{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:46:35Z","timestamp":1792737995893,"version":"4.5.0"},"reference-count":29,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T00:00:00Z","timestamp":1729468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Enhanced recovery after surgery (ERAS) protocols optimize perioperative care and improve recovery. This study evaluated the effectiveness of ERAS in one- or two-level posterior lumbar fusion surgeries, focusing on perioperative medication use, pain management, and functional outcomes. Methods: Eighty-eight patients undergoing lumbar fusion surgery between March 2021 and February 2022 were allocated into pre-ERAS (n = 41) and post-ERAS (n = 47) groups. Outcomes included opioid and antiemetic consumption, pain scores (numerical rating scale (NRS)), functional recovery (Oswestry Disability Index (ODI) and EuroQol 5 Dimension (EQ-5D)), and complication rates. Pain was assessed daily for the first four postoperative days and at 6 months. Linear Mixed Effects Model analysis evaluated pain trajectories. Results: The post-ERAS group showed significantly lower opioid (p = 0.005) and antiemetic (p &lt; 0.001) use. No significant differences were observed in NRS pain scores in the first 4 postoperative days. At 6 months, the post-ERAS group reported significantly lower leg pain (p = 0.002). The time:group interaction was not significant for back (p = 0.848) or leg (p = 0.503) pain. Functional outcomes at 6 months, particularly ODI and EQ-5D scores, showed significant improvement in the post-ERAS group. Complication rates were lower in the post-ERAS group (4.3% vs. 19.5%, p = 0.024), while hospital stay and fusion rates remained similar. Conclusions: The ERAS protocol significantly reduced opioid and antiemetic use, improved long-term pain management and functional recovery, and lowered complication rates in lumbar fusion patients. These findings support the implementation of ERAS protocols in spinal surgery, emphasizing their role in enhancing postoperative care.<\/jats:p>","DOI":"10.3390\/jcm13206285","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T10:49:22Z","timestamp":1729507762000},"page":"6285","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Enhanced Recovery After Surgery Protocols in One- or Two-Level Posterior Lumbar Fusion: Improving Postoperative Outcomes"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0728-5198","authenticated-orcid":false,"given":"Ji Uk","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, Asan Medical Center, University of Ulsan College of Medicine 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4144-4535","authenticated-orcid":false,"given":"Tae-Hong","family":"Kee","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Asan Medical Center, University of Ulsan College of Medicine 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Asan Medical Center, University of Ulsan College of Medicine 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Ju","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Asan Medical Center, University of Ulsan College of Medicine 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sehan","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Asan Medical Center, University of Ulsan College of Medicine 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1178-9778","authenticated-orcid":false,"given":"Jae Hwan","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Asan Medical Center, University of Ulsan College of Medicine 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1093\/bja\/78.5.606","article-title":"Multimodal approach to control postoperative pathophysiology and rehabilitation","volume":"78","author":"Kehlet","year":"1997","journal-title":"Br. J. Anaesth."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.spinee.2021.01.001","article-title":"Consensus statement for perioperative care in lumbar spinal fusion: Enhanced Recovery After Surgery (ERAS(R)) Society recommendations","volume":"21","author":"Debono","year":"2021","journal-title":"Spine J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1001\/jamasurg.2016.4952","article-title":"Enhanced Recovery After Surgery: A Review","volume":"152","author":"Ljungqvist","year":"2017","journal-title":"JAMA Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.spinee.2021.01.003","article-title":"Enhanced recovery pathway in adult patients undergoing thoracolumbar deformity surgery","volume":"21","author":"Kim","year":"2021","journal-title":"Spine J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/j.spinee.2022.04.007","article-title":"Enhanced recovery after surgery (ERAS) improves return of physiological function in frail patients undergoing one- to two-level TLIFs: An observational retrospective cohort study","volume":"22","author":"Porche","year":"2022","journal-title":"Spine J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.jocn.2015.01.003","article-title":"Best evidence in multimodal pain management in spine surgery and means of assessing postoperative pain and functional outcomes","volume":"22","author":"Devin","year":"2015","journal-title":"J. Clin. Neurosci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1097\/ALN.0b013e31828866b3","article-title":"Pain intensity on the first day after surgery: A prospective cohort study comparing 179 surgical procedures","volume":"118","author":"Gerbershagen","year":"2013","journal-title":"Anesthesiology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jspd.2013.12.002","article-title":"The Seattle Spine Team Approach to Adult Deformity Surgery: A Systems-Based Approach to Perioperative Care and Subsequent Reduction in Perioperative Complication Rates","volume":"2","author":"Sethi","year":"2014","journal-title":"Spine Deform."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/s12630-014-0264-0","article-title":"Physiologic considerations of Enhanced Recovery After Surgery (ERAS) programs: Implications of the stress response","volume":"62","author":"Carli","year":"2015","journal-title":"Can. J. Anaesth."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1097\/IGC.0000000000001198","article-title":"The Impact of an Enhanced Recovery After Surgery Program on Patients Treated for Gynecologic Cancer in the Community Hospital Setting","volume":"28","author":"Mendivil","year":"2018","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.surg.2010.11.003","article-title":"Enhanced recovery pathways optimize health outcomes and resource utilization: A meta-analysis of randomized controlled trials in colorectal surgery","volume":"149","author":"Adamina","year":"2011","journal-title":"Surgery"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.bpa.2015.11.001","article-title":"Enhanced recovery after surgery (ERAS) and its applicability for major spine surgery","volume":"30","author":"Wainwright","year":"2016","journal-title":"Best. Pract. Res. Clin. Anaesthesiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.31616\/asj.2022.0435","article-title":"Lumbar Interbody Fusion and Osteobiologics for Lumbar Fusion","volume":"16","author":"Kim","year":"2022","journal-title":"Asian Spine J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"807","DOI":"10.31616\/asj.2022.0448","article-title":"Comparative Outcome Data Using Different Techniques for Posterior Lumbar Fusion: A Large Single-Center Study","volume":"17","author":"Lewis","year":"2023","journal-title":"Asian Spine J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s11916-017-0611-2","article-title":"Concept of the Ambulatory Pain Physician","volume":"21","author":"Thomas","year":"2017","journal-title":"Curr. Pain. Headache Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.spinee.2011.04.029","article-title":"Fusion rates of a morselized local bone graft in polyetheretherketone cages in posterior lumbar interbody fusion by quantitative analysis using consecutive three-dimensional computed tomography scans","volume":"11","author":"Lee","year":"2011","journal-title":"Spine J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1213\/ANE.0000000000003746","article-title":"Enhanced Recovery Pathways: Looking into the Future","volume":"128","author":"Joshi","year":"2019","journal-title":"Anesth. Analg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1213\/ANE.0000000000000002","article-title":"Consensus guidelines for the management of postoperative nausea and vomiting","volume":"118","author":"Gan","year":"2014","journal-title":"Anesth. Analg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1097\/ACO.0000000000001063","article-title":"Management of postoperative nausea and vomiting in adults: Current controversies","volume":"34","author":"Rajan","year":"2021","journal-title":"Curr. Opin. Anaesthesiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1213\/ANE.0000000000002433","article-title":"An Evidence-Based Approach to the Prescription Opioid Epidemic in Orthopedic Surgery","volume":"125","author":"Soffin","year":"2017","journal-title":"Anesth. Analg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1097\/AJP.0000000000000170","article-title":"The Relationship of Pain and Nausea in Postoperative Patients for 1 Week After Ambulatory Surgery","volume":"31","author":"Rayens","year":"2015","journal-title":"Clin. J. Pain."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"52","DOI":"10.2174\/1874434601105010052","article-title":"Patients\u2019 experiences of pain following day surgery\u2014At 48 hours, seven days, and three months","volume":"5","author":"Bergh","year":"2011","journal-title":"Open Nurs. J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.2146\/ajhp140179","article-title":"Effect of i.v. acetaminophen on total hip or knee replacement surgery: A case-matched evaluation of a national patient database","volume":"72","author":"Apfel","year":"2015","journal-title":"Am. J. Health Syst. Pharm."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"American Society of Anesthesiologists Task Force on Acute Pain Management (2012). Practice guidelines for acute pain management in the perioperative setting: An updated report by the American Society of Anesthesiologists Task Force on Acute Pain Management. Anesthesiology, 116, 248\u2013273.","DOI":"10.1097\/ALN.0b013e31823c1030"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"632","DOI":"10.31616\/asj.2022.0358","article-title":"Perioperative Intravenous Nefopam on Pain Management and Ambulation after Open Spine Surgery: A Randomized Double-Blind Controlled Study","volume":"17","author":"Chalermkitpanit","year":"2023","journal-title":"Asian Spine J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"161","DOI":"10.4097\/kjae.2007.52.2.161","article-title":"A Clinical Study to Evaluate the Safety and Efficacy of a Patient-Controlled Analgesia Pump in Post-Surgical Patients","volume":"52","author":"Jeong","year":"2007","journal-title":"Korean J. Anesthesiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e34345","DOI":"10.1097\/MD.0000000000034345","article-title":"Differences in postoperative knee joint function and prognostic quality of life in patients undergoing posterior cruciate ligament reconstruction at different surgical timing under enhanced recovery after surgery","volume":"102","author":"Jin","year":"2023","journal-title":"Medicine"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Burgess, L.C., and Wainwright, T.W. (2019). What Is the Evidence for Early Mobilisation in Elective Spine Surgery? A Narrative Review. Healthcare, 7.","DOI":"10.3390\/healthcare7030092"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"S66","DOI":"10.4103\/2152-7806.130674","article-title":"A review article on the benefits of early mobilization following spinal surgery and other medical\/surgical procedures","volume":"5","author":"Epstein","year":"2014","journal-title":"Surg. Neurol. 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