{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T06:44:38Z","timestamp":1787985878906,"version":"build-2784847793"},"reference-count":129,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T00:00:00Z","timestamp":1729296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Federico II University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The interventional treatment of coronary artery disease (CAD) has undergone significant improvements thanks to technological innovations. Nowadays, percutaneous coronary intervention (PCI) with drug-eluting stent (DES) implantation is the standard of care for the treatment of CAD. Nevertheless, the non-negligible incidence of in-stent restenosis (ISR) and suboptimal results in various anatomical settings has led to the development of drug-coated balloons (DCBs). DCBs are catheter-based balloons whose surface is coated with an anti-proliferative drug (mainly Paclitaxel or Sirolimus) loaded onto the balloon surface with different technologies and dose concentrations. In the beginning, these devices were used for the treatment of ISR showing an excellent efficacy profile in the inhibition of intimal hyperplasia. Subsequently, several studies evaluated their use in other angiographical and clinical contexts such as de novo lesions, small vessel disease, diffuse coronary disease, bifurcation lesions, acute coronary syndromes, high-bleeding risk and diabetic patients. This comprehensive review aims to describe the main DCB platforms on the market, their fields of application with the main supporting studies and their future perspectives.<\/jats:p>","DOI":"10.3390\/jcm13206243","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T10:49:22Z","timestamp":1729507762000},"page":"6243","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Contemporary Use of Drug-Coated Balloons for Coronary Angioplasty: A Comprehensive Review"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9951-679X","authenticated-orcid":false,"given":"Nicola","family":"Verde","sequence":"first","affiliation":[{"name":"Division of Cardiology, Catheterization Laboratory, Montevergine Clinic, 83013 Mercogliano, Italy"},{"name":"Department of Advanced Biomedical Sciences, Federico II University, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Ciliberti","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Catheterization Laboratory, Montevergine Clinic, 83013 Mercogliano, Italy"},{"name":"Institute of Cardiology, Fondazione Policlinico Universitario A. Gemelli IRCSS, Catholic University of Sacred Heart, 00136 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Pittorino","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Catheterization Laboratory, Montevergine Clinic, 83013 Mercogliano, Italy"},{"name":"Department of Clinical and Molecular Medicine, Sapienza University of Rome, Cardiology Division, Sant\u2019Andrea University Hospital, 00189 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Ferrone","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Catheterization Laboratory, Montevergine Clinic, 83013 Mercogliano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Franzese","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Catheterization Laboratory, Montevergine Clinic, 83013 Mercogliano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Russo","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Catheterization Laboratory, Montevergine Clinic, 83013 Mercogliano, Italy"},{"name":"Division of Cardiology, Department of Systems Medicine, Tor Vergata University, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4324-4227","authenticated-orcid":false,"given":"Angelo","family":"Cioppa","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Catheterization Laboratory, Montevergine Clinic, 83013 Mercogliano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grigore","family":"Popusoi","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Catheterization Laboratory, Montevergine Clinic, 83013 Mercogliano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1238-4489","authenticated-orcid":false,"given":"Luigi","family":"Salemme","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Catheterization Laboratory, Montevergine Clinic, 83013 Mercogliano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9118-4612","authenticated-orcid":false,"given":"Tullio","family":"Tesorio","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Catheterization Laboratory, Montevergine Clinic, 83013 Mercogliano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3297-8399","authenticated-orcid":false,"given":"Giuseppe","family":"Di Gioia","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Catheterization Laboratory, Montevergine Clinic, 83013 Mercogliano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1056\/NEJM197907123010201","article-title":"Nonoperative dilatation of coronary-artery stenosis: Percutaneous transluminal coronary angioplasty","volume":"301","author":"Senning","year":"1979","journal-title":"N. 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