of chromosome 18","volume":"67","author":"Bolmasova","year":"2021","journal-title":"Probl. Endokrinol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s11154-023-09868-4","article-title":"Diagnosing and Treating Anterior Pituitary Hormone Deficiency in Pediatric Patients","volume":"25","author":"Rey","year":"2024","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/s41574-020-00437-2","article-title":"Insights into Non-Classic and Emerging Causes of Hypopituitarism","volume":"17","author":"Prodam","year":"2021","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s41572-022-00351-z","article-title":"Hypothalamic Syndrome","volume":"8","author":"Tauber","year":"2022","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"261","DOI":"10.18786\/2072-0505-2021-49-047","article-title":"The prevalence rate of hypopituitarism in patients with pituitary macroadenomas with various hormonal activities","volume":"49","author":"Krivosheeva","year":"2021","journal-title":"Alm. Clin. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/s11102-014-0563-z","article-title":"Hypopituitarism Patterns and Prevalence among Men with Macroprolactinomas","volume":"18","author":"Tirosh","year":"2015","journal-title":"Pituitary"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Zhou, Z., Zhang, S., and Hu, F. (2021). Endocrine Disorder in Patients with Craniopharyngioma. Front. Neurol., 12.","DOI":"10.3389\/fneur.2021.737743"},{"key":"ref_19","first-page":"19","article-title":"Hypopituitarism mode in patients with craniopharyngioma in relation to tumor growth pattern","volume":"98","author":"Qi","year":"2018","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s00234-023-03120-1","article-title":"Neoplasms and Tumor-like Lesions of the Sellar Region: Imaging Findings with Correlation to Pathology and 2021 WHO Classification","volume":"65","author":"Ugga","year":"2023","journal-title":"Neuroradiology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1210\/clinem\/dgaa474","article-title":"Pituitary Gangliocytoma Producing TSH and TRH: A Review of \u201cGangliocytomas of the Sellar Region","volume":"105","author":"Sakata","year":"2020","journal-title":"\u201d J. Clin. Endocrinol. Metab."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Asa, S.L., and Mete, O. (2019). Hypothalamic Endocrine Tumors: An Update. J. Clin. Med., 8.","DOI":"10.20944\/preprints201909.0314.v1"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/B978-0-12-820683-6.00006-3","article-title":"Hypothalamic Hormone-Producing Tumors","volume":"181","author":"Asa","year":"2021","journal-title":"Handb. Clin. Neurol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Tang, O.Y., Chen, J.-S., Monje, S., Kumarapuram, S., Eloy, J.A., and Liu, J.K. (2024). Comparison of Surgical Modalities for Giant Pituitary Adenoma: A Systematic Review and Meta-Analysis of 1413 Patients. Oper. Neurosurg.","DOI":"10.1227\/ons.0000000000001238"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Shafiq, I., Williams, Z.R., and Vates, G.E. (2024). Advancement in Perioperative Management of Pituitary Adenomas-Current Concepts and Best Practices. J. Neuroendocrinol., e13427.","DOI":"10.1111\/jne.13427"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"14571","DOI":"10.1111\/jcmm.16086","article-title":"Cranial Irradiation Alters Neuroinflammation and Neural Proliferation in the Pituitary Gland and Induces Late-Onset Hormone Deficiency","volume":"24","author":"Xu","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e266","DOI":"10.1016\/j.prro.2019.01.009","article-title":"Hypopituitarism After Cranial Irradiation for Meningiomas: A Single-Institution Experience","volume":"9","author":"Lamba","year":"2019","journal-title":"Pract. Radiat. Oncol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1586\/era.12.27","article-title":"Radiotherapy-Induced Hypopituitarism: A Review","volume":"12","author":"Sathyapalan","year":"2012","journal-title":"Expert Rev. Anticancer Ther."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.3171\/2018.5.JNS18509","article-title":"Hypopituitarism after Gamma Knife Radiosurgery for Pituitary Adenomas: A Multicenter, International Study","volume":"131","author":"Cordeiro","year":"2018","journal-title":"J. Neurosurg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1210\/endrev\/bnab040","article-title":"Hypothalamic-Pituitary and Other Endocrine Surveillance Among Childhood Cancer Survivors","volume":"43","author":"Mulder","year":"2022","journal-title":"Endocr. Rev."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1210\/jc.2018-01175","article-title":"Hypothalamic-Pituitary and Growth Disorders in Survivors of Childhood Cancer: An Endocrine Society Clinical Practice Guideline","volume":"103","author":"Sklar","year":"2018","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e220490","DOI":"10.1530\/EC-22-0490","article-title":"The Impact of Radiotherapy on the Hypothalamo-Pituitary Axis: Old vs New Radiotherapy Techniques","volume":"12","author":"McLaren","year":"2023","journal-title":"Endocr. Connect."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1210\/jc.2005-1616","article-title":"Conventional Pituitary Irradiation Is Effective in Lowering Serum Growth Hormone and Insulin-like Growth Factor-I in Patients with Acromegaly","volume":"91","author":"Jenkins","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.radonc.2009.09.011","article-title":"Radiotherapy for Pituitary Adenomas: Long-Term Efficacy and Toxicity","volume":"93","author":"Erridge","year":"2009","journal-title":"Radiother. Oncol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"773","DOI":"10.3171\/2024.1.JNS232285","article-title":"Long-Term Radiographic and Endocrinological Outcomes of Stereotactic Radiosurgery for Recurrent or Residual Nonfunctioning Pituitary Adenomas","volume":"141","author":"Shaaban","year":"2024","journal-title":"J. Neurosurg."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1210\/jc.2011-0306","article-title":"Pituitary Dysfunction in Adult Patients after Cranial Radiotherapy: Systematic Review and Meta-Analysis","volume":"96","author":"Kokshoorn","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/cen.13971","article-title":"Hypothalamic-Pituitary Axis Irradiation Dose Thresholds for the Development of Hypopituitarism in Adult-Onset Gliomas","volume":"91","author":"Kyriakakis","year":"2019","journal-title":"Clin. Endocrinol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/cen.14499","article-title":"Occurrence of Pituitary Hormone Deficits in Relation to Both Pituitary and Hypothalamic Doses after Radiotherapy for Skull Base Meningioma","volume":"95","author":"Partoune","year":"2021","journal-title":"Clin. Endocrinol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Iglesias, P. (2024). Pituitary Apoplexy: An Updated Review. J. Clin. Med., 13.","DOI":"10.3390\/jcm13092508"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Gheorghe, A.-M., Trandafir, A.I., Ionovici, N., Carsote, M., Nistor, C., Popa, F.L., and Stanciu, M. (2023). Pituitary Apoplexy in Patients with Pituitary Neuroendocrine Tumors (PitNET). Biomedicines, 11.","DOI":"10.3390\/biomedicines11030680"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e711","DOI":"10.1210\/clinem\/dgad541","article-title":"A Prospective, Multicenter, Observational Study of Surgical vs Nonsurgical Management for Pituitary Apoplexy","volume":"109","author":"Mamelak","year":"2024","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s11102-023-01372-x","article-title":"Pituitary Apoplexy Score, toward Standardized Decision-Making: A Descriptive Study","volume":"27","author":"Salle","year":"2024","journal-title":"Pituitary"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1055\/a-0640-2915","article-title":"Neuro-Endocrine Recovery After Pituitary Apoplexy: Prolactin as a Predictive Factor","volume":"128","author":"Lammert","year":"2020","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Marin-Casta\u00f1eda, L.A., Gorbachev, J., de Lopez-Zepeda, P.T., Choque-Ayala, L.C., Shubhangi, F.N.U., Vasconcellos, F.D.N., and Pichardo-Rojas, P.S. (2024). Pituitary Apoplexy and The Current Understanding of Its Management: A Meta-Analysis of 908 Patients. World Neurosurg.","DOI":"10.1016\/j.wneu.2024.07.103"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"16092","DOI":"10.1038\/nrdp.2016.92","article-title":"Sheehan Syndrome","volume":"2","author":"Karaca","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"338","DOI":"10.4103\/ijem.IJEM_345_20","article-title":"Clinical, Endocrine, Metabolic Profile, and Bone Health in Sheehan\u2019s Syndrome","volume":"24","author":"Mandal","year":"2020","journal-title":"Indian. J. Endocrinol. Metab."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1007\/s00404-021-06294-2","article-title":"Acute Sheehan\u2019s Syndrome Manifesting Initially with Diabetes Insipidus Postpartum: A Case Report and Systematic Literature Review","volume":"306","author":"Olmes","year":"2022","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e257504","DOI":"10.1136\/bcr-2023-257504","article-title":"Sheehan\u2019s Syndrome Presenting as Massive Pericardial Effusion, Ventricular Tachycardia and Diabetes Insipidus","volume":"16","author":"Alam","year":"2023","journal-title":"BMJ Case Rep."},{"key":"ref_49","first-page":"116","article-title":"Neuroendocrinology Area of Knowledge of the Spanish Society of Endocrinology and Nutrition (SEEN). Executive Summary of the Consensus Document on Hypophysitis of the Neuroendocrinology Area of Knowledge of the Spanish Society of Endocrinology and Nutrition","volume":"70","author":"Iglesias","year":"2023","journal-title":"Endocrinol. Diabetes Nutr. (Engl. Ed.)"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"R59","DOI":"10.1530\/EJE-19-1051","article-title":"MECHANISMS IN ENDOCRINOLOGY: Autoimmune Hypopituitarism: Novel Mechanistic Insights","volume":"182","author":"Takahashi","year":"2020","journal-title":"Eur. J. Endocrinol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1007\/s11102-021-01141-8","article-title":"Isolated ACTH Deficiency Induced by Cancer Immunotherapy: A Systematic Review","volume":"24","author":"Iglesias","year":"2021","journal-title":"Pituitary"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1530\/ERC-21-0228","article-title":"Immunotherapy-Induced Isolated ACTH Deficiency in Cancer Therapy","volume":"28","author":"Iglesias","year":"2021","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1016\/j.humpath.2007.06.011","article-title":"Hypophysitis Presented as Inflammatory Pseudotumor in Immunoglobulin G4-Related Systemic Disease","volume":"38","author":"Wong","year":"2007","journal-title":"Hum. Pathol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"bnz003","DOI":"10.1210\/endrev\/bnz003","article-title":"Autoimmune Pituitary Disease: New Concepts with Clinical Implications","volume":"41","author":"Yamamoto","year":"2020","journal-title":"Endocr. Rev."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1007\/s11102-018-0901-7","article-title":"Isolated Adrenocorticotropic Hormone Deficiency as a Form of Paraneoplastic Syndrome","volume":"21","author":"Bando","year":"2018","journal-title":"Pituitary"},{"key":"ref_56","first-page":"300","article-title":"Lymphocytic Hypophysitis\u2014Various Course of the Disease and Individualized Therapeutic Approach. An Algorithm of the Follow-Up","volume":"75","author":"Tkacz","year":"2024","journal-title":"Endokrynol. Pol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1136\/jim-2021-002099","article-title":"Immune Checkpoint Inhibitor-Induced Hypophysitis: Lessons Learnt from a Large Cancer Cohort","volume":"70","author":"Kotwal","year":"2022","journal-title":"J. Investig. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"4078","DOI":"10.1210\/jc.2014-2306","article-title":"Ipilimumab-Induced Hypophysitis: A Detailed Longitudinal Analysis in a Large Cohort of Patients with Metastatic Melanoma","volume":"99","author":"Faje","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1530\/ERC-20-0513","article-title":"Immune Checkpoint Inhibitor Related Hypophysitis: Diagnostic Criteria and Recovery Patterns","volume":"28","author":"Nguyen","year":"2021","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3892\/etm.2022.11709","article-title":"Diabetes Insipidus: A Rare Endocrine Complication of Immune Check Point Inhibitors: A Case Report and Literature Review","volume":"25","author":"Angelousi","year":"2023","journal-title":"Exp. Ther. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1007\/s12032-010-9794-7","article-title":"Hyponatremia Associated with Ipilimumab-Induced Hypophysitis","volume":"29","author":"Barnard","year":"2012","journal-title":"Med. Oncol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1200\/OP.23.00023","article-title":"Endocrine Dysfunction From Immune Checkpoint Inhibitors: Pearls and Pitfalls in Evaluation and Management","volume":"19","author":"Kotwal","year":"2023","journal-title":"JCO Oncol. Pract."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1507\/endocrj.EJ16-0161","article-title":"Nivolumab-Induced Hypophysitis in a Patient with Advanced Malignant Melanoma","volume":"63","author":"Okano","year":"2016","journal-title":"Endocr. J."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1530\/EJE-13-0642","article-title":"The Prevalence of IgG4-Related Hypophysitis in 170 Consecutive Patients with Hypopituitarism and\/or Central Diabetes Insipidus and Review of the Literature","volume":"170","author":"Bando","year":"2014","journal-title":"Eur. J. Endocrinol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"bvaa194","DOI":"10.1210\/jendso\/bvaa194","article-title":"Two Cases of Anti-PIT-1 Hypophysitis Exhibited as a Form of Paraneoplastic Syndrome Not Associated with Thymoma","volume":"5","author":"Kanie","year":"2021","journal-title":"J. Endocr. Soc."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e415","DOI":"10.1210\/clinem\/dgaa771","article-title":"Hypothalamitis: A Novel Autoimmune Endocrine Disease. A Literature Review and Case Report","volume":"106","author":"Harput","year":"2021","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/B978-0-12-820683-6.00003-8","article-title":"Empty Sella Syndrome: Multiple Endocrine Disorders","volume":"181","author":"Chiloiro","year":"2021","journal-title":"Handb. Clin. Neurol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/s11102-012-0416-6","article-title":"Primary Empty Sella (PES): A Review of 175 Cases","volume":"16","author":"Guitelman","year":"2013","journal-title":"Pituitary"},{"key":"ref_69","first-page":"99","article-title":"Primary Empty Sella Syndrome and the Prevalence of Hormonal Dysregulation","volume":"115","author":"Auer","year":"2018","journal-title":"Dtsch. Arztebl. Int."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"102830","DOI":"10.1016\/j.bas.2024.102830","article-title":"Acute Neuroendocrine Changes after Traumatic Brain Injury","volume":"4","author":"Stankovics","year":"2024","journal-title":"Brain Spine"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1159\/000529327","article-title":"Post-Traumatic Hypopituitarism: A Neglected Consequence of Traumatic Brain Injury","volume":"113","author":"Miksiewicz","year":"2023","journal-title":"Neuroendocrinology"},{"key":"ref_72","first-page":"312","article-title":"A Review of Systemic Infiltrative Diseases and Associated Endocrine Diseases","volume":"68","year":"2021","journal-title":"Endocrinol. Diabetes Nutr. (Engl. Ed.)"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s11102-008-0090-x","article-title":"All Patients with \u201cidiopathic\u201d Hypopituitarism Should Be Screened for Hemochromatosis","volume":"12","author":"Lewis","year":"2009","journal-title":"Pituitary"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/qjmed\/hct193","article-title":"The Causes of Hypopituitarism in the Absence of Abnormal Pituitary Imaging","volume":"107","author":"Wilson","year":"2014","journal-title":"QJM"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1007\/s40618-016-0451-7","article-title":"Endocrine Dysfunction in Hereditary Hemochromatosis","volume":"39","author":"Pelusi","year":"2016","journal-title":"J. Endocrinol. Investig."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"629","DOI":"10.7326\/0003-4819-101-5-629","article-title":"Hypogonadism in Hemochromatosis: Reversal with Iron Depletion","volume":"101","author":"Kelly","year":"1984","journal-title":"Ann. Intern. Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1136\/pgmj.71.835.297","article-title":"Hypopituitarism in Primary Haemochromatosis; Recovery after Iron Depletion","volume":"71","author":"Gama","year":"1995","journal-title":"Postgrad. Med. J."},{"key":"ref_78","first-page":"1183","article-title":"Hypopituitarism Associated with Systemic Amyloidosis","volume":"83","author":"Las","year":"1983","journal-title":"N. Y. State J. Med."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s13256-018-1719-7","article-title":"Anterior Hypopituitarism in a Patient with Amyloidosis Secondary to Crohn\u2019s Disease: A Case Report","volume":"12","author":"Verbeke","year":"2018","journal-title":"J. Med. Case Rep."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3109\/13506129.2010.545961","article-title":"Amyloid Goiter and Hypopituitarism in a Patient with Systemic Amyloidosis","volume":"18","author":"Ozdemir","year":"2011","journal-title":"Amyloid"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"e235077","DOI":"10.1136\/bcr-2020-235077","article-title":"Neurosarcoidosis Presenting with Hypopituitarism","volume":"13","author":"Liu","year":"2020","journal-title":"BMJ Case Rep."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s11102-015-0678-x","article-title":"Hypothalamic-Pituitary Sarcoidosis with Vision Loss and Hypopituitarism: Case Series and Literature Review","volume":"19","author":"Anthony","year":"2016","journal-title":"Pituitary"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1056\/NEJM198910263211704","article-title":"The Frequency and Natural History of Diabetes Insipidus in Children with Langerhans-Cell Histiocytosis","volume":"321","author":"Dunger","year":"1989","journal-title":"N. Engl. J. Med."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1007\/s00381-024-06456-y","article-title":"Langerhans Cell Histiocytosis of the Sella in a Pediatric Patient: Case Report with Review of the Literature","volume":"40","author":"Orr","year":"2024","journal-title":"Childs Nerv. Syst."},{"key":"ref_85","unstructured":"Tillotson, C.V., Anjum, F., and Patel, B.C. (2024). Langerhans Cell Histiocytosis. StatPearls, StatPearls Publishing."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/jpc.16521","article-title":"Endocrine Features of Langerhans Cell Histiocytosis in Paediatric Patients: A 30-Year Review","volume":"60","author":"Alexander","year":"2024","journal-title":"J. Paediatr. Child. Health"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.aace.2020.11.012","article-title":"A Case of Burnt-Out Langerhans Cell Histiocytosis Presenting as Postpartum Hypopituitarism","volume":"7","author":"Karri","year":"2021","journal-title":"AACE Clin. Case Rep."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1016\/S0140-6736(24)00342-8","article-title":"Hypopituitarism","volume":"403","author":"Fleseriu","year":"2024","journal-title":"Lancet"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1002\/ccr3.2521","article-title":"Neurosarcoidosis Manifesting as Panhypopituitarism","volume":"7","author":"Oye","year":"2019","journal-title":"Clin. Case Rep."},{"key":"ref_90","unstructured":"Feingold, K.R., Anawalt, B., Blackman, M.R., Boyce, A., Chrousos, G., Corpas, E., de Herder, W.W., Dhatariya, K., Dungan, K., and Hofland, J. (2000). Infections of the Hypothalamic-Pituitary Region. Endotext, MDText.com, Inc."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s13023-023-02788-1","article-title":"Pituitary Abscess: A Case Report and Systematic Review of 488 Cases","volume":"18","author":"Stringer","year":"2023","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s11102-021-01202-y","article-title":"Opioids and Pituitary Function: Expert Opinion","volume":"25","author":"Gadelha","year":"2022","journal-title":"Pituitary"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1210\/clinem\/dgae250","article-title":"European Society of Endocrinology and Endocrine Society Joint Clinical Guideline: Diagnosis and Therapy of Glucocorticoid-Induced Adrenal Insufficiency","volume":"109","author":"Beuschlein","year":"2024","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.beem.2009.08.003","article-title":"Drugs That Suppress TSH or Cause Central Hypothyroidism","volume":"23","author":"Haugen","year":"2009","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1528-1157.1989.tb05280.x","article-title":"Effects of Carbamazepine on Pituitary Responsiveness to Luteinizing Hormone-Releasing Hormone, Thyrotropin-Releasing Hormone, and Metoclopramide in Epileptic Patients","volume":"30","author":"Pakarinen","year":"1989","journal-title":"Epilepsia"},{"key":"ref_96","first-page":"747","article-title":"Chronic Glue Sniffing with Transient Central Hypothyroidism and Hypergonadotropism","volume":"66","author":"Chen","year":"2003","journal-title":"J. Chin. Med. Assoc."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1507\/endocrj.52.265","article-title":"Suppression of Thyrotropin by Morphine in a Severely Stressed Patient","volume":"52","author":"Ogrin","year":"2005","journal-title":"Endocr. J."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Urhan, E., and Karaca, Z. (2024). Diagnosis of Hypoprolactinemia. Rev. Endocr. Metab. Disord.","DOI":"10.1007\/s11154-024-09896-8"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1007\/s00210-023-02803-z","article-title":"Pharmacological Hyperprolactinemia: A Retrospective Analysis of 501 Hyperprolactinemia Cases in Primary Care Setting","volume":"397","author":"Rosillo","year":"2024","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1093\/qjmed\/hcq214","article-title":"Hypopituitarism Following Envenoming by Russell\u2019s Vipers (Daboia Siamensis and D. Russelii) Resembling Sheehan\u2019s Syndrome: First Case Report from Sri Lanka, a Review of the Literature and Recommendations for Endocrine Management","volume":"104","author":"Antonypillai","year":"2011","journal-title":"QJM"},{"key":"ref_101","unstructured":"Feingold, K.R., Anawalt, B., Blackman, M.R., Boyce, A., Chrousos, G., Corpas, E., de Herder, W.W., Dhatariya, K., Dungan, K., and Hofland, J. (2000). Snakebite Envenomation and Endocrine Dysfunction. Endotext, MDText.com, Inc."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/B978-0-12-820683-6.00005-1","article-title":"Septo-Optic Dysplasia","volume":"181","author":"Sataite","year":"2021","journal-title":"Handb. Clin. Neurol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"e23266","DOI":"10.1097\/MD.0000000000023266","article-title":"Pituitary Stalk Interruption Syndrome: A Rare Case Report and Literature Review","volume":"99","author":"Zhang","year":"2020","journal-title":"Medicine"},{"key":"ref_104","unstructured":"Feingold, K.R., Anawalt, B., Blackman, M.R., Boyce, A., Chrousos, G., Corpas, E., de Herder, W.W., Dhatariya, K., Dungan, K., and Hofland, J. (2000). Hypopituitarism. Endotext, MDText.com, Inc."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1055\/a-0822-3637","article-title":"Congenital Hypopituitarism: Various Genes, Various Phenotypes","volume":"51","author":"Xatzipsalti","year":"2019","journal-title":"Horm. Metab. Res."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"100881","DOI":"10.1016\/j.gim.2023.100881","article-title":"Identification of Genetic Variants and Phenotypic Characterization of a Large Cohort of Patients with Congenital Hypopituitarism and Related Disorders","volume":"25","author":"Gregory","year":"2023","journal-title":"Genet. Med."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"e220254","DOI":"10.20945\/2359-4292-2022-0254","article-title":"Genetic Diagnosis of Congenital Hypopituitarism in Turkish Patients by a Target Gene Panel: Novel Pathogenic Variants in GHRHR, GLI2, LHX4 and POU1F1 Genes","volume":"68","author":"Acar","year":"2023","journal-title":"Arch. Endocrinol. Metab."},{"key":"ref_108","unstructured":"Feingold, K.R., Anawalt, B., Blackman, M.R., Boyce, A., Chrousos, G., Corpas, E., de Herder, W.W., Dhatariya, K., Dungan, K., and Hofland, J. (2000). Genetic Etiology of Congenital Hypopituitarism. Endotext, MDText.com, Inc."},{"key":"ref_109","unstructured":"Sonne, J., and Lopez-Ojeda, W. (2024). Kallmann Syndrome. StatPearls, StatPearls Publishing."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/01658107.2023.2276187","article-title":"Septo-Optic Dysplasia: A Case Series of 33 Patients","volume":"48","author":"Nalawade","year":"2024","journal-title":"Neuroophthalmology"},{"key":"ref_111","first-page":"235","article-title":"Prader-Willi Syndrome: The More We Know, the Less We Know","volume":"121","author":"Whitman","year":"2024","journal-title":"Mo. Med."},{"key":"ref_112","unstructured":"(2024, August 06). Bardet-Biedl Syndrome: A Clinical Overview Focusing on Diagnosis, Outcomes and Best-Practice Management\u2014PubMed, Available online: https:\/\/pubmed.ncbi.nlm.nih.gov\/38383825\/."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.eprac.2021.09.011","article-title":"Secondary Adrenal Insufficiency: Recent Updates and New Directions for Diagnosis and Management","volume":"28","author":"Gruber","year":"2022","journal-title":"Endocr. Pract."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S2213-8587(14)70142-1","article-title":"Diagnosis and Management of Adrenal Insufficiency","volume":"3","author":"Bancos","year":"2015","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41572-021-00252-7","article-title":"Adrenal Insufficiency","volume":"7","author":"Hahner","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"3888","DOI":"10.1210\/jc.2016-2118","article-title":"Hormonal Replacement in Hypopituitarism in Adults: An Endocrine Society Clinical Practice Guideline","volume":"101","author":"Fleseriu","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_117","unstructured":"Feingold, K.R., Anawalt, B., Blackman, M.R., Boyce, A., Chrousos, G., Corpas, E., de Herder, W.W., Dhatariya, K., Dungan, K., and Hofland, J. (2000). Glucocorticoid Therapy and Adrenal Suppression. Endotext, MDText.com, Inc."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/nrendo.2017.47","article-title":"Central Hypothyroidism\u2014A Neglected Thyroid Disorder","volume":"13","author":"Rodari","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1159\/000491388","article-title":"2018 European Thyroid Association (ETA) Guidelines on the Diagnosis and Management of Central Hypothyroidism","volume":"7","author":"Persani","year":"2018","journal-title":"Eur. Thyroid J."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"81","DOI":"10.6061\/clinics\/2013(Sup01)09","article-title":"Hypogonadotropic Hypogonadism Revisited","volume":"68","author":"Fraietta","year":"2013","journal-title":"Clinics"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1210\/er.2018-00116","article-title":"Clinical Management of Congenital Hypogonadotropic Hypogonadism","volume":"40","author":"Young","year":"2019","journal-title":"Endocr. Rev."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.ecl.2024.01.008","article-title":"Hypogonadotropic Hypogonadism","volume":"53","author":"Fuqua","year":"2024","journal-title":"Endocrinol. Metab. Clin. N. Am."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S2213-8587(24)00199-2","article-title":"Male Hypogonadism: Pathogenesis, Diagnosis, and Management","volume":"12","author":"Papanikolaou","year":"2024","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.sxmr.2019.06.006","article-title":"Sex Hormone Binding Globulin: A Review of Its Interactions with Testosterone and Age, and Its Impact on Mortality in Men with Type 2 Diabetes","volume":"7","author":"Ramachandran","year":"2019","journal-title":"Sex. Med. Rev."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.1365-2265.1992.tb02347.x","article-title":"The Growth Hormone Deficiency Syndrome in Adults","volume":"37","author":"Cuneo","year":"1992","journal-title":"Clin. Endocrinol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1210\/edrv-16-1-63","article-title":"Clinical Aspects of Growth Hormone Deficiency in Adults","volume":"16","author":"Blok","year":"1995","journal-title":"Endocr. Rev."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1056\/NEJM198912283212605","article-title":"The Effects of Treatment with Recombinant Human Growth Hormone on Body Composition and Metabolism in Adults with Growth Hormone Deficiency","volume":"321","author":"Salomon","year":"1989","journal-title":"N. Engl. J. Med."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"239","DOI":"10.5114\/reum\/170244","article-title":"The Influence of Growth Hormone Deficiency on Bone Health and Metabolisms","volume":"61","author":"Wydra","year":"2023","journal-title":"Reumatologia"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1530\/eje.1.02179","article-title":"Determinants of Cardiovascular Risk in 2589 Hypopituitary GH-Deficient Adults\u2014A KIMS Database Analysis","volume":"155","author":"Abs","year":"2006","journal-title":"Eur. J. Endocrinol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1210\/jcem.87.5.8509","article-title":"Sensitivity and Specificity of Six Tests for the Diagnosis of Adult GH Deficiency","volume":"87","author":"Biller","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000502231","article-title":"Diagnosis, Genetics, and Therapy of Short Stature in Children: A Growth Hormone Research Society International Perspective","volume":"92","author":"Ambler","year":"2019","journal-title":"Horm. Res. Paediatr."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Karaca, Z., Unluhizarci, K., and Kelestimur, F. (2023). Hypoprolactinemia. Does It Matter? Redefining the Hypopituitarism and Return from a Mumpsimus: \u201cAbsence of Proof Is Not the Proof of Absence\u201d. Rev. Endocr. Metab. Disord.","DOI":"10.1007\/s11154-023-09847-9"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1530\/EJE-16-0105","article-title":"Cut-off Limits of the Peak GH Response to Stimulation Tests for the Diagnosis of GH Deficiency in Children and Adolescents: Study in Patients with Organic GHD","volume":"175","author":"Guzzetti","year":"2016","journal-title":"Eur. J. Endocrinol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"4712","DOI":"10.1210\/jc.2014-2830","article-title":"Overweight\/Obese Adults with Pituitary Disorders Require Lower Peak Growth Hormone Cutoff Values on Glucagon Stimulation Testing to Avoid Overdiagnosis of Growth Hormone Deficiency","volume":"99","author":"Dichtel","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Mele, C., Pigni, S., Caputo, M., Birtolo, M.F., Ciamparini, C., Mazziotti, G., Lania, A.G.A., Marzullo, P., Prodam, F., and Aimaretti, G. (2024). Could Low Prolactin Levels after Radiotherapy Predict the Onset of Hypopituitarism?. Rev. Endocr. Metab. Disord.","DOI":"10.1007\/s11154-024-09900-1"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/s41574-024-00985-x","article-title":"Arginine Vasopressin Deficiency: Diagnosis, Management and the Relevance of Oxytocin Deficiency","volume":"20","author":"Atila","year":"2024","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Newell-Price, J., Drummond, J.B., Gurnell, M., Levy, M., McCormack, A., Cooper, D., Wass, J., Christ-Crain, M., and Verbalis, J.G. (2024). Approach to the Patient with Suspected Hypotonic Polyuria. J. Clin. Endocrinol. Metab., dgae565.","DOI":"10.1210\/clinem\/dgae565"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1210\/jc.2014-4507","article-title":"Diagnostic Accuracy of Copeptin in the Differential Diagnosis of the Polyuria-Polydipsia Syndrome: A Prospective Multicenter Study","volume":"100","author":"Timper","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1056\/NEJMoa1803760","article-title":"A Copeptin-Based Approach in the Diagnosis of Diabetes Insipidus","volume":"379","author":"Fenske","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1056\/NEJMoa2306263","article-title":"Arginine or Hypertonic Saline-Stimulated Copeptin to Diagnose AVP Deficiency","volume":"389","author":"Refardt","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1007\/s12020-017-1332-3","article-title":"Hypopituitarism Is Associated with Lower Oxytocin Concentrations and Reduced Empathic Ability","volume":"57","author":"Daughters","year":"2017","journal-title":"Endocrine"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.1210\/jc.2018-02608","article-title":"Low Plasma Oxytocin Levels and Increased Psychopathology in Hypopituitary Men with Diabetes Insipidus","volume":"104","author":"Aulinas","year":"2019","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s11102-019-00936-0","article-title":"Oxytocin Alterations and Neurocognitive Domains in Patients with Hypopituitarism","volume":"22","author":"Eisenberg","year":"2019","journal-title":"Pituitary"},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Wei, J., Zheng, H., Li, G., Chen, Z., Fang, G., and Yan, J. (2023). Involvement of Oxytocin Receptor Deficiency in Psychiatric Disorders and Behavioral Abnormalities. Front. Cell Neurosci., 17.","DOI":"10.3389\/fncel.2023.1164796"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jpsychires.2023.12.032","article-title":"Decreased Oxytocin Plasma Levels and Oxytocin Receptor Expression Associated with Aggressive Behavior in Aggressive-Impulsive Disorders","volume":"170","author":"MacDowell","year":"2024","journal-title":"J. Psychiatr. Res."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/s41380-022-01719-z","article-title":"Advances in Human Oxytocin Measurement: Challenges and Proposed Solutions","volume":"28","author":"Tabak","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1530\/EJE-21-0346","article-title":"Oxytocin Levels in Response to Pituitary Provocation Tests in Healthy Volunteers","volume":"185","author":"Sailer","year":"2021","journal-title":"Eur. J. Endocrinol."},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Gnocchi, D., and Bruscalupi, G. (2017). Circadian Rhythms and Hormonal Homeostasis: Pathophysiological Implications. Biology, 6.","DOI":"10.3390\/biology6010010"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1530\/JME-13-0118","article-title":"Interactions between Endocrine and Circadian Systems","volume":"52","author":"Tsang","year":"2014","journal-title":"J. Mol. Endocrinol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"18","DOI":"10.4103\/2230-8210.77573","article-title":"Stress and Hormones","volume":"15","author":"Ranabir","year":"2011","journal-title":"Indian. J. Endocrinol. Metab."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0950-351X(87)80069-1","article-title":"Prolactin, Growth Hormone and Thyrotropin-Thyroid Hormone Secretion during Stress States in Man","volume":"1","author":"Delitala","year":"1987","journal-title":"Baillieres Clin. Endocrinol. Metab."},{"key":"ref_152","unstructured":"Melmed, S. (2022). Chapter 13\u2014Drugs and Pituitary Function. The Pituitary, Academic Press. [5th ed.]."},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Alvarez-Payares, J.C., Bello-Simanca, J.D., De La Pe\u00f1a-Arrieta, E.D.J., Agamez-Gomez, J.E., Garcia-Rueda, J.E., Rodriguez-Arrieta, A., and Rodriguez-Arrieta, L.A. (2021). Common Pitfalls in the Interpretation of Endocrine Tests. Front. Endocrinol., 12.","DOI":"10.3389\/fendo.2021.727628"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/bs.acc.2022.03.005","article-title":"Immunoassay Design and Biotin Interference","volume":"109","author":"Dasgupta","year":"2022","journal-title":"Adv. Clin. Chem."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S0140-6736(21)00136-7","article-title":"Adrenal Insufficiency","volume":"397","author":"Husebye","year":"2021","journal-title":"Lancet"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.cca.2020.01.029","article-title":"Adrenal Insufficiency: Physiology, Clinical Presentation and Diagnostic Challenges","volume":"505","author":"Dineen","year":"2020","journal-title":"Clin. Chim. Acta"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.1210\/jc.2014-2260","article-title":"Androgen Therapy in Women: A Reappraisal: An Endocrine Society Clinical Practice Guideline","volume":"99","author":"Wierman","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1080\/13543784.2024.2311207","article-title":"Novel Agents to Treat Adrenal Insufficiency: Findings of Preclinical and Early Clinical Trials","volume":"33","author":"Peel","year":"2024","journal-title":"Expert Opin. Investig. Drugs"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1089\/thy.2014.0028","article-title":"Guidelines for the Treatment of Hypothyroidism: Prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement","volume":"24","author":"Jonklaas","year":"2014","journal-title":"Thyroid"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"R231","DOI":"10.1530\/EJE-17-0947","article-title":"MANAGEMENT OF ENDOCRINE DISEASE: Pitfalls on the Replacement Therapy for Primary and Central Hypothyroidism in Adults","volume":"178","author":"Graf","year":"2018","journal-title":"Eur. J. Endocrinol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"4115","DOI":"10.1210\/jc.2007-0297","article-title":"Thyroid Hormone Replacement for Central Hypothyroidism: A Randomized Controlled Trial Comparing Two Doses of Thyroxine (T4) with a Combination of T4 and Triiodothyronine","volume":"92","author":"Slawik","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1111\/j.1365-2265.2011.04037.x","article-title":"Treatment of Central Hypothyroidism","volume":"74","year":"2011","journal-title":"Clin. Endocrinol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"550","DOI":"10.4158\/EP.14.5.550","article-title":"Optimal Free Thyroxine Levels for Thyroid Hormone Replacement in Hypothyroidism","volume":"14","author":"Iverson","year":"2008","journal-title":"Endocr. Pract."},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Ide, V., Vanderschueren, D., and Antonio, L. (2020). Treatment of Men with Central Hypogonadism: Alternatives for Testosterone Replacement Therapy. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22010021"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1177\/00912700022009486","article-title":"Modeling of Circadian Testosterone in Healthy Men and Hypogonadal Men","volume":"40","author":"Gupta","year":"2000","journal-title":"J. Clin. Pharmacol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1365-2265.2006.02696.x","article-title":"A Diurnal Variation in Testicular Hormone Production Is Maintained Following Gonadotrophin Suppression in Normal Men","volume":"66","author":"Walton","year":"2007","journal-title":"Clin. Endocrinol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ucl.2021.12.008","article-title":"Medical Treatment of Hypogonadism in Men","volume":"49","author":"Mani","year":"2022","journal-title":"Urol. Clin. N. Am."},{"key":"ref_168","first-page":"543","article-title":"Testosterone Replacement Therapy for Male Hypogonadism","volume":"109","author":"Heidelbaugh","year":"2024","journal-title":"Am. Fam. Physician"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"133","DOI":"10.17925\/EE.2022.18.2.133","article-title":"Testosterone Replacement Therapy: A Narrative Review with a Focus on New Oral Formulations","volume":"18","author":"Bhat","year":"2022","journal-title":"touchREV Endocrinol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/cen.14633","article-title":"Society for Endocrinology Guidelines for Testosterone Replacement Therapy in Male Hypogonadism","volume":"96","author":"Jayasena","year":"2022","journal-title":"Clin. Endocrinol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.2174\/1381612826666200523175806","article-title":"Gonadotropin Treatment for the Male Hypogonadotropic Hypogonadism","volume":"27","author":"Boeri","year":"2021","journal-title":"Curr. Pharm. Des."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0015-0282(16)54476-8","article-title":"Pharmacodynamics and Pharmacokinetics after Subcutaneous and Intramuscular Injection of Human Chorionic Gonadotropin","volume":"56","author":"Saal","year":"1991","journal-title":"Fertil. Steril."},{"key":"ref_173","first-page":"572","article-title":"Hypogonadism in Male and Female: Which Is the Best Treatment?","volume":"73","author":"Bertelli","year":"2021","journal-title":"Minerva Pediatr."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.fertnstert.2008.07.1720","article-title":"A Combined Analysis of Data to Identify Predictive Factors for Spermatogenesis in Men with Hypogonadotropic Hypogonadism Treated with Recombinant Human Follicle-Stimulating Hormone and Human Chorionic Gonadotropin","volume":"92","author":"Warne","year":"2009","journal-title":"Fertil. Steril."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"680","DOI":"10.4103\/1008-682X.193568","article-title":"Pulsatile Gonadotropin-Releasing Hormone Therapy Is Associated with Earlier Spermatogenesis Compared to Combined Gonadotropin Therapy in Patients with Congenital Hypogonadotropic Hypogonadism","volume":"19","author":"Mao","year":"2017","journal-title":"Asian J. Androl."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"e230101","DOI":"10.20945\/2359-4292-2023-0101","article-title":"Pulsatile Gonadotropin Releasing Hormone Therapy for Spermatogenesis in Congenital Hypogonadotropic Hypogonadism Patients Who Had Poor Response to Combined Gonadotropin Therapy","volume":"68","author":"Huang","year":"2024","journal-title":"Arch. Endocrinol. Metab."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1080\/14647273.2021.1998929","article-title":"Management of Congenital Hypogonadotropic Hypogonadism in Females","volume":"26","author":"Naseem","year":"2023","journal-title":"Hum. Fertil."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/humupd\/dmy039","article-title":"The Route of Administration, Timing, Duration and Dose of Postmenopausal Hormone Therapy and Cardiovascular Outcomes in Women: A Systematic Review","volume":"25","author":"Glisic","year":"2019","journal-title":"Hum. Reprod. Update"},{"key":"ref_179","doi-asserted-by":"crossref","unstructured":"Jayasena, C.N., Devine, K., Barber, K., Comninos, A.N., Conway, G.S., Crown, A., Davies, M.C., Ewart, A., Seal, L.J., and Smyth, A. (2024). Society for Endocrinology Guideline for Understanding, Diagnosing and Treating Female Hypogonadism. Clin. Endocrinol.","DOI":"10.1111\/cen.15097"},{"key":"ref_180","first-page":"464","article-title":"A Switch from Oral (2 Mg\/Day) to Transdermal (50 Microg\/Day) 17beta-Estradiol Therapy Increases Serum Insulin-like Growth Factor-I Levels in Recombinant Human Growth Hormone (GH)-Substituted Women with GH Deficiency","volume":"85","author":"Janssen","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"dgz112","DOI":"10.1210\/clinem\/dgz112","article-title":"Fertility and Pregnancy in Women with Hypopituitarism: A Systematic Literature Review","volume":"105","author":"Vila","year":"2020","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"Daya, S., and Gunby, J. (2000). Recombinant versus Urinary Follicle Stimulating Hormone for Ovarian Stimulation in Assisted Reproduction Cycles. Cochrane Database Syst. Rev., CD002810.","DOI":"10.1002\/14651858.CD002810"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/S0015-0282(99)00519-1","article-title":"Follicle-Stimulating Hormone or Human Menopausal Gonadotropin for Ovarian Stimulation in in Vitro Fertilization Cycles: A Meta-Analysis","volume":"73","author":"Agrawal","year":"2000","journal-title":"Fertil. Steril."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0015-0282(16)57734-6","article-title":"Follicle-Stimulating Hormone versus Human Menopausal Gonadotropin for in Vitro Fertilization Cycles: A Meta-Analysis","volume":"64","author":"Daya","year":"1995","journal-title":"Fertil. Steril."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/ijgo.15602","article-title":"Comparison of Stimulation Protocols for Dose Determination of Gonadotropins: A Systematic Review and Bayesian Network Meta-Analysis Based on Randomized Controlled Trials","volume":"167","author":"Peng","year":"2024","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/S0015-0282(00)01619-8","article-title":"Successful Pregnancy and Birth after Sequential Cotreatment with Growth Hormone and Gonadotropins in a Woman with Panhypopituitarism: A New Treatment Protocol","volume":"74","author":"Salle","year":"2000","journal-title":"Fertil. Steril."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1080\/09513590601137533","article-title":"Ovulation Induction in a Poor Responder with Panhypopituitarism: A Case Report and Review of the Literature","volume":"23","author":"Park","year":"2007","journal-title":"Gynecol. Endocrinol."},{"key":"ref_188","first-page":"356429","article-title":"Adjuvant Growth Hormone for Ovulation Induction with Gonadotropins in the Treatment of a Woman with Hypopituitarism","volume":"2012","author":"Daniel","year":"2012","journal-title":"Case Rep. Endocrinol."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.fertnstert.2007.12.077","article-title":"How to Improve the Probability of Pregnancy in Poor Responders Undergoing in Vitro Fertilization: A Systematic Review and Meta-Analysis","volume":"91","author":"Kyrou","year":"2009","journal-title":"Fertil. Steril."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.fertnstert.2011.09.049","article-title":"The Value of Growth Hormone Supplements in ART for Poor Ovarian Responders","volume":"96","author":"Streuli","year":"2011","journal-title":"Fertil. Steril."},{"key":"ref_191","first-page":"CD000099","article-title":"Growth Hormone for in Vitro Fertilization","volume":"2010","author":"Duffy","year":"2010","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_192","first-page":"125","article-title":"Comparison of Exogenous Gonadotropins and Pulsatile Gonadotropin-Releasing Hormone for Induction of Ovulation in Hypogonadotropic Amenorrhea","volume":"77","author":"Martin","year":"1993","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/humrep\/8.suppl_2.193","article-title":"Pulsatile Intravenous Gonadotrophin Releasing Hormone for Ovulation Induction: Determinants of Follicular and Luteal Phase Responses","volume":"8","author":"Jansen","year":"1993","journal-title":"Hum. Reprod."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1093\/humrep\/8.suppl_2.184","article-title":"Pulsatile Administration of Gonadotrophin Releasing Hormone and Oral Administration of Naltrexone in Hypothalamic Amenorrhoea","volume":"8","author":"Leyendecker","year":"1993","journal-title":"Hum. Reprod."},{"key":"ref_195","first-page":"1215","article-title":"Treatment of Anovulation with Pulsatile Gonadotropin-Releasing Hormone: Prognostic Factors and Clinical Results in 600 Cycles","volume":"79","author":"Filicori","year":"1994","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1056\/NEJMra1817346","article-title":"Pathogenesis and Diagnosis of Growth Hormone Deficiency in Adults","volume":"380","author":"Melmed","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_197","doi-asserted-by":"crossref","unstructured":"Iglesias, P. (2024). Clinical Management of Postoperative Growth Hormone Deficiency in Hypothalamic-Pituitary Tumors. J. Clin. Med., 13.","DOI":"10.3390\/jcm13154307"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1159\/000452150","article-title":"Guidelines for Growth Hormone and Insulin-Like Growth Factor-I Treatment in Children and Adolescents: Growth Hormone Deficiency, Idiopathic Short Stature, and Primary Insulin-Like Growth Factor-I Deficiency","volume":"86","author":"Grimberg","year":"2016","journal-title":"Horm. Res. Paediatr."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1210\/jc.2012-4012","article-title":"Idiopathic Adult Growth Hormone Deficiency","volume":"98","author":"Melmed","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"106805","DOI":"10.1016\/j.phrs.2023.106805","article-title":"Efficacy, Safety, Quality of Life, Adherence and Cost-Effectiveness of Long-Acting Growth Hormone Replacement Therapy Compared to Daily Growth Hormone in Children with Growth Hormone Deficiency: A Systematic Review and Meta-Analysis","volume":"193","author":"Mameli","year":"2023","journal-title":"Pharmacol. Res."},{"key":"ref_201","doi-asserted-by":"crossref","unstructured":"Zhu, J., Yuan, K., Rana, S., Jakki, S.L., Bhat, A.S., Liang, L., and Wang, C. (2024). Long-Acting Growth Hormone in the Treatment of Growth Hormone Deficiency in Children: A Systematic Literature Review and Network Meta-Analysis. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-58616-4"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"101788","DOI":"10.1016\/j.beem.2023.101788","article-title":"Comparing Treatment with Daily and Long-Acting Growth Hormone Formulations in Adults with Growth Hormone Deficiency: Challenging Issues, Benefits, and Risks","volume":"37","year":"2023","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1159\/000523791","article-title":"Long-Acting Growth Hormone Preparations and Their Use in Children with Growth Hormone Deficiency","volume":"96","author":"Pampanini","year":"2023","journal-title":"Horm. Res. Paediatr."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2337\/dc11-0449","article-title":"Incidence of Diabetes Mellitus and Evolution of Glucose Parameters in Growth Hormone-Deficient Subjects during Growth Hormone Replacement Therapy: A Long-Term Observational Study","volume":"35","author":"Luger","year":"2012","journal-title":"Diabetes Care"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1210\/clinem\/dgac381","article-title":"Diagnosis and Management of Central Diabetes Insipidus in Adults","volume":"107","author":"Tomkins","year":"2022","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"104093","DOI":"10.1016\/j.lpm.2021.104093","article-title":"Diabetes Insipidus","volume":"50","author":"Gaisl","year":"2021","journal-title":"Presse Med."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s12020-011-9492-z","article-title":"Desmopressin Duration of Antidiuretic Action in Patients with Central Diabetes Insipidus","volume":"40","author":"Juul","year":"2011","journal-title":"Endocrine"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1210\/endo-95-1-140","article-title":"Structural Changes in the Arginine Vasopressin Molecule That Prolong Its Antidiuretic Action","volume":"95","author":"Sawyer","year":"1974","journal-title":"Endocrinology"},{"key":"ref_209","first-page":"259","article-title":"Individual Differences in the Antidiuretic Response Induced by Single Doses of 1-Deamino-8-D-Arginine-Vasopressin (DDAVP) in Patients with Pituitary Diabetes Insipidus","volume":"14","author":"Marosi","year":"1976","journal-title":"Int. J. Clin. Pharmacol. Biopharm."},{"key":"ref_210","first-page":"e937557","article-title":"Use and Effects of Augmentation of Labor with Oxytocin: A Single-Center, Retrospective, Case-Control Study of 4350 Women in Warsaw, Poland, 2015\u20132020","volume":"28","author":"Rychlewicz","year":"2022","journal-title":"Med. Sci. Monit."},{"key":"ref_211","first-page":"CD009332","article-title":"Intravenous versus Intramuscular Prophylactic Oxytocin for the Third Stage of Labour","volume":"11","author":"Oladapo","year":"2020","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s11102-012-0428-2","article-title":"Mortality and Morbidity in Adult Craniopharyngioma","volume":"16","author":"Erfurth","year":"2013","journal-title":"Pituitary"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1469-8749.2004.tb00476.x","article-title":"Outcome of Craniopharyngioma in Children: Long-Term Complications and Quality of Life","volume":"46","author":"Poretti","year":"2004","journal-title":"Dev. Med. Child. Neurol."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"e32112","DOI":"10.1016\/j.heliyon.2024.e32112","article-title":"Craniopharyngioma: A Comprehensive Review of the Clinical Presentation, Radiological Findings, Management, and Future Perspective","volume":"10","author":"Alboqami","year":"2024","journal-title":"Heliyon"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/cen.13909","article-title":"Oxytocin Therapy in Hypopituitarism: Challenges and Opportunities","volume":"90","author":"Bhargava","year":"2019","journal-title":"Clin. Endocrinol."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1159\/000530701","article-title":"Glucocorticoids and Water Balance: Implications for Hyponatremia Management and Pituitary Surgery","volume":"113","author":"Goldschlager","year":"2023","journal-title":"Neuroendocrinology"},{"key":"ref_217","first-page":"R635","article-title":"Glucocorticoid Inhibition of Neurohypophysial Vasopressin Secretion","volume":"252","author":"Raff","year":"1987","journal-title":"Am. J. Physiol."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"bcr2014206390","DOI":"10.1136\/bcr-2014-206390","article-title":"Neurosarcoidosis-Associated Central Diabetes Insipidus Masked by Adrenal Insufficiency","volume":"2015","author":"Non","year":"2015","journal-title":"BMJ Case Rep."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"e22939","DOI":"10.1097\/MD.0000000000022939","article-title":"Central Diabetes Insipidus Unveiled by Glucocorticoid Therapy in a Patient with an Empty Sella: A Case Report and Literature Review","volume":"99","author":"Yang","year":"2020","journal-title":"Medicine"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1136\/bmj.292.6529.1185","article-title":"Acute Adrenal Crisis Precipitated by Thyroxine","volume":"292","author":"Fonseca","year":"1986","journal-title":"Br. Med. J. (Clin. Res. Ed.)"},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1111\/j.1651-2227.2004.tb00860.x","article-title":"Thyroxine Unmasks Addison\u2019s Disease","volume":"93","author":"Shaikh","year":"2004","journal-title":"Acta Paediatr."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1097\/gme.0b013e31803867a","article-title":"A Randomized, Open-Label, Crossover Study Comparing the Effects of Oral versus Transdermal Estrogen Therapy on Serum Androgens, Thyroid Hormones, and Adrenal Hormones in Naturally Menopausal Women","volume":"14","author":"Shifren","year":"2007","journal-title":"Menopause"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1089\/105072504323024561","article-title":"Interaction of Estrogen Therapy and Thyroid Hormone Replacement in Postmenopausal Women","volume":"14","author":"Mazer","year":"2004","journal-title":"Thyroid"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"E1191","DOI":"10.1152\/ajpendo.2001.281.6.E1191","article-title":"Oral Estrogen Antagonizes the Metabolic Actions of Growth Hormone in Growth Hormone-Deficient Women","volume":"281","author":"Wolthers","year":"2001","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1530\/EJE-07-0412","article-title":"Administration Route-Dependent Effects of Estrogens on IGF-I Levels during Fixed GH Replacement in Women with Hypopituitarism","volume":"157","author":"Biermasz","year":"2007","journal-title":"Eur. J. Endocrinol."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.beem.2017.03.003","article-title":"Sex Steroids and the GH Axis: Implications for the Management of Hypopituitarism","volume":"31","author":"Birzniece","year":"2017","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_227","doi-asserted-by":"crossref","unstructured":"Spaziani, M., Tarantino, C., Tahani, N., Gianfrilli, D., Sbardella, E., Isidori, A.M., Lenzi, A., and Radicioni, A.F. (2021). Clinical, Diagnostic, and Therapeutic Aspects of Growth Hormone Deficiency During the Transition Period: Review of the Literature. Front. Endocrinol., 12.","DOI":"10.3389\/fendo.2021.634288"},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1089\/neu.2022.0384","article-title":"Growth Hormone Deficiency Following Traumatic Brain Injury in Pediatric and Adolescent Patients: Presentation, Treatment, and Challenges of Transitioning from Pediatric to Adult Services","volume":"40","author":"Wexler","year":"2023","journal-title":"J. Neurotrauma"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.4158\/GL-2019-0405","article-title":"American Association of Clinical Endocrinologists and American College of Endocrinology guidelines for management of growth hormone deficiency in adults and patients transitioning from pediatric to adult care","volume":"25","author":"Yuen","year":"2019","journal-title":"Endocr. Pract."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"101316","DOI":"10.1016\/j.ghir.2020.101316","article-title":"Treatment of the Adult Growth Hormone Deficiency Syndrome with Growth Hormone: What Are the Implications for Other Hormone Replacement Therapies for Hypopituitarism?","volume":"52","author":"Fierro","year":"2020","journal-title":"Growth Horm. IGF Res."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"5397","DOI":"10.1210\/jc.2004-1114","article-title":"Effect of Recombinant Human Growth Hormone (GH) Replacement on the Hypothalamic-Pituitary-Adrenal Axis in Adult GH-Deficient Patients","volume":"89","author":"Giavoli","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s12020-017-1495-y","article-title":"Effects of Growth Hormone on Thyroid Function Are Mediated by Type 2 Iodothyronine Deiodinase in Humans","volume":"59","author":"Yamauchi","year":"2018","journal-title":"Endocrine"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1089\/thy.2008.0266","article-title":"Long-Term Effects of Growth Hormone Replacement Therapy on Thyroid Function in Adults with Growth Hormone Deficiency","volume":"18","author":"Losa","year":"2008","journal-title":"Thyroid"},{"key":"ref_234","doi-asserted-by":"crossref","unstructured":"Witkowska-S\u0119dek, E., Kucharska, A.M., Rumi\u0144ska, M., Paluchowska, M., and Pyr\u017cak, B. (2021). Decreased Thyroxine Levels during rhGH Therapy in Children with Growth Hormone Deficiency. J. Clin. Med., 10.","DOI":"10.3390\/jcm10215100"},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1365-2265.2009.03612.x","article-title":"Occurrence of Impaired Fasting Glucose in GH-Deficient Adults Receiving GH Replacement Compared with Untreated Subjects","volume":"72","author":"Woodmansee","year":"2010","journal-title":"Clin. Endocrinol."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/cen.13256","article-title":"The Effect of Growth Hormone (GH) Replacement on Blood Glucose Homeostasis in Adult Nondiabetic Patients with GH Deficiency: Real-Life Data from the NordiNet\u00ae International Outcome Study","volume":"86","author":"Weber","year":"2017","journal-title":"Clin. 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